外周血中性粒细胞-淋巴细胞比值、血小板-淋巴细胞比值在妇科肿瘤中的研究进展
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摘要
近年来炎症在肿瘤发生发展中的作用研究已日益成为热点,并且取得了很多成果。中性粒细胞-淋巴细胞比值(NLR)、血小板-淋巴细胞比值(PLR)是研究较多的两种生物学指标,在多种肿瘤研究中发现NLR、PLR与肿瘤临床病理特征存在关系,并可评估病人预后。该文现就NLR、PLR在肿瘤中的作用以及在妇科恶性肿瘤中的最新进展进行综述。
In recent years,the role of inflammation in the development of tumors has increasingly becoming a hot spot,and many achievements have been made.Neutrophil-lymphocyte ratio(NLR) and platelet-lymphocyte ratio(PLR) as two kinds of biological indicators are more often researched in a wide variety of tumor study.The relationship of the two kinds of biological indicators and clinical-pathological features of tumors has been found in a variety of cancer research,and people found it can also assess the prognosis of patients.This article reviews the role of NLR,PLR in tumors,and summarizes the latest progress in gynecologic malignant tumor.
In recent years,the role of inflammation in the development of tumors has increasingly becoming a hot spot,and many achievements have been made.Neutrophil-lymphocyte ratio(NLR) and platelet-lymphocyte ratio(PLR) as two kinds of biological indicators are more often researched in a wide variety of tumor study.The relationship of the two kinds of biological indicators and clinical-pathological features of tumors has been found in a variety of cancer research,and people found it can also assess the prognosis of patients.This article reviews the role of NLR,PLR in tumors,and summarizes the latest progress in gynecologic malignant tumor.
引文
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[13] 杨军文,吴玲玲,倪观太.中性粒细胞与淋巴细胞比值在宫颈癌根治术预后评估中的价值[J].实用医学杂志,2015,31(16):2662-2665.
[14] 周文毓,张建平.ⅠB2～ⅡB期宫颈癌新辅助化疗治疗前中性粒细胞与淋巴细胞比值对疗效及预后预测意义[J].临床军医杂志,2016(2):119-123.
[15] 李文婷,田男,古丽娜·库尔班.中性粒细胞与淋巴细胞比值对宫颈癌放疗及同步放化疗疗效及预后的影响[J].实用医学杂志,2015,31(22):3697-3700.
[16] WANG L,JIA J,LIN L,et al.Predictive value of hematological markers of systemic inflammation for managing cervical cancer[J].Oncotarget,2017,8(27):44824-44832.
[17] 王晔,吴美艳.早期宫颈癌患者术前炎性指标与预后相关性的研究[J].癌症进展,2015(3):338-341.
[18] ACMAZ G,AKSOY H,UNAL D,et al.Are neutrophil/lymphocyte and platelet/lymphocyte ratios associated with endometrial precancerous and cancerous lesions in patients with abnormal uterine bleeding?[J].Asian Pacific Journal of Cancer Prevention Apjcp,2014,15(4):1689-1692.
[19] HARUMA T,NAKAMURA K,NISHIDA T,et al.Pre-treatment Neutrophil to Lymphocyte Ratio Is a Predictor of Prognosis in Endometrial Cancer.[J].Anticancer Research,2015,35(1):337-343.
[20] CUMMINGS M,MERONE L,KEEBLE C,et al.Preoperative neutrophil:lymphocyte and platelet:lymphocyte ratios predict endometrial cancer survival[J].British Journal of Cancer,2015,113(2):311-320.
[21] KIM HS,HAN KH,CHUNG HH,et al.Neutrophil to lymphocyte ratio for preoperative diagnosis of uterine sarcomas:a case-matched comparison[J].Eeur J Surg Oncol,2010,36(7):691-698.
[22] 曾庆红.中性粒细胞/淋巴细胞比值在子宫肉瘤术前诊断的应用[D].大连:大连医科大学,2011.
[23] 李梅.白细胞介素-6、糖类抗原72-4、血清癌抗原125联合人附睾蛋白4对卵巢癌的诊断价值[J].安徽医药,2016,20(6):1138-1140.
[24] 王鑫,张虹.术前NLR和PLR对上皮性卵巢癌患者预后的评估价值[J].现代妇产科进展,2016,25(6):433-436.
[25] HUANG QT,MAN QQ,HU J,et al.Prognostic significance of neutrophil-to-lymphocyte ratio in cervical cancer:A systematic review and meta-analysis of observational studies[J].Oncotarget,2017,8(10):16755-16764.
[26] FENG Z,WEN H,BI R,et al.Preoperative Neutrophil-to-Lymphocyte Ratio as a Predictive and Prognostic Factor for High-Grade Serous Ovarian Cancer[J].Plos One,2016,11(5):e0156101.DOI:10.1371/journal.pone.0156101.
[27] 张维维,李小庭,赵可雷,等.术前中性粒细胞/淋巴细胞比值与卵巢癌患者预后的关系[J].临床肿瘤学杂志,2014(9):824-828.
[28] HUANG CY,YANG YC,WANG KL,et al.Possible surrogate marker for an effective dose-dense chemotherapy in treating ovarian cancer[J].Taiwanese Journal of Obstetrics & Gynecology,2016,55(3):405-409.
[29] ALLENSWORTH SK,LANGSTRAAT CL,MARTIN JR,et al.Evaluating the prognostic significance of preoperative thrombocytosis in epithelial ovarian cancer.[J].Gynecologic Oncology,2013,130(3):499-504.
[30] SATO E,OLSON SH,AHN J,et al.Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(51):18538-18543.
[31] ASHER V,LEE J,INNAMAA A,et al.Preoperative platelet lymphocyte ratio as an independent prognostic marker in ovarian cancer[J].Clinical and Translational Oncology,2011,13(7):499-503.
[2] KYRIAZI V,THEODOULOU E.Assessing the risk and prognosis of thrombotic complications in cancer patients[J].Archives of Pathology & Laboratory Medicine,2013,137(9):1286-1295.
[3] YILDIZ P,BAYRAKTAROGLU M.The prognostic impact of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with non-small cell lung cancer[J].European Respiratory Journal,2016,48(suppl 60):PA511.
[4] SATPATHY SR,JALA VR,BODDULURI SR,et al.Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth[J].Nat Commun,2015,6:7064.
[5] GAIDA MM,STEFFEN TG,GüNTHER F,et al.Polymorphonuclear neutrophils promote dyshesion of tumor cells and elastase-mediated degradation of E-cadherin in pancreatic tumors[J].Eur J Immunol,2012,42 (12):3369-3380.
[6] DERYUGINA EI,ZAJAC E,JUNCKER-JENSEN A,et al.Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment[J].Neoplasia,2014,16 (10):771-788.
[7] RODRIGUEZ PC,ERNSTOFF MS,HERNANDEZ C,et al.Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes[J].Cancer Res,2009,69 (4):1553-1560.
[8] LEVIN J,CONLEY CL.THROMBOCYTOSIS ASSOCIATED WITH MALIGNANT DISEASE[J].Archives of Internal Medicine,1964,114(4):497-500.
[9] GASIC GJ,GASIC TB,GALANTI N,et al.Platelet-tumor-cell interactions in mice.The role of platelets in the spread of malignant disease[J].Int J Cancer,1973,11(3):704-718.
[10] JOHNSON KE,MCALLISTER SS,ITALIANO JE,et al.The Role of Platelets in the Tumor Microenvironment[J].Int J Cancer,2017,11(1):125-127.
[11] 熊巍.术前中性粒细胞/淋巴细胞比值在外阴鳞癌与外阴上皮内瘤变的诊断中应用[D].北京:北京协和医学院,2015.
[12] ERTAS I E,GUNGORDUK K,AKMAN L,et al.Can preoperative neutrophil:lymphocyte and platelet:lymphocyte ratios be used as predictive markers for lymph node metastasis in squamous cell carcinoma of the vulva[J].European Journal of Obstetrics Gynecology & Reproductive Biology,2013,171(1):138-142.
[13] 杨军文,吴玲玲,倪观太.中性粒细胞与淋巴细胞比值在宫颈癌根治术预后评估中的价值[J].实用医学杂志,2015,31(16):2662-2665.
[14] 周文毓,张建平.ⅠB2～ⅡB期宫颈癌新辅助化疗治疗前中性粒细胞与淋巴细胞比值对疗效及预后预测意义[J].临床军医杂志,2016(2):119-123.
[15] 李文婷,田男,古丽娜·库尔班.中性粒细胞与淋巴细胞比值对宫颈癌放疗及同步放化疗疗效及预后的影响[J].实用医学杂志,2015,31(22):3697-3700.
[16] WANG L,JIA J,LIN L,et al.Predictive value of hematological markers of systemic inflammation for managing cervical cancer[J].Oncotarget,2017,8(27):44824-44832.
[17] 王晔,吴美艳.早期宫颈癌患者术前炎性指标与预后相关性的研究[J].癌症进展,2015(3):338-341.
[18] ACMAZ G,AKSOY H,UNAL D,et al.Are neutrophil/lymphocyte and platelet/lymphocyte ratios associated with endometrial precancerous and cancerous lesions in patients with abnormal uterine bleeding?[J].Asian Pacific Journal of Cancer Prevention Apjcp,2014,15(4):1689-1692.
[19] HARUMA T,NAKAMURA K,NISHIDA T,et al.Pre-treatment Neutrophil to Lymphocyte Ratio Is a Predictor of Prognosis in Endometrial Cancer.[J].Anticancer Research,2015,35(1):337-343.
[20] CUMMINGS M,MERONE L,KEEBLE C,et al.Preoperative neutrophil:lymphocyte and platelet:lymphocyte ratios predict endometrial cancer survival[J].British Journal of Cancer,2015,113(2):311-320.
[21] KIM HS,HAN KH,CHUNG HH,et al.Neutrophil to lymphocyte ratio for preoperative diagnosis of uterine sarcomas:a case-matched comparison[J].Eeur J Surg Oncol,2010,36(7):691-698.
[22] 曾庆红.中性粒细胞/淋巴细胞比值在子宫肉瘤术前诊断的应用[D].大连:大连医科大学,2011.
[23] 李梅.白细胞介素-6、糖类抗原72-4、血清癌抗原125联合人附睾蛋白4对卵巢癌的诊断价值[J].安徽医药,2016,20(6):1138-1140.
[24] 王鑫,张虹.术前NLR和PLR对上皮性卵巢癌患者预后的评估价值[J].现代妇产科进展,2016,25(6):433-436.
[25] HUANG QT,MAN QQ,HU J,et al.Prognostic significance of neutrophil-to-lymphocyte ratio in cervical cancer:A systematic review and meta-analysis of observational studies[J].Oncotarget,2017,8(10):16755-16764.
[26] FENG Z,WEN H,BI R,et al.Preoperative Neutrophil-to-Lymphocyte Ratio as a Predictive and Prognostic Factor for High-Grade Serous Ovarian Cancer[J].Plos One,2016,11(5):e0156101.DOI:10.1371/journal.pone.0156101.
[27] 张维维,李小庭,赵可雷,等.术前中性粒细胞/淋巴细胞比值与卵巢癌患者预后的关系[J].临床肿瘤学杂志,2014(9):824-828.
[28] HUANG CY,YANG YC,WANG KL,et al.Possible surrogate marker for an effective dose-dense chemotherapy in treating ovarian cancer[J].Taiwanese Journal of Obstetrics & Gynecology,2016,55(3):405-409.
[29] ALLENSWORTH SK,LANGSTRAAT CL,MARTIN JR,et al.Evaluating the prognostic significance of preoperative thrombocytosis in epithelial ovarian cancer.[J].Gynecologic Oncology,2013,130(3):499-504.
[30] SATO E,OLSON SH,AHN J,et al.Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(51):18538-18543.
[31] ASHER V,LEE J,INNAMAA A,et al.Preoperative platelet lymphocyte ratio as an independent prognostic marker in ovarian cancer[J].Clinical and Translational Oncology,2011,13(7):499-503.