针刺降压机制实验研究进展
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摘要
高血压不仅是一种慢性疾病,也是心脑血管疾病的高危发病因素之一。因其导致的并发症如心力衰竭、慢性肾衰、脑卒中、冠心病等对人体的致残和致死率也在逐年上升,极其影响居民的健康生活水平。近年来针刺治疗高血压的有效性和多样性在临床上得到验证,对其降压机制的研究也逐渐深入,现从多角度概括总结近年来的研究进展,综述如下。
Hypertension is not only a chronic disease,but also a high risk factor of cardio and cerebrovascular diseases. The disability and mortality rate on human body of many complications such as heart failure,chronic renal failure,stroke and coronary heart disease,are also increasing year by year,which greatly affects the healthy living standard of the residents. In recent years,the efficacy and diversity of acupuncture in the treatment of hypertension have been proved in clinical,and the research on its mechanism has also been gradually deepened. The following artical reviews development in recent years from multiple perspectives.
Hypertension is not only a chronic disease,but also a high risk factor of cardio and cerebrovascular diseases. The disability and mortality rate on human body of many complications such as heart failure,chronic renal failure,stroke and coronary heart disease,are also increasing year by year,which greatly affects the healthy living standard of the residents. In recent years,the efficacy and diversity of acupuncture in the treatment of hypertension have been proved in clinical,and the research on its mechanism has also been gradually deepened. The following artical reviews development in recent years from multiple perspectives.
引文
[1]种冠峰,相有章.中国高血压病流行病学及影响因素研究进展[J].中国公共卫生,2010,26(3):301-302.
[2]闻杰.试论以多靶点药物治疗高血压[J].医学信息,2014(37):337-337.
[3]吴奕富.中医药对高血压病多靶点作用的研究近况[J].医药世界,2007(8):111-112.
[4]唐有为,陈淑红.针灸与人体的传统观和科学观[J].国外医学:中国中医分册,1998(5):25-29.
[5]王少锦.针灸效应与细胞信息传导关系的初步探讨[J].中国中医基础医学杂志,2004,10(11):31-33.
[6]易受乡,彭艳.针灸对效应靶器官细胞跨膜信号转导影响的研究进展[J].针刺研究,2009,34(5):356-361.
[7]刘西建,韩涛,卢岩,等.针药配伍对高血压大鼠血清ACE、血浆AngⅡ含量的影响[J].辽宁中医药大学学报,2011,13(8):106-107.
[8]钱春艳,陈邦国,魏丹,等.电针曲池穴对高血压模型大鼠血压及血管紧张素Ⅱ的影响[J].湖北中医学院学报,2008,29(3):5-7.
[9]XIN JJ,GAO JH,WANG YY,et al. Antihypertensive and antihypertrophic effects of acupuncture at PC6 acupoints in spontaneously hypertensive rats and the underlying mechanisms[J]. Evid Based Complement Alternat Med,2017,2017:1-9.
[10]HUO ZJ,LI Q,TIAN GH,et al. The ameliorating effects of long-term electroacupuncture on cardiovascular remodeling in spontaneously hypertensive rats[J]. BMC Complement Altern Med,2014,14:118.
[11]DU D,CHEN J,LIU M,et al. The effects of angiotensin II and angiotensin-(1-7)in the rostral ventrolateral medulla of rats on stress-induced hypertension[J]. PLoS One,2013,8(8):1-10.
[12]颜艾明.电针“足三里”、“曲池”穴对高血压前期大鼠炎症因子影响的实验研究[D].沈阳:辽宁中医药大学,2015.
[13]王晶,林晓杰,罗晓舟,等.针刺太溪穴降低SHR血压及调节延髓TNF-α、IL-6蛋白表达[J].暨南大学学报(自然科学与医学版),2016,37(4):327-330.
[14]孙静文.捻转补泻手法对自发性高血压大鼠肾组织NO、ET-1、TGF-β1的影响[D].北京:北京中医药大学,2015.
[15]沈燕,宋文婷,樊小农,等.针刺人迎穴对自发性高血压大鼠血压、内皮素及一氧化氮的影响[J].山西中医,2015,31(2):56-59.
[16]王家有,唐纯志,贺振泉,等.针刺太冲穴对自发性高血压大鼠收缩压、血浆内皮素-1和血清NO的影响[J].广东医学,2010,36(15):1943-1945.
[17]井明鑫,王丽,支建梅,等.捻转补泻手法对应激性高血压大鼠vWF、ET含量的影响[C]//中国针灸学会.中国针灸学会第九届全国中青年针灸推拿学术研讨会论文集.上海:中国针灸学会,2011.
[18]Leung S B,Zhang H,Lau C W,et al. Attenuation of blood pressure in spontaneously hypertensive rats by acupuncture was associated with reduction oxidative stress and improvement from endothelial dysfunction[J]. Chin Med,2016,11(1):38.
[19]LIU W,ZHU L,CHEN S,et al. Effect of twirling-reinforcingreducingneedlingmanipulationsoncontentsofserum acetylcholine and arterial NOS and cGMP in stress-induced hypertension rats[J]. Zhen Ci Yan Jiu,2015,40(2):136-140.
[20]W A N GS,Z H A N GD,T A N GL,e ta l.E f f e c t so f electroacupuncture stimulation at“Zusanli”acupoint on hepatic NO release and blood perfusion in mice[J]. Evid Based Complement Alternat Med,2015,2015:18.
[21]XIONG X,YOU C,FENG Q,et al. Pulse width modulation electro-acupuncture on cardiovascular remodeling and plasma nitric oxide in spontaneously hypertensive rats[J]. Evid Based Complement Alternat Med,2011,2011:23-31.
[22]HUANG Y,FAN M,WANG J,et al. Effects of acupuncture on nNOS and iNOS expression in the rostral ventrolateral medulla of stress-induced hypertensive rats[J]. Acupunct Electrother Res,2005,30(3-4):263-273.
[23]沈攀攀.针刺对自发性高血压大鼠的降压效应及其中枢Asp、Glu调节机制[D].杭州:浙江中医药大学,2017.
[24]田贵华.长期电针刺激百会、足三里对SHR大鼠海马CA1区微血管和神经元损伤的改善作用[D].北京:北京中医药大学,2012.
[25]支建梅,王朝阳,王丽,等.不同刺激量捻转补泻手法对应激性高血压大鼠颈交感神经放电的影响[J].中医杂志,2009(9):811-813.
[26]王延荣,王锦,李莉,等.针刺或褪黑素的中枢降压作用与延髓氨基酸递质改变的关系[J].上海针灸杂志,2007,26(6):41-45.
[27]YANG J W,YE Y,WANG XR,et al. Acupuncture attenuates renal sympathetic activity and blood pressure via beta-adrenergic receptors in spontaneously hypertensive rats[J]. Neural Plast,2017,2017:131-142.
[28]Kimura K,Ishida K,Takahashi N,et al. Effects of acupuncture at the ST-36 point on muscle sympathetic nerve activity and blood pressure in normal adults[J]. Auton Neurosci,2017,8:1016.
[29]LIM,Tjen-A-LooiSC,GUOZL,etal.Repetitive electroacupuncture attenuates cold-induced hypertension through enkephalin in the rostral ventral lateral medulla[J]. Sci Rep,2106,11:35791.
[30]TAN YY,WANG YY,ZHANG Q. Electroacupuncture of"Quchi"(LI 11)inhibits the elevation of arterial blood pressure and abnormal sympathetic nerve activity in hypertension rats[J].Zhen Ci Yan Jiu,2016,41(2):144-149.
[31]ZHANG C,XIA C,JIANG M,et al. Repeated electroacupuncture attenuating of apelin expression and function in the rostral ventrolateral medulla in stress-induced hypertensive rats[J].Brain Res Bull,2013,97:53-62.
[32]吴家睿.建立在系统生物学基础上的精准医学[J].生命科学,2015,27(5):558-563.
[33]李晓喆.针刺太冲穴在自发性高血压大鼠小脑差异蛋白表达的研究[D].广州:广州中医药大学,2016.
[34]王家有.针刺太冲与非经非穴对自发性高血压大鼠血压及延髓蛋白表达的影响[D].广州:广州中医药大学,2010.
[35]朱华超,纪智,郭文,等.基因芯片研究针刺对应激性高血压前期大鼠心脏基因表达的影响[J].针灸临床杂志,2016,32(4):77-81.
[36]纪智.以基因芯片探究针刺泻法对应激性高血压前期大鼠肾脏基因表达的影响[D].北京:北京中医药大学,2016.
[37]LAI X,WANG J,Nabar N,et al. Proteomic response to acupuncture treatment in spontaneously hypertensive rats[J].PLoS One,2012,7(9):21.
[38]XIEX,GUOY,LIUQ,etal.Astudyoneffectof electroacupuncture on gene expression in hypothalamus of rats with stress-induced prehypertension based on gene chip technology[J]. Evid Based Complement Alternat Med,2015,2015:1-12.
[39]孙启胜,郭骐影,贾文睿,等.针刺捻转泻法对应激性高血压前期大鼠下丘脑基因表达谱的影响[J].针刺研究,2017,42(3):209-216.
[40]热依扎·阿仁哈孜,木胡牙提.高血压与靶器官损伤相关性[J].心血管病学进展,2010,31(3):427-429.
[41]杜宇征,蔡婓.石学敏院士针刺治疗高血压临证经验[J].中国针灸,2013,33(11):1000-1003.
[42]李阳,王莹,郭琳.针刺对自发性高血压大鼠左心室病理形态的影响[J].针灸临床杂志,2015,31(5):65-66.
[43]陈志娟.电针刺激“足三里”、“曲池”穴对自发性高血压大鼠血压和肾功能影响的机制研究[D].沈阳:辽宁中医药大学,2013.
[44]王珊珊.电针刺激“足三里”、“曲池”穴对自发性高血压大鼠血压及心肌纤维化的影响[D].沈阳:辽宁中医药大学,2013.
[45]霍则军,田贵华,孙凯,等.百会、足三里的长期电针刺激对自发性高血压大鼠血压和心肌肥大的改善作用及其机理[C]//中国中西医结合学会微循环专业委员会.第十二次中国中西医结合微循环学术会议论文集.北京:中国中西医结合学会微循环专业委员会,2012.
[46]李欣欣,张立德,曲怡.电针对高血压前期大鼠肾脏上皮-间质转化的机制研究[J].中华中医药学刊,2017,35(4):943-945.
[2]闻杰.试论以多靶点药物治疗高血压[J].医学信息,2014(37):337-337.
[3]吴奕富.中医药对高血压病多靶点作用的研究近况[J].医药世界,2007(8):111-112.
[4]唐有为,陈淑红.针灸与人体的传统观和科学观[J].国外医学:中国中医分册,1998(5):25-29.
[5]王少锦.针灸效应与细胞信息传导关系的初步探讨[J].中国中医基础医学杂志,2004,10(11):31-33.
[6]易受乡,彭艳.针灸对效应靶器官细胞跨膜信号转导影响的研究进展[J].针刺研究,2009,34(5):356-361.
[7]刘西建,韩涛,卢岩,等.针药配伍对高血压大鼠血清ACE、血浆AngⅡ含量的影响[J].辽宁中医药大学学报,2011,13(8):106-107.
[8]钱春艳,陈邦国,魏丹,等.电针曲池穴对高血压模型大鼠血压及血管紧张素Ⅱ的影响[J].湖北中医学院学报,2008,29(3):5-7.
[9]XIN JJ,GAO JH,WANG YY,et al. Antihypertensive and antihypertrophic effects of acupuncture at PC6 acupoints in spontaneously hypertensive rats and the underlying mechanisms[J]. Evid Based Complement Alternat Med,2017,2017:1-9.
[10]HUO ZJ,LI Q,TIAN GH,et al. The ameliorating effects of long-term electroacupuncture on cardiovascular remodeling in spontaneously hypertensive rats[J]. BMC Complement Altern Med,2014,14:118.
[11]DU D,CHEN J,LIU M,et al. The effects of angiotensin II and angiotensin-(1-7)in the rostral ventrolateral medulla of rats on stress-induced hypertension[J]. PLoS One,2013,8(8):1-10.
[12]颜艾明.电针“足三里”、“曲池”穴对高血压前期大鼠炎症因子影响的实验研究[D].沈阳:辽宁中医药大学,2015.
[13]王晶,林晓杰,罗晓舟,等.针刺太溪穴降低SHR血压及调节延髓TNF-α、IL-6蛋白表达[J].暨南大学学报(自然科学与医学版),2016,37(4):327-330.
[14]孙静文.捻转补泻手法对自发性高血压大鼠肾组织NO、ET-1、TGF-β1的影响[D].北京:北京中医药大学,2015.
[15]沈燕,宋文婷,樊小农,等.针刺人迎穴对自发性高血压大鼠血压、内皮素及一氧化氮的影响[J].山西中医,2015,31(2):56-59.
[16]王家有,唐纯志,贺振泉,等.针刺太冲穴对自发性高血压大鼠收缩压、血浆内皮素-1和血清NO的影响[J].广东医学,2010,36(15):1943-1945.
[17]井明鑫,王丽,支建梅,等.捻转补泻手法对应激性高血压大鼠vWF、ET含量的影响[C]//中国针灸学会.中国针灸学会第九届全国中青年针灸推拿学术研讨会论文集.上海:中国针灸学会,2011.
[18]Leung S B,Zhang H,Lau C W,et al. Attenuation of blood pressure in spontaneously hypertensive rats by acupuncture was associated with reduction oxidative stress and improvement from endothelial dysfunction[J]. Chin Med,2016,11(1):38.
[19]LIU W,ZHU L,CHEN S,et al. Effect of twirling-reinforcingreducingneedlingmanipulationsoncontentsofserum acetylcholine and arterial NOS and cGMP in stress-induced hypertension rats[J]. Zhen Ci Yan Jiu,2015,40(2):136-140.
[20]W A N GS,Z H A N GD,T A N GL,e ta l.E f f e c t so f electroacupuncture stimulation at“Zusanli”acupoint on hepatic NO release and blood perfusion in mice[J]. Evid Based Complement Alternat Med,2015,2015:18.
[21]XIONG X,YOU C,FENG Q,et al. Pulse width modulation electro-acupuncture on cardiovascular remodeling and plasma nitric oxide in spontaneously hypertensive rats[J]. Evid Based Complement Alternat Med,2011,2011:23-31.
[22]HUANG Y,FAN M,WANG J,et al. Effects of acupuncture on nNOS and iNOS expression in the rostral ventrolateral medulla of stress-induced hypertensive rats[J]. Acupunct Electrother Res,2005,30(3-4):263-273.
[23]沈攀攀.针刺对自发性高血压大鼠的降压效应及其中枢Asp、Glu调节机制[D].杭州:浙江中医药大学,2017.
[24]田贵华.长期电针刺激百会、足三里对SHR大鼠海马CA1区微血管和神经元损伤的改善作用[D].北京:北京中医药大学,2012.
[25]支建梅,王朝阳,王丽,等.不同刺激量捻转补泻手法对应激性高血压大鼠颈交感神经放电的影响[J].中医杂志,2009(9):811-813.
[26]王延荣,王锦,李莉,等.针刺或褪黑素的中枢降压作用与延髓氨基酸递质改变的关系[J].上海针灸杂志,2007,26(6):41-45.
[27]YANG J W,YE Y,WANG XR,et al. Acupuncture attenuates renal sympathetic activity and blood pressure via beta-adrenergic receptors in spontaneously hypertensive rats[J]. Neural Plast,2017,2017:131-142.
[28]Kimura K,Ishida K,Takahashi N,et al. Effects of acupuncture at the ST-36 point on muscle sympathetic nerve activity and blood pressure in normal adults[J]. Auton Neurosci,2017,8:1016.
[29]LIM,Tjen-A-LooiSC,GUOZL,etal.Repetitive electroacupuncture attenuates cold-induced hypertension through enkephalin in the rostral ventral lateral medulla[J]. Sci Rep,2106,11:35791.
[30]TAN YY,WANG YY,ZHANG Q. Electroacupuncture of"Quchi"(LI 11)inhibits the elevation of arterial blood pressure and abnormal sympathetic nerve activity in hypertension rats[J].Zhen Ci Yan Jiu,2016,41(2):144-149.
[31]ZHANG C,XIA C,JIANG M,et al. Repeated electroacupuncture attenuating of apelin expression and function in the rostral ventrolateral medulla in stress-induced hypertensive rats[J].Brain Res Bull,2013,97:53-62.
[32]吴家睿.建立在系统生物学基础上的精准医学[J].生命科学,2015,27(5):558-563.
[33]李晓喆.针刺太冲穴在自发性高血压大鼠小脑差异蛋白表达的研究[D].广州:广州中医药大学,2016.
[34]王家有.针刺太冲与非经非穴对自发性高血压大鼠血压及延髓蛋白表达的影响[D].广州:广州中医药大学,2010.
[35]朱华超,纪智,郭文,等.基因芯片研究针刺对应激性高血压前期大鼠心脏基因表达的影响[J].针灸临床杂志,2016,32(4):77-81.
[36]纪智.以基因芯片探究针刺泻法对应激性高血压前期大鼠肾脏基因表达的影响[D].北京:北京中医药大学,2016.
[37]LAI X,WANG J,Nabar N,et al. Proteomic response to acupuncture treatment in spontaneously hypertensive rats[J].PLoS One,2012,7(9):21.
[38]XIEX,GUOY,LIUQ,etal.Astudyoneffectof electroacupuncture on gene expression in hypothalamus of rats with stress-induced prehypertension based on gene chip technology[J]. Evid Based Complement Alternat Med,2015,2015:1-12.
[39]孙启胜,郭骐影,贾文睿,等.针刺捻转泻法对应激性高血压前期大鼠下丘脑基因表达谱的影响[J].针刺研究,2017,42(3):209-216.
[40]热依扎·阿仁哈孜,木胡牙提.高血压与靶器官损伤相关性[J].心血管病学进展,2010,31(3):427-429.
[41]杜宇征,蔡婓.石学敏院士针刺治疗高血压临证经验[J].中国针灸,2013,33(11):1000-1003.
[42]李阳,王莹,郭琳.针刺对自发性高血压大鼠左心室病理形态的影响[J].针灸临床杂志,2015,31(5):65-66.
[43]陈志娟.电针刺激“足三里”、“曲池”穴对自发性高血压大鼠血压和肾功能影响的机制研究[D].沈阳:辽宁中医药大学,2013.
[44]王珊珊.电针刺激“足三里”、“曲池”穴对自发性高血压大鼠血压及心肌纤维化的影响[D].沈阳:辽宁中医药大学,2013.
[45]霍则军,田贵华,孙凯,等.百会、足三里的长期电针刺激对自发性高血压大鼠血压和心肌肥大的改善作用及其机理[C]//中国中西医结合学会微循环专业委员会.第十二次中国中西医结合微循环学术会议论文集.北京:中国中西医结合学会微循环专业委员会,2012.
[46]李欣欣,张立德,曲怡.电针对高血压前期大鼠肾脏上皮-间质转化的机制研究[J].中华中医药学刊,2017,35(4):943-945.