摘要
目的探讨子宫颈环形电切除术(LEEP)对子宫颈上皮内瘤变(CIN)患者术后妊娠分娩的影响。方法随访2013年1月至2015年12月在中国医科大学附属盛京医院妇科门诊因CIN行LEEP治疗且术后成功妊娠的患者,分析其自然流产率、早产率、低出生体质量率以及剖宫产率等。结果 35例患者术后成功妊娠,完成随访并获得妊娠结局30例,人工流产1例(3.3%),胚胎停育3例(10.0%),早产4例(13.3%),足月产22例(73.3%)。2例低出生体质量儿,新生儿均健康。已分娩的26例患者中,自然分娩11例(42.3%),剖宫产15例(57.7%)。早产率与锥切深度、锥切直径、手术次数及妊娠距手术的间隔时间均不相关(P>0.05)。结论LEEP对术后妊娠分娩影响较小,合理的切除范围不增加不良结局,术后3个月以上可考虑妊娠。LEEP锥切手术史不是剖宫产指征。
Objective To assess the effect of a loop electrosurgical excision procedure(LEEP) on subsequent pregnancy outcomes and the delivery mode in women diagnosed with cervical intraepithelial neoplasia(CIN). Methods A retrospective study was performed at Shengjing Hospital of China Medical University between January 2013 and December 2015. We studied women diagnosed with CIN who got pregnant after a LEEP. The rates of abortion,preterm births,low birth weight newborns,and cesarean sections performed were analyzed. Results Of the 35 women enrolled,data regarding follow-up pregnancy outcomes were available for only 30,One woman(3.3%) showed artificial abortion,3(10.0%) showed spontaneous abortion,4(13.3%) showed preterm labor,and 22(73.3%) showed full-term birth. All newborns were healthy,although 2 had low birth weight. Of the 26 women who had delivered,11(42.3%) underwent spontaneous labor and 15(57.7%) underwent a cesarean section,The risk of preterm labor was not associated with the depth of conization,diameter of LEEP,number of operations,and the time interval between the LEEP and the pregnancy(P > 0.05). Conclusion The effect of LEEP on obstetric outcomes is mild. Optimal surgery should be chosen based on the lesion. We propose that women can get pregnant 3 months after an LEEP and that a history of LEEP is not an indication to perform a cesarean section.
引文
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