母体血清IL-10和RANTES预测早产发生的研究
摘要
目的通过对母体血清中白介素-10 (IL-10)和调节活化正常T细胞表达与分泌的趋化因子(RANTES)测定,探讨IL-10和RANTES在预测早产发生中的作用。方法收集2015年7月-2017年2月该院诊治的先兆早产女性240例为先兆早产组,早产临产100例为早产临产组,随机选取同期孕龄相近的正常妊娠妇女70例作为对照组。测定治疗前母体血清IL-10和RANTES浓度,并对研究对象随访至分娩。结果先兆早产和早产临产组母体血清IL-10和RANTES水平低于正常妊娠组(P<0. 05);早产组母体血清IL-10水平高于足月组(P <0. 05),而两组间RANTES水平差异无统计学意义(P> 0. 05);母体血清IL-10水平与早产存在相关性,预测早产发生的临界值为80. 33μg/L,其灵敏度为66. 7%,特异度为63. 0%。结论母体血清IL-10水平预测早产发生具有较高的灵敏度和特异度,可为临床早产预测提供参考依据; RANTES与早产发生无明显相关。
引文
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[14]Yang Q,El-Sayed Y,Rosenberg-Hasson Y,et al.Multiple cytokine profile in plasma and amniotic fluid in a mouse model of pre-term labor[J].Am J Reprod Immunol,2009,62(5):339-347.
[2]Woodward LJ,Moor S,Hood KM,et al.Very preterm children show impairments across multiple neurodevelopmental domains by age4 years[J].Arch Dis Child Fetal Neonatal Ed,2009,94(5):339-344.
[3]Melamed N,Hiersch L,Domniz N,et al.Predictive value of cervical length in women with threatened preterm labor[J].Obstet Gynecol,2013,122(6):1279-1287.
[4]van Baaren GJ,Vis JY,Grobman WA,et al.Cost-effectiveness analysis of cervical length measurement and fibronectin testing in women with threatened preterm labor[J].Am J Obstet Gynecol,2013,209(5):436.
[5]Tsiartas P,Holst RM,Wennerholm UB,et al.Prediction of spontaneous preterm delivery in women with threatened preterm labour:a prospective cohort study of multiple proteins in maternal serum[J].BJOG,2012,119(7):866-873.
[6]Rameez MFM,Lankeshwara D,Dias T,et al.Preterm delivery:current concepts[J].Sri Lanka J Obstet Gynaecol,2013,35(1):22-28.
[7]Boyle AK,Rinaldi SF,Norman JE,et al.Preterm birth:Inflammation,fetal injury and treatment strategies[J].J Reprod Immunol,2017,119(1):62-66.
[8]Agrawal V,Hirsch E.Intrauterine infection and preterm labor[J].Semin Fetal Neonatal Med,2012,17(1):12-19.
[9]Klimaviciute A,Calciolari J,Bertucci E,et al.Corticotropin-releasing hormone,its binding protein and receptors in human cervical tissue at preterm and term labor in comparison to non-pregnant state[J].Reprod Biol Endocrinol,2006,4(1):29.
[10]Kramer MS,Lydon J,Goulet L,et al.Maternal stress/distress,hormonal pathways and spontaneous preterm birth[J].Paediatr Perinat Epidemiol,2013,27(3):237-246.
[11]Menon R,Merialdi M,Lombardi SJ,et al.Differences in the placental membrane cytokine response:a possible explanation for the racial disparity in preterm birth[J].Am J Reprod Immunol,2006,56(2):112-118.
[12]Klein LL,Gibbs RS.Infection and preterm birth[J].Obstet Gynecol Clin North Am,2005,32(3):397-410.
[13]汪玮.利托君对先兆早产患者外周血CRH、NO、PGE2和IL-10水平的影响[J].临床检验杂志:电子版,2017,6(1):83-85.
[14]Yang Q,El-Sayed Y,Rosenberg-Hasson Y,et al.Multiple cytokine profile in plasma and amniotic fluid in a mouse model of pre-term labor[J].Am J Reprod Immunol,2009,62(5):339-347.