摘要
目的分析消化道癌症患者家族癌症史、家族消化道癌症史发生情况。方法采用面对面调查的方法依据《人群疾病家族史和病史调查表》对江苏省苏州市某6个乡镇的消化道癌症患者进行调查,内容包括:一般情况、一二三级亲属家系构成及其亲属患癌症情况。结果 720位消化道癌症患者中阳性家族癌症史、阳性消化道癌症家族史发生率分别为36.67%、28.61%;病例的家族癌症史及家族消化道癌症史的发生率性别差异无统计学意义(P均>0.05);病例家族患癌症和消化道癌症的成员人数多集中在3人及以下,患病成员越多的家族越少见(趋势χ~2检验P<0.05);一级亲属癌症史、消化道癌症史发生率分别为4.46%和3.37%,均明显高于二三级亲属(P均<0.05)。结论针对性地开展宣教活动,提高对消化道癌症高危家族的鉴别能力,进而对其进行重点健康教育工作,全面落实疾病三级预防网络,将对苏州市消化道癌症防控工作有极其重要意义。
Objective To analyze the family cancer and digestive tract cancer history in patients with digestive tract cancer. Methods Patients with digestive tract cancer in some six townships in Suzhou city were investigated by means of face-to-face survey based on the "Family History and History of Population Diseases Questionnaire" which includes general conditions, the composition and cancer occurrence of all three degree relatives. Results The incidence of positive family cancer and digestive tract cancer history in 720 patients with digestive tract cancer was 36.67% and 28.61%, respectively. There is no gender difference in the incidence of family cancer and digestive tract cancer history with P both above 0.05; the number of members of these cases' family suffering from cancer and digestive tract cancer is mostly concentrated in 3 people or less, and the more families with more members, the less common they are(Trend χ~2 test,P<0.05); the incidence of first-degree relatives' cancer and digestive tract cancer history was 4.46% and 3.37%, respectively, which was significantly higher than the second-level and third-level relatives with P all below 0.05. Conclusion Carrying out some activities focusing on improving the ability to identify some high-risk families of digestive tract cancer, and conducting key health education work with fully implement the three-level disease prevention network will be extremely important
引文
[1] Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016 A Systematic Analysis for the Global Burden of Disease Study[J].JAMA Oncol. Published online June 2, 2018.
[2] CHEN W, ZHENG R, ZHANG S, et al. Cancer incidence and mortality in China,2013[J].Cancer Lett,2017,401:63-71.
[3] 张国强,蒋海华,刘倩倩,等. 2010—2014年江苏某三甲医院住院病例死亡分析[J].公共卫生与预防医学,2016,(3):118-120.
[4] 王芹,章新琼,王秋萍,等.消化道癌症患者化疗期的症状群及其与心理一致感的关系[J].中国心理卫生杂志,2017,(9):685-689.
[5] Stoffel EM, Mangu PB, Gruber SB, et al. Hereditary colorectal cancer syndromes: American Society of Clinical Oncology Clinical Practice Guideline endorsement of the familial risk-colorectal cancer:European Society for Medical Oncology Clinical Practice Guidelines[J]. J Clin Oncol, 2015, 33(2): 209-217.
[6] 王立东,胡守佳.食管癌基础研究进展及临床应用前景[J].河南医学研究, 2016,25(8):1345-1347.
[7] 侯睿智,舒振波.大肠癌相关基因突变与大肠癌遗传易感性的研究[J].中国实验诊断学,2017,21(1):173-176.
[8] 郭瑾,魏胜义.幽门螺杆菌感染、十二指肠溃疡及家族史与胃癌发生的相关性[J].实用癌症杂志,2017(12):2012-2013.
[9] 郑伟慧,徐晓玲,刘玮,等.浙江沿海与内陆地区食管癌家族史的分布比较[J].转化医学电子杂志,2017,4(6):49-53.
[10] WEN D,SHAN B. A positive family history of esophageal/gastric cardia cancer with gastric cardia adenocarcinoma is associated with a younger age at onset and more likely with another synchronous[J].Eur J Med Genet,2010,53(5):250-255.
[11] Yaghoobi M, Bijarchi R,Narod SA. Family history andtherisk ofgastric cancer[J]. British Journal of Cancer, 2010, 102(2):237-242.
[12] Nam JH,Choi IJ,Cho SJ,et al. Helicobacter pylori infection and histological changes in siblings of young gastric cancer patients[J].J Gastroenterol Hepatol, 2011,26(7):1157-1163.
[13] Shin CM,Kin N,Yang HJ,et al. Stomach cancer risk in gastric cancer relatives: interaction between Helicobacter pylori infection and family history of gastric cancer for the risk of stomach cancer[J].J Clin Gastroenterol, 2010, 44(2):34-39.
[14] Rokkas T, Sechopoulos P, Pistiolas D, et al. Helicobacter pylori infection and gastric histology in first-degree relatives of gastric cancer patients: a meta-analysis[J].Eur J Gastroenterol Hepatol, 2010, 22(9):1128-1133.
[15] 郑莹,吴春晓.中国75岁以上老年人胃肠道恶性肿瘤流行状况和发展趋势[J].中华胃肠外科杂志,2016(5):481-485.