国内外巴贝虫病流行现状与研究进展
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摘要
巴贝虫病是一种新发寄生虫病,在全球包括欧洲、亚洲、非洲、南美洲、北美洲及澳洲等地区均有流行,美国是巴贝虫病病例数最多的国家。我国巴贝虫病主要分布在东北地区,其次是西南地区。作为一种新发虫媒传染病,该病对人类健康造成严重威胁,但研究基础相对薄弱,应引起足够重视。巴贝虫病相关研究重点主要包括巴贝虫病诊断抗原筛选、巴贝虫与宿主及其他病原体共感染互作机制。本文就目前国内外巴贝虫病流行分布情况、巴贝虫病诊断抗原筛选、宿主免疫应答机制及共感染现象等研究热点进行综述。
Babesiosis is an emerging parasitic disease,distributed globally in Europe,Asia,Africa,North and South America,and Australia,and the United States is still the country with the largest number of babesiosis cases reported.Babesiosis in China is mainly distributed in the northeast,followed by the southwest and other regions.As a new vector-borne infectious disease,babesiosis poses a serious threat to human health,and its research foundation is relatively weak,so it requires more attention and recognition.The research hot spots on babesiosis are screening of diagnostic antigens,and the mechanisms of Babesia and the hosts,co-infections between Babesia and other pathogens.The epidemic distribution,screening of diagnostic antigens,host immune response mechanism and co-infection of babesiosis in our country and abroad are reviewed in this paper.
Babesiosis is an emerging parasitic disease,distributed globally in Europe,Asia,Africa,North and South America,and Australia,and the United States is still the country with the largest number of babesiosis cases reported.Babesiosis in China is mainly distributed in the northeast,followed by the southwest and other regions.As a new vector-borne infectious disease,babesiosis poses a serious threat to human health,and its research foundation is relatively weak,so it requires more attention and recognition.The research hot spots on babesiosis are screening of diagnostic antigens,and the mechanisms of Babesia and the hosts,co-infections between Babesia and other pathogens.The epidemic distribution,screening of diagnostic antigens,host immune response mechanism and co-infection of babesiosis in our country and abroad are reviewed in this paper.
引文
[1]诸欣平,苏川.人体寄生虫学[M].9版.北京:人民卫生出版社,2018:82-84.
[2]Vannier E,Krause PJ.Human babesiosis[J].N Engl J Med,2012,366(25):2397-2407.
[3]Zhou X,Xia S,Huang JL,et al.Human babesiosis,an emerging tick-borne disease in the People's Republic of China[J].Parasit Vectors,2014,7:509.
[4]Barreira JD,Rossi MI,Pires FA,et al.The effect of different strains Babesia bovis(Babes,1888)on tick of Boophilus microplus(Canestrini,1887)][J].Rev Bras Parasitol Vet,2006,15(4):138-142.
[5]Smith TF.Thrombosis of inferior vena cava[J].Br Med J,1893,1(1671):9.
[6]洪式闾.北碚所见类似动物疟原虫第二报告[J].热带病研究所刊物,1943:2-4.
[7]洪式闾.北碚所见类似动物疟原虫初步报告[J].中国预防医学研究所论文,1943,7:1-2.
[8]瞿逢伊.我国医学寄生虫学发展百年历史回顾与评述[J].中国寄生虫学与寄生虫病杂志,2007,25(4):259-273.
[9]Skrabalo Z,Deanovic Z.Piroplasmosis in man:report of a case[J].Doc Med Geogr Trop,1957,9(1):11-16.
[10]Fitzpatrick JE,Kennedy CC,McGeown MG,et al.Further details of third recorded case of redwater(babesiosis)in man[J].Br Med J,1969,4(5686):770-772.
[11]Herwaldt B,Persing DH,Precigout EA,et al.A fatal case of babesiosis in Missouri:identification of another piroplasm that infects humans[J].Ann Intern Med,1996,124(7):643-650.
[12]Woolley AE,Montgomery MW,Savage WJ,et al.Post-babesiosis warm autoimmune hemolytic anemia[J].N Engl J Med,2017,376(10):939-946.
[13]Karkoska K,Louie J,Appiah-Kubi AO,et al.Transfusion-transmitted babesiosis leading to severe hemolysis in two patients with sickle cell anemia[J].Pediatr Blood Cancer,2018,65(1):e26734.
[14]Surveillance for Babesiosis-United States,2014[EB/OL].[2016-02-19].(2018-11-28).https://www.cdc.gov/parasites/babesiosis/resources/babesiosis_surveillance_summary_2016.pdf.
[15]Quick RE,HerwaldtBL,Thomford JW,et al.Babesiosis in Washington state:a new species of Babesia?[J].Ann Intern Med,1993,119(4):284-290.
[16]Conrad PA,Kjemtrup AM,Carreno RA,et al.Description of Babesia duncani n.sp.(Apicomplexa:Babesiidae)from humans and its differentiation from other piroplasms[J].Int J Parasitol,2006,36(7):779-789.
[17]Bullard JM,Ahsanuddin AN,Perry AM,et al.The first case of locally acquired tick-borne Babesia microti infection in Canada[J].Can J Infect Dis Med Microbiol,2014,25(6):e87-e89.
[18]Rios L,Alvarez G,Blair S.Serological and parasitological study and report of the first case of human babesiosis in Colombia[J].Rev Soc Bras Med Trop,2003,36(4):493-498.
[19]Gorenflot A,PietteM.Seventh world case of human babesiosis(piroplasmosis).Scanning electron microscopic view of blood parasites[J].Ann Pharm Fr,1976,34(3/4):89-94.
[20]Symmers WS.Babesiosis in man[J].Br Med J,1979,2(6198):1141.
[21]Gorenflot A,MoubriK,Precigout E,et al.Human babesiosis[J].Ann Trop Med Parasitol,1998,92(4):489-501.
[22]Hildebrandt A,Gray JS,Hunfeld KP.Human babesiosis in Europe:what clinicians need to know[J].Infection,2013,41(6):1057-1072.
[23]Hildebrandt A,Hunfeld KP,Baier M,et al.First confirmed autochthonous case of human Babesia microti infection in Europe[J].Eur JClin Microbiol Infect Dis,2007,26(8):595-601.
[24]Holler JG,Roser D,Nielsen HV,et al.A case of human babesiosis in Denmark[J].Travel Med Infect Dis,2013,11(5):324-328.
[25]Morch K,Holmaas G,Frolander PS,et al.Severe human Babesia divergens infection in Norway[J].Int J Infect Dis,2015,33:37-38.
[26]Gonzalez LM,Castro E,Lobo CA,et al.First report of Babesia divergens infection in an HIV patient[J].Int J Infect Dis,2015,33:202-204.
[27]Arsuaga M,Gonzalez LM,Lobo CA,et al.First report of Babesia microti-caused babesiosis in Spain[J].Vector Borne Zoonotic Dis,2016,16(10):677-679.
[28]Welc-Faleciak R,PawelczykA,Radkowski M,et al.First report of two asymptomatic cases of human infection with Babesia microti(Franca,1910)in Poland[J].Ann Agric Environ Med,2015,22(1):51-54.
[29]Moniuszko-Malinowska A,Swiecicka I,Dunaj J,et al.Infection with Babesia microti in humans with non-specific symptoms in North East Poland[J].Infect Dis(Lond),2016,48(7):537-543.
[30]O'Connell S,Lyons C,Abdou M et al.Splenic dysfunction from celiac disease resulting in severe babesiosis[J].Ticks Tick Borne Dis,2017,8(4):537-539.
[31]Blackberg J,LazarevicVL,Hunfeld KP,et al.Low-virulent Babesia enatorum infection masquerading as hemophagocytic syndrome[J].Ann Hematol,2018,97(4):731-733.
[32]Asensi V,Gonzalez LM,Fernandez-Suarez J,et al.A fatal case of Babesia divergens infection in northwestern Spain[J].Ticks Tick Borne Dis,2018,9(3):730-734.
[33]El-Bahnasawy MM,Khalil HH,Morsy T.Babesiosis in an Egyptian boy acquired from pet dog,and a general review[J].J Egypt SocParasitol,2011,41(1):99-108.
[34]Bush JB,Isaacson M,Mohamed AS,et al.Human babesiosis-a preliminary report of 2 suspected cases in South Africa[J].S Afr Med J,1990,78(11):699.
[35]Burri C,Dupasquier C,Bastic V,et al.Pathogens of emerging tickborne diseases,Anaplasma phagocytophilum,Rickettsia spp.,and Babesia spp.,in ixodes ticks collected from rodents at four sites in Switzerland(Canton of Bern)[J].Vector Borne Zoonotic Dis,2011,11(7):939-944.
[36]Socolovschi C,Doudier B,Pages F,et al.Ticks and human tickborne diseases in Africa[J].Med Trop(Mars),2008,68(2):119-133.
[37]Loutan L,Rossier J,Zufferey G,et al.Imported babesiosis diagnosed as malaria[J].Lancet,1993,342(8873):749.
[38]Bloch EM,Mabula K,Levin A,et al.Babesia microti and malaria infection in Africa:A pilot serosurvey in Kilosa District,Tanzania[J].Am J Trop Med Hyg,2018,99(1):51-56.
[39]Jy K,Cho SH,Joo HN,et al.First case of human babesiosis in Korea:detection and characterization of a novel type of Babesia sp.(KO1)similar to ovine Babesia[J].J Clin Microbiol,2007,45(6):2084-2087.
[40]Marathe A,Tripathi J,Handa V,et al.Human babesiosis-a case report[J].Indian J Med Microbiol,2005,23(4):267-269.
[41]Jiang JF,Li H,Cao WC.Epidemiological profile of"Babesia venatorum"-authors.reply[J].Lancet Infect Dis,2015,15(8):878.
[42]Na YJ,Jy C,Jung BK,et al.An imported case of severe falciparum malaria with prolonged hemolytic anemia clinically mimicking a coinfection with babesiosis[J].Korean J Parasitol,2014,52(6):667-672.
[43]Senanayake SN,Paparini A,Latimer M,et al.First report of human babesiosis in Australia[J].Med J Aust,2012,196(5):350-352.
[44]Fuller A,Manitta J,Marks R,et al.First reported case of imported human Babesia microti infection in Australia[J].Pathology,2012,44(6):580-582.
[45]Mayne PJ.Emerging incidence of Lyme borreliosis,babesiosis,bartonellosis,and granulocytic ehrlichiosis in Australia[J].Int J Gen Med,2011,4:845-852.
[46]李世荣,王红,齐文杰,等.克林霉素,阿奇霉素联合双氢青蒿素哌喹治愈人巴贝西虫病一例[J].中华传染病杂志,2014,32(10):631.
[47]Jiang JF,Yc Z,Jiang RR,et al.Epidemiological,clinical,and laboratory characteristics of 48 cases of"Babesia venatorum"infection in China:a descriptivestudy[J].LancetInfectDis,2015,15(2):196-203.
[48]Jia N,Yc Z,Jiang JF.et al.Human babesiosis caused by a babesiacrassa-Like pathogen:a case series[J].Clin Infect Dis,2018,67(7):1110-1119.
[49]石珍宝,李珍珍,高权荣,等.人体感染巴贝虫一例[J].中国寄生虫学与寄生虫病杂志,1996,14(3):240.
[50]Sun Y,Li SG,Jiang JF,et al.Babesia venatorum infection in child,China[J].Emerg Infect Dis,2014,20(5):896-897.
[51]苏关关,赵年丰,叶有新.巴贝虫病例报道[J].中国人兽共患病杂志,2002,18(5):112-112.
[52]姚立农,阮卫,曾长佑,等.1例人感染巴贝虫的诊断与病原体鉴定[J].中国寄生虫学与寄生虫病杂志,2012,30(2):118-121.
[53]Qi C,Zhou D,Liu J,et al.Detection of Babesia divergens using molecular methods in anemic patients in Shandong province,China[J].Parasitol Res,2011,109(1):241-245.
[54]Man SQ,Qiao K,Cui J,et al.A case of human infection with a novel Babesia species in China[J].Infect Dis Poverty,2016,5:28.
[55]张继明,胡越凯.巴贝虫病1例[N].中国医学论坛报,2016-02-19(7).
[56]Huang S,Zhang L,Yao L,et al.Human babesiosis in southeast China:a case report[J].Int J Infect Dis,2018,68:36-38.
[57]欧阳榕,陈朱云,林耀莹.等.福建省1例巴贝虫病的诊断与鉴定[J].中国人兽共患病学报,2018,34(5):492-494.
[58]王惠萱.昆明地区巴贝西虫病一例分析[J].国际医学寄生虫病杂志,2012,39(3):190-192.
[59]陈要朋,彭恒,刘铁牛,等.1例人感染田鼠巴贝虫的实验室诊断及文献复习[J].国际医学寄生虫病杂志,2014,41(3):143-147.
[60]李金福,孟大邦,王庆芳,等.人巴贝斯焦虫病的发现[J].中国兽医杂志,1984,20(6):19-20.
[61]Zhou X,Li SG,Chen SB,et al.Co-infections with Babesia microti and Plasmodium parasites along the China-Myanmar border[J].Infect Dis Poverty,2013,2(1):24.
[62]Hsu NH,Cross JH.Serologic survey for human babesiosis on Taiwan[J].Taiwan Yi Xue Hui Za Zhi,1977,76(12):950-954.
[63]Shi CM,Liu LP,Chung WC,et al.Human babesiosis in Taiwan:asymptomatic infection with a Babesia microti-like organism in a taiwaneseWoman[J].J ClinMicrobiol,1997,35(2):450-454.
[64]张加,陈家旭.田鼠巴贝虫病的诊断技术研究进展[J].中国人兽共患病学报,2013,29(7):714-718,723.
[65]Luo Y,Terkawi MA,Jia H,et al.A double antibody sandwich enzyme-linked immunosorbent assay for detection of secreted antigen1 of Babesia microti using hamster model[J].Exp Parasitol,2012,130(2):178-182.
[66]Ooka H,Terkawi MA,Goo YK,et al.Babesia microti:molecular and antigenic characterizations of a novel 94-kDa protein(BmP94)[J].ExpParasitol,2011,127(1):287-293.
[67]Cai YC,Wu F,Hu W,et al.Molecular characterization of Babesia microti seroreactive antigen 5-1-1 and development of rapid detection methods for anti-B.microti antibodies in serum[J].Acta Trop,2018,185:371-379.
[68]胡薇,孙嘉慧,徐斌,等.田鼠巴贝虫Bm7重组抗原蛋白及其制备方法和用途:中国,CN201510124956.7[P].2015-03-20[2018-11-28].
[69]Zhou X,Huang JL,Shen HM,et al.Immunomics analysis of Babesia microti protein markers by high-throughput screening assay[J].Ticks Tick Borne Dis,2018,9(6):1468-1474.
[70]Xu B,Liu XF,Cai YC,et al.Screening for biomarkers reflecting the progression of Babesia microti infection[J].Parasit Vectors,2018,11(1):379.
[71]Lobo CA,Rodriguez M,Cursino-Santos JR.Babesia and red cell invasion[J].Curr Opin Hematol,2012,19(3):170-175.
[72]Montero E,Rodriguez M,Oksov Y,et al.Babesia divergens apical membrane antigen 1 and its interaction with the human red blood cell[J].Infect Immun,2009,77(11):4783-4793.
[73]Ord RL,Rodriguez M,Cursino-Santos JR,et al.Identification and characterization of the rhoptry neck protein 2 in Babesia divergens and B.microti[J].Infect Immun,2016,84(5):1574-1584.
[74]Parker ML,Penarete-Vargas DM,Hamilton PT,et al.Dissecting the interface between apicomplexan parasite and host cell:insights from a divergent AMA-RON2 pair[J].Proc Natl Acad Sci U S A,2016,113(2):398-403.
[75]Wynn TA,Chawla A,Pollard JW.Macrophage biology in development,homeostasis and disease[J].Nature,2013,496(7446):445-455.
[76]沈慧敏,蔡玉春,郑葵阳,等.细胞因子在巴贝虫感染中的作用研究进展[J].中国病原生物学杂志,2018,13(10):1175-1178.
[77]Knapp KL,Rice NA.Human coinfection with Borrelia burgdorferi and Babesia microti in the United States[J].J Parasitol Res,2015,2015:587131.
[78]Coleman JL,Levine D,Thill C,et al.Babesia microti and Borrelia burgdorferi follow independent courses of infection in mice[J].J Infect Dis,2005,192(9):1634-1641.
[79]Van DL,Voorberg-van der Wel A,van der Werff NM,et al.Suppression of Plasmodium cynomolgi in rhesus macaques by coinfection with Babesia microti[J].Infect Immun,2010,78(3):1032-1039.
[80]Martinez-Balzano C,Hess M,MalhotraA,et al.Severe babesiosis and Borrelia burgdorferico-infection[J].QJM,2015,108(2):141-143.20181213
[2]Vannier E,Krause PJ.Human babesiosis[J].N Engl J Med,2012,366(25):2397-2407.
[3]Zhou X,Xia S,Huang JL,et al.Human babesiosis,an emerging tick-borne disease in the People's Republic of China[J].Parasit Vectors,2014,7:509.
[4]Barreira JD,Rossi MI,Pires FA,et al.The effect of different strains Babesia bovis(Babes,1888)on tick of Boophilus microplus(Canestrini,1887)][J].Rev Bras Parasitol Vet,2006,15(4):138-142.
[5]Smith TF.Thrombosis of inferior vena cava[J].Br Med J,1893,1(1671):9.
[6]洪式闾.北碚所见类似动物疟原虫第二报告[J].热带病研究所刊物,1943:2-4.
[7]洪式闾.北碚所见类似动物疟原虫初步报告[J].中国预防医学研究所论文,1943,7:1-2.
[8]瞿逢伊.我国医学寄生虫学发展百年历史回顾与评述[J].中国寄生虫学与寄生虫病杂志,2007,25(4):259-273.
[9]Skrabalo Z,Deanovic Z.Piroplasmosis in man:report of a case[J].Doc Med Geogr Trop,1957,9(1):11-16.
[10]Fitzpatrick JE,Kennedy CC,McGeown MG,et al.Further details of third recorded case of redwater(babesiosis)in man[J].Br Med J,1969,4(5686):770-772.
[11]Herwaldt B,Persing DH,Precigout EA,et al.A fatal case of babesiosis in Missouri:identification of another piroplasm that infects humans[J].Ann Intern Med,1996,124(7):643-650.
[12]Woolley AE,Montgomery MW,Savage WJ,et al.Post-babesiosis warm autoimmune hemolytic anemia[J].N Engl J Med,2017,376(10):939-946.
[13]Karkoska K,Louie J,Appiah-Kubi AO,et al.Transfusion-transmitted babesiosis leading to severe hemolysis in two patients with sickle cell anemia[J].Pediatr Blood Cancer,2018,65(1):e26734.
[14]Surveillance for Babesiosis-United States,2014[EB/OL].[2016-02-19].(2018-11-28).https://www.cdc.gov/parasites/babesiosis/resources/babesiosis_surveillance_summary_2016.pdf.
[15]Quick RE,HerwaldtBL,Thomford JW,et al.Babesiosis in Washington state:a new species of Babesia?[J].Ann Intern Med,1993,119(4):284-290.
[16]Conrad PA,Kjemtrup AM,Carreno RA,et al.Description of Babesia duncani n.sp.(Apicomplexa:Babesiidae)from humans and its differentiation from other piroplasms[J].Int J Parasitol,2006,36(7):779-789.
[17]Bullard JM,Ahsanuddin AN,Perry AM,et al.The first case of locally acquired tick-borne Babesia microti infection in Canada[J].Can J Infect Dis Med Microbiol,2014,25(6):e87-e89.
[18]Rios L,Alvarez G,Blair S.Serological and parasitological study and report of the first case of human babesiosis in Colombia[J].Rev Soc Bras Med Trop,2003,36(4):493-498.
[19]Gorenflot A,PietteM.Seventh world case of human babesiosis(piroplasmosis).Scanning electron microscopic view of blood parasites[J].Ann Pharm Fr,1976,34(3/4):89-94.
[20]Symmers WS.Babesiosis in man[J].Br Med J,1979,2(6198):1141.
[21]Gorenflot A,MoubriK,Precigout E,et al.Human babesiosis[J].Ann Trop Med Parasitol,1998,92(4):489-501.
[22]Hildebrandt A,Gray JS,Hunfeld KP.Human babesiosis in Europe:what clinicians need to know[J].Infection,2013,41(6):1057-1072.
[23]Hildebrandt A,Hunfeld KP,Baier M,et al.First confirmed autochthonous case of human Babesia microti infection in Europe[J].Eur JClin Microbiol Infect Dis,2007,26(8):595-601.
[24]Holler JG,Roser D,Nielsen HV,et al.A case of human babesiosis in Denmark[J].Travel Med Infect Dis,2013,11(5):324-328.
[25]Morch K,Holmaas G,Frolander PS,et al.Severe human Babesia divergens infection in Norway[J].Int J Infect Dis,2015,33:37-38.
[26]Gonzalez LM,Castro E,Lobo CA,et al.First report of Babesia divergens infection in an HIV patient[J].Int J Infect Dis,2015,33:202-204.
[27]Arsuaga M,Gonzalez LM,Lobo CA,et al.First report of Babesia microti-caused babesiosis in Spain[J].Vector Borne Zoonotic Dis,2016,16(10):677-679.
[28]Welc-Faleciak R,PawelczykA,Radkowski M,et al.First report of two asymptomatic cases of human infection with Babesia microti(Franca,1910)in Poland[J].Ann Agric Environ Med,2015,22(1):51-54.
[29]Moniuszko-Malinowska A,Swiecicka I,Dunaj J,et al.Infection with Babesia microti in humans with non-specific symptoms in North East Poland[J].Infect Dis(Lond),2016,48(7):537-543.
[30]O'Connell S,Lyons C,Abdou M et al.Splenic dysfunction from celiac disease resulting in severe babesiosis[J].Ticks Tick Borne Dis,2017,8(4):537-539.
[31]Blackberg J,LazarevicVL,Hunfeld KP,et al.Low-virulent Babesia enatorum infection masquerading as hemophagocytic syndrome[J].Ann Hematol,2018,97(4):731-733.
[32]Asensi V,Gonzalez LM,Fernandez-Suarez J,et al.A fatal case of Babesia divergens infection in northwestern Spain[J].Ticks Tick Borne Dis,2018,9(3):730-734.
[33]El-Bahnasawy MM,Khalil HH,Morsy T.Babesiosis in an Egyptian boy acquired from pet dog,and a general review[J].J Egypt SocParasitol,2011,41(1):99-108.
[34]Bush JB,Isaacson M,Mohamed AS,et al.Human babesiosis-a preliminary report of 2 suspected cases in South Africa[J].S Afr Med J,1990,78(11):699.
[35]Burri C,Dupasquier C,Bastic V,et al.Pathogens of emerging tickborne diseases,Anaplasma phagocytophilum,Rickettsia spp.,and Babesia spp.,in ixodes ticks collected from rodents at four sites in Switzerland(Canton of Bern)[J].Vector Borne Zoonotic Dis,2011,11(7):939-944.
[36]Socolovschi C,Doudier B,Pages F,et al.Ticks and human tickborne diseases in Africa[J].Med Trop(Mars),2008,68(2):119-133.
[37]Loutan L,Rossier J,Zufferey G,et al.Imported babesiosis diagnosed as malaria[J].Lancet,1993,342(8873):749.
[38]Bloch EM,Mabula K,Levin A,et al.Babesia microti and malaria infection in Africa:A pilot serosurvey in Kilosa District,Tanzania[J].Am J Trop Med Hyg,2018,99(1):51-56.
[39]Jy K,Cho SH,Joo HN,et al.First case of human babesiosis in Korea:detection and characterization of a novel type of Babesia sp.(KO1)similar to ovine Babesia[J].J Clin Microbiol,2007,45(6):2084-2087.
[40]Marathe A,Tripathi J,Handa V,et al.Human babesiosis-a case report[J].Indian J Med Microbiol,2005,23(4):267-269.
[41]Jiang JF,Li H,Cao WC.Epidemiological profile of"Babesia venatorum"-authors.reply[J].Lancet Infect Dis,2015,15(8):878.
[42]Na YJ,Jy C,Jung BK,et al.An imported case of severe falciparum malaria with prolonged hemolytic anemia clinically mimicking a coinfection with babesiosis[J].Korean J Parasitol,2014,52(6):667-672.
[43]Senanayake SN,Paparini A,Latimer M,et al.First report of human babesiosis in Australia[J].Med J Aust,2012,196(5):350-352.
[44]Fuller A,Manitta J,Marks R,et al.First reported case of imported human Babesia microti infection in Australia[J].Pathology,2012,44(6):580-582.
[45]Mayne PJ.Emerging incidence of Lyme borreliosis,babesiosis,bartonellosis,and granulocytic ehrlichiosis in Australia[J].Int J Gen Med,2011,4:845-852.
[46]李世荣,王红,齐文杰,等.克林霉素,阿奇霉素联合双氢青蒿素哌喹治愈人巴贝西虫病一例[J].中华传染病杂志,2014,32(10):631.
[47]Jiang JF,Yc Z,Jiang RR,et al.Epidemiological,clinical,and laboratory characteristics of 48 cases of"Babesia venatorum"infection in China:a descriptivestudy[J].LancetInfectDis,2015,15(2):196-203.
[48]Jia N,Yc Z,Jiang JF.et al.Human babesiosis caused by a babesiacrassa-Like pathogen:a case series[J].Clin Infect Dis,2018,67(7):1110-1119.
[49]石珍宝,李珍珍,高权荣,等.人体感染巴贝虫一例[J].中国寄生虫学与寄生虫病杂志,1996,14(3):240.
[50]Sun Y,Li SG,Jiang JF,et al.Babesia venatorum infection in child,China[J].Emerg Infect Dis,2014,20(5):896-897.
[51]苏关关,赵年丰,叶有新.巴贝虫病例报道[J].中国人兽共患病杂志,2002,18(5):112-112.
[52]姚立农,阮卫,曾长佑,等.1例人感染巴贝虫的诊断与病原体鉴定[J].中国寄生虫学与寄生虫病杂志,2012,30(2):118-121.
[53]Qi C,Zhou D,Liu J,et al.Detection of Babesia divergens using molecular methods in anemic patients in Shandong province,China[J].Parasitol Res,2011,109(1):241-245.
[54]Man SQ,Qiao K,Cui J,et al.A case of human infection with a novel Babesia species in China[J].Infect Dis Poverty,2016,5:28.
[55]张继明,胡越凯.巴贝虫病1例[N].中国医学论坛报,2016-02-19(7).
[56]Huang S,Zhang L,Yao L,et al.Human babesiosis in southeast China:a case report[J].Int J Infect Dis,2018,68:36-38.
[57]欧阳榕,陈朱云,林耀莹.等.福建省1例巴贝虫病的诊断与鉴定[J].中国人兽共患病学报,2018,34(5):492-494.
[58]王惠萱.昆明地区巴贝西虫病一例分析[J].国际医学寄生虫病杂志,2012,39(3):190-192.
[59]陈要朋,彭恒,刘铁牛,等.1例人感染田鼠巴贝虫的实验室诊断及文献复习[J].国际医学寄生虫病杂志,2014,41(3):143-147.
[60]李金福,孟大邦,王庆芳,等.人巴贝斯焦虫病的发现[J].中国兽医杂志,1984,20(6):19-20.
[61]Zhou X,Li SG,Chen SB,et al.Co-infections with Babesia microti and Plasmodium parasites along the China-Myanmar border[J].Infect Dis Poverty,2013,2(1):24.
[62]Hsu NH,Cross JH.Serologic survey for human babesiosis on Taiwan[J].Taiwan Yi Xue Hui Za Zhi,1977,76(12):950-954.
[63]Shi CM,Liu LP,Chung WC,et al.Human babesiosis in Taiwan:asymptomatic infection with a Babesia microti-like organism in a taiwaneseWoman[J].J ClinMicrobiol,1997,35(2):450-454.
[64]张加,陈家旭.田鼠巴贝虫病的诊断技术研究进展[J].中国人兽共患病学报,2013,29(7):714-718,723.
[65]Luo Y,Terkawi MA,Jia H,et al.A double antibody sandwich enzyme-linked immunosorbent assay for detection of secreted antigen1 of Babesia microti using hamster model[J].Exp Parasitol,2012,130(2):178-182.
[66]Ooka H,Terkawi MA,Goo YK,et al.Babesia microti:molecular and antigenic characterizations of a novel 94-kDa protein(BmP94)[J].ExpParasitol,2011,127(1):287-293.
[67]Cai YC,Wu F,Hu W,et al.Molecular characterization of Babesia microti seroreactive antigen 5-1-1 and development of rapid detection methods for anti-B.microti antibodies in serum[J].Acta Trop,2018,185:371-379.
[68]胡薇,孙嘉慧,徐斌,等.田鼠巴贝虫Bm7重组抗原蛋白及其制备方法和用途:中国,CN201510124956.7[P].2015-03-20[2018-11-28].
[69]Zhou X,Huang JL,Shen HM,et al.Immunomics analysis of Babesia microti protein markers by high-throughput screening assay[J].Ticks Tick Borne Dis,2018,9(6):1468-1474.
[70]Xu B,Liu XF,Cai YC,et al.Screening for biomarkers reflecting the progression of Babesia microti infection[J].Parasit Vectors,2018,11(1):379.
[71]Lobo CA,Rodriguez M,Cursino-Santos JR.Babesia and red cell invasion[J].Curr Opin Hematol,2012,19(3):170-175.
[72]Montero E,Rodriguez M,Oksov Y,et al.Babesia divergens apical membrane antigen 1 and its interaction with the human red blood cell[J].Infect Immun,2009,77(11):4783-4793.
[73]Ord RL,Rodriguez M,Cursino-Santos JR,et al.Identification and characterization of the rhoptry neck protein 2 in Babesia divergens and B.microti[J].Infect Immun,2016,84(5):1574-1584.
[74]Parker ML,Penarete-Vargas DM,Hamilton PT,et al.Dissecting the interface between apicomplexan parasite and host cell:insights from a divergent AMA-RON2 pair[J].Proc Natl Acad Sci U S A,2016,113(2):398-403.
[75]Wynn TA,Chawla A,Pollard JW.Macrophage biology in development,homeostasis and disease[J].Nature,2013,496(7446):445-455.
[76]沈慧敏,蔡玉春,郑葵阳,等.细胞因子在巴贝虫感染中的作用研究进展[J].中国病原生物学杂志,2018,13(10):1175-1178.
[77]Knapp KL,Rice NA.Human coinfection with Borrelia burgdorferi and Babesia microti in the United States[J].J Parasitol Res,2015,2015:587131.
[78]Coleman JL,Levine D,Thill C,et al.Babesia microti and Borrelia burgdorferi follow independent courses of infection in mice[J].J Infect Dis,2005,192(9):1634-1641.
[79]Van DL,Voorberg-van der Wel A,van der Werff NM,et al.Suppression of Plasmodium cynomolgi in rhesus macaques by coinfection with Babesia microti[J].Infect Immun,2010,78(3):1032-1039.
[80]Martinez-Balzano C,Hess M,MalhotraA,et al.Severe babesiosis and Borrelia burgdorferico-infection[J].QJM,2015,108(2):141-143.20181213