主治肝肾亏虚证的成方制剂用药规律分析
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摘要
目的:分析《中华人民共和国卫生部药品标准·中药成方制剂》(以下简称《中药成方制剂》)中主治肝肾亏虚证的成方制剂用药规律。方法:收集主治肝肾亏虚证的所有成方制剂,运用中医传承辅助平台(V2.5)的关联规则分析等数据挖掘方法分析其用药规律,并比较3种高频疾病的用药异同。结果:主治肝肾亏虚证成方制剂共154首。其中涉及药物309种,高频药物有补血之熟地黄、生地黄、当归、白芍,补肝肾之何首乌、枸杞、女贞子、牛膝、菟丝子、五味子、杜仲,健脾益气之茯苓、黄芪、甘草、党参。核心药物组合以补肝肾(女贞子、墨旱莲、枸杞子、何首乌、牛膝)、养血(熟地黄、当归、白芍)和健脾之品(山药、茯苓)为主。涉及疾病67种,高频疾病为眩晕、耳鸣、不寐。治疗眩晕和耳鸣的药物组合基本相似,均以六味地黄丸、二至丸为基础加减,治疗不寐的药物组合以左归饮、二至丸为基础加减。结论:治疗肝肾亏虚证成方制剂以补肝肾、养血、健脾药物配伍为主,不同疾病肝肾亏虚证的用药很相似,但也有不同,体现了中医学异病同治,辨证与辨病相结合的治疗原则。本研究结果对指导临床实践及开发新药均有一定价值。
Objective: To analyze the medication rules of prescription in treating the Ganshen Kuixu deficiency( 肝 肾 亏 虚 证). Methods: All of the TCM prescriptions of the Ganshen Kuixu deficiency were collected and their medication rules were analyzed using data mining methods of TCM Inheritance Support Platform(V2.5) for association regulation analysis etc. Results: There were a total of 154 prescriptions of the Ganshen Kuixu deficiency. There were a total of 309 medicines, among which high frequency medicines were prepared. There were a total of 67 diseases. Among them, high frequency diseases were vertigo, tinnitus and insomnia. Medicine combination for the treatment of vertigo and tinnitus were very similar, both of them were based on the Liuwei Dihuang pill( 六味地黄丸) and Erzhi pill( 二至丸). Medicine combination for the treatment of insomnia was based on the Zuogui decoction( 左归饮) and Erzhi pill. Conclusion: The medicine combination of prescriptions of the Ganshen Kuixu deficiency were mainly for nourishing liver and kidney, nourishing blood and strengthening spleen drugs. The medication ofthe Ganshen Kuixu deficiency of different disease was very similar, but there were differences, too. The treatment principle of the combination of syndrome differentiation and disease differentiation was presented. This conclusion was valuable in directing clinical practice and developing new drugs.
Objective: To analyze the medication rules of prescription in treating the Ganshen Kuixu deficiency( 肝 肾 亏 虚 证). Methods: All of the TCM prescriptions of the Ganshen Kuixu deficiency were collected and their medication rules were analyzed using data mining methods of TCM Inheritance Support Platform(V2.5) for association regulation analysis etc. Results: There were a total of 154 prescriptions of the Ganshen Kuixu deficiency. There were a total of 309 medicines, among which high frequency medicines were prepared. There were a total of 67 diseases. Among them, high frequency diseases were vertigo, tinnitus and insomnia. Medicine combination for the treatment of vertigo and tinnitus were very similar, both of them were based on the Liuwei Dihuang pill( 六味地黄丸) and Erzhi pill( 二至丸). Medicine combination for the treatment of insomnia was based on the Zuogui decoction( 左归饮) and Erzhi pill. Conclusion: The medicine combination of prescriptions of the Ganshen Kuixu deficiency were mainly for nourishing liver and kidney, nourishing blood and strengthening spleen drugs. The medication ofthe Ganshen Kuixu deficiency of different disease was very similar, but there were differences, too. The treatment principle of the combination of syndrome differentiation and disease differentiation was presented. This conclusion was valuable in directing clinical practice and developing new drugs.
引文
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[3]姜超,唐先平.基于中医传承辅助系统分析唐先平主任医师治疗痛风急性关节炎期用药经验[J].中医临床研究,2016,8(35):4-8.
[4]唐仕欢,申丹,卢朋,等.中医传承辅助平台应用评述[J].中华中医药杂志,2015,30(2):330-331.
[5]唐仕欢,申丹,杨洪军.《中药成方制剂》中治疗疼痛方剂的用药规律比较[J].中华中医药杂志,2015,30(1):59.
[6]张向磊,李勇.基于中医传承辅助平台的中医药治疗慢性乙肝用药规律分析[J].中国中医基础医学杂志,2016,22(9):1245.
[7]杨雪,杨娟,宋丹,等.基于中医传承辅助平台系统的糖尿病气阴两虚型组方用药规律分析[J].中医临床研究,2017(35):4-7.
[8]杨洪军,唐仕欢,卢明.中医传承辅助平台的开发与应用[M].福州:福建科学技术出版社,2013:10.
[9]邵卫荣,申丹,唐仕欢.主治气血两虚证的成方制剂组方规律分析研究[J].中国中药杂志,2015,40(9):1818.
[10]唐仕欢,卢朋,李健,等.《中医方剂大辞典》中治疗哮病方剂组方规律分析[J].中医杂志,2012,53(14):1231.
[11]唐仕欢,杨洪军.中医组方用药规律研究进展述评[J].中国实验方剂学杂志,2013,19(5):360.