乳腺超声造影、彩色多普勒超声在评估乳腺癌新辅助化疗疗效中的对比观察
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摘要
目的探讨乳腺超声造影、彩色多普勒超声在评估乳腺癌新辅助化疗疗效。方法选取2016年10月～2017年9月在我院行新辅助化疗的乳腺癌患者86例为研究对象,分别使用彩色多普勒超声对治疗前后的多项指标进行记录,并选取32例患者进行超声造影检查,记录造影时间、峰值等相关参数。对比患者治疗前后的多项指标及疗效评价。结果新辅助化疗后患者的病灶最大直径低于化疗前,差异有统计学意义(P<0.05)。新辅助化疗后的形态规则、边界清晰、内部回声均匀、周边声带存在,均优于化疗前,差异有统计学意义(P<0.05)。化疗后的至肿瘤时间、达峰时间均高于化疗前,差异有统计学意义(P<0.05)。化疗后的达峰强度低于化疗前,差异有统计学意义(P<0.05)。结论多普勒超声可检测乳腺癌的多项指标,超声造影实现乳腺癌的动态监测,依据多个指标的变化对新辅助化疗的治疗效果进行评估。
Objective To explore the role of breast ultrasound contrast and color Doppler ultrasound in evaluating the efficacy of neoadjuvant chemotherapy for breast cancer. Methods Eighty-six breast cancer patients who underwent neoadjuvant chemotherapy in our hospital from October 2016 to September 2017 were enrolled in the study. Color Doppler ultrasound was used to record multiple indicators before and after treatment; 32 patients were selected for contrast-enhanced ultrasonography, and related parameters such as imaging time and peak value were recorded. Multiple indicators before and after treatment, as well as the efficacy evaluation, were compared and statistically analyzed. Results After neoadjuvant chemotherapy, the maximum diameter of the lesion was smaller than that before chemotherapy,and the difference was statistically significant(P<0.05). After neoadjuvant chemotherapy, the tumor showed regular morphology, clear boundary, uniform internal echo and peripheral echogenic band, which were superior to those before chemotherapy, and the difference was statistically significant( P<0.05). The time to tumor and the peak time after chemotherapy were higher than those before chemotherapy, and the difference was statistically significant(P<0.05). The peak intensity after chemotherapy was lower than that before chemotherapy, and the difference was statistically significant(P<0.05). Conclusion Doppler ultrasound can detect multiple indicators of breast cancer, and ultrasound contract can achieve dynamic monitoring of breast cancer, and evaluate the therapeutic effect of neoadjuvant chemotherapy according to changes of multiple indicators.
Objective To explore the role of breast ultrasound contrast and color Doppler ultrasound in evaluating the efficacy of neoadjuvant chemotherapy for breast cancer. Methods Eighty-six breast cancer patients who underwent neoadjuvant chemotherapy in our hospital from October 2016 to September 2017 were enrolled in the study. Color Doppler ultrasound was used to record multiple indicators before and after treatment; 32 patients were selected for contrast-enhanced ultrasonography, and related parameters such as imaging time and peak value were recorded. Multiple indicators before and after treatment, as well as the efficacy evaluation, were compared and statistically analyzed. Results After neoadjuvant chemotherapy, the maximum diameter of the lesion was smaller than that before chemotherapy,and the difference was statistically significant(P<0.05). After neoadjuvant chemotherapy, the tumor showed regular morphology, clear boundary, uniform internal echo and peripheral echogenic band, which were superior to those before chemotherapy, and the difference was statistically significant( P<0.05). The time to tumor and the peak time after chemotherapy were higher than those before chemotherapy, and the difference was statistically significant(P<0.05). The peak intensity after chemotherapy was lower than that before chemotherapy, and the difference was statistically significant(P<0.05). Conclusion Doppler ultrasound can detect multiple indicators of breast cancer, and ultrasound contract can achieve dynamic monitoring of breast cancer, and evaluate the therapeutic effect of neoadjuvant chemotherapy according to changes of multiple indicators.
引文
[1]董丽楠,宋海霞,李碧丽.彩色多普勒超声及超声造影在乳腺癌新辅助化疗疗效评估中的价值[J].转化医学杂志,2016,5(2):74-77.
[2]李玲,李玉明,李华斌,等.超声造影对乳腺癌患者新辅助化疗效果的评估价值[J].西南国防医药,2015,25(7):737-740.
[3]胡正明,孙德胜,钟洁愉,等.彩色多普勒超声评估乳腺癌新辅助化疗疗效[J].中国临床医学影像杂志,2013,24(8):548-550.
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[13]Chiu AG,Vaughan WC.Revision endoscopic frontal sinus surgery with surgical navigation[J].Otolaryngology--head and neck surgery:Official journal of American A-cademy of Otolaryngology-Head and Neck Surgery,2004,130(3):312-318.
[14]Koreas GB.Combine traditional Chinese and Western medicine clinical results[J].Tianjing People′s Publishing House,2013,12(9):7-13.
[15]Kew J,Rees GL,Close D.Multiplanar reconstructed computed tomography images improves depiction and understanding of the anatomy of the frontal sinus and recess[J].Am J Rhinol,2002,16(2):119-123.
[16]Lee SY,Kim JH,Han YH,et al.The effect of modulated electro-hyperthermia on temperature and blood flow in human cervical carcinoma[J].International journal of hyperthermia:The Official Journal of European Society for Hyperthermic Oncology,North American Hyperthermia Group,2018,34(7):953-960.
[17]Wang Y,Zhang PY,Liu K,et al.Evaluation of changes in right ventricular myocardial mechanical properties in breast cancer patients receiving pirarubicin using threedimensional speckle tracking imaging[J].Journal of Southern Medical University,2018,38(9):1032-1038.
[18]Zhao M,Liu MY.New avenues for nanoparticle-related therapies[J].Nanoscale Research Letters,2018,13(1):136.
[19]Ma Y,Lai WJ,Zhao MZ,et al.Plastin 3 down-regulation augments the sensitivity of MDA-MB-231 cells to paclitaxel via the p38 MAPK signalling pathway[J].Artificial cells,Nanomedicine,and Biotechnology,2019,47(1):685-695.
[20]Ruiz MC,Kljun J,Turel I,et al.Comparative antitumor studies of organoruthenium complexes with 8-hydroxyquinolines on 2D and 3D cell models of bone,lung and breast cancer[J].Metallomics:Integrated biometal science,2019,11(3):666-675.
[2]李玲,李玉明,李华斌,等.超声造影对乳腺癌患者新辅助化疗效果的评估价值[J].西南国防医药,2015,25(7):737-740.
[3]胡正明,孙德胜,钟洁愉,等.彩色多普勒超声评估乳腺癌新辅助化疗疗效[J].中国临床医学影像杂志,2013,24(8):548-550.
[4]邹群,童晓文.国产唑来膦酸治疗乳腺癌骨转移的临床疗效观察[J].实用临床医药杂志,2011,15(15):99-101.
[5]沈海瑞,陈坚.唑来膦酸联合全身静脉化疗治疗乳腺癌骨转移的疗效分析[J].世界最新医学信息文摘(连续型电子期刊),2016,16(64):107-108.
[6]Várady E,Feher E,Levai A,et a l.Estimation of vessel age and early diagnose of atherosclerosis in progeria syndrome by using echo-tracking[J].Clin Hemorheol Microcirc,2017,44(4):297-301.
[7]Guerin O,Soto ME,Brocker P,et al.Nutritional status assessment during Alzheimer’s disease[J].Nutr Health Aging,2016,9(2):81-84.
[8]Araki T,Emoto M,Teramura M,et al.Effect of adiponectin on carotid arterial stiffness in type 2 diabetic patients treated with pioglitazone and metformin[J].Metabolism,2012,55(8):996-1001.
[9]Brodszki J,Lnne T,Marsál K,et al.Impaired vascular growth in late adolescence after intraute rine growth restriction[J].Circulation,2015,11(20):2623-2628.
[10]Mor IA,Uchida N,Inomo A,et al.Stiffness of systemic arteries in appropriate-and small-for-gestational-age new born in fants[J].Pediatrics,2016,118(3):1035-1041.
[11]Hoegh A,Lindholt JS.Basic science review.Vascular distensibility asapredictive tool in the management of small asymptomatic abdominal aortic aneurysms[J].Vasc Endovascular Surg,2017,43(4):333-338.
[12]Shingu Y,Shiiya N,Ooka T,etal.Augmentation index is elevated in aortic aneurysm and dissection[J].Ann Thorac Surg,2016,87(5):1373-1377.
[13]Chiu AG,Vaughan WC.Revision endoscopic frontal sinus surgery with surgical navigation[J].Otolaryngology--head and neck surgery:Official journal of American A-cademy of Otolaryngology-Head and Neck Surgery,2004,130(3):312-318.
[14]Koreas GB.Combine traditional Chinese and Western medicine clinical results[J].Tianjing People′s Publishing House,2013,12(9):7-13.
[15]Kew J,Rees GL,Close D.Multiplanar reconstructed computed tomography images improves depiction and understanding of the anatomy of the frontal sinus and recess[J].Am J Rhinol,2002,16(2):119-123.
[16]Lee SY,Kim JH,Han YH,et al.The effect of modulated electro-hyperthermia on temperature and blood flow in human cervical carcinoma[J].International journal of hyperthermia:The Official Journal of European Society for Hyperthermic Oncology,North American Hyperthermia Group,2018,34(7):953-960.
[17]Wang Y,Zhang PY,Liu K,et al.Evaluation of changes in right ventricular myocardial mechanical properties in breast cancer patients receiving pirarubicin using threedimensional speckle tracking imaging[J].Journal of Southern Medical University,2018,38(9):1032-1038.
[18]Zhao M,Liu MY.New avenues for nanoparticle-related therapies[J].Nanoscale Research Letters,2018,13(1):136.
[19]Ma Y,Lai WJ,Zhao MZ,et al.Plastin 3 down-regulation augments the sensitivity of MDA-MB-231 cells to paclitaxel via the p38 MAPK signalling pathway[J].Artificial cells,Nanomedicine,and Biotechnology,2019,47(1):685-695.
[20]Ruiz MC,Kljun J,Turel I,et al.Comparative antitumor studies of organoruthenium complexes with 8-hydroxyquinolines on 2D and 3D cell models of bone,lung and breast cancer[J].Metallomics:Integrated biometal science,2019,11(3):666-675.