中药制剂便通灵胶囊的质量标准研究
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摘要
目的制订医院中药制剂便通灵胶囊的质量标准。方法采用TLC法鉴别处方中的大黄成分,HPLC法测定大黄五种主要成分及总蒽醌的含量。结果便通灵经过TLC和HPLC检测方法进行鉴别获得了较强的专属性,有效控制了该制剂的药品质量。结论提高了中药制剂便通灵胶囊的质量标准,可更好的控制其质量。
Objective To make the quality standards of Chinese medicine preparation of biantongling capsules. Methods The rhubarb component in the prescriptions was identified by the TLC method, and the five main components and total content of anthraquinone were measured by the HPLC method. Results The strong specificity of biantongling was obtained by the identificaion of TLC and HPLC test methods and the drug quality of this prepration was effectively controlled. Conclusion The improvement of quality standards of Chinese medicine preparation of biantongling capsules can better control its quality.
Objective To make the quality standards of Chinese medicine preparation of biantongling capsules. Methods The rhubarb component in the prescriptions was identified by the TLC method, and the five main components and total content of anthraquinone were measured by the HPLC method. Results The strong specificity of biantongling was obtained by the identificaion of TLC and HPLC test methods and the drug quality of this prepration was effectively controlled. Conclusion The improvement of quality standards of Chinese medicine preparation of biantongling capsules can better control its quality.
引文
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[8]寿林均,程巧鸳,黄柳倩,等.高效液相色谱法测定益之康胶囊中总蒽醌(大黄素和大黄素甲醚)的含量[J].食品工业科技.
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[10]吴迪,袁海铭,曾宪仪,等.HPLC法测定大黄总蒽醌胶囊5种蒽醌苷元及5种游离蒽醌含量[J].江西中医药大学学报,2016(1):68-70.
[2]井明博,段春燕,肖朝霞,等.均匀设计法优选掌叶大黄总蒽醌类物质的薄层层析展开剂体系[J].陇东学院学报,2015(5):66-69.
[3]中华人民共和国药典2015版I部[S]:187.
[4]许波,窦志华,卞理,等.多指标综合加权评分法优选大黄药材中蒽醌类成分提取工艺[J].中南药学,2016(4):370-374.
[5]谢伟雪,刘孝敏,谢伟敬.超声波法提取大黄蒽醌类成分的工艺研究[J].中国处方药,2015(11):22-24.
[6]王银娟,陆崟,汪玥,等.紫元胶囊的质量标准研究[J].中国医药导报,2015(18):89-91.
[7]冯素香,王哲,郝蕊,等.HPLC法同时测定不同产地掌叶大黄中10个蒽醌类化合物[J].药物分析杂志,2017(5):783-788.
[8]寿林均,程巧鸳,黄柳倩,等.高效液相色谱法测定益之康胶囊中总蒽醌(大黄素和大黄素甲醚)的含量[J].食品工业科技.
[9]庞婷,谢臻,陈勇,等.HPLC同时测定大黄配伍药对中7个蒽醌类化合物的含量[J].中国新药杂志,2017(9):1079-1088.
[10]吴迪,袁海铭,曾宪仪,等.HPLC法测定大黄总蒽醌胶囊5种蒽醌苷元及5种游离蒽醌含量[J].江西中医药大学学报,2016(1):68-70.