摘要
目的比较奥美拉唑与泮托拉唑治疗非幽门螺杆菌感染十二指肠溃疡的临床效果。方法选取2015年1月~2017年6月于九江市柴桑区人民医院住院的84例非幽门螺杆菌感染十二指肠溃疡患者作为研究对象。依据随机数字分组法,将其分为病例组和对照组,每组各42例。病例组患者给予泮托拉唑静点,对照组患者给予奥美拉唑静点。比较两组患者的临床疗效、临床症状积分和不良反应发生情况。结果病例组患者的总有效率为97.62%,高于对照组的85.71%,差异有统计学意义(P<0.05)。两组患者治疗后的临床症状积分均明显低于治疗前,差异有统计学意义(P<0.05);病例组患者治疗后的临床症状积分明显低于对照组,差异有统计学意义(P<0.05)。病例组患者的不良反应总发生率为7.14%,与对照组的9.52%比较,差异无统计学意义(P>0.05)。结论奥美拉唑与泮托拉唑临床效果相近,不良反应无明显差异,但后者的临床症状积分明显优于前者,安全性高,值得临床推广。
Objective To compare the clinical effects of Omeprazole and Pantoprazole in the treatment of duodenal ulcer caused by non-Helicobacter pylori infection. Methods A total of 84 patients with duodenal ulcer caused by nonHelicobacter pylori infection hospitalized in People′s Hospital in Chaisang District of Jiujiang City from January 2015 to June 2017 were selected as subjects. According to the random number grouping method, the patients were divided into case group and control group, with 42 cases in each group. Pantoprazole was given to the case group and Omeprazole was given to the control group. The clinical efficacy, clinical symptom score and incidence of adverse reactions were compared between the two groups. Results The total effective rate of the case group was 97.62%, higher than that of the control group(85.71%), the difference was statistically significant(P<0.05). The scores of clinical symptoms in the two groups after treatment were significantly lower than those before treatment, the differences were statistically significant(P<0.05). The scores of clinical symptoms in the case group after treatment were significantly lower than those in the control group, the differences were statistically significant(P<0.05). The total incidence of adverse reactions was 7.14% in the case group and 9.52% in the control group, there was no significant difference between the two groups(P>0.05). Conclusion The clinical efficacy of Omeprazole and Pantoprazole is similar, and there is no significant difference in adverse reactions, but the clinical symptom score of the latter is significantly better than the former, and the safety is high, which is worthy of clinical promotion.
引文
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