一种四极质谱仪射频电源控制与数据采集系统的研制
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摘要
四极杆射频电源是四极质谱仪的核心部件,传统的四极杆射频电源控制与数据采集一般采用模数转换器(ADC)与主控芯片搭配来实现,先将信号进行预分频,再用ADC采集,处理速度慢、功能单一。本文基于微控制器(ARM)和现场可编程门阵列(FPGA),研制了一种新型的射频电源控制与数据采集系统。ARM用于与上位机通讯及模块间的级联控制,FPGA负责交直流控制电压的输出、扫描时序产生及数据采集,进而实现仪器的质量数扫描、跳峰扫描等功能。选用基于上述设计的电感耦合等离子体质谱仪(ICP-MS)样机,依照四极杆电感耦合等离子体质谱仪校准规范JJF 1159—2006进行了分辨率、灵敏度、质量轴稳定性和线性测定试验,测定结果符合该规范要求。
The quadrupole radio frequency power was the core component of quadrupole mass spectrometer.The traditional quadrupole radio frequency power control and data acquisition were usually realized by the match of analog-digital converter(ADC)and main control chip.The signals were treated by prescale followed by ADC acquisition.The processing speed was low and the function was single.A novel radio frequency power control and data acquisition system was developed based on microcontroller(ARM)and field programmable gate array(FPGA).ARM was used for the communication with upper-computer and cascade control among modules,while FPGA was responsible for the output of alternating currecnt(AC)/direct current(DC)control voltage,the generation of scan sequence and the data acquisition,thus realizing the instrumental functions such as mass number scanning and jump peak scanning.The model machine of inductively coupled plasma source mass spectrometer(ICP-MS)with above designs was used for the tests of resolution ratio,sensitivity,mass axis stability and linearity determination according to the calibration specification(JJF 1159-2006)for quadrupole inductively coupled plasma mass spectrometer.The results indicated that the determination results could meet the requirements of this specification.
The quadrupole radio frequency power was the core component of quadrupole mass spectrometer.The traditional quadrupole radio frequency power control and data acquisition were usually realized by the match of analog-digital converter(ADC)and main control chip.The signals were treated by prescale followed by ADC acquisition.The processing speed was low and the function was single.A novel radio frequency power control and data acquisition system was developed based on microcontroller(ARM)and field programmable gate array(FPGA).ARM was used for the communication with upper-computer and cascade control among modules,while FPGA was responsible for the output of alternating currecnt(AC)/direct current(DC)control voltage,the generation of scan sequence and the data acquisition,thus realizing the instrumental functions such as mass number scanning and jump peak scanning.The model machine of inductively coupled plasma source mass spectrometer(ICP-MS)with above designs was used for the tests of resolution ratio,sensitivity,mass axis stability and linearity determination according to the calibration specification(JJF 1159-2006)for quadrupole inductively coupled plasma mass spectrometer.The results indicated that the determination results could meet the requirements of this specification.
引文
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[4]李凯,李明,唐兴斌,等.直接数字频率合成技术在四极质谱仪射频电源中的应用[J].冶金分析,2014,34(2):20-24.LI Kai,LI Ming,TANG Xing-bin,et al.Application of direct digital frequency synthesis technology in radio-frequency power of quadrupole mass spectrometer[J].Metallurgical Analysis,2014,34(2):20-24.
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[6]朱萍.四极质谱计数据采集及处理系统的设计[D].南京:东南大学,2004.
[7]江游,吴保军,穰瑜,等.四极质谱仪通用数字控制系统结构的研究[J].质谱学报,2008,29(2):65-69.JIANG You,WU Bao-jun,RANG YU,et al.Research on universal digital control system architecture of quadrupole mass filter and quadrupole ion trap mass spectrometer[J].Journal of Chinese Mass Spectrometry Society,2008,29(2):65-69.
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[12]中华人民共和国国家质量监督检验检疫总局,全国物理化学计量技术委员会.JJF 1159—2006四极杆电感耦合等离子体质谱仪校准规范[S].北京:中国计量出版社,2007.
[2]Thomas R.Practical guide to ICP-MS:A tutorial for beginners[M].New York:CRC Press,2008:69-73.
[3]刘虎生,邵宏翔.电感耦合等离子体质谱技术及应用[M].北京:化学工业出版社,2005:225-230.
[4]李凯,李明,唐兴斌,等.直接数字频率合成技术在四极质谱仪射频电源中的应用[J].冶金分析,2014,34(2):20-24.LI Kai,LI Ming,TANG Xing-bin,et al.Application of direct digital frequency synthesis technology in radio-frequency power of quadrupole mass spectrometer[J].Metallurgical Analysis,2014,34(2):20-24.
[5]李冰,杨红霞.电感耦合等离子体质谱原理和应用[M].北京:地质出版社,2005:112-120.
[6]朱萍.四极质谱计数据采集及处理系统的设计[D].南京:东南大学,2004.
[7]江游,吴保军,穰瑜,等.四极质谱仪通用数字控制系统结构的研究[J].质谱学报,2008,29(2):65-69.JIANG You,WU Bao-jun,RANG YU,et al.Research on universal digital control system architecture of quadrupole mass filter and quadrupole ion trap mass spectrometer[J].Journal of Chinese Mass Spectrometry Society,2008,29(2):65-69.
[8]NXP Semiconductors.LPC17XX 32-bit ARM Cotex-M3microcontroller datasheet[G].Eindhoven:NXP Semiconductors,2012:1-2.
[9]Analog devices.AD823 Dual,16MHz,Rail-to-Rail FET input amplifier datasheet[G].Massachusetts:Analog Devices,1995:1-2.
[10]Christopher G.Mass spectrometry basics[M].New York:CRC Press,2002:88-92.
[11]National Semiconductor.DS90LV018 3V LVDS Single CMOS Differential Line Receiver datasheet[G].California:National Semiconductor,1998:1-2.
[12]中华人民共和国国家质量监督检验检疫总局,全国物理化学计量技术委员会.JJF 1159—2006四极杆电感耦合等离子体质谱仪校准规范[S].北京:中国计量出版社,2007.