肺炎支原体肺炎患儿免疫球蛋白水平及意义
摘要
目的探讨肺炎支原体(MP)肺炎患儿免疫球蛋白水平及意义。方法选取2018年1-12月在我院治疗的MP肺炎患儿210例(MP组),同时选取健康体检患儿200例作为对照组,检测免疫球蛋白水平,同时采用临床肺部感染评分(CPIS)评价MP组病情。结果 MP组Ig M为(1. 80±0. 21) g/L,明显高于对照组(P<0. 05),而Ig G和Ig A分别为(5. 40±1. 00) g/L和(0. 55±0. 24) g/L,明显低于对照组(P<0. 05); MP组CPIS评分≥6分患儿Ig M为(2. 01±0. 30) g/L,明显高于CPIS评分<6分患儿(P<0. 05); MP患儿Ig M水平与CPIS评分均呈正相关(r=0. 311,P<0. 05)。结论 MP肺炎患儿Ig M明显升高,而Ig G、Ig A明显降低,Ig M水平与病情严重程度有一定关系。
引文
[1]陈秀英,赖茂.免疫球蛋白联合甲强龙对重症支原体肺炎患儿免疫功能的影响[J].中国妇幼保健,2017,32(2):305.
[2]郭飞波,韩利蓉,余卉,等.血清补体、免疫球蛋白及炎性细胞因子动态检测在儿童肺炎支原体感染中的应用价值[J].中国免疫学杂志,2017,33(6):910.
[3]宋宏玲.异丙托溴胺联合布地奈德雾化吸入对病毒性肺炎患儿血清免疫球蛋白、T淋巴细胞和炎性因子的影响[J].河北医药,2016,38(13):1946.
[4]王良玉,辛德莉.肺炎支原体感染实验室诊断的研究进展[J].传染病信息,2017,30(1):51.
[5]LI J,CHEN T,YUAN C,et al.Effect of intravenous immunoglobulin on the function of Treg cells derived from immunosuppressed mice with Pseudomonas aeruginosapneumonia[J].Plos One,2017,12(5):e0176843.
[6]颜海峰,霍开明,韩栋光,等.肺炎支原体感染对哮喘患儿血清Ig E、白细胞介素水平及肺功能的影响[J].山东医药,2017,57(34):78.
[7]雷勋明,陈全景.EB病毒合并肺炎支原体感染传染性单核细胞增多症的免疫指标变化[J].检验医学与临床,2017,14(A02):216.
[8]ZDZIARSKI P,GAMIAN A,DWORACKI G.A case report of lymphoid intestitial pneumonia in common variable immunodeficiency:Oligoclonal expansion of effector lymphocytes with preferential cytomegalovirus-specific immune response and lymphoproliferative disease promotion[J].Medicine,2017,96(23):e7031.
[9]WEI L,LIU Y,ZHAO X,et al.Th1/Th2 cytokine profile and its diagnostic value in mycoplasma pneumoniae pneumonia[J].Iranian Journal of Pediatrics,2016,26(1):e3807.
[10]贵仁伍,任静,赵润.喜炎平注射液联合阿奇霉素对儿童肺炎患儿炎症细胞因子、淋巴细胞亚群、红细胞免疫指标及免疫球蛋白的影响[J].中国妇幼保健,2017,32(20):5010.
[11]郭飞波,韩利蓉,余卉,等.血清补体、免疫球蛋白及炎性细胞因子动态检测在儿童肺炎支原体感染中的应用价值[J].中国免疫学杂志,2017,33(6):910.
[12]EDGAR J D M,RICHTER A G,HUISSOON A P,et al.Prescribing immunoglobulin replacement therapy for patients with non-classical and secondary antibody deficiency:an analysis of the practice of clinical immunologists in the UK and Republic of Ireland[J].Journal of Clinical Immunology,2018,38(2):204.
[2]郭飞波,韩利蓉,余卉,等.血清补体、免疫球蛋白及炎性细胞因子动态检测在儿童肺炎支原体感染中的应用价值[J].中国免疫学杂志,2017,33(6):910.
[3]宋宏玲.异丙托溴胺联合布地奈德雾化吸入对病毒性肺炎患儿血清免疫球蛋白、T淋巴细胞和炎性因子的影响[J].河北医药,2016,38(13):1946.
[4]王良玉,辛德莉.肺炎支原体感染实验室诊断的研究进展[J].传染病信息,2017,30(1):51.
[5]LI J,CHEN T,YUAN C,et al.Effect of intravenous immunoglobulin on the function of Treg cells derived from immunosuppressed mice with Pseudomonas aeruginosapneumonia[J].Plos One,2017,12(5):e0176843.
[6]颜海峰,霍开明,韩栋光,等.肺炎支原体感染对哮喘患儿血清Ig E、白细胞介素水平及肺功能的影响[J].山东医药,2017,57(34):78.
[7]雷勋明,陈全景.EB病毒合并肺炎支原体感染传染性单核细胞增多症的免疫指标变化[J].检验医学与临床,2017,14(A02):216.
[8]ZDZIARSKI P,GAMIAN A,DWORACKI G.A case report of lymphoid intestitial pneumonia in common variable immunodeficiency:Oligoclonal expansion of effector lymphocytes with preferential cytomegalovirus-specific immune response and lymphoproliferative disease promotion[J].Medicine,2017,96(23):e7031.
[9]WEI L,LIU Y,ZHAO X,et al.Th1/Th2 cytokine profile and its diagnostic value in mycoplasma pneumoniae pneumonia[J].Iranian Journal of Pediatrics,2016,26(1):e3807.
[10]贵仁伍,任静,赵润.喜炎平注射液联合阿奇霉素对儿童肺炎患儿炎症细胞因子、淋巴细胞亚群、红细胞免疫指标及免疫球蛋白的影响[J].中国妇幼保健,2017,32(20):5010.
[11]郭飞波,韩利蓉,余卉,等.血清补体、免疫球蛋白及炎性细胞因子动态检测在儿童肺炎支原体感染中的应用价值[J].中国免疫学杂志,2017,33(6):910.
[12]EDGAR J D M,RICHTER A G,HUISSOON A P,et al.Prescribing immunoglobulin replacement therapy for patients with non-classical and secondary antibody deficiency:an analysis of the practice of clinical immunologists in the UK and Republic of Ireland[J].Journal of Clinical Immunology,2018,38(2):204.