双歧杆菌三联活菌辅助蓝光照射治疗新生儿黄疸的疗效分析
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摘要
目的 探讨双歧杆菌三联活菌辅助蓝光照射治疗新生儿黄疸的疗效分析。方法 将2016年8月—2018年8月在该院新生儿科治疗的90例新生儿黄疸患儿随机分为两组,对照组采用蓝光照射治疗,在此基础上观察组采用双歧杆菌三联活菌辅助治疗,比较两组患儿的胆红素水平、黄疸消退时间、临床疗效。结果 观察组治疗后1 d、3 d、5 d的经皮胆红素水平分别为(252.46±42.75)μmol/L、(207.68±34.83)μmol/L、(143.94±32.94)μmol/L明显低于对照组的(266.84±41.92)μmol/L、(239.77±38.48)μmol/L、(194.57±41.39)μmol/L(t=4.032,4.414,5.346,P<0.05);观察组黄疸消退时间为(3.74±0.53)d明显短于对照组的(5.25±0.39)d,而日均胆红素下降值为(24.31±5.46)μmol/L明显高于对照组的(15.27±5.68)μmol/L(t=4.303,4.987,P<0.05);观察组治疗有效率为97.78%,明显高于对照组的80.00%(χ~2=10.21,P<0.05);观察组腹泻、稀便、褐色便等不良反应发生率明显低于对照组(χ~2=11.34,P<0.05)。以上差异有统计学意义(P<0.05)。结论 双歧杆菌三联活菌辅助蓝光照射来治疗新生儿黄疸的疗效显著,更能有效促进胆红素分解,改善高胆红素血症,促进黄疸的快速消退,具有积极的临床意义。
Objective To investigate the efficacy of Bifidobacterium triple viable bacteria combined with blue light irradiation in the treatment of neonatal jaundice. Methods A total of 90 cases of neonatal jaundice treated in our hospital from August 2016 to August2018 were randomly divided into two groups. The control group was treated with blue light irradiation. On this basis, the observation group was treated with Bifidobacterium triple live bacterium adjuvant therapy. The bilirubin level, jaundice subsidence time and clini-cal efficacy of the two groups were compared. Results The levels of transdermal bilirubin in the observation group were(252.46 ±42.75)μmol/L,(207.68±34.83)μmol/L,(143.94±32.94)μmol/L on the 1 st, 3 rd and 5 th day after treatment, respectively, which were significantly lower than those in the control group(266.84 ±41.92)μmol/L,(239.77±38.48) μmol/L,(194.57±41.39)μmol/L,(P<0.05)(t=4.032,4.414,5.346, P<0.05). The astragalus regression time was(3.74±0.53) d in the observation group, which was significantly shorter than that in the control group(5.25±0.39) d. And the daily mean bilirubin decrease value was(24.31±5.46) micromol/L in the observation group, which was significantly higher than that in the control group(15.27 ±5.68)μmol/L(t=4.303,4.987, P<0.05). The effective rate in the observation group was 97.78%, which was significantly higher than that in the control group 80%(χ~2=10.21, P<0.05). The incidence of adverse reactions such as diarrhea, dilution and defecation in the observation group were significantly lower than that of the control group(χ~2=11.34, P<0.05). the difference was statistically significant.Conclusion Bifidobacterium triple viable bacteria com-bined with blue light irradiation is effective in the treatment of neonatal jaundice. It can effectively promote bilirubin decomposition,improve hyperbilirubinemia, and promote the rapid regression of jaundice. It has positive clinical significance.
Objective To investigate the efficacy of Bifidobacterium triple viable bacteria combined with blue light irradiation in the treatment of neonatal jaundice. Methods A total of 90 cases of neonatal jaundice treated in our hospital from August 2016 to August2018 were randomly divided into two groups. The control group was treated with blue light irradiation. On this basis, the observation group was treated with Bifidobacterium triple live bacterium adjuvant therapy. The bilirubin level, jaundice subsidence time and clini-cal efficacy of the two groups were compared. Results The levels of transdermal bilirubin in the observation group were(252.46 ±42.75)μmol/L,(207.68±34.83)μmol/L,(143.94±32.94)μmol/L on the 1 st, 3 rd and 5 th day after treatment, respectively, which were significantly lower than those in the control group(266.84 ±41.92)μmol/L,(239.77±38.48) μmol/L,(194.57±41.39)μmol/L,(P<0.05)(t=4.032,4.414,5.346, P<0.05). The astragalus regression time was(3.74±0.53) d in the observation group, which was significantly shorter than that in the control group(5.25±0.39) d. And the daily mean bilirubin decrease value was(24.31±5.46) micromol/L in the observation group, which was significantly higher than that in the control group(15.27 ±5.68)μmol/L(t=4.303,4.987, P<0.05). The effective rate in the observation group was 97.78%, which was significantly higher than that in the control group 80%(χ~2=10.21, P<0.05). The incidence of adverse reactions such as diarrhea, dilution and defecation in the observation group were significantly lower than that of the control group(χ~2=11.34, P<0.05). the difference was statistically significant.Conclusion Bifidobacterium triple viable bacteria com-bined with blue light irradiation is effective in the treatment of neonatal jaundice. It can effectively promote bilirubin decomposition,improve hyperbilirubinemia, and promote the rapid regression of jaundice. It has positive clinical significance.
引文
[1]赵炜琨,黄桂华.酪酸梭菌活菌散剂配合蓝光治疗新生儿高胆红素血症的效果[J].中国当代医药,2018,25(29):79-81.
[2]陈艳,郑意楠.茵栀黄及双歧杆菌三联活菌辅助光照治疗新生儿黄疸疗效分析[J].中国全科医学,2012,15(21):2480-2481.
[3]王铁锋.茵栀黄颗粒联合蓝光及双歧杆菌三联活菌治疗新生儿黄疸的疗效观察[J].实用中西医结合临床,2017,17(1):79.
[4]钟晓波.茵栀黄颗粒联合间隙蓝光照射佐以双歧杆菌三联活菌治疗新生儿黄疸临床分析[J].中药材,2015,38(3):643-644.
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[7]谭延红.双歧杆菌三联活菌片联合茵栀黄口服液辅助蓝光照射治疗新生儿黄疸疗效观察[J].临床医学研究与实践,2017,2(16):110-111.
[8]陈岚.茵栀黄口服液联合间隙蓝光照射佐以双歧杆菌三联活菌治疗新生儿黄疸的临床效果[J].中国医药导报,2016,13(11):96-99.
[9]李庆范.茵栀黄颗粒联合间隙蓝光照射佐以双歧杆菌三联活菌治疗新生儿黄疸临床效果观察[J].河南医学研究,2016,25(11):2061-2062.
[10]林淑敏.双歧杆菌三联活菌肠溶胶囊联合蓝光照射治疗新生儿黄疸临床观察[J].深圳中西医结合杂志,2016,26(20):124-125.
[11]徐拔群,吕海涛,张立春.双歧杆菌三联活菌散辅助治疗足月新生儿黄疸的疗效分析[J].儿科药学杂志,2017(1):26-28.
[12]王铁锋.茵栀黄颗粒联合蓝光及双歧杆菌三联活菌治疗新生儿黄疸的疗效观察[J].实用中西医结合临床,2017,17(1):79.
[2]陈艳,郑意楠.茵栀黄及双歧杆菌三联活菌辅助光照治疗新生儿黄疸疗效分析[J].中国全科医学,2012,15(21):2480-2481.
[3]王铁锋.茵栀黄颗粒联合蓝光及双歧杆菌三联活菌治疗新生儿黄疸的疗效观察[J].实用中西医结合临床,2017,17(1):79.
[4]钟晓波.茵栀黄颗粒联合间隙蓝光照射佐以双歧杆菌三联活菌治疗新生儿黄疸临床分析[J].中药材,2015,38(3):643-644.
[5]郭立波.双歧杆菌三联活菌散辅助治疗新生儿黄疽的临床效果观察[J].中国当代医药,2013,20(8):84-85.
[6]高波,李科兴,宋霞等.茵栀黄与双歧杆菌治疗新生儿黄疸的疗效及对谷丙转氨酶和总胆汁酸的影响[J].中国妇幼保健,2018,33(3):606-609.
[7]谭延红.双歧杆菌三联活菌片联合茵栀黄口服液辅助蓝光照射治疗新生儿黄疸疗效观察[J].临床医学研究与实践,2017,2(16):110-111.
[8]陈岚.茵栀黄口服液联合间隙蓝光照射佐以双歧杆菌三联活菌治疗新生儿黄疸的临床效果[J].中国医药导报,2016,13(11):96-99.
[9]李庆范.茵栀黄颗粒联合间隙蓝光照射佐以双歧杆菌三联活菌治疗新生儿黄疸临床效果观察[J].河南医学研究,2016,25(11):2061-2062.
[10]林淑敏.双歧杆菌三联活菌肠溶胶囊联合蓝光照射治疗新生儿黄疸临床观察[J].深圳中西医结合杂志,2016,26(20):124-125.
[11]徐拔群,吕海涛,张立春.双歧杆菌三联活菌散辅助治疗足月新生儿黄疸的疗效分析[J].儿科药学杂志,2017(1):26-28.
[12]王铁锋.茵栀黄颗粒联合蓝光及双歧杆菌三联活菌治疗新生儿黄疸的疗效观察[J].实用中西医结合临床,2017,17(1):79.