基于石墨烯量子点的全印刷纸质生物传感器
|
摘要
用于医疗保健的及时诊断技术及移动检测方式要求新一代低成本、准确、灵敏且适于大批量生产的生物传感器。采用印刷方式制备传感器的方案推陈出新,全印刷技术为实现传感器的大批量生产提供新思路。纸材料低廉环保,在低成本制作传感器方面有良好的应用前景。石墨烯量子点具有优异的导电性、优良的生物相容性、稳定的荧光等特点,在改善和提高传感器性能方面存在很大潜力。对目前的全印刷传感器、纸质传感器和基于石墨烯量子点的传感器进行综述,提出一种基于石墨烯量子点的全印刷纸质生物传感器方案。
The point-of-care diagnosis and mobile diagnostics for health care require a new generation of biosensors that are low-cost,accurate,sensitive and suitable for mass production.There are more and more schemes for fabricating biosensors by printing,and the all-printed technology provides a new idea for fabricating biosensors in bulk. Paper is cheap and environmentally friendly,and has appeared as a very promising platform for the production of cost effective sensors.Graphene quantum dots have great potential in improving the performance of sensor thanks to its excellent conductivity,outstanding biocompatibility,and stable fluorescence.This article reviewed all-printed paper-based sensors and some graphene quantum dots-based sensors,and a new sensor called all-printed paper biosensor based on graphene quantum dots was proposed.
The point-of-care diagnosis and mobile diagnostics for health care require a new generation of biosensors that are low-cost,accurate,sensitive and suitable for mass production.There are more and more schemes for fabricating biosensors by printing,and the all-printed technology provides a new idea for fabricating biosensors in bulk. Paper is cheap and environmentally friendly,and has appeared as a very promising platform for the production of cost effective sensors.Graphene quantum dots have great potential in improving the performance of sensor thanks to its excellent conductivity,outstanding biocompatibility,and stable fluorescence.This article reviewed all-printed paper-based sensors and some graphene quantum dots-based sensors,and a new sensor called all-printed paper biosensor based on graphene quantum dots was proposed.
引文
[1]张李建,廉飞宇.生物传感器的发展现状及其应用展望[J].中国高新技术企业,2016(3):53.
[2]吴海云.几种新型电化学生物传感器的构建与应用研究[D].晋中:山西农业大学,2013.
[3]滕渊洁.基于丝网印刷电极电化学生物传感器研究[D].上海:华东理工大学,2011.
[4]CLARK L J,LYONS C.Electrode systems for continuous monitoring in cardiovascular surgery[J].Annals of the New York academy of science,1962,102:29.
[5]UPDIKE S J,HICKS G P.The enzyme electrode[J].Nature,1967,214:986.
[6]CASS A E G,DAVIS G,FRANCIS G D,et al.Ferrocene-mediated enzyme electrode for amperometric determination of glucose[J].Analytical chemistry,1984,56(4):667.
[7]李祥高,吴宪,王世荣.印刷电子技术在生物传感器中的应用[J].中国材料进展,2014,33(3):156.
[8]王作晓.丝网印刷电极的制备及其在血液检测中的应用[D].武汉:武汉大学,2016.
[9]KOMURO N,TAKAKI S,SUZUKI K,et al.Inkjet printed(bio)chemical sensing devices[J].Analytical and bioanalytical chemistry,2013,405(17):5785.
[10]赵广英,吴艳燕.丝网印刷碳电极传感器检测茶叶中痕量铅研究[J].茶叶科学,2008(2):93.
[11]RICCI F,AMINE A,PALLESCHI G,et al.Prussian blue based screen printed biosensors with improved characteristics of longterm life time and p H stability[J].Biosens bioelectron,2003,18(2/3):165.
[12]裴为华,国冬梅,耿照新,等.印刷传感技术[J].中国材料进展,2014(3):172.
[13]SOPHIE L,NADINE R,MOHAMMED B.One-step screen-printed electrode modified in its bulk with HRP based on direct electron transfer for hydrogen peroxide detection in flow injection mode[J].Biosensors and bioelectronics,2006,21:1591.
[14]BENI V,NILSSON D,ARVEN P,et al.Printed electrochemical instruments for biosensors[J].ECS journal of solid state science and technology,2015,10(4):S3001.
[15]SU W,COOK B S,COOPER J R,et al.Low-cost flexible allinkjet-printed microfluidic sensor[J].Systems for chemistry and life sciences,2015,10:25.
[16]KOJI A,KOJI S,DANIEL C.Inkjet-printed microfluidic multianalyte chemical sensing paper[J].American chemical society,2008,80:6928.
[17]BANDODKAR A J,NUEZ-FLORES R,JIA W.All-printed stretchable electrochemical[J].Advance materials,2015,27:3060.
[18]BANDODKAR A J,JEERAPAN I,YOU J,et al.Highly stretchable fully-printed CNT-based electrochemical sensors and biofuel cells:combining intrinsic and design-induced stretchability[J].Nano letter,2016,16:721.
[19]党雪平.一氧化氮光电化学微传感界面的设计与应用[D].武汉:武汉大学,2012.
[20]POLAVARAPU L,LIZ-MARZN L M.Towards low-cost flexible substrates for nanoplasmonic sensing[J].Phyical chemistry chemical physics,2013,15:5288.
[21]YU W W,WHITE I M.Inkjet printed surface enhanced raman spectroscopy array on cellulose paper[J].Analytical chemistry,2010,82:9626.
[22]INALAINEN P,MAJUMDAR H,VIITALA T,et al.Application of paper-supported gold electrodes for impedimetric immunosensor development[J].Biosensors,2013,3(1):1.
[23]付相庭.便携式纸基电化学分析仪研究[D].宁波:宁波大学,2015.
[24]黄辉洪.纸基微流控芯片用于葡萄糖快速检测的实验研究[D].福州:福建医科大学,2014.
[25]DELANEY J L,HOGAN C F,TIAN J,et al.Electrogenerated chemiluminescence detection in paper-based microfluidic sensors[J].Analytical chemistry,2011,83(4):1300.
[26]DUNGCHAI W,CHAILAPAKUL O,HENRY C S.Electrochemical detection for paper-based microfluidics[J].Analytical chemistry,2009,81(14):5821.
[27]NIE Z,DEISS F,LIU X,et al.Integration of paper-based microfluidic devices with commercial electrochemical readers[J].Lab on a chip,2010,10:3163.
[28]VELLA S J,BEATTIE P,CADEMARTIRI R,et al.Measuring markers of liver function using a micropatterned paper device designed for blood from a fingerstick[J].Analytical chemistry,2012,84(6):2883.
[29]王娇娇,冯苗,詹红兵.石墨烯量子点的制备[J].化学进展,2013(1):86.
[30]TANG L,JI R,CAO X,et al.Deep ultraviolet photoluminescence of water-soluble self-passivated grapheme quantum dots[J].ACS nano,2012,6:5102.
[31]ZHUO S,SHAO M,LEE S T.Upconversion and downconversion fluorescent grapheme quantum dots:ultrasonic preparation and photocatalysis[J].ACS nano,2012,6:1059.
[32]ZHU S,ZHANG J,TANG S,et al.Surface chemistry roules to modulate the photoluminescence of grapheme quanlum dots:from fluorescence to up-conversion bioimaging applications[J].Advanced functional materials,2012,22:4732.
[33]ZHU S,ZHANG J,QIAO C,et al.Strongly green-photoluminescent grapheme quantum dots for bioimaging applications[J].Chemical communications,2011,47:6858.
[34]张晓蕾,杨小弟.石墨烯量子点在生物传感和成像技术中的应用[J].化工时刊,2014,28(4):38.
[35]陈帅.石墨烯量子点的制备及在传感和成像中的应用研究[D].沈阳:东北大学,2015.
[36]PAOLA R,ROBERT L,ELAHE J,et al.Single-step synthesis of graphene quantum dots by femtosecond laser ablation of graphene oxidedispersions[J].Nanoscale,2016,8:8863.
[37]ELAHE J,EHSAN T.Aerosol-jet printing of highly flexible and conductive graphene/silver patterns[J].Materials letters,2016,174:40.
[38]PREETI N J,SHOBHA W.Graphene quantum dot-based on-chip electrochemical DNA hybridization sensor for pancreatic cancer[J].Reports in electrochemistry,2016,6:31.
[39]ZHAO J,CHEN G,ZHU L,et al.Graphene quantum dots-based platform for the fabrication of electrochemical biosensors[J].Electrochemistry communications,2011,13:31.
[40]RAZMI H,MOHAMMAL-REZAEI R.Graphene quantum dots as a new substrate for immobilization and direct electrochemistry of glucose oxidase:application to sensitive glucose determination[J].Biosensors and bioelectronics,2013,41:498.
[41]LU J,YAN M,GE L,et al.Electrochemiluminescence of blueluminescent graphene quantum dots as a fluorescent its application in ultrasensitive aptasensor for adenosine triphosphate detection[J].Biosensors and bioelectronics,2013,47:271.
[42]LI L,LI W P,MA C,et al.Paper-based electrochemiluminescence immunodevice for carcinoembryonic antigen using nanoporous gold-chitosan hybrids and graphene quantum dots functionalized Au@Pt[J].Sensors and actuators B,2014,(202):314.
[2]吴海云.几种新型电化学生物传感器的构建与应用研究[D].晋中:山西农业大学,2013.
[3]滕渊洁.基于丝网印刷电极电化学生物传感器研究[D].上海:华东理工大学,2011.
[4]CLARK L J,LYONS C.Electrode systems for continuous monitoring in cardiovascular surgery[J].Annals of the New York academy of science,1962,102:29.
[5]UPDIKE S J,HICKS G P.The enzyme electrode[J].Nature,1967,214:986.
[6]CASS A E G,DAVIS G,FRANCIS G D,et al.Ferrocene-mediated enzyme electrode for amperometric determination of glucose[J].Analytical chemistry,1984,56(4):667.
[7]李祥高,吴宪,王世荣.印刷电子技术在生物传感器中的应用[J].中国材料进展,2014,33(3):156.
[8]王作晓.丝网印刷电极的制备及其在血液检测中的应用[D].武汉:武汉大学,2016.
[9]KOMURO N,TAKAKI S,SUZUKI K,et al.Inkjet printed(bio)chemical sensing devices[J].Analytical and bioanalytical chemistry,2013,405(17):5785.
[10]赵广英,吴艳燕.丝网印刷碳电极传感器检测茶叶中痕量铅研究[J].茶叶科学,2008(2):93.
[11]RICCI F,AMINE A,PALLESCHI G,et al.Prussian blue based screen printed biosensors with improved characteristics of longterm life time and p H stability[J].Biosens bioelectron,2003,18(2/3):165.
[12]裴为华,国冬梅,耿照新,等.印刷传感技术[J].中国材料进展,2014(3):172.
[13]SOPHIE L,NADINE R,MOHAMMED B.One-step screen-printed electrode modified in its bulk with HRP based on direct electron transfer for hydrogen peroxide detection in flow injection mode[J].Biosensors and bioelectronics,2006,21:1591.
[14]BENI V,NILSSON D,ARVEN P,et al.Printed electrochemical instruments for biosensors[J].ECS journal of solid state science and technology,2015,10(4):S3001.
[15]SU W,COOK B S,COOPER J R,et al.Low-cost flexible allinkjet-printed microfluidic sensor[J].Systems for chemistry and life sciences,2015,10:25.
[16]KOJI A,KOJI S,DANIEL C.Inkjet-printed microfluidic multianalyte chemical sensing paper[J].American chemical society,2008,80:6928.
[17]BANDODKAR A J,NUEZ-FLORES R,JIA W.All-printed stretchable electrochemical[J].Advance materials,2015,27:3060.
[18]BANDODKAR A J,JEERAPAN I,YOU J,et al.Highly stretchable fully-printed CNT-based electrochemical sensors and biofuel cells:combining intrinsic and design-induced stretchability[J].Nano letter,2016,16:721.
[19]党雪平.一氧化氮光电化学微传感界面的设计与应用[D].武汉:武汉大学,2012.
[20]POLAVARAPU L,LIZ-MARZN L M.Towards low-cost flexible substrates for nanoplasmonic sensing[J].Phyical chemistry chemical physics,2013,15:5288.
[21]YU W W,WHITE I M.Inkjet printed surface enhanced raman spectroscopy array on cellulose paper[J].Analytical chemistry,2010,82:9626.
[22]INALAINEN P,MAJUMDAR H,VIITALA T,et al.Application of paper-supported gold electrodes for impedimetric immunosensor development[J].Biosensors,2013,3(1):1.
[23]付相庭.便携式纸基电化学分析仪研究[D].宁波:宁波大学,2015.
[24]黄辉洪.纸基微流控芯片用于葡萄糖快速检测的实验研究[D].福州:福建医科大学,2014.
[25]DELANEY J L,HOGAN C F,TIAN J,et al.Electrogenerated chemiluminescence detection in paper-based microfluidic sensors[J].Analytical chemistry,2011,83(4):1300.
[26]DUNGCHAI W,CHAILAPAKUL O,HENRY C S.Electrochemical detection for paper-based microfluidics[J].Analytical chemistry,2009,81(14):5821.
[27]NIE Z,DEISS F,LIU X,et al.Integration of paper-based microfluidic devices with commercial electrochemical readers[J].Lab on a chip,2010,10:3163.
[28]VELLA S J,BEATTIE P,CADEMARTIRI R,et al.Measuring markers of liver function using a micropatterned paper device designed for blood from a fingerstick[J].Analytical chemistry,2012,84(6):2883.
[29]王娇娇,冯苗,詹红兵.石墨烯量子点的制备[J].化学进展,2013(1):86.
[30]TANG L,JI R,CAO X,et al.Deep ultraviolet photoluminescence of water-soluble self-passivated grapheme quantum dots[J].ACS nano,2012,6:5102.
[31]ZHUO S,SHAO M,LEE S T.Upconversion and downconversion fluorescent grapheme quantum dots:ultrasonic preparation and photocatalysis[J].ACS nano,2012,6:1059.
[32]ZHU S,ZHANG J,TANG S,et al.Surface chemistry roules to modulate the photoluminescence of grapheme quanlum dots:from fluorescence to up-conversion bioimaging applications[J].Advanced functional materials,2012,22:4732.
[33]ZHU S,ZHANG J,QIAO C,et al.Strongly green-photoluminescent grapheme quantum dots for bioimaging applications[J].Chemical communications,2011,47:6858.
[34]张晓蕾,杨小弟.石墨烯量子点在生物传感和成像技术中的应用[J].化工时刊,2014,28(4):38.
[35]陈帅.石墨烯量子点的制备及在传感和成像中的应用研究[D].沈阳:东北大学,2015.
[36]PAOLA R,ROBERT L,ELAHE J,et al.Single-step synthesis of graphene quantum dots by femtosecond laser ablation of graphene oxidedispersions[J].Nanoscale,2016,8:8863.
[37]ELAHE J,EHSAN T.Aerosol-jet printing of highly flexible and conductive graphene/silver patterns[J].Materials letters,2016,174:40.
[38]PREETI N J,SHOBHA W.Graphene quantum dot-based on-chip electrochemical DNA hybridization sensor for pancreatic cancer[J].Reports in electrochemistry,2016,6:31.
[39]ZHAO J,CHEN G,ZHU L,et al.Graphene quantum dots-based platform for the fabrication of electrochemical biosensors[J].Electrochemistry communications,2011,13:31.
[40]RAZMI H,MOHAMMAL-REZAEI R.Graphene quantum dots as a new substrate for immobilization and direct electrochemistry of glucose oxidase:application to sensitive glucose determination[J].Biosensors and bioelectronics,2013,41:498.
[41]LU J,YAN M,GE L,et al.Electrochemiluminescence of blueluminescent graphene quantum dots as a fluorescent its application in ultrasensitive aptasensor for adenosine triphosphate detection[J].Biosensors and bioelectronics,2013,47:271.
[42]LI L,LI W P,MA C,et al.Paper-based electrochemiluminescence immunodevice for carcinoembryonic antigen using nanoporous gold-chitosan hybrids and graphene quantum dots functionalized Au@Pt[J].Sensors and actuators B,2014,(202):314.