阿司匹林临床应用研究进展
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摘要
阿司匹林是经典的解热镇痛和抗炎抗风湿药,随着适应证研究的深入,阿司匹林在结直肠癌、肝癌、肿瘤、感染病、神经性疾病、心脑血管早期急性呼吸窘迫综合征、女性不孕症和习惯性流产等诸多方面均有疗效。现通过查阅国内外指南及CNKI等数据库文献作一综述,以期为阿司匹林的进一步研究和开发提供参考。
Aspirin is a classic antipyretic,analgesic,anti-inflammatory and anti-rheumatic drug. With the research on indications,so many curative effects of aspirin have been reported in colorectal cancer,liver cancer,tumor,infectious disease,neuropathy,early cardiocerebrovascular acute respiratory distress syndrome Female infertility and habitual abortion respectively. In order to provide further research and development of aspirin,the domestic-foreign guidelines and CNKI database literatures are reviewed in this paper.
Aspirin is a classic antipyretic,analgesic,anti-inflammatory and anti-rheumatic drug. With the research on indications,so many curative effects of aspirin have been reported in colorectal cancer,liver cancer,tumor,infectious disease,neuropathy,early cardiocerebrovascular acute respiratory distress syndrome Female infertility and habitual abortion respectively. In order to provide further research and development of aspirin,the domestic-foreign guidelines and CNKI database literatures are reviewed in this paper.
引文
[1]温淼,杨波,魏娜,等.阿司匹林对重症脑血管病早期发生急性呼吸窘迫综合征的影响[J].中国卒中杂志,2017,12(9):776-780.
[2]黄金君.阿司匹林与尼莫地平治疗偏头痛的有效性和安全性比较[J].临床合理药,2018,11(1):82-83.
[3]贺昭忠,郑淑芳,刘福生,等.长期服用阿司匹林对脑出血周围水肿组织的影响[J].中华神经外科疾病研究杂志,2018,17(2):110-113.
[4]苏梅,崔涛,吴德松,等.祛瘀通脉胶囊活血化瘀作用的实验研究[J].云南中医中药杂志,2011,32(1):54-56.
[5]郭爽,张强,田志浩,等.三七总皂苷联用阿司匹林对后者抗血小板凝集作用的影响[J].中国实验方剂学杂志,2018,24(9):116-120.
[6]王萍.小剂量阿司匹林结合美托洛尔对老年心力衰竭患者血液高凝及心功能的改善作用[J].现代医药卫生,2018,34(9):1404-1406.
[7]王伟峰,张卉田.西洛他唑联合阿司匹林治疗腔隙性脑梗死效果观察[J].河南医学究,2018,27(2):310-311.
[8]褚怀德.硫酸氢氯吡格雷联合阿司匹林治疗不稳定型心绞痛的疗效分析[J].中西医结合心血病杂志,2018,6(7):62-64.
[9]王歆,甄杰,孙亚红.阿司匹林、氯吡格雷和阿托伐他汀三联治疗老年冠心病心绞痛患者的疗效观察[J].中国民康医学,2018,30(8):18-19.
[10]侯俊玲,张玲.氯吡格雷联合阿司匹林治疗不稳定型心绞痛180例疗效观察[J].临床医药文献杂志,2017,4(64):12647-12647.
[11]黎友琴.华法林与阿司匹林治疗老年非瓣膜性心脏病合并心房颤动疗效对比[J].现代医院,2018,18(4):584-588.
[12]辛文平.华法林与阿司匹林预防非瓣膜病性心房颤动栓塞发生的疗效评价[J].中西医结合心血管病杂志,2017,5(25):61-62.
[13]陈汉文,邢祖民,刘中杰,等.不同体重指数对顺苯磺酸阿曲库铵药效学的影响[J].热带医学杂志,2014,14(5):686-688.
[14]颜博.阿司匹林在不同年龄段脑梗死病人中的二级预防[J].中国临床神经外科杂志,2018,23(3):189-191.
[15] Wang YJ,Zhang SM,Zhang L,et al. Chinese guidelines for the secondary prevention of ischemic sroke and transient is chemic attack 2010[J]. CNS Neurosci Ther,2012,18:93-101.
[16] Ant ithrombotic Trialists Collaboration. Aspirin in the primary and secondary prevention of vascular disease:collaborative meta-analysis of individual participant data from randomised trials[J]. Lancet,2009,373:1849-1860.
[17]林瑞典.拜阿司匹林肠溶片与阿司匹林肠溶片治疗短暂性脑缺血发作的效果观察[J].临床与实践,2018,16(12):28-29.
[18]李同.氯吡格雷与阿司匹林联合治疗急性脑卒中的临床效果[J].海峡药学,2018,30(4):165-166.
[19]蔡松泉,蔡小杭.奥扎格雷钠联合阿司匹林在脑梗塞治疗中的应用价值[J].临床医药文献杂志,2017,4(70):13799-13802.
[20]李雪靖,王梅.阿司匹林在结直肠癌中预防治疗的研究进展[J].临床合理用药,2017,10(8):180-181.
[21]郭旭飞,倪秉强,陈日新,等.阿司匹林作为直肠癌新辅助放化疗辅助用药的临床研究[J].检验医学与临床,2017,15(12):1796-1799.
[22]邵仟仟,林国乐. 2017. V1版《NCCN结直肠癌诊治指南》更新解读[J].中国全科医学2017,20(6):635-638.
[23]陈哲.纪立伟,谢晓慧.住院糖尿病患者阿司匹林使用合理性评价[J].中国药学杂志,201 8,53(3):234-238.
[24]王景尚,孙明月,殷惠军,等.阿司匹林对波动高糖诱导内皮损伤过程中血小板活化的影响[J].中国药理学通报,2018,34(1):50-54.
[25] American Diabetes Association. Standards of medical care in diabetes-2016abridged for primary care providers[J]. Clin Diabetes,2016,34(1):3-21.
[26]朱思雅,王梦琳,金娟.低剂量阿司匹林诱导产生的自噬减弱其对人肝癌Hep G2细胞的抑制作用[J].安徽医科大学学报,2018,53(3):373-377.
[27]周亚滨.阿司匹林与两性霉素B联合应用抑制念珠菌生物被膜效应的研究[D].山东:山东大学,2013.
[28]李翠灵.阿司匹林联合硫酸镁治疗妊娠高血压的临床效果观察[J].河南医学研究,2018,2 7(1):75-76.
[29]陶翠.阿司匹林对高血压患者血尿酸的影响[J].中国现代药物应用,2018,12(3):88-89.
[30]梅德华.低分子肝素联合阿司匹林对血栓前状态致复发性流产患者性激素水平及妊娠结局的影响[J].临床医学,2018,38(1):86-87.
[31]高珊珊.低分子肝素与阿司匹林治疗习惯性流产的疗效观察[J].现代诊断与治疗,2017,28(19):2599-3600.
[32]洪恩,马玉琴,陈颖.阿司匹林对早期复发性流产女性血栓前状态、激素水平和妊娠结局的影响[J].中国妇幼保健,2018,33(2):281-283.
[33]张书筠,张弘,王云洁,等.低分子肝素联合阿司匹林治疗抗磷脂抗体引起的复发性流产的临床效果分析[J].河北医学,2018,24(3):422-426.
[34] American College of Obstetricians and Gynecologists,Task Force on Hypertension in Pregnan cy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists'task force on hypertension in pregnancy[J]. Obstet Gynecol,2013,122(5):1122-1131.
[35] Redman CW. Hypertension in pregnancy:the NICE guidelines[J]. Heart,2011,97(23):1967-1969.
[36] Cook KA,White AA. Rapid aspirin challenge in patients with aspirin allergy and acute coro-nary syndromes[J]. Curr Allergy Asthma Rep,2016,16(2):11.
[37] Jenkins C,Costello J,Hodge L. Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice[J]. BM J,2004,328(7437):434.
[38]柳晖,刘菲.血清胃蛋白酶原和幽门螺杆菌感染与阿司匹林相关胃十二指肠损伤的相关性研究[J].胃肠病学,2018,23(1):8-12.
[39]明雅南.药物性肝损伤发病机制研究进展[J].实用肝脏病杂志,2014,17(6):657-660.
[40]李小鹰.从国内外指南看阿司匹林在心血管疾病一级预防中的作用[J].中华老年心脑血管病杂志,2018,20(1):92-94.
[41]孙涛,于建设.阿司匹林抵抗的研究进展[J].医学综述,2018,14(5):853-857.
[2]黄金君.阿司匹林与尼莫地平治疗偏头痛的有效性和安全性比较[J].临床合理药,2018,11(1):82-83.
[3]贺昭忠,郑淑芳,刘福生,等.长期服用阿司匹林对脑出血周围水肿组织的影响[J].中华神经外科疾病研究杂志,2018,17(2):110-113.
[4]苏梅,崔涛,吴德松,等.祛瘀通脉胶囊活血化瘀作用的实验研究[J].云南中医中药杂志,2011,32(1):54-56.
[5]郭爽,张强,田志浩,等.三七总皂苷联用阿司匹林对后者抗血小板凝集作用的影响[J].中国实验方剂学杂志,2018,24(9):116-120.
[6]王萍.小剂量阿司匹林结合美托洛尔对老年心力衰竭患者血液高凝及心功能的改善作用[J].现代医药卫生,2018,34(9):1404-1406.
[7]王伟峰,张卉田.西洛他唑联合阿司匹林治疗腔隙性脑梗死效果观察[J].河南医学究,2018,27(2):310-311.
[8]褚怀德.硫酸氢氯吡格雷联合阿司匹林治疗不稳定型心绞痛的疗效分析[J].中西医结合心血病杂志,2018,6(7):62-64.
[9]王歆,甄杰,孙亚红.阿司匹林、氯吡格雷和阿托伐他汀三联治疗老年冠心病心绞痛患者的疗效观察[J].中国民康医学,2018,30(8):18-19.
[10]侯俊玲,张玲.氯吡格雷联合阿司匹林治疗不稳定型心绞痛180例疗效观察[J].临床医药文献杂志,2017,4(64):12647-12647.
[11]黎友琴.华法林与阿司匹林治疗老年非瓣膜性心脏病合并心房颤动疗效对比[J].现代医院,2018,18(4):584-588.
[12]辛文平.华法林与阿司匹林预防非瓣膜病性心房颤动栓塞发生的疗效评价[J].中西医结合心血管病杂志,2017,5(25):61-62.
[13]陈汉文,邢祖民,刘中杰,等.不同体重指数对顺苯磺酸阿曲库铵药效学的影响[J].热带医学杂志,2014,14(5):686-688.
[14]颜博.阿司匹林在不同年龄段脑梗死病人中的二级预防[J].中国临床神经外科杂志,2018,23(3):189-191.
[15] Wang YJ,Zhang SM,Zhang L,et al. Chinese guidelines for the secondary prevention of ischemic sroke and transient is chemic attack 2010[J]. CNS Neurosci Ther,2012,18:93-101.
[16] Ant ithrombotic Trialists Collaboration. Aspirin in the primary and secondary prevention of vascular disease:collaborative meta-analysis of individual participant data from randomised trials[J]. Lancet,2009,373:1849-1860.
[17]林瑞典.拜阿司匹林肠溶片与阿司匹林肠溶片治疗短暂性脑缺血发作的效果观察[J].临床与实践,2018,16(12):28-29.
[18]李同.氯吡格雷与阿司匹林联合治疗急性脑卒中的临床效果[J].海峡药学,2018,30(4):165-166.
[19]蔡松泉,蔡小杭.奥扎格雷钠联合阿司匹林在脑梗塞治疗中的应用价值[J].临床医药文献杂志,2017,4(70):13799-13802.
[20]李雪靖,王梅.阿司匹林在结直肠癌中预防治疗的研究进展[J].临床合理用药,2017,10(8):180-181.
[21]郭旭飞,倪秉强,陈日新,等.阿司匹林作为直肠癌新辅助放化疗辅助用药的临床研究[J].检验医学与临床,2017,15(12):1796-1799.
[22]邵仟仟,林国乐. 2017. V1版《NCCN结直肠癌诊治指南》更新解读[J].中国全科医学2017,20(6):635-638.
[23]陈哲.纪立伟,谢晓慧.住院糖尿病患者阿司匹林使用合理性评价[J].中国药学杂志,201 8,53(3):234-238.
[24]王景尚,孙明月,殷惠军,等.阿司匹林对波动高糖诱导内皮损伤过程中血小板活化的影响[J].中国药理学通报,2018,34(1):50-54.
[25] American Diabetes Association. Standards of medical care in diabetes-2016abridged for primary care providers[J]. Clin Diabetes,2016,34(1):3-21.
[26]朱思雅,王梦琳,金娟.低剂量阿司匹林诱导产生的自噬减弱其对人肝癌Hep G2细胞的抑制作用[J].安徽医科大学学报,2018,53(3):373-377.
[27]周亚滨.阿司匹林与两性霉素B联合应用抑制念珠菌生物被膜效应的研究[D].山东:山东大学,2013.
[28]李翠灵.阿司匹林联合硫酸镁治疗妊娠高血压的临床效果观察[J].河南医学研究,2018,2 7(1):75-76.
[29]陶翠.阿司匹林对高血压患者血尿酸的影响[J].中国现代药物应用,2018,12(3):88-89.
[30]梅德华.低分子肝素联合阿司匹林对血栓前状态致复发性流产患者性激素水平及妊娠结局的影响[J].临床医学,2018,38(1):86-87.
[31]高珊珊.低分子肝素与阿司匹林治疗习惯性流产的疗效观察[J].现代诊断与治疗,2017,28(19):2599-3600.
[32]洪恩,马玉琴,陈颖.阿司匹林对早期复发性流产女性血栓前状态、激素水平和妊娠结局的影响[J].中国妇幼保健,2018,33(2):281-283.
[33]张书筠,张弘,王云洁,等.低分子肝素联合阿司匹林治疗抗磷脂抗体引起的复发性流产的临床效果分析[J].河北医学,2018,24(3):422-426.
[34] American College of Obstetricians and Gynecologists,Task Force on Hypertension in Pregnan cy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists'task force on hypertension in pregnancy[J]. Obstet Gynecol,2013,122(5):1122-1131.
[35] Redman CW. Hypertension in pregnancy:the NICE guidelines[J]. Heart,2011,97(23):1967-1969.
[36] Cook KA,White AA. Rapid aspirin challenge in patients with aspirin allergy and acute coro-nary syndromes[J]. Curr Allergy Asthma Rep,2016,16(2):11.
[37] Jenkins C,Costello J,Hodge L. Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice[J]. BM J,2004,328(7437):434.
[38]柳晖,刘菲.血清胃蛋白酶原和幽门螺杆菌感染与阿司匹林相关胃十二指肠损伤的相关性研究[J].胃肠病学,2018,23(1):8-12.
[39]明雅南.药物性肝损伤发病机制研究进展[J].实用肝脏病杂志,2014,17(6):657-660.
[40]李小鹰.从国内外指南看阿司匹林在心血管疾病一级预防中的作用[J].中华老年心脑血管病杂志,2018,20(1):92-94.
[41]孙涛,于建设.阿司匹林抵抗的研究进展[J].医学综述,2018,14(5):853-857.