摘要
目的探讨职业性高温接触对男性钢铁工人罹患2型糖尿病(T2DM)的影响。方法采用整群随机抽样法,以唐山市某钢铁企业职业性高温接触的684名男性钢铁工人为高温组,以无职业性高温接触的1 153名男性钢铁工人为对照组。测量2组工人工作场所高温水平,计算高温累积暴露量(CE),并对其进行职业健康检查;采用多因素Logistic回归分析和限制性立方样条分析高温CE与T2DM患病的关系。结果高温组工人T2DM患病率高于对照组(13. 0%vs 7. 9%,P <0. 01)。多因素Logistic回归分析结果显示:调整年龄、体质指数、吸烟、饮酒、体育锻炼以及父母患糖尿病等混杂因素后,高温组工人罹患T2DM的风险高于对照组(P <0. 05),比值比及其95%可信区间为1. 65(1. 17~2. 33)。限制性立方样条分析结果显示,高温CE与工人T2DM患病相关(P <0. 01),且呈线性关系(非线性检验,P> 0. 05)。结论职业性高温接触与男性钢铁工人罹患T2DM有关。男性钢铁工人高温CE越高,罹患T2DM的风险越高。
Objective To explore the effect of occupational high temperature exposure on type 2 diabetes( T2 DM) in male steel workers. Methods A cluster random sampling method was used to select 684 male steel workers,who exposed to occupational high temperature in a steel enterprise in Tangshan City,as the high temperature group,and 1 153 male steel workers without occupational high temperature exposure as the control group. The high temperature level of workers in these two groups was measured. The cumulative exposure( CE) of high temperature was calculated,and occupational health exam was performed. The multivariate logistic regression analysis and restricted cubic splines were used to analyze the relationship between high temperature CE and T2 DM. Results The prevalence of T2 DM in high-temperature group was higher than that in the control group( 13. 0% vs 7. 9%,P < 0. 05). The multivariate logistic regression analysis results showed that the risk of T2 DM in the high temperature group was higher than that in the control group after adjusting for age,body mass index,smoking,drinking,physical exercise and parents with diabetes( P < 0. 05). The 95% confidence interval was 1. 65( 1. 17-2. 33). Restricted cubic spline analysis showed that the high temperature CE was correlated with the prevalence of T2 DM in workers( P < 0. 01) and showed a linear correlation( nonlinearity test,P > 0. 05). Conclusion Occupational high temperature exposure is associated with the occurrence of T2 DM in male steel workers. The male steel workers with high temperature CE show high prevalence of T2 DM risk.
引文
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