中药治疗肠系膜淋巴结炎临床疗效观察
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摘要
目的观察中药治疗肠系膜淋巴结炎的临床疗效和安全性。方法选择2016年4月至2018年7月广州中医药大学第一附属医院儿科诊治的40例肠系膜淋巴结炎患儿为研究对象,根据随机数表法将患儿分为对照组和观察组,每组20例,对照组患儿给予基础抗感染治疗3 d,观察组患儿则在对照组基础上增加中药治疗3 d,方剂由姜厚朴10 g、醋延胡索10 g、佛手10 g、山楂10 g、麦芽10 g、鸡内金10 g、连翘10 g、夏枯草15 g、浙贝母10 g、蒲公英10 g组成,水煎剂,每天1剂,分早晚两次服用。观察并比较两组患儿的临床疗效、退热时间、腹痛消失时间、肠系膜淋巴结缩小程度、外周血白细胞(WBC)计数、超敏C反应蛋白(hs-CRP)水平和并发症的发生情况。结果观察组患儿的治疗总有效率为100.0%,明显高于对照组的80.0%,差异有统计学意义(P<0.05);观察组患儿的退热时间、腹痛消失时间分别为(2.03±0.69) h、(2.83±0.75) h,均小于对照组的(3.69±0.92) h、(4.15±1.08) h,差异均有统计学意义(P<0.05);两组患儿治疗后肠系膜淋巴结大小、外周血WBC、hs-CRP值显著降低,观察组肠系膜淋巴结大小、外周血WBC、hs-CRP值分别为(8.72±1.16) mm、(4.14±1.27)×109/L、(6.03±2.51) mg/L,均明显小于或低于对照组的(10.21±2.05) mm、(5.02±0.93)×109/L、(12.01±4.35) mg/L,差异均有统计学意义(P<0.05);两组患儿治疗过程中均未出现严重并发症。结论在西医治疗基础上增加中药治疗可缓解肠系膜淋巴结炎患儿临床症状,提高治疗效果,且不增加并发症风险,优于单独西药治疗。
Objective To observe the clinical efficacy and safety of traditional Chinese medicine in the treatment of mesenteric lymphadenitis. Methods Forty children with mesenteric lymphadenitis treated in Department of Pediatrics, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from April 2016 to July2018 were selected as the research objects. According to the random number table method, the children were divided into two groups, with 20 cases in each group. The control group received basic anti-infective treatment for 3 days, and the study group was additionally treated with traditional Chinese medicine for 3 days on the basis of the control group. The prescription consists of Ginger Magnolia Officinalis 10 g, Vinegar Corydalis 10 g, Bergamot 10 g, Hawthorn 10 g, Malt10 g, gallus domesticus brisson 10 g, Forsythia suspense 10 g, Prunella vulgaris 15 g, Fritillaria thunbergii 10 g, Dandelion 10 g, in water decoction, one dose a day, twice a day(in the morning and evening). The curative effect, time of fever abatement, time of abdominal pain disappearance, mesenteric lymph node shrinkage, peripheral blood leukocyte(WBC)count, high sensitivity C-reactive protein(hs-CRP) level, and complication rate of the two groups were observed and compared. Results The effective rate of treatment(100.0%) in the observation group was higher than that of control group(80.0%), and the difference was statistically significant(P<0.05). The time of fever abatement and abdominal pain disappearance in study group were(2.03 ± 0.69) h and(2.83 ± 0.75) h, respectively, which were significantly less than(3.69±0.92) h and(4.15±1.08) h in the control group(P<0.05). After treatment, the size of mesenteric lymph nodes, levels of WBC, and hs-CRP in peripheral blood were significantly decreased in the two groups. The size of mesenteric lymph nodes, WBC, and hs-CRP in peripheral blood of the study group were(8.72±1.16) mm,(4.14±1.27)×109/L,(6.03±2.51) mg/L after treatment, respectively, which were significantly smaller or lower than(10.21±2.05) mm,(5.02±0.93)×109/L,(12.01 ± 4.35) mg/L in the control group(P<0.05). No serious complications occurred during the treatment of the two groups. Conclusion On the basis of Western medicine treatment, adding traditional Chinese medicine treatment can alleviate the clinical symptoms of children with mesenteric lymphadenitis, improve the therapeutic effect, and do not increase the risk of complications, which is superior to Western medicine alone.
Objective To observe the clinical efficacy and safety of traditional Chinese medicine in the treatment of mesenteric lymphadenitis. Methods Forty children with mesenteric lymphadenitis treated in Department of Pediatrics, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from April 2016 to July2018 were selected as the research objects. According to the random number table method, the children were divided into two groups, with 20 cases in each group. The control group received basic anti-infective treatment for 3 days, and the study group was additionally treated with traditional Chinese medicine for 3 days on the basis of the control group. The prescription consists of Ginger Magnolia Officinalis 10 g, Vinegar Corydalis 10 g, Bergamot 10 g, Hawthorn 10 g, Malt10 g, gallus domesticus brisson 10 g, Forsythia suspense 10 g, Prunella vulgaris 15 g, Fritillaria thunbergii 10 g, Dandelion 10 g, in water decoction, one dose a day, twice a day(in the morning and evening). The curative effect, time of fever abatement, time of abdominal pain disappearance, mesenteric lymph node shrinkage, peripheral blood leukocyte(WBC)count, high sensitivity C-reactive protein(hs-CRP) level, and complication rate of the two groups were observed and compared. Results The effective rate of treatment(100.0%) in the observation group was higher than that of control group(80.0%), and the difference was statistically significant(P<0.05). The time of fever abatement and abdominal pain disappearance in study group were(2.03 ± 0.69) h and(2.83 ± 0.75) h, respectively, which were significantly less than(3.69±0.92) h and(4.15±1.08) h in the control group(P<0.05). After treatment, the size of mesenteric lymph nodes, levels of WBC, and hs-CRP in peripheral blood were significantly decreased in the two groups. The size of mesenteric lymph nodes, WBC, and hs-CRP in peripheral blood of the study group were(8.72±1.16) mm,(4.14±1.27)×109/L,(6.03±2.51) mg/L after treatment, respectively, which were significantly smaller or lower than(10.21±2.05) mm,(5.02±0.93)×109/L,(12.01 ± 4.35) mg/L in the control group(P<0.05). No serious complications occurred during the treatment of the two groups. Conclusion On the basis of Western medicine treatment, adding traditional Chinese medicine treatment can alleviate the clinical symptoms of children with mesenteric lymphadenitis, improve the therapeutic effect, and do not increase the risk of complications, which is superior to Western medicine alone.
引文
[1]张春红.中西医结合治疗小儿肠系膜淋巴结炎50例疗效观察[J].中医儿科杂志, 2015, 11(2):54-56.
[2]楼宏亮,周向峰,胡国华,等.中西医结合治疗小儿肠系膜淋巴结炎的临床疗效观察[J].中国中西医结合消化杂志, 2014, 22(11):680-681.
[3]胡亚美,江载芳.诸福棠实用儿科学[M]. 8版.北京:人民卫生出版社, 2012:1362-1363.
[4]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社, 1994:79.
[5]张静,张云洲.小儿肠系膜淋巴结炎中西医研究概况[J].贵阳中医学院学报, 2010, 32(6):66-67.
[6]马学梅,李小玲,王佐佑.小儿急性肠系膜淋巴结炎的研究现状[J].医学综述, 2014, 20(4):698-700.
[7]夏焙,吴瑛.小儿超声诊断学[M].北京:人民卫生出版社, 2001:322.
[8]李倩,孙远岭.小儿肠系膜淋巴结炎的中医病因病机与证治[J].广州中医药大学学报, 2010, 27(3):297-299.
[9]王叶芳.消炎散核冲剂治疗小儿肠系膜淋巴结炎临床观察[J].新中医, 2012, 44(3):62-63.
[10]张谦.抗菌药物序贯疗法联合喜炎平注射液治疗细菌感染所致儿童急性肠系膜淋巴结炎的疗效及对PCT、T淋巴细胞功能的影响[J].现代中西医结合杂志, 2017, 26(20):2232-2234.
[11]张小林,沈媛,钟宝珠,等.七味白术散加减治疗脾虚湿困型小儿肠系膜淋巴结炎疗效观察[J].广州中医药大学学报, 2017, 34(4):496-500.
[12]郭晶,张敏涛.柴胡达原饮加味联合四逆散治疗小儿肠系膜淋巴结炎临床观察[J].陕西中医, 2017, 38(5):640-642.
[13]李婷,杨舒然,陈敏,等.姜厚朴水提物对大肠杆菌和金黄色葡萄球菌的抑菌机理研究[J].现代食品科技, 2016, 32(2):84-92.
[2]楼宏亮,周向峰,胡国华,等.中西医结合治疗小儿肠系膜淋巴结炎的临床疗效观察[J].中国中西医结合消化杂志, 2014, 22(11):680-681.
[3]胡亚美,江载芳.诸福棠实用儿科学[M]. 8版.北京:人民卫生出版社, 2012:1362-1363.
[4]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社, 1994:79.
[5]张静,张云洲.小儿肠系膜淋巴结炎中西医研究概况[J].贵阳中医学院学报, 2010, 32(6):66-67.
[6]马学梅,李小玲,王佐佑.小儿急性肠系膜淋巴结炎的研究现状[J].医学综述, 2014, 20(4):698-700.
[7]夏焙,吴瑛.小儿超声诊断学[M].北京:人民卫生出版社, 2001:322.
[8]李倩,孙远岭.小儿肠系膜淋巴结炎的中医病因病机与证治[J].广州中医药大学学报, 2010, 27(3):297-299.
[9]王叶芳.消炎散核冲剂治疗小儿肠系膜淋巴结炎临床观察[J].新中医, 2012, 44(3):62-63.
[10]张谦.抗菌药物序贯疗法联合喜炎平注射液治疗细菌感染所致儿童急性肠系膜淋巴结炎的疗效及对PCT、T淋巴细胞功能的影响[J].现代中西医结合杂志, 2017, 26(20):2232-2234.
[11]张小林,沈媛,钟宝珠,等.七味白术散加减治疗脾虚湿困型小儿肠系膜淋巴结炎疗效观察[J].广州中医药大学学报, 2017, 34(4):496-500.
[12]郭晶,张敏涛.柴胡达原饮加味联合四逆散治疗小儿肠系膜淋巴结炎临床观察[J].陕西中医, 2017, 38(5):640-642.
[13]李婷,杨舒然,陈敏,等.姜厚朴水提物对大肠杆菌和金黄色葡萄球菌的抑菌机理研究[J].现代食品科技, 2016, 32(2):84-92.