桉树脑与皮肤屏障相关性研究进展
|
摘要
桉树脑(1,8-桉叶素)是一种从桉树提取的单萜类化合物,是桉叶油的主要成分,具有广泛的生物活性,包括抗微生物、抗炎、抗氧化、保湿、抗肿瘤、抗组胺、促进伤口愈合、促渗透、抗焦虑等生物学活性。完整的皮肤屏障功能包括表皮角质层足够的保湿能力、皮肤抗感染、抗炎能力。本文总结了国内外近年对天然植物成分桉树脑的生物学活性研究进展,并就其在皮肤科,特别是皮肤屏障修复方面的临床应用前景进行了综述。
引文
[1] RAMOS ALVARENGA R F,WAN B,INUI T,et al.Airborne antituberculosis activity of Eucalyptus citriodora essential oil[J].J Nat Prod,2014,77(3):603-610.
[2] SEOL G H,KIM K Y.Eucalyptol and its role in chronic diseases[J].Adv Exp Med Biol,2016,929:389-398.
[3] FERREIRA-DA-SILVA F W,DA SILVA-ALVES K S,ALVES-FERNANDES T A,et al.Effects of 1,8-cineole on Na(+) currents of dissociated superior cervical ganglia neurons[J].Neurosci Lett,2015,595:45-49.
[4] FEDERICO A,MORGILLO F,TUCCILLO C,et al.Chronic inflammation and oxidative stress in human carcinogenesis[J].Int J Cancer,2007,121(11):2381-2386.
[5] 兰颐,王景雁,刘艳,等.萜烯类经皮促透剂对皮肤活性表皮层的影响及其机制研究[J].中国中药杂志,2015,40(4):643-648.
[6] 周志明,张锡宝.丝聚合蛋白基因突变及其相关皮肤病的研究进展[J].皮肤性病诊疗学杂志,2016,23(2):139-142.
[7] DHAKAD A K,PANDEY V V,BEG S,et al.Biological,medicinal and toxicological significance of Eucalyptus leaf essential oil:a review[J].J Sci Food Agric,2018,98(3):833-848.
[8] LIU X L,ZHANG X J,FU Y J,et al.Cajanol inhibits the growth of Escherichia coli and Staphylococcus aureus by acting on membrane and DNA damage[J].Planta Med,2011,77(2):158-163.
[9] WU M,WU P,XIE H,et al.Monoterpenoid indole alkaloids mediating DNA strand scission from Turpinia arguta[J].Planta Med,2011,77(3):284-286.
[10] YADAV N,CHANDRA H.Suppression of inflammatory and infection responses in lung macrophages by eucalyptus oil and its constituent 1,8-cineole:Role of pattern recognition receptors TREM-1 and NLRP3,the MAP kinase regulator MKP-1,and NFkappaB[J].PLoS One,2017,12(11):e188232.
[11] ZHOU L J,LI F R,HUANG L J,et al.Antifungal activity of eucalyptus oil against rice blast fungi and the possible mechanism of gene expression pattern[J].Molecules,2016,21(5):pii:E621.
[12] JUERGENS U R.Anti-inflammatory properties of the monoterpene 1.8-cineole:current evidence for co-medication in inflammatory airway diseases[J].Drug Res (Stuttg),2014,64(12):638-646.
[13] LINGHU K,LIN D,YANG H,et al.Ameliorating effects of 1,8-cineole on LPS-induced human umbilical vein endothelial cell injury by suppressing NF-kappaB signaling in vitro[J].Eur J Pharmacol,2016,789:195-201.
[14] KHAN A,VAIBHAV K,JAVED H,et al.1,8-cineole (eucalyptol) mitigates inflammation in amyloid Beta toxicated PC12 cells:relevance to Alzheimer’s disease[J].Neurochem Res,2014,39(2):344-352.
[15] JUERGENS U R,DETHLEFSEN U,STEINKAMP G,et al.Anti-inflammatory efficacy of 1.8-cineole (eucalyptole) in bronchial asthma:a double-blind placebo-controlled trial[J].Respir Med,2003,97(3):250-256.
[16] ITOI-OCHI S,TERAO M,MUROTA H,et al.Local corticosterone activation by 11β-hydroxysteroid dehydrogenase 1 in keratinocytes:the role in narrow-band UVB-induced dermatitis[J].Dermatoendocrinol,2016,8(1):e1119958.
[17] H?NEL K H,CORNELISSEN C,LüSCHER B,et al.Cytokines and the skin barrier[J].Int J Mol Sci,2013,14(4):6720-6745.
[18] ROCHA CALDAS G F,OLIVEIRA A R,ARAúJO A V,et al.Gastroprotective mechanisms of the monoterpene 1,8-Cineole (Eucalyptol)[J].PLoS One,2015,10(8):e134558.
[19] KENNEDY-FEITOSA E,OKURO R T,PINHO RIBEIRO V,et al.Eucalyptol attenuates cigarette smoke-induced acute lung inflammation and oxidative stress in the mouse[J].Pulm Pharmacol Ther,2016,41:11-18.
[20] LIMA P R,DE MELO T S,CARVALHO K M,et al.1,8-cineole (eucalyptol) ameliorates cerulein-induced acute pancreatitis via modulation of cytokines,oxidative stress and NF-κB activity in mice[J].Life Sci,2013,92(24-26):1195-1201.
[21] RYU S,PARK H,SEOL G H,et al.1,8-Cineole ameliorates oxygen-glucose deprivation/reoxygenation-induced ischaemic injury by reducing oxidative stress in rat cortical neuron/glia[J].J Pharm Pharmacol,2014,66(12):1818-1826.
[22] MOON H K,KANG P,LEE H S,et al.Effects of 1,8-cineole on hypertension induced by chronic exposure to nicotine in rats[J].J Pharm Pharmacol,2014,66(5):688-693.
[23] ISHIKAWA J,SHIMOTOYODOME Y,CHEN S,et al.Eucalyptus increases ceramide levels in keratinocytes and improves stratum corneum function[J].Int J Cosmet Sci,2012,34(1):17-22.
[24] LEE J,HA S J,PARK J,et al.1,8-cineole prevents UVB-induced skin carcinogenesis by targeting the aryl hydrocarbon receptor[J].Oncotarget,2017,8(62):105995-106008.
[25] LAWAL T O,ADENIYI B A,OLALEYE S B.Ulcer-healing promoting activities of methanol extracts of Eucalyptus camaldulensis Dehnh.And Eucalyptus torelliana F.Muell in rat[J].Arch Basic Appl Med,2014,2:147-152.
[26] BIRUSS B,K?HLIG H,VALENTA C.Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones[J].Int J Pharm,2007,328(2):142-151.
[27] CASEY A L,KARPANEN T J,CONWAY B R,et al.Enhanced chlorhexidine skin penetration with 1,8-cineole[J].BMC Infect Dis,2017,17(1):350.
[28] JUN Y S,KANG P,MIN S S,et al.Effect of eucalyptus oil inhalation on pain and inflammatory responses after total knee replacement:a randomized clinical trial[J].Evid Based Complement Alternat Med,2013:502727.
[29] KIM K Y,SEO H J,MIN S S,et al.The effect of 1,8-cineole inhalation on preoperative anxiety:a randomized clinical trial[J].Evid Based Complement Alternat Med,2014:820126.
[2] SEOL G H,KIM K Y.Eucalyptol and its role in chronic diseases[J].Adv Exp Med Biol,2016,929:389-398.
[3] FERREIRA-DA-SILVA F W,DA SILVA-ALVES K S,ALVES-FERNANDES T A,et al.Effects of 1,8-cineole on Na(+) currents of dissociated superior cervical ganglia neurons[J].Neurosci Lett,2015,595:45-49.
[4] FEDERICO A,MORGILLO F,TUCCILLO C,et al.Chronic inflammation and oxidative stress in human carcinogenesis[J].Int J Cancer,2007,121(11):2381-2386.
[5] 兰颐,王景雁,刘艳,等.萜烯类经皮促透剂对皮肤活性表皮层的影响及其机制研究[J].中国中药杂志,2015,40(4):643-648.
[6] 周志明,张锡宝.丝聚合蛋白基因突变及其相关皮肤病的研究进展[J].皮肤性病诊疗学杂志,2016,23(2):139-142.
[7] DHAKAD A K,PANDEY V V,BEG S,et al.Biological,medicinal and toxicological significance of Eucalyptus leaf essential oil:a review[J].J Sci Food Agric,2018,98(3):833-848.
[8] LIU X L,ZHANG X J,FU Y J,et al.Cajanol inhibits the growth of Escherichia coli and Staphylococcus aureus by acting on membrane and DNA damage[J].Planta Med,2011,77(2):158-163.
[9] WU M,WU P,XIE H,et al.Monoterpenoid indole alkaloids mediating DNA strand scission from Turpinia arguta[J].Planta Med,2011,77(3):284-286.
[10] YADAV N,CHANDRA H.Suppression of inflammatory and infection responses in lung macrophages by eucalyptus oil and its constituent 1,8-cineole:Role of pattern recognition receptors TREM-1 and NLRP3,the MAP kinase regulator MKP-1,and NFkappaB[J].PLoS One,2017,12(11):e188232.
[11] ZHOU L J,LI F R,HUANG L J,et al.Antifungal activity of eucalyptus oil against rice blast fungi and the possible mechanism of gene expression pattern[J].Molecules,2016,21(5):pii:E621.
[12] JUERGENS U R.Anti-inflammatory properties of the monoterpene 1.8-cineole:current evidence for co-medication in inflammatory airway diseases[J].Drug Res (Stuttg),2014,64(12):638-646.
[13] LINGHU K,LIN D,YANG H,et al.Ameliorating effects of 1,8-cineole on LPS-induced human umbilical vein endothelial cell injury by suppressing NF-kappaB signaling in vitro[J].Eur J Pharmacol,2016,789:195-201.
[14] KHAN A,VAIBHAV K,JAVED H,et al.1,8-cineole (eucalyptol) mitigates inflammation in amyloid Beta toxicated PC12 cells:relevance to Alzheimer’s disease[J].Neurochem Res,2014,39(2):344-352.
[15] JUERGENS U R,DETHLEFSEN U,STEINKAMP G,et al.Anti-inflammatory efficacy of 1.8-cineole (eucalyptole) in bronchial asthma:a double-blind placebo-controlled trial[J].Respir Med,2003,97(3):250-256.
[16] ITOI-OCHI S,TERAO M,MUROTA H,et al.Local corticosterone activation by 11β-hydroxysteroid dehydrogenase 1 in keratinocytes:the role in narrow-band UVB-induced dermatitis[J].Dermatoendocrinol,2016,8(1):e1119958.
[17] H?NEL K H,CORNELISSEN C,LüSCHER B,et al.Cytokines and the skin barrier[J].Int J Mol Sci,2013,14(4):6720-6745.
[18] ROCHA CALDAS G F,OLIVEIRA A R,ARAúJO A V,et al.Gastroprotective mechanisms of the monoterpene 1,8-Cineole (Eucalyptol)[J].PLoS One,2015,10(8):e134558.
[19] KENNEDY-FEITOSA E,OKURO R T,PINHO RIBEIRO V,et al.Eucalyptol attenuates cigarette smoke-induced acute lung inflammation and oxidative stress in the mouse[J].Pulm Pharmacol Ther,2016,41:11-18.
[20] LIMA P R,DE MELO T S,CARVALHO K M,et al.1,8-cineole (eucalyptol) ameliorates cerulein-induced acute pancreatitis via modulation of cytokines,oxidative stress and NF-κB activity in mice[J].Life Sci,2013,92(24-26):1195-1201.
[21] RYU S,PARK H,SEOL G H,et al.1,8-Cineole ameliorates oxygen-glucose deprivation/reoxygenation-induced ischaemic injury by reducing oxidative stress in rat cortical neuron/glia[J].J Pharm Pharmacol,2014,66(12):1818-1826.
[22] MOON H K,KANG P,LEE H S,et al.Effects of 1,8-cineole on hypertension induced by chronic exposure to nicotine in rats[J].J Pharm Pharmacol,2014,66(5):688-693.
[23] ISHIKAWA J,SHIMOTOYODOME Y,CHEN S,et al.Eucalyptus increases ceramide levels in keratinocytes and improves stratum corneum function[J].Int J Cosmet Sci,2012,34(1):17-22.
[24] LEE J,HA S J,PARK J,et al.1,8-cineole prevents UVB-induced skin carcinogenesis by targeting the aryl hydrocarbon receptor[J].Oncotarget,2017,8(62):105995-106008.
[25] LAWAL T O,ADENIYI B A,OLALEYE S B.Ulcer-healing promoting activities of methanol extracts of Eucalyptus camaldulensis Dehnh.And Eucalyptus torelliana F.Muell in rat[J].Arch Basic Appl Med,2014,2:147-152.
[26] BIRUSS B,K?HLIG H,VALENTA C.Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones[J].Int J Pharm,2007,328(2):142-151.
[27] CASEY A L,KARPANEN T J,CONWAY B R,et al.Enhanced chlorhexidine skin penetration with 1,8-cineole[J].BMC Infect Dis,2017,17(1):350.
[28] JUN Y S,KANG P,MIN S S,et al.Effect of eucalyptus oil inhalation on pain and inflammatory responses after total knee replacement:a randomized clinical trial[J].Evid Based Complement Alternat Med,2013:502727.
[29] KIM K Y,SEO H J,MIN S S,et al.The effect of 1,8-cineole inhalation on preoperative anxiety:a randomized clinical trial[J].Evid Based Complement Alternat Med,2014:820126.