复方玄驹胶囊治疗少弱精子症的Meta分析
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摘要
目的应用Meta分析的方法评价复方玄驹胶囊治疗少弱精子症的疗效及安全性。方法全面检索CENTRAL,EMBASE,MEDLINE(ovid),中国知网(CNKI),维普VIP,万方数据库、中国生物医学文献服务系统(CBM)等电子数据库,并检索中国临床试验注册中心(Chi CTR),国际临床试验注册协作网(ICTRP)等检索在研研究。依据Cochrane Handbook严格筛选文献,纳入复方玄驹胶囊治疗少弱精子症的随机对照试验,并进行研究质量评级及数据提取。采用Rev Man 5.3软件对有关数据进行Meta分析。结果 10个RCTs共966名患者纳入研究,其中复方玄驹胶囊537例,对照组429例。Meta分析结果表明,与对照组相比,复方玄驹胶囊能升高精子密度[MD=4.64,95%CI(0.06,9.22)],差异无统计学意义(P=0.05);能升高A级级精子百分率[MD=4.77,95%CI(0.67,8.87)],差异有统计学意义(P=0.02);能升高(A+B)级精子百分率[MD=8.17,95%CI(-3.58,19.91)],差异无统计学意义(P=0.17);能升高正常精子形态百分率[MD=10.05,95%CI(3.13,16.97)],差异有统计学意义(P=0.004)。纳入研究均未发现明显不良反应。结论复方玄驹胶囊治疗少弱精子症能有效提高精子数量和精子活力,起到生精助育作用,且未发现明显不良反应。
Objective To evaluate the effect and safety of compound Xuanju capsule in the treatment of oligozoospermia by meta-analysis.Methods We searched CENTRAL,EMBASE,MEDLINE(ovid),CNKI,VIP,Wanfang Database,CBM,ChiCTR and ICTRP for randomized controlled trials of compound Xuanju capsule for the treatment of oligozoospermia.According to the Cochrane Handbook literature,the randomized controlled trial of compound Xuanju capsule for treatment of oligozoospermia was carried out,and the quality rating and data extraction were carried out.We evaluated the quality of the identified literature and performed meta-analysis using RevMan 5.3.Results A total of 966 patients with 10 RCTs were included in the study,including 537 cases of compound Xuanju capsule and 429 cases of control group.The results of meta analysis showed that compound Xuanju capsule could increase sperm density compared with control group(MD=4.64,95% CI 0.06 to 9.22,P=0.05).A grade sperm ratio was increased(MD=4.77,95% CI 0.67 to 8.87,P=0.02).(A+B) grade sperm ratio was increased(MD=8.17,95% CI-3.58 to 19.91,P=0.17).The rate of normal sperm morphology was increased(MD=10.05,95% CI 3.13 to 16.97,P=0.004).No significant adverse reactions were found in the study.Conclusion Compound Xuanju capsule could significantly increase the sperm amout and motility without adverse reactions,play spermatogenic and fertility effect,and no obvious adverse reactions have been found.
Objective To evaluate the effect and safety of compound Xuanju capsule in the treatment of oligozoospermia by meta-analysis.Methods We searched CENTRAL,EMBASE,MEDLINE(ovid),CNKI,VIP,Wanfang Database,CBM,ChiCTR and ICTRP for randomized controlled trials of compound Xuanju capsule for the treatment of oligozoospermia.According to the Cochrane Handbook literature,the randomized controlled trial of compound Xuanju capsule for treatment of oligozoospermia was carried out,and the quality rating and data extraction were carried out.We evaluated the quality of the identified literature and performed meta-analysis using RevMan 5.3.Results A total of 966 patients with 10 RCTs were included in the study,including 537 cases of compound Xuanju capsule and 429 cases of control group.The results of meta analysis showed that compound Xuanju capsule could increase sperm density compared with control group(MD=4.64,95% CI 0.06 to 9.22,P=0.05).A grade sperm ratio was increased(MD=4.77,95% CI 0.67 to 8.87,P=0.02).(A+B) grade sperm ratio was increased(MD=8.17,95% CI-3.58 to 19.91,P=0.17).The rate of normal sperm morphology was increased(MD=10.05,95% CI 3.13 to 16.97,P=0.004).No significant adverse reactions were found in the study.Conclusion Compound Xuanju capsule could significantly increase the sperm amout and motility without adverse reactions,play spermatogenic and fertility effect,and no obvious adverse reactions have been found.
引文
[1]张运涛,袁建林,汪涌,等.复方玄驹胶囊对少精子症患者的疗效观察[J].中国男科学杂志,2009,23(2):52-54.
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[5]尹传民,那永刚,肖克兵.复方玄驹胶囊与麒麟丸治疗少弱精症的临床观察[J].国际泌尿系统杂志,2014,34(5):699-701.
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[10]唐喜,梁季鸿,万良,等.复方玄驹胶囊联合左旋精氨酸治疗少弱精症60例的临床观察[J].广西医学,2012,34(10):1344-1345,1351.
[11]刘刚,刘淳,崔志刚,等.复方玄驹胶囊联合十一酸睾酮胶丸治疗少弱精子症的临床观察[J].现代药物与临床,2014,29(9):998-1002.
[12]安琪,刘德忠,邹练.复方玄驹胶囊治疗男性不育症的Meta分析[J].中国男科学杂志,2015,29(6):48-53.
[13]袁平成,陈小刚,姜卫东,等.西药联合生精胶囊治疗少、弱精子症的Meta分析[J].时珍国医国药,2014(8):1910-1912.
[14]周坤燕,许良智,耿素梅,等.复方玄驹胶囊治疗多囊卵巢综合征不孕的系统评价[J].中医学报,2014(6):800-803.
[15]崔海,伍燕青.复方玄驹胶囊治疗不孕不育临床疗效观察[J].亚太传统医药,2014,10(6):128-129.
[16]张作涛,谢高宇,陈凯,等.腺嘌呤致大鼠睾丸损伤中标志酶的变化及淫羊藿总黄酮的干预作用[J].重庆医学,2012,41(7):683-685.
[17]袁娟丽,谢金鲜.蛇床子对生殖系统损伤小鼠睾丸和附睾组织形态的影响[J].江西医学院学报,2008,48(2):23-25.
[18]田元春.枸杞多糖生殖保护作用研究进展[J].中国新药杂志,2013,22(12):1421-1424,1451.
[19]贾伟,薛京,王永新,等.复方玄驹胶囊免疫调节和抗炎作用的研究[J].中草药,2003,34(2):154-157.
[20]许超,姜先洲,马林,等.联合应用复方玄驹胶囊对慢性前列腺炎患者临床症状影响的meta分析[J].中华男科学杂志,2012,18(12):1130-1134.
[2]CHECK J H.Treatment of male infertility.Clin Exp Obstet Gynecol,2007,34(4):201-206.
[3]孙艳,刘凯峰.复方玄驹胶囊对弱精子症患者精子质量指标的观察[J].中成药,2013,35(6):1353-1355.
[4]林贤仁,廖相,蓝广和,等.复方玄驹胶囊治疗弱精子症40例的临床分析[J].中外健康文摘,2012,9(10):53-54.
[5]尹传民,那永刚,肖克兵.复方玄驹胶囊与麒麟丸治疗少弱精症的临床观察[J].国际泌尿系统杂志,2014,34(5):699-701.
[6]义建伟,王泽波.复方玄驹胶囊治疗男性不育症临床研究[J].山西医科大学学报,2010,41(3):272-274.
[7]吴义启.复方玄驹胶囊治疗少、弱精子症50例疗效观察[J].咸宁学院学报(医学版),2012,26(2):132-133.
[8]王界宇,曹信杰,王玉山.复方玄驹胶囊联合左卡尼汀口服液治疗少弱精子症临床分析[J].中国误诊学杂志,2010,10(27):6582-6583.
[9]杨险峰,潘周辉,孙琳,等.复方玄驹胶囊联合左卡尼汀治疗少弱精子症疗效观察[J].中国误诊学杂志,2011,11(21):5140-5141.
[10]唐喜,梁季鸿,万良,等.复方玄驹胶囊联合左旋精氨酸治疗少弱精症60例的临床观察[J].广西医学,2012,34(10):1344-1345,1351.
[11]刘刚,刘淳,崔志刚,等.复方玄驹胶囊联合十一酸睾酮胶丸治疗少弱精子症的临床观察[J].现代药物与临床,2014,29(9):998-1002.
[12]安琪,刘德忠,邹练.复方玄驹胶囊治疗男性不育症的Meta分析[J].中国男科学杂志,2015,29(6):48-53.
[13]袁平成,陈小刚,姜卫东,等.西药联合生精胶囊治疗少、弱精子症的Meta分析[J].时珍国医国药,2014(8):1910-1912.
[14]周坤燕,许良智,耿素梅,等.复方玄驹胶囊治疗多囊卵巢综合征不孕的系统评价[J].中医学报,2014(6):800-803.
[15]崔海,伍燕青.复方玄驹胶囊治疗不孕不育临床疗效观察[J].亚太传统医药,2014,10(6):128-129.
[16]张作涛,谢高宇,陈凯,等.腺嘌呤致大鼠睾丸损伤中标志酶的变化及淫羊藿总黄酮的干预作用[J].重庆医学,2012,41(7):683-685.
[17]袁娟丽,谢金鲜.蛇床子对生殖系统损伤小鼠睾丸和附睾组织形态的影响[J].江西医学院学报,2008,48(2):23-25.
[18]田元春.枸杞多糖生殖保护作用研究进展[J].中国新药杂志,2013,22(12):1421-1424,1451.
[19]贾伟,薛京,王永新,等.复方玄驹胶囊免疫调节和抗炎作用的研究[J].中草药,2003,34(2):154-157.
[20]许超,姜先洲,马林,等.联合应用复方玄驹胶囊对慢性前列腺炎患者临床症状影响的meta分析[J].中华男科学杂志,2012,18(12):1130-1134.