蛭蛇通络胶囊对脑梗死恢复期患者血脂、血液流变学的影响
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摘要
目的:观察蛭蛇通络胶囊对脑梗死恢复期患者血脂和血液流变学指标的影响。方法:将112例脑梗死恢复期患者随机分为对照组和治疗组各56例。两组均采用基础规范治疗和脑卒中的三级康复治疗方案,治疗组加用蛭蛇通络胶囊,每次4粒,每日3次,用药4周。观察两组患者治疗前后血脂和血液流变学指标的变化和中医证候积分改善情况。结果:用药4周后,对照组和治疗组的总有效率分别为67.8%和89.2%,治疗组的总有效率明显优于对照组(P<0.05)。与治疗前比较,两组患者用药4周后CHOL、TG、LDL-C、HDL-C和WBV、HSRV、LSRV、FIB、ESR水平均有改善(P<0.05或P<0.01);用药4周后LDL-C、HDL-C和WBV、FIB、ESR水平较对照组改善程度更为显著(P<0.05或P<0.01)。结论:蛭蛇通络胶囊可有效地改善脑梗死恢复期患者血脂和血液流变学和临床中医证候积分,具有一定的临床疗效。
Objective: To study the effect of the blood lipid and blood rheology in patients with cerebral infarction recovery period treated with Zhishe Tongluo Capsule. Methods: A total of 112 patients with cerebral infarction recovery period were randomly divided into control group and treatment group,56 cases in each. Two groups both used standard treatment and tertiary rehabilitation treatment for cerebral apoplexy. The treatment group additionally used Zhishe Tongluo Capsule,4 grain once,3 times a day,treatment for 4 weeks. Observe two groups' blood lipid and blood rheology levels,TCM syndrome integral before and after treatment. Results: After treatment for 4 weeks,the control group and treatment group's total effective rate was 67. 8% and 89. 2%. The total effective rate of treatment group was obviously better than the control group's( P < 0. 05). Compared with before treatment,two groups' CHOL,TG,LDL,HDL-C,LDL-C and WBV,HSRV,LSRV,FIB and ESR levels after 4 weeks treatment( P < 0. 05 or P < 0. 01). After 4 weeks treatment,LDL-C,HDL-C,WBV,FIB and ESR levels were obvious improved significantly( P < 0. 05 or P < 0. 01). Conclusion: Zhishe Tongluo Capsule can effectively improve the blood lipid,blood rheology and clinical TCM syndrome integral in patients with cerebral infarction in recovery period. It has a certain clinical curative effect.
Objective: To study the effect of the blood lipid and blood rheology in patients with cerebral infarction recovery period treated with Zhishe Tongluo Capsule. Methods: A total of 112 patients with cerebral infarction recovery period were randomly divided into control group and treatment group,56 cases in each. Two groups both used standard treatment and tertiary rehabilitation treatment for cerebral apoplexy. The treatment group additionally used Zhishe Tongluo Capsule,4 grain once,3 times a day,treatment for 4 weeks. Observe two groups' blood lipid and blood rheology levels,TCM syndrome integral before and after treatment. Results: After treatment for 4 weeks,the control group and treatment group's total effective rate was 67. 8% and 89. 2%. The total effective rate of treatment group was obviously better than the control group's( P < 0. 05). Compared with before treatment,two groups' CHOL,TG,LDL,HDL-C,LDL-C and WBV,HSRV,LSRV,FIB and ESR levels after 4 weeks treatment( P < 0. 05 or P < 0. 01). After 4 weeks treatment,LDL-C,HDL-C,WBV,FIB and ESR levels were obvious improved significantly( P < 0. 05 or P < 0. 01). Conclusion: Zhishe Tongluo Capsule can effectively improve the blood lipid,blood rheology and clinical TCM syndrome integral in patients with cerebral infarction in recovery period. It has a certain clinical curative effect.
引文
[1]贾建平,陈生弟.神经病学[M].北京:人民卫生出版社,2013:175-198.
[2]中华预防医学会卒中预防与控制专业委员会介入组,急性缺血性脑卒中血管内治疗中国专家共识组.急性缺血性脑卒中血管内治疗中国专家共识[S].中华医学杂志,2014,94(27):2097-2102.
[3]中华医学会神经病学分会神经康复学组,中华医学会神经病学分会脑血管病学组,卫生部脑卒中筛查与防治工程委员会.中国脑卒中康复治疗指南[S].中国康复理论与实践,2012,18(4):301-308.
[4]陈薇,胡玉英.中医药治疗缺血性中风研究进展[J].中西医结合心脑血管病杂志,2012,10(4):474-476.
[5]中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南[S].中华神经科杂志,2010,43(2):1-8.
[6]周仲瑛.中医内科学[M].北京:中国中医药出版社,2007:304-314.
[7]中华医学会神经病学分会神经康复学组,中华医学会神经病学分会脑血管病学组,卫生部脑卒中筛查与防治工程委员会.中国脑卒中康复治疗指南[S].中国康复理论与实践,2012,18(4):301-308.
[8]王永刚,郑刚.优势病种-中西医结合诊疗方案[M].西安:陕西科学技术出版社,2013:43-49.
[9]李军.玉鼎集-国医大师张学文学术思想鉴赏[M].西安:第四军医大学出版社,2014:218-228.
[10]游小江.蛭蛇通络胶囊治疗脑梗死恢复期64例[J].中国医药指南,2012,10(21):627-629.
[11]张勤.丹红注射液对脑梗死的疗效及血脂、血液流变学的影响[J].中医药导报,2009,15(7):17-18.
[12]方显明,黄红英.活血化瘀药防治高脂血症作用机制研究[J].中医药学刊,2005,23(5):804-808.
[13]苏斌,王志斌,宋程程,等.水蛭抗凝血作用实验研究[J].山东中医杂志,2014,33(11):920-923.
[14]赖真,王沙燕,耿小茵.益气活血药对缺血性脑损伤后的神经细胞保护作用[J].中国医药学报,2002,17(2):90-93.
[15]饶萍.活血化瘀药对缺血性脑卒中的治疗作用[J].中华脑血管病杂志(电子版),2013,7(4):225-228.
[16]陈凤兰,梁少琴,王益俊,等.益气活血通络汤治疗脑梗死恢复期气虚血瘀证临床观察[J].中医药导报,2011,17(2):13-16.
[17]李灿辉,李智雄.益气活血养阴法治疗脑梗死恢复期30例临床观察[J].中医药导报,2014,20(5):15-18.
[18]张崇泉,肖奕,赵瑞成.益气活血通络汤治疗脑梗死恢复期气虚血瘀证临床观察[J].中医药导报,2010,17(2):13-15.
[2]中华预防医学会卒中预防与控制专业委员会介入组,急性缺血性脑卒中血管内治疗中国专家共识组.急性缺血性脑卒中血管内治疗中国专家共识[S].中华医学杂志,2014,94(27):2097-2102.
[3]中华医学会神经病学分会神经康复学组,中华医学会神经病学分会脑血管病学组,卫生部脑卒中筛查与防治工程委员会.中国脑卒中康复治疗指南[S].中国康复理论与实践,2012,18(4):301-308.
[4]陈薇,胡玉英.中医药治疗缺血性中风研究进展[J].中西医结合心脑血管病杂志,2012,10(4):474-476.
[5]中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南[S].中华神经科杂志,2010,43(2):1-8.
[6]周仲瑛.中医内科学[M].北京:中国中医药出版社,2007:304-314.
[7]中华医学会神经病学分会神经康复学组,中华医学会神经病学分会脑血管病学组,卫生部脑卒中筛查与防治工程委员会.中国脑卒中康复治疗指南[S].中国康复理论与实践,2012,18(4):301-308.
[8]王永刚,郑刚.优势病种-中西医结合诊疗方案[M].西安:陕西科学技术出版社,2013:43-49.
[9]李军.玉鼎集-国医大师张学文学术思想鉴赏[M].西安:第四军医大学出版社,2014:218-228.
[10]游小江.蛭蛇通络胶囊治疗脑梗死恢复期64例[J].中国医药指南,2012,10(21):627-629.
[11]张勤.丹红注射液对脑梗死的疗效及血脂、血液流变学的影响[J].中医药导报,2009,15(7):17-18.
[12]方显明,黄红英.活血化瘀药防治高脂血症作用机制研究[J].中医药学刊,2005,23(5):804-808.
[13]苏斌,王志斌,宋程程,等.水蛭抗凝血作用实验研究[J].山东中医杂志,2014,33(11):920-923.
[14]赖真,王沙燕,耿小茵.益气活血药对缺血性脑损伤后的神经细胞保护作用[J].中国医药学报,2002,17(2):90-93.
[15]饶萍.活血化瘀药对缺血性脑卒中的治疗作用[J].中华脑血管病杂志(电子版),2013,7(4):225-228.
[16]陈凤兰,梁少琴,王益俊,等.益气活血通络汤治疗脑梗死恢复期气虚血瘀证临床观察[J].中医药导报,2011,17(2):13-16.
[17]李灿辉,李智雄.益气活血养阴法治疗脑梗死恢复期30例临床观察[J].中医药导报,2014,20(5):15-18.
[18]张崇泉,肖奕,赵瑞成.益气活血通络汤治疗脑梗死恢复期气虚血瘀证临床观察[J].中医药导报,2010,17(2):13-15.