鱼腥草氯仿部位的化学成分研究
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摘要
运用色谱方法对鱼腥草氯仿部位的化学成分进行研究,并利用现代波谱技术对已分离得到的化合物进行结构鉴定。从中分离并鉴定了9个化合物,分别鉴定为:(S)-5,6,6a,7-四氢-2,10-二甲氧基-4H-二苯并[DE,G]喹啉-1,9-二醇(1)、(+)-isoboldineβ-N-oxide (2)、liriotulipiferine (3)、telitoxinone (4)、异波尔定碱(5)、(-)-clovane-2β,9α-diol (6)、苯甲酸(7)、acantrifoside E (8)、邻苯二甲酸二丁酯(9)。其中化合物2～9为首次从鱼腥草中分离得到,化合物1为新的阿朴菲类生物碱,命名为鱼腥草碱A。
Nine compounds were isolated from chloroform fraction of Houttuynia cordata,and the isolates were identified as follows:( S)-5,6,6 a,7-tetrahydro-2,10-dimethoxy-4 H-dibenzo [DE,G] quinoline-1,9-diol( 1),( +)-isoboldine β-N-oxide( 2),liriotulipiferine( 3),telitoxinone( 4),isoboldine( 5),(-)-clovane-2β,9α-diol( 6),benzoic acid( 7),acantrifoside E( 8),and dibutyl phthalate( 9). Among them,compound 1 was new,and compounds 2-9 were reported from this species for the first time.
Nine compounds were isolated from chloroform fraction of Houttuynia cordata,and the isolates were identified as follows:( S)-5,6,6 a,7-tetrahydro-2,10-dimethoxy-4 H-dibenzo [DE,G] quinoline-1,9-diol( 1),( +)-isoboldine β-N-oxide( 2),liriotulipiferine( 3),telitoxinone( 4),isoboldine( 5),(-)-clovane-2β,9α-diol( 6),benzoic acid( 7),acantrifoside E( 8),and dibutyl phthalate( 9). Among them,compound 1 was new,and compounds 2-9 were reported from this species for the first time.
引文
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[2] Kim S K,Ryu S Y,No J,et al. Cytotoxic alkaloids from Houttuynia cordata[J]. Arch Pharm Res,2001,24(6):518.
[3]孟江,和殿峰,周毅生,等.鱼腥草不同提取部位的药理活性比较研究[J].时珍国医国药,2008,19(5):1050.
[4]梁慧超,孟江,卢国勇,等.鱼腥草总生物碱提取工艺的研究[J].成都医学院学报,2010,5(4):311.
[5]孟江,梁慧超,陈磊,等.鱼腥草总生物碱的大孔吸附树脂纯化工艺[J].中国实验方剂学杂志,2012,18(7):13.
[6]薛兴阳,吴华振,付腾飞,等.鱼腥草生物碱抑制人大细胞肺癌细胞生长研究[J].现代中西医结合杂志,2016,25(27):2972.
[7] Tao F,Yan X,Xiang H C,et al. Antimicrobially active isoquinoline alkaloids from litsea cubeba[J]. Planta Med,2009,75(1):76.
[8] Chen C L,Chang H M,Cowling E B,et al. Aporphine alkaloids and lignans formed in response to injury of sapwood in Liriodendron tulipifera[J]. Phytochemistry,1976,15(7):1161.
[9]李慧梁.岩黄连活性成分系统研究及藜芦毒性成分研究[D].上海:第二军医大学,2006:44.
[10] Mary D M,Geoffrey W B,Robert C G. Telisatin A,telisatin B,and telitoxinone,three new aporphinoids from Telitoxicum peruvianum[J]. J Nat Prod,1995,58(12):1945.
[11]高光耀,陈四保,王立为,等.狭序唐松草化学成分的研究(Ⅲ)[J].中草药,2000,31(5):324.
[12] Liu H Y,He H P,Shen S G,et al. Two new diterpenoids from Callicarpa pedunculata[J]. Helv Chim Acta,2006,89(5):1017.
[13]尹伟,刘金旗,张国升.桂花果实的化学成分研究[J].中国中药杂志,2013,38(24):4329.
[14] Phan V K,Chau V M,Nguyen T D,et al. Two new phenylpropanoid glycosides from the stem bark of acanthoanax trifoliatus[J]. Arch Pharm Res,2003,26(12):1014.
[15]薛刚强,杜婧,潘新艳,等.玄参化学成分研究[J].中药材,2014,37(9):1597.
[16] Jhonny E C,Carlos H R,Amparo del R C. Minor alkaloids from Guatteria dumetorum with antileishmanial activity[J]. Planta Med,2006,72(3):270.
[17] Seied M V,Mehrdad I,Amirhossein S. Cytotoxic activities of phytochemicals from Ferula species[J]. J Pharm Sci,2013,21(1):1.
[18]李珅.广东紫珠的化学成分研究[D].天津:南开大学,2016.