摘要
目的探索新生儿体内降钙素原变化的临床意义。方法 120例新生儿为研究对象,根据新生儿感染程度分为重症感染组、局部感染组和非感染组,每组40例,对比分子三组新生儿的降钙素原、C反应蛋白、白细胞介素-6检测水平。结果重症感染组患儿的降钙素原为(34.05±12.36)ng/ml、白细胞介素-6为(178.56±24.36)ng/L、C反应蛋白为(26.31±5.36)mg/L,局部感染组患儿的降钙素原为(12.30±1.05)ng/ml、白细胞介素-6为(75.39±10.02)ng/L、C反应蛋白为(12.36±2.04)mg/L,非感染组新生儿的降钙素原为(0.32±0.41)ng/ml、白细胞介素-6为(8.36±2.04)ng/L、C反应蛋白为(7.62±2.05)mg/L。重症感染组均高于局部感染组和非感染组,局部感染组均高于非感染组,差异均具有统计学意义(P<0.05)。降钙素原在重症感染患儿中敏感性为93.75%,特异性为87.50%,漏诊率为6.25%,误诊率为12.50%。降钙素原在局部感染患儿中的敏感度为96.67%,特异度为90.00%,漏诊率为3.33%,误诊率为10.00%。结论降钙素原能够反映新生儿感染程度,持续性升高可提示预后差。
Objective To explore the clinical significance of changes of procalcitonin in newborns.Methods A total of 120 newborns as study subjects were divided by degrees of neonatal infections into severe infection group,local infection,non infection group,with 40 cases in each group.Comparison were made on procalcitonin,C-reactive protein,interleukin-6 levels in three groups.Results The severe infection group had procalcitonin as(34.05±12.36) ng/ml,interleukin-6 as(178.56±24.36)ng/L and C-reactive protein as(26.31±5.36) mg/L,local infection group had procalcitonin as(12.30±1.05) ng/ml,interleukin-6 as(75.39±10.02) ng/L and C-reactive protein as(12.36±2.04) mg/L,and non infection group had procalcitonin as(0.32±0.41) ng/ml,interleukin-6 as(8.36±2.04) ng/L and C-reactive protein as(7.62±2.05) mg/L.The severe infection group had higher indexes than local infection group and non infection group,and local infection group had higher indexes than non infection group.All their differences had statistical significance(P<0.05).Procalcitonin had sensitivity as 93.75%,specificity as 87.50%,missed diagnosis rate as 6.25%,and misdiagnosis rate as 12.50%in severe infection children.Procalcitonin had sensitivity as 96.67%,specificity as 90.00%,missed diagnosis rate as 3.33%,and misdiagnosis rate as 10.00%.Conclusion Procalcitonin can reflect the degree of neonatal infection,and continuous rise may indicate poor prognosis.
引文
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