尼尔雌醇在老年性阴道炎和老年性尿路感染中的应用
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摘要
女性的卵巢内分泌功能自35岁起明显衰退,50岁左右出现绝经,不少妇女产生围绝经期症状,如老年性阴道炎、老年性尿路感染,严重地影响了生活质量。20世纪起临床上应用尼尔雌醇治疗老年性阴道炎和老年性尿路感染获得良好疗效。本文重点分析女性生殖和泌尿系统的发育特点、解剖生理特点,总结尼尔雌醇的药物特性及其治疗老年性阴道炎和老年性尿路感染的方案和注意事项,期待着尼尔雌醇的重新应用为改善老年妇女的生活质量带来福音。
The ovarian endocrine function of women has declined significantly since the age of 35 and menopause around 50 years old. Many women suffer from perimenopausal symptoms which impact on quality of life, such as senile vaginitis and senile urinary tract infection. In the 20 th century, the clinical application of nilestriol in treating senile vaginit is and senile urinary tract infection has achieved good results. The characteristics of development, anatomy and physiology of female reproductive and urinary system are analyzed in this paper. And the drug properties, therapeutic regimen and precautions of nilestriol in treating senile vaginitis and senile urinary tract infection are summarized. We look forward to the reapplication of nilestriol can improve quality of life of elderly women.
The ovarian endocrine function of women has declined significantly since the age of 35 and menopause around 50 years old. Many women suffer from perimenopausal symptoms which impact on quality of life, such as senile vaginitis and senile urinary tract infection. In the 20 th century, the clinical application of nilestriol in treating senile vaginit is and senile urinary tract infection has achieved good results. The characteristics of development, anatomy and physiology of female reproductive and urinary system are analyzed in this paper. And the drug properties, therapeutic regimen and precautions of nilestriol in treating senile vaginitis and senile urinary tract infection are summarized. We look forward to the reapplication of nilestriol can improve quality of life of elderly women.
引文
[1]邵敬於.雌激素在妇科的合理选用[J].中国新药与临床杂志,2004,23(12):897-900.
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[7]张茜.不同治疗方法治疗老年性阴道炎的疗效对比[J].中国老年学杂志,2012,32(14):3039-3040.
[8]钱桐荪.重视老年尿路感染的防治[J].实用老年医学杂志,1997,11(6):241.
[9]曹宁生,郝丽娜,黄琼.女性尿道综合征动力学病因分析[J].中华泌尿外科杂志,1995,16(11):658-660.
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[11]王珊珊,曾慧琳,符旭东.雌二醇阴道用制剂的临床应用[J].医药导报,2015,34(4):498-501.
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[13]CARDOZO L,LOSE G,Mc CLISH D,et al.A systematic review of estrogens for recurrent urinary tract infections:third report of the hormones and urogenital therapy(HUT)committee[J].Int Urogynecol J Pelvic Floor Dysfunct,2001,12(1):15-20.
[14]ROBINSON D,CARDOZO LD.The role of estrogens in female lower urinary tract dysfunction[J].Urology,2003,62(4 Suppl1):45-51.
[15]GRADY D,BROWN JS,VITTINGHOFF E,et al.Postmenopausal hormones and incontinence:the Heart and Estrogen/Progestin Replacement Study[J].Obstet Gynecol,2001,97(1):116-120.
[16]ROZENBERG S,PASTIJN A,GEVERS R,et al.Estrogen therapy in older patients with recurrent urinary tract infections:a review[J].Int J Fertil Womens Med,2004,49(2):71-74.
[17]陆湘云,颜本元.尼尔雌醇治疗更年期综合征339例[J].新药与临床,1989,8(3):183-186.
[18]田冬珍.低剂量尼尔雌醇治疗绝经后妇女泌尿生殖道症状[J].中国药业,2001,10(6):41.
[19]王丽英.尼尔雌醇治疗绝经后妇女复发性泌尿生殖道感染的临床分析[J].中国现代药物应用,2010,4(18):155-156.
[20]张秀云,周岩.抗生素配合尼尔雌醇治疗绝经后复发性泌尿生殖道感染[J].泰山卫生,2003,27(3):32-33.
[21]郑丽莉.低剂量尼尔雌醇治疗绝经后妇女泌尿生殖道感染的疗效观察[J].天津药学,2011,23(4):35-37.
[2]丰有吉,沈铿.妇产科学[M].2版.北京:人民卫生出版社,2011:7.
[3]杨冬梓.小儿和青春期妇科学[M].北京:人民卫生出版社,2003:1-19.
[4]邵敬於.性激素的临床应用[M].上海:复旦大学出版社,2003:90-96.
[5]De CHERNEY AH,NATHAN L.现代妇产科疾病诊断与治疗[M].刘新民,万小军,宋玉琴,译.北京:人民卫生出版社,1998:1071-1072.
[6]DEMIREZEN S.Bacterial vaginitis:general overview[J].Mikrobiyol Bul,2003,37(1):99-104.
[7]张茜.不同治疗方法治疗老年性阴道炎的疗效对比[J].中国老年学杂志,2012,32(14):3039-3040.
[8]钱桐荪.重视老年尿路感染的防治[J].实用老年医学杂志,1997,11(6):241.
[9]曹宁生,郝丽娜,黄琼.女性尿道综合征动力学病因分析[J].中华泌尿外科杂志,1995,16(11):658-660.
[10]SUCKLING J,LETHABY A,KENNEDY R.Local oestrogen for vaginal atrophy in postmenopausal women[J].Cochrane Database Syst Rev,2003,(4):CD001500.
[11]王珊珊,曾慧琳,符旭东.雌二醇阴道用制剂的临床应用[J].医药导报,2015,34(4):498-501.
[12]MOEHRER B,HEXTALL A,JACKSON S.Oestrogens for urinary incontinence in women[J].Cochrane Database Syst Rev,2003,(2):CD001405.
[13]CARDOZO L,LOSE G,Mc CLISH D,et al.A systematic review of estrogens for recurrent urinary tract infections:third report of the hormones and urogenital therapy(HUT)committee[J].Int Urogynecol J Pelvic Floor Dysfunct,2001,12(1):15-20.
[14]ROBINSON D,CARDOZO LD.The role of estrogens in female lower urinary tract dysfunction[J].Urology,2003,62(4 Suppl1):45-51.
[15]GRADY D,BROWN JS,VITTINGHOFF E,et al.Postmenopausal hormones and incontinence:the Heart and Estrogen/Progestin Replacement Study[J].Obstet Gynecol,2001,97(1):116-120.
[16]ROZENBERG S,PASTIJN A,GEVERS R,et al.Estrogen therapy in older patients with recurrent urinary tract infections:a review[J].Int J Fertil Womens Med,2004,49(2):71-74.
[17]陆湘云,颜本元.尼尔雌醇治疗更年期综合征339例[J].新药与临床,1989,8(3):183-186.
[18]田冬珍.低剂量尼尔雌醇治疗绝经后妇女泌尿生殖道症状[J].中国药业,2001,10(6):41.
[19]王丽英.尼尔雌醇治疗绝经后妇女复发性泌尿生殖道感染的临床分析[J].中国现代药物应用,2010,4(18):155-156.
[20]张秀云,周岩.抗生素配合尼尔雌醇治疗绝经后复发性泌尿生殖道感染[J].泰山卫生,2003,27(3):32-33.
[21]郑丽莉.低剂量尼尔雌醇治疗绝经后妇女泌尿生殖道感染的疗效观察[J].天津药学,2011,23(4):35-37.