尼尔雌醇在绝经后妇女取出宫内节育器前的应用
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摘要
宫内节育器是一种长期、高效、安全、简便的避孕方法,且可逆。绝经后女性雌激素水平急剧下降,导致阴道、宫颈和子宫体萎缩,宫颈变得狭窄、缺乏弹性,导致取器困难。尼尔雌醇为长效口服型雌三醇衍生物,有较强雌激素活性,能选择性作用于阴道及宫颈,而对子宫内膜作用很小。雌激素可以促进阴道黏膜上皮及宫颈组织增生、黏膜分泌物增多、弹性增加,从而使萎缩的阴道、宫颈变软,易于扩张。绝经后妇女取器术前口服尼尔雌醇可软化宫颈,提高取器成功率。
Intrauterine device is a long-term, efficient, safe, simple and reversible method of contraception.The postmenopausal women with a sharp decline in estrogen levels leading to the vagina, cervix and uterus atrophy, cervical stenosis and lack of elasticity, increase the difficulty of the intrauterine contraception removal.Nilestriol is a long-acting orally administered estriol derivative with strong estrogen activity that selectively acts on the vagina and cervix with little effect on the endometrium. Estrogen can make vagina mucosa and cervical hyperplasia, mucous secretion and elasticity increased, thus the vagina and cervix become soft, easy to expand.Postmenopausal women take orally nilestriol before operation can soften the cervix and improve the success rate of the removing intrauterine device.
Intrauterine device is a long-term, efficient, safe, simple and reversible method of contraception.The postmenopausal women with a sharp decline in estrogen levels leading to the vagina, cervix and uterus atrophy, cervical stenosis and lack of elasticity, increase the difficulty of the intrauterine contraception removal.Nilestriol is a long-acting orally administered estriol derivative with strong estrogen activity that selectively acts on the vagina and cervix with little effect on the endometrium. Estrogen can make vagina mucosa and cervical hyperplasia, mucous secretion and elasticity increased, thus the vagina and cervix become soft, easy to expand.Postmenopausal women take orally nilestriol before operation can soften the cervix and improve the success rate of the removing intrauterine device.
引文
[1]南秀牌,吴明辉.宫内节育器移位、异位的诊治与预防[J].实用妇产科杂志,2003,19(6):329-330.
[2]王海云,殷明红,王玮.宫内节育器取出5613例临床分析[J].生殖与避孕,2009,29(10):696-698.
[3]王海云.性激素在流产与引产中的应用[M]//邵敬於.性激素的临床应用.上海:复旦大学出版社,2003:283-297.
[4]沈奕,曹树军,原玮,等.非孕妇女口服米非司酮对宫颈软化作用的观察及其机制的探讨[J].中国妇幼保健,2011,26(9):1306-1309.
[5]丰有吉,沈铿.妇产科学[M].2版.北京:人民卫生出版社,2012:23.
[6]王中海,邵敬於.尼尔雌醇对绝经期妇女子宫内膜的影响[J].中国新药与临床杂志,1998,17(6):368-369.
[7]王慧颖,韩凤英,邢丹,等.促宫颈软化药物治疗的临床研究及应用进展[J].临床医药文献杂志,2017,4(28):5535-5536.
[8]汪沙,段华,付凤仙,等.卡前列甲酯用于子宫腔疾病诊断术前宫颈预处理的疗效观察[J].中国计划生育和妇产科,2013,5(5):33-35.
[9]速存梅,叶汉风,邹燕,等.绝经后妇女宫内节育器取出术前应用尼尔雌醇扩张宫颈的临床评价[J].中国计划生育学杂志,2010,(11):648-652.
[10]纪静,时秀洁,纪昕.尼尔雌醇和米非司酮在绝经后宫内节育器取出术中的应用[J].宁夏医科大学学报,2014,36(4):439-441.
[11]石莉,黄江萍.尼尔雌醇联合米非司酮用于绝经后IUD取出的临床观察[J].中国医学创新,2014,11(3):24-25.
[12]冀凤香.三种药物联合用于绝经后宫内节育器取出的临床效果比较[J].中国药物与临床,2014,14(9):1243-1245.
[13]张继,王素梅,刘瑞敏.米索前列醇在绝经后妇女宫内节育器取出术中的应用[J].中国计划生育和妇产科,2010,2(3):45-47.
[14]张秀艳.尼尔雌醇配伍盐酸丁卡因凝胶用于绝经后妇女取宫内节育器的效果观察[J].生殖医学杂志,2013,22(8):622-623.
[2]王海云,殷明红,王玮.宫内节育器取出5613例临床分析[J].生殖与避孕,2009,29(10):696-698.
[3]王海云.性激素在流产与引产中的应用[M]//邵敬於.性激素的临床应用.上海:复旦大学出版社,2003:283-297.
[4]沈奕,曹树军,原玮,等.非孕妇女口服米非司酮对宫颈软化作用的观察及其机制的探讨[J].中国妇幼保健,2011,26(9):1306-1309.
[5]丰有吉,沈铿.妇产科学[M].2版.北京:人民卫生出版社,2012:23.
[6]王中海,邵敬於.尼尔雌醇对绝经期妇女子宫内膜的影响[J].中国新药与临床杂志,1998,17(6):368-369.
[7]王慧颖,韩凤英,邢丹,等.促宫颈软化药物治疗的临床研究及应用进展[J].临床医药文献杂志,2017,4(28):5535-5536.
[8]汪沙,段华,付凤仙,等.卡前列甲酯用于子宫腔疾病诊断术前宫颈预处理的疗效观察[J].中国计划生育和妇产科,2013,5(5):33-35.
[9]速存梅,叶汉风,邹燕,等.绝经后妇女宫内节育器取出术前应用尼尔雌醇扩张宫颈的临床评价[J].中国计划生育学杂志,2010,(11):648-652.
[10]纪静,时秀洁,纪昕.尼尔雌醇和米非司酮在绝经后宫内节育器取出术中的应用[J].宁夏医科大学学报,2014,36(4):439-441.
[11]石莉,黄江萍.尼尔雌醇联合米非司酮用于绝经后IUD取出的临床观察[J].中国医学创新,2014,11(3):24-25.
[12]冀凤香.三种药物联合用于绝经后宫内节育器取出的临床效果比较[J].中国药物与临床,2014,14(9):1243-1245.
[13]张继,王素梅,刘瑞敏.米索前列醇在绝经后妇女宫内节育器取出术中的应用[J].中国计划生育和妇产科,2010,2(3):45-47.
[14]张秀艳.尼尔雌醇配伍盐酸丁卡因凝胶用于绝经后妇女取宫内节育器的效果观察[J].生殖医学杂志,2013,22(8):622-623.