莫西克汀浇泼剂的制备及其稳定性研究
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摘要
目的:制备莫西克汀浇泼剂并对其进行稳定性研究。方法:选用美国富道动物保健公司产品(Fort Dodge Animal Health,商品名为CYDECTIN~Pour-On)为对照制剂,通过透皮吸收实验筛选处方,按照药品稳定指南对处方进行初步稳定性考察。结果:自制样品与对照制剂有同等的透过效果且质量稳定。结论:成功制备安全等效稳定的莫西克汀浇泼剂。
Objective: To prepare moxidectin pour-on and study its stability. Methods: Transdermal absorption experiment was used to screen prescription with reference listed drug(RLD)from Fort Dodge Animal Health(Brand Name: CYDECTIN詳Pour-On),and a short-term accelerate research in 40 ℃/RH75% was carried out to studt the sample stability. Results: Both of the sample and RLD had equal transdermal absorption effect and stable quality. Conclusion: Moxidectin Pour-On is successful prepared with safety, stability and equal transdermal absorption effect to RLD.
Objective: To prepare moxidectin pour-on and study its stability. Methods: Transdermal absorption experiment was used to screen prescription with reference listed drug(RLD)from Fort Dodge Animal Health(Brand Name: CYDECTIN詳Pour-On),and a short-term accelerate research in 40 ℃/RH75% was carried out to studt the sample stability. Results: Both of the sample and RLD had equal transdermal absorption effect and stable quality. Conclusion: Moxidectin Pour-On is successful prepared with safety, stability and equal transdermal absorption effect to RLD.
引文
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[2]Awasthi A,Razzak M,Al-Kassas R,et al.Isolation and characterization of degradation products in moxidectin using LC,LTQ FT-MS,H/D exchange and NMR[J].Analytical and Bioanalytical Chemistry,2012,404(8):2203-2222.
[3]Douglas D,Colwell.Persistent activity of moxidectin pour on and injectable against sucking and biting louse infestations of cattle[J].Veterinary Parasitology,2002,104(4):319-326.
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[5]谢等龙,邵伍军,陈金凤,等.一种莫西克汀浇泼剂及其制备方法[P].中国,CN102133173A.2013.04.03.
[6]王相晶,孙丽鹏,向文胜.尼莫克汀、莫西克汀水乳剂、微乳剂、悬浮剂的制备[P].中国,1947507A.2007.04.18.
[7]R C罗.药用辅料手册[M].第4版.北京:化学工业出版社,2005:359-360.
[8]中国兽药典委员会.中国兽药典[M].2010版一部.北京:中国农业出版社,2011:附录246-249.
[2]Awasthi A,Razzak M,Al-Kassas R,et al.Isolation and characterization of degradation products in moxidectin using LC,LTQ FT-MS,H/D exchange and NMR[J].Analytical and Bioanalytical Chemistry,2012,404(8):2203-2222.
[3]Douglas D,Colwell.Persistent activity of moxidectin pour on and injectable against sucking and biting louse infestations of cattle[J].Veterinary Parasitology,2002,104(4):319-326.
[4]Losson B,Lonneux J F.Field efficacy of moxidectin0.5%pour-on against Chorioptes bovis,Damalinia bovis,Linognathus vituli and Psoroptes ovis in naturally infected cattle[J].Veterinary parasitology,1996,63(1):119-130.
[5]谢等龙,邵伍军,陈金凤,等.一种莫西克汀浇泼剂及其制备方法[P].中国,CN102133173A.2013.04.03.
[6]王相晶,孙丽鹏,向文胜.尼莫克汀、莫西克汀水乳剂、微乳剂、悬浮剂的制备[P].中国,1947507A.2007.04.18.
[7]R C罗.药用辅料手册[M].第4版.北京:化学工业出版社,2005:359-360.
[8]中国兽药典委员会.中国兽药典[M].2010版一部.北京:中国农业出版社,2011:附录246-249.