壳聚糖/海藻酸钠/多孔淀粉-茶树精油微胶囊制备及释放性能分析
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摘要
以多孔淀粉(PS)为芯材载体吸附茶树精油(TTEO),以海藻酸钠(SA)-壳聚糖(CS)为壁材,戊二醛(GA)为固化交联剂,通过聚电解质复合凝聚法成功制备了CS/SA/PS-TTEO微胶囊。优化后的制备条件为:多孔淀粉与茶树精油的最佳比例为0.88∶1,海藻酸钠浓度为3.0%,壳聚糖浓度为3.0%,戊二醛浓度为2.0%,反应温度为30℃。采用透射电子显微镜(TEM)、热重分析(TGA)、红外光谱(FT-IR)、稳定性测试和释放率实验对CS/SA/PS-TTEO微胶囊的形成、性质和释放行为进行了分析。结果表明,CS/SA/PS-TTEO微胶囊在敞开体系中,TTEO的14天累积释放率为15.77%,单日释放率最低为0.20%;在封闭体系中14天累积释放率为7.37%,在10天左右释放趋于平稳,单日释放率最低仅为0.04%,表明CS/SA/PS-TTEO微胶囊具有一定的缓释能力。在-18～50℃温度下,CS/SA/PS-TTEO微胶囊与化妆品常用溶剂可稳定共存,此性质有利于提高TTEO类化妆品储存和运输稳定性。
The microcapsules of chitosan/sodium alginate/porous starch-tea tree essential oil(CS/SA/PS-TTEO) were successfully prepared by polyelectrolyte complex coacervation method with PS as the core material carrier to adsorb TTEO, SA-CS as the wall material, and glutaraldehyde(GA) as crosslinker. The preparation conditions were optimized as follows. The optimum ratio of PS to TTEO was 0.88∶1, the concentration of SA was 3.0%, the concentration of CS was 3.0%, the concentration of GA was 2.0%, and the reaction temperature was 30℃. The formation, properties and release behaviors of CS/SA/PS-TTEO microcapsules were analyzed by scanning electron microscope(TEM), thermogravimetry(TGA), Fourier transform infrared spectroscopy(FT-IR), stability test and release rate experiments. The results showed that in the open system, cumulative release rate of CS/SA/PS-TTEO microcapsules for 14 days was 15.77%, and the lowest release rate for a single day was 0.20%. In the closed system, the cumulative release rate of 14 days was 7.37%, and the release rate tended to be stable in about 10 days, with the lowest release rate of 0.04% in a single day, which proved that CS/SA/PS-TTEO microcapsules had the ability of slow release. CS/SA/PS-TTEO microcapsule was stable at-18℃ to 50℃ in the commonly used cosmetic solvent, and this property was beneficial to improve the stability of the storage and transport of cosmetics containing TTEO.
The microcapsules of chitosan/sodium alginate/porous starch-tea tree essential oil(CS/SA/PS-TTEO) were successfully prepared by polyelectrolyte complex coacervation method with PS as the core material carrier to adsorb TTEO, SA-CS as the wall material, and glutaraldehyde(GA) as crosslinker. The preparation conditions were optimized as follows. The optimum ratio of PS to TTEO was 0.88∶1, the concentration of SA was 3.0%, the concentration of CS was 3.0%, the concentration of GA was 2.0%, and the reaction temperature was 30℃. The formation, properties and release behaviors of CS/SA/PS-TTEO microcapsules were analyzed by scanning electron microscope(TEM), thermogravimetry(TGA), Fourier transform infrared spectroscopy(FT-IR), stability test and release rate experiments. The results showed that in the open system, cumulative release rate of CS/SA/PS-TTEO microcapsules for 14 days was 15.77%, and the lowest release rate for a single day was 0.20%. In the closed system, the cumulative release rate of 14 days was 7.37%, and the release rate tended to be stable in about 10 days, with the lowest release rate of 0.04% in a single day, which proved that CS/SA/PS-TTEO microcapsules had the ability of slow release. CS/SA/PS-TTEO microcapsule was stable at-18℃ to 50℃ in the commonly used cosmetic solvent, and this property was beneficial to improve the stability of the storage and transport of cosmetics containing TTEO.
引文
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24 LI Guo-Ming,LIU Cong.Chinese J.Appl.Chem.,2008,25(11):1352-1355李国明,刘聪.应用化学,2008,25(11):1352-1355
2 GE Yan,GE Ming-Qiao.J.Funct.Mater.,2014,9(45):9136-9140葛彦,葛明桥.功能材料,2014,9(45):9136-9140
3 Zong W,Hu Y,Su Y C,Luo N,Zhang X N,Li Q C,Han X J.J.Microencapsul.,2016,33:257-262
4 Zhang X N,Zong W,Hu Y,Luo N,Cheng W L,Han X J.J.Microencapsul.,2016,33:663-668
5 Callander J T,James P J.Vet.Parasitol.,2012,184:271-278
6 Carson C F,Hammer K A,Riley T V.Clin.Microbiol.Rev.,2006,19(1):50-62
7 Lahlou M.Flavour.Frag.J.,2004,19:159-165
8 Goni M G,Tomadoni B,Moreira M R,Roura S I.Food Sci.Technol.,2013,54(1):107-113
9 Hammer K A,Carson C F,Riley T V.J.Appl.Microbiol.,2003,95:853-860
10 Lins R F,Lustri W R,Minharro S.Colloid Surf.A,2016,497:271-279
11 Wang B,Adhikari B,Mathesh M,Yang W R.Barrow C J.Powder Technol.,2018,doi:10.1016/j.powtec.2018.07.034
12 Zuo J D,Zhan J,Luo C Y,Dong B Q,Xing F,Chen D Z.Adv.Powder Technol.,2017,28:2805-2811
13 Li Y,Wu C H,Wu T T,Wang L P,Chen S G,Ding T,Hu Y Q.J.Food Eng.,2018,217:108-114
14 Petrovic L B,Sovilj N J,Katona J M,Milanovic J L.J.Colloid Interf.Sci.,2010,342(2):333-339
15 El Asbahani A,Miladi K,Badri W,Sala M,A?t Addi E H,Casabianca H,El Mousadik A,Hartmann D,Jilale A,Renaud F N R,Elaissari A.Int.J.Pharm.,2015,483:220-243
16 Shchukin D G,M?hwald H.Adv.Funct.Mater.,2017,17 (9):1451-1458
17 Nemeth B,Nemeth A S,Ujhidy A,Toth J,Trif L,Gyenis J,Feczko T.Sol.Energy,2018,170:314-322
18 Sato T,Shibako S,Yamamoto T,Ichikawa K,Dobashi T.J.Membr.Sci.,2003,213:25-31
19 Yamamoto T,Dobashi T,Kimura M,Chang C P.Colloids Surf.B,2002,25:305-311
20 Catanzano O,Straccia M.C,Miro A,Ungaro F,Romano I,Mazzarella G,Santagata G,Quaglia F,Laurienzo P,Malinconico M.Eur.J.Pharm.Sci.,2015,66:20-28
21 Yeh K W,Chang C P,Yamamoto T,Dobashi T.Colloid Surf.A,2011,380:152-155
22 LI Sha,HOU Xin-Pu.Acta Pharm.Sin.,2003,38(5):380-383李沙,侯新朴.药学学报,2003,38(5):380-383
23 Ribeiro A J,Silva C,Ferreira D,Veiga F.Eur.J.Pharm.Sci.,2005,25:31-40
24 LI Guo-Ming,LIU Cong.Chinese J.Appl.Chem.,2008,25(11):1352-1355李国明,刘聪.应用化学,2008,25(11):1352-1355