参芪降糖颗粒辅助治疗气阴两虚型2型糖尿病临床研究
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摘要
目的:观察参芪降糖颗粒辅助治疗气阴两虚型2型糖尿病的临床疗效。方法:将120例气阴两虚型2型糖尿病患者随机分为对照组和观察组各60例。对照组给予二甲双胍和格列美脲治疗,观察组在对照组基础上给予参芪降糖颗粒辅助治疗。观察2组治疗前后血糖指标、血脂指标及中医证候积分的变化,对比2组治疗效果。结果:治疗后,2组空腹血糖(FBG)、餐后2 h血糖(P2hBG)及糖化血红蛋白(HbA1c)水平均较治疗前降低(P <0.05);观察组3项血糖指标水平均低于对照组(P <0.05)。治疗后,2组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)含量均较治疗前降低(P <0.05),高密度脂蛋白胆固醇(HDL-C)含量均较治疗前提高(P <0.05);观察组TC、TG和LDL-C含量低于对照组(P <0.05),HDL-C含量高于对照组(P <0.05)。治疗后,2组中医证候积分均较治疗前降低(P <0.05);观察组中医证候积分低于对照组(P <0.05)。总有效率对照组75.00%,观察组90.00%,2组比较,差异有统计学意义(P <0.05)。结论:参芪降糖颗粒辅助治疗气阴两虚型2型糖尿病,能有效改善患者的糖脂代谢和中医证候,提高疗效。
Objective:To observe the clinical effect of Shenqi Jiangtang granules in adjuvant therapy for type 2 diabetes of qi-yin deficiency type. Methods:A total of 120 cases of patients with type 2 diabetes of qi-yin deficiency type were randomly divided into the control group and the observation group, 60 cases in each group. The control group was treated with metformin and glimepiride,while the observation group was given Shenqi Jiangtang granules as adjuvant therapy based on the treatment of the control group. The changes of glycemic index, serum lipids index and Chinese medicine syndrome scores in the two groups were observed before and after treatment,and the clinical effect in the two groups were compared.Results: After treatment, the levels of fasting blood glucose(FBG), postprandial 2-hour blood glucose(P2 hBG) and hemoglobin A1 c(HbA1 c) in the two groups were decreased when compared with those before treatment(P < 0.05),and the levels of the three glycemic indexes in the observation group were lower than those in the control group,differences being significant(P < 0.05). After treatment, the contents of total cholesterol(TC), triglyceride(TG) and low-density lipoprotein cholesterol(LDL-C) in the two groups were decreased when compared with those before treatment(P > 0.05), and the contents of high-density lipoprotein cholesterol(HDL-C) in the two groups were increased when compared with those before treatment(P < 0.05);the contents of TC,TG and LDL-C in the observation group were lower than those in the control group(P < 0.05), and the content of HDL-C in the observation group was higher than that in the control group(P < 0.05). After treatment, Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P < 0.05),and the Chinese medicine syndrome score in the observation group was lower than that in the control group(P < 0.05). The total effective rate was 75.00% in the control group and 90.00% in the observation group,the difference being significant(P < 0.05). Conclusion:Shenqi Jiangtang granules in adjuvant therapy for type 2 diabetes of qi-yin deficiency type can effectively improve glucose and lipid metabolism and Chinese medicine syndromes of patients,as well as improvethe curative effect.
Objective:To observe the clinical effect of Shenqi Jiangtang granules in adjuvant therapy for type 2 diabetes of qi-yin deficiency type. Methods:A total of 120 cases of patients with type 2 diabetes of qi-yin deficiency type were randomly divided into the control group and the observation group, 60 cases in each group. The control group was treated with metformin and glimepiride,while the observation group was given Shenqi Jiangtang granules as adjuvant therapy based on the treatment of the control group. The changes of glycemic index, serum lipids index and Chinese medicine syndrome scores in the two groups were observed before and after treatment,and the clinical effect in the two groups were compared.Results: After treatment, the levels of fasting blood glucose(FBG), postprandial 2-hour blood glucose(P2 hBG) and hemoglobin A1 c(HbA1 c) in the two groups were decreased when compared with those before treatment(P < 0.05),and the levels of the three glycemic indexes in the observation group were lower than those in the control group,differences being significant(P < 0.05). After treatment, the contents of total cholesterol(TC), triglyceride(TG) and low-density lipoprotein cholesterol(LDL-C) in the two groups were decreased when compared with those before treatment(P > 0.05), and the contents of high-density lipoprotein cholesterol(HDL-C) in the two groups were increased when compared with those before treatment(P < 0.05);the contents of TC,TG and LDL-C in the observation group were lower than those in the control group(P < 0.05), and the content of HDL-C in the observation group was higher than that in the control group(P < 0.05). After treatment, Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P < 0.05),and the Chinese medicine syndrome score in the observation group was lower than that in the control group(P < 0.05). The total effective rate was 75.00% in the control group and 90.00% in the observation group,the difference being significant(P < 0.05). Conclusion:Shenqi Jiangtang granules in adjuvant therapy for type 2 diabetes of qi-yin deficiency type can effectively improve glucose and lipid metabolism and Chinese medicine syndromes of patients,as well as improvethe curative effect.
引文
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[8]李建会,李云,任治兴,等.黄芪联合胰岛素对糖尿病大鼠胰岛素抵抗的作用及其机制[J].吉林大学学报(医学版),2013,39(2):246-250.
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[10]赵燕燕,张秋燕,李挥,等.麦冬消渴胶囊对四氧嘧啶糖尿病大鼠血糖血脂的影响[J].河北大学学报(自然科学版),2005,25(3):281-284.
[11]皮子凤,门丽慧,张静,等.五味子治疗大鼠糖尿病肾病作用机制的血清代谢组学研究[J].分析化学,2015,43(2):169-175.
[2]牛东升.胰岛素或磺脲类药物联合二甲双胍治疗初发2型糖尿病疗效观察[J].山东医药,2013,53(33):62-63.
[3]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中国糖尿病杂志,2014,22(8):2-42.
[4]国家中医药管理局.ZY/T001.1~001.9-94中医病证诊断疗效标准[S].南京:南京大学出版社,1994:25-26.
[5]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:233-237.
[6]龚敏,王爱华.二甲双胍和瑞舒伐他汀联合用于治疗初诊肥胖型2型糖尿病的疗效观察[J].河北医学,2018,24(2):251-255.
[7]孟凡丽,苏晓田,郑毅男.人参皂苷Rb3对糖尿病模型小鼠的降血糖和抗氧化作用[J].华南农业大学学报,2013,34(4):553-557.
[8]李建会,李云,任治兴,等.黄芪联合胰岛素对糖尿病大鼠胰岛素抵抗的作用及其机制[J].吉林大学学报(医学版),2013,39(2):246-250.
[9]宁萌,潘亮,谢文利,等.麦冬提取物的降糖作用及其抗胰岛素抵抗的机制研究[J].解放军医学杂志,2013,38(1):26-29.
[10]赵燕燕,张秋燕,李挥,等.麦冬消渴胶囊对四氧嘧啶糖尿病大鼠血糖血脂的影响[J].河北大学学报(自然科学版),2005,25(3):281-284.
[11]皮子凤,门丽慧,张静,等.五味子治疗大鼠糖尿病肾病作用机制的血清代谢组学研究[J].分析化学,2015,43(2):169-175.