On the road to new treatments for multiple sclerosis: targeting dendritic cell migration into the central nervous system
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摘要
<正>Distinct migratory pathways and trafficking of dendritic cells to the central nervous system (CNs):The immune system is a host defense mechanism protecting against invaders, such as bacteria and viruses,while maintaining tolerance to self. Nonetheless, a few sites throughout the body are believed to be immunologically inert, such as the testes,the eye and the brain. Indeed, experiments in the mid-20~(th) century gave
引文
Aung LL,Fitzgerald-Bocarsly P,Dhib-Jalbut S,Balashov K(2010)Plasmacytoid dendritic cells in multiple sclerosis:Chemokine and chemokine receptor modulation by interferon-beta.J Neuroimmunol 226:158-164.
De Andrés C,Teijeiro R,Alonso B,Sánchez-Madrid F,Martínez ML,de Villoria JG,Fernández-Cruz E,Sánchez-Ramón S(2012)Long-term decrease in VLA-4 expression and functional impairment of dendritic cells during natalizumab therapy in patients with multiple sclerosis.PLoS One7:e34103.
De Laere M,Berneman ZN,Cools N(2018)To the brain and back:migratory paths of dendritic cells in multiple sclerosis.J Neuropathol Exp Neurol 77:178-192.
De Laere M,Sousa C,Meena M,Buckinx R,Timmermans JP,Berneman Z,Cools N(2017)Increased transendothelial transport of CCL3 is insufficient to drive immune cell transmigration through the blood-brain barrier under inflammatory conditions in vitro.Mediators Inflamm2017:6752756.
Greter M,Heppner FL,Lemos MP,Odermatt BM,Goebels N,Laufer T,Noelle RJ,Becher B(2005)Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.Nat Med 11:328-334.
Jain P,Coisne C,Enzmann G,Rottapel R,Engelhardt B(2010)α4β1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis.J Immunol 184:7196-7206.
Lan YY,De Creus A,Colvin BL,Abe M,Brinkmann V,Coates PT,Thomson AW(2005)The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo.Am J Transplant 5:2649-2659.
Nuyts AH,Ponsaerts P,Van Tendeloo VF,Lee WP,Stein B,Nagels G,D’hooghe MB,Willekens B,Cras P,Wouters K,Goossens H,Berneman ZN,Cools N(2014)Except for CC chemokine receptor 7 expression,monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls.Cytotherapy16:1024-1030.
Pashenkov M,Huang YM,Kostulas V,Haglund M,S?derstr?m M,Link H(2001)Two subsets of dendritic cells are present in human cerebrospinal fluid.Brain 124:480-492.
Sadiq SA,Puccio LM,Brydon EW(2010)JCV detection in multiple sclerosis patients treated with natalizumab.J Neurol 257:954-958.
Thewissen K,Nuyts AH,Deckx N,Wijmeersch BV,Nagels G,D’hooghe M,Willekens B,Cras P,Eijnde BO,Goossens H,Van Tendeloo VF,Stinissen P,Berneman ZN,Hellings N,Cools N(2014)Circulating dendritic cells of multiple sclerosis patients are proinflammatory and their frequency is correlated with MS-associated genetic risk factors.Mult Scler 20:548-557.
Yogev N,Frommer F,Lukas D,Kautz-Neu K,Karram K,Ielo D,von Stebut E,Probst HC,van den Broek M,Riethmacher D,Birnberg T(2012)Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor+regulatory T cells.Immunity 37:264-275.
De Andrés C,Teijeiro R,Alonso B,Sánchez-Madrid F,Martínez ML,de Villoria JG,Fernández-Cruz E,Sánchez-Ramón S(2012)Long-term decrease in VLA-4 expression and functional impairment of dendritic cells during natalizumab therapy in patients with multiple sclerosis.PLoS One7:e34103.
De Laere M,Berneman ZN,Cools N(2018)To the brain and back:migratory paths of dendritic cells in multiple sclerosis.J Neuropathol Exp Neurol 77:178-192.
De Laere M,Sousa C,Meena M,Buckinx R,Timmermans JP,Berneman Z,Cools N(2017)Increased transendothelial transport of CCL3 is insufficient to drive immune cell transmigration through the blood-brain barrier under inflammatory conditions in vitro.Mediators Inflamm2017:6752756.
Greter M,Heppner FL,Lemos MP,Odermatt BM,Goebels N,Laufer T,Noelle RJ,Becher B(2005)Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.Nat Med 11:328-334.
Jain P,Coisne C,Enzmann G,Rottapel R,Engelhardt B(2010)α4β1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis.J Immunol 184:7196-7206.
Lan YY,De Creus A,Colvin BL,Abe M,Brinkmann V,Coates PT,Thomson AW(2005)The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo.Am J Transplant 5:2649-2659.
Nuyts AH,Ponsaerts P,Van Tendeloo VF,Lee WP,Stein B,Nagels G,D’hooghe MB,Willekens B,Cras P,Wouters K,Goossens H,Berneman ZN,Cools N(2014)Except for CC chemokine receptor 7 expression,monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls.Cytotherapy16:1024-1030.
Pashenkov M,Huang YM,Kostulas V,Haglund M,S?derstr?m M,Link H(2001)Two subsets of dendritic cells are present in human cerebrospinal fluid.Brain 124:480-492.
Sadiq SA,Puccio LM,Brydon EW(2010)JCV detection in multiple sclerosis patients treated with natalizumab.J Neurol 257:954-958.
Thewissen K,Nuyts AH,Deckx N,Wijmeersch BV,Nagels G,D’hooghe M,Willekens B,Cras P,Eijnde BO,Goossens H,Van Tendeloo VF,Stinissen P,Berneman ZN,Hellings N,Cools N(2014)Circulating dendritic cells of multiple sclerosis patients are proinflammatory and their frequency is correlated with MS-associated genetic risk factors.Mult Scler 20:548-557.
Yogev N,Frommer F,Lukas D,Kautz-Neu K,Karram K,Ielo D,von Stebut E,Probst HC,van den Broek M,Riethmacher D,Birnberg T(2012)Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor+regulatory T cells.Immunity 37:264-275.