尼可地尔治疗微血管性心绞痛效果观察
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摘要
目的观察尼可地尔治疗微血管性心绞痛的效果。方法随机选取我院2016年1月~2017年2月收治的微血管性心绞痛患者80例,按照随机数字表法分为治疗组和对照组,每组患者40例,对照组进行常规治疗,治疗组使用尼可地尔进行治疗,对比分析两组患者血清学指标、治疗效果和不良反应。结果治疗组患者在ET-1、NO、CRP等血清学指标均明显优于对照组,经对比P<0.05,具有统计学意义。治疗组患者治疗总有效率为95.00%,对照组患者治疗总有效率75.00%,经统计学对比分析,差异有统计学意义(χ2=6.274,P=0.000<0.05)。两组患者在治疗不良反应发生率差异不大,组间对比差异无统计学意义(P>0.05)。结论尼可地尔能够有效治疗微血管性心绞痛病症,促使患者更快恢复身体健康,具有较高的临床应用价值。
Objective To observe the effect of nicorandil in treatment of microvascular angina effect. Methods Eighty patients with microvascular angina from January 2016 to February 2017 in our hospital were selected and randomly divided into treatment group and control group, with 40 cases in each group. The control group was given conventional treatment, the treatment group were treated with nicorandil. The serological indexes, therapeutic effects and adverse reactions of the two groups were compared and analyzed. Results The serological indexes such as ET-1, NO and CRP in the treatment group were significantly better than those in the control group, P < 0.05, with statistical significance. The total effective rate of the treatment group was 95.00%, and the total effective rate of the control group was 75.00%. There was no statistically significant difference between the two groups(χ2=6.274, P=0.000 < 0.05). There was no significant difference in the incidence of adverse reactions in the two groups, and there was no significant difference between the groups(P > 0.05). Conclusion Nicorandil can effectively treat microvascular angina symptoms, promote patients recover faster health, it has high value in clinical application.
Objective To observe the effect of nicorandil in treatment of microvascular angina effect. Methods Eighty patients with microvascular angina from January 2016 to February 2017 in our hospital were selected and randomly divided into treatment group and control group, with 40 cases in each group. The control group was given conventional treatment, the treatment group were treated with nicorandil. The serological indexes, therapeutic effects and adverse reactions of the two groups were compared and analyzed. Results The serological indexes such as ET-1, NO and CRP in the treatment group were significantly better than those in the control group, P < 0.05, with statistical significance. The total effective rate of the treatment group was 95.00%, and the total effective rate of the control group was 75.00%. There was no statistically significant difference between the two groups(χ2=6.274, P=0.000 < 0.05). There was no significant difference in the incidence of adverse reactions in the two groups, and there was no significant difference between the groups(P > 0.05). Conclusion Nicorandil can effectively treat microvascular angina symptoms, promote patients recover faster health, it has high value in clinical application.
引文
[1]刘涛,李论,朱朋飞,等.尼可地尔治疗微血管性心绞痛的效果、安全性以及临床依从性[J].广东医学,2016,37(5):754-755.
[2]徐银祯.尼可地尔治疗稳定型微血管病性心绞痛的临床效果[J].甘肃科技,2017,33(8):127-128.
[3]盛红宇,王卯,李志军,等.尼可地尔联合单硝酸异山梨酯应用于老年顽固性心绞痛患者的疗效评价[J].中华老年多器官疾病杂志,2016,15(9):695-696.
[4]陈福恒.尼可地尔治疗微血管性心绞痛的疗效观察[J].医药前沿,2016,6(28):143-144.
[5]岑运光,李伟,张旭日,等.尼可地尔治疗微血管性心绞痛的疗效及其对血管内皮功能的影响[J].海南医学,2014,25(6):807-809.
[6]贺学魁,董静,赵运,等.尼可地尔对心脏X综合征的疗效及对血管内皮功能的影响[J].中国循环杂志,2017,32(7):676-679.
[7]冯泽瑞,王芬,常方圆,等.心可舒联合尼可地尔对X综合征患者疗效及血管内皮功能的影响[J].中华老年心脑血管病杂志,2017,19(4):381-383.
[8]李杰,唐可清,张立平,等.尼可地尔对经皮冠状动脉介入治疗后心绞痛合并2型糖尿病患者的疗效[J].岭南心血管病杂志,2014,20(3):300-302.
[9]王东霞.曲美他嗪与尼可地尔治疗微血管性心绞痛的疗效对比研究[J].中西医结合心血管病电子杂志,2016,4(26):41,44.
[10]宋柏奇,齐锋.针刺治疗气虚血瘀型微血管性心绞痛的临床观察[J].临床医药文献电子杂志,2017,4(31):5958-5959.
[11]段宏宇.尼可地尔联合复方丹参滴丸治疗微血管性心绞痛疗效比较[J].中西医结合心血管病电子杂志,2017,5(17):15,18.
[12]罗碧辉,吴平生,曾昭华,等.尼可地尔与硝酸酯类药物对稳定型心绞痛疗效的Meta分析[J].中国全科医学,2013,16(33):3939-3943.
[13]杨艳红,李守贤.中西医结合治疗微血管心绞痛的疗效观察[J].中国中西医结合急救杂志,2017,24(1):21-23.
[14]吴先军,路平,王瑞峰,等.比索洛尔与尼可地尔联用对冠心病介入治疗后心绞痛的影响[J].中西医结合心脑血管病杂志,2012,10(11):1286-1287.
[15]刘长红,李广平.尼可地尔对部分血运重建患者心绞痛治疗效果观察[J].天津医科大学学报,2012,18(2):214-216.
[16]靳刚强.尼可地尔治疗微血管性心绞痛的疗效及其对血管内皮功能的影响[J].当代医学,2016,22(23):131-132.
[2]徐银祯.尼可地尔治疗稳定型微血管病性心绞痛的临床效果[J].甘肃科技,2017,33(8):127-128.
[3]盛红宇,王卯,李志军,等.尼可地尔联合单硝酸异山梨酯应用于老年顽固性心绞痛患者的疗效评价[J].中华老年多器官疾病杂志,2016,15(9):695-696.
[4]陈福恒.尼可地尔治疗微血管性心绞痛的疗效观察[J].医药前沿,2016,6(28):143-144.
[5]岑运光,李伟,张旭日,等.尼可地尔治疗微血管性心绞痛的疗效及其对血管内皮功能的影响[J].海南医学,2014,25(6):807-809.
[6]贺学魁,董静,赵运,等.尼可地尔对心脏X综合征的疗效及对血管内皮功能的影响[J].中国循环杂志,2017,32(7):676-679.
[7]冯泽瑞,王芬,常方圆,等.心可舒联合尼可地尔对X综合征患者疗效及血管内皮功能的影响[J].中华老年心脑血管病杂志,2017,19(4):381-383.
[8]李杰,唐可清,张立平,等.尼可地尔对经皮冠状动脉介入治疗后心绞痛合并2型糖尿病患者的疗效[J].岭南心血管病杂志,2014,20(3):300-302.
[9]王东霞.曲美他嗪与尼可地尔治疗微血管性心绞痛的疗效对比研究[J].中西医结合心血管病电子杂志,2016,4(26):41,44.
[10]宋柏奇,齐锋.针刺治疗气虚血瘀型微血管性心绞痛的临床观察[J].临床医药文献电子杂志,2017,4(31):5958-5959.
[11]段宏宇.尼可地尔联合复方丹参滴丸治疗微血管性心绞痛疗效比较[J].中西医结合心血管病电子杂志,2017,5(17):15,18.
[12]罗碧辉,吴平生,曾昭华,等.尼可地尔与硝酸酯类药物对稳定型心绞痛疗效的Meta分析[J].中国全科医学,2013,16(33):3939-3943.
[13]杨艳红,李守贤.中西医结合治疗微血管心绞痛的疗效观察[J].中国中西医结合急救杂志,2017,24(1):21-23.
[14]吴先军,路平,王瑞峰,等.比索洛尔与尼可地尔联用对冠心病介入治疗后心绞痛的影响[J].中西医结合心脑血管病杂志,2012,10(11):1286-1287.
[15]刘长红,李广平.尼可地尔对部分血运重建患者心绞痛治疗效果观察[J].天津医科大学学报,2012,18(2):214-216.
[16]靳刚强.尼可地尔治疗微血管性心绞痛的疗效及其对血管内皮功能的影响[J].当代医学,2016,22(23):131-132.