糖尿病合并急性冠状动脉综合征与血浆网膜素水平的关系研究
|
摘要
目的评价糖尿病合并急性冠状动脉综合征与血浆网膜素水平的关系。方法选择该院心内科及内分泌科糖尿病合并冠心病患者45例,均经冠状动脉造影确定至少一支冠状动脉直径狭窄程度大于或等于50%者为试验组,其后再根据患者的具体临床症状分出不稳定型心绞痛(UAP)和急性心肌梗死(AMI)两亚组。对照组选择同期于该院就诊,经冠状动脉造影确定冠状动脉直径狭窄程度小于50%的糖尿病患者40例,其后也根据患者的具体临床症状分出UAP和AMI两亚组。采用酶联免疫吸附试验(ELISA)检测患者网膜素水平。结果冠状动脉狭窄程度大于或等于50%的糖尿病患者男性比例、AMI例数均高于对照组(P<0.01),网膜素水平低于对照组(P<0.01)。而年龄、UAP例数差异均无统计学意义(P>0.05)。结论血浆网膜素水平与糖尿病患者冠状动脉病变严重程度密切相关,而冠状动脉病变严重程度与急性冠状动脉综合征显著相关。
Objective To evaluate the relationship between diabetes complicating acute coronary syndrome with plasma omentin levels.Methods Forty-five patients with diabetes complicating coronary heart disease in the cardiology and endocrinology department of this hospital were selected,and those confirmed as at least one coronary artery diameter stenosis degree≥50%by coronary angiography served as the experimental group.Then they were divided into the unstable angina subgroup(UAP)and acute myocardial infarction(AMI)subgroup according to the specific clinical symptoms.At the same time 40 diabetic patients with coronary artery diameter stenosis degree<50% confirmed by coronary angiography were selected as the control group,and then they were divided into the UAP subgroup and AMI subgroup.The omentin level was measured by adopting the enzyme-linked immunosorbent assay(ELISA).Results The male proportion and AMI cases in diabetic patients with coronary artery stenosis degree≥ 50% were higher than those in the control group(P<0.01),while the omentin level was significantly lower than that in the control group(P<0.01).The age and UAP cases had no statistically significant difference between the experimental group and the control group(P>0.05).Conclusion The plasma omentin level is closely correlated to the severity of coronary artery lesion in diabetic patients,while the severity of coronary arterial lesion is significantly correlated with acute coronary syndrome.
Objective To evaluate the relationship between diabetes complicating acute coronary syndrome with plasma omentin levels.Methods Forty-five patients with diabetes complicating coronary heart disease in the cardiology and endocrinology department of this hospital were selected,and those confirmed as at least one coronary artery diameter stenosis degree≥50%by coronary angiography served as the experimental group.Then they were divided into the unstable angina subgroup(UAP)and acute myocardial infarction(AMI)subgroup according to the specific clinical symptoms.At the same time 40 diabetic patients with coronary artery diameter stenosis degree<50% confirmed by coronary angiography were selected as the control group,and then they were divided into the UAP subgroup and AMI subgroup.The omentin level was measured by adopting the enzyme-linked immunosorbent assay(ELISA).Results The male proportion and AMI cases in diabetic patients with coronary artery stenosis degree≥ 50% were higher than those in the control group(P<0.01),while the omentin level was significantly lower than that in the control group(P<0.01).The age and UAP cases had no statistically significant difference between the experimental group and the control group(P>0.05).Conclusion The plasma omentin level is closely correlated to the severity of coronary artery lesion in diabetic patients,while the severity of coronary arterial lesion is significantly correlated with acute coronary syndrome.
引文
[1]王佳丽,朱慧娟,曾勇.脂肪因子与冠状动脉粥样硬化关系的研究进展[J].中国心血管杂志,2013,18(3):227-229.
[2]FAIN J N,SACKS H S,BUEHRER B,et al.Identification of omentin mRNA in human epicardial adipose tissue:comparison to omentin in subcutaneous,internal mammary artery periadventitial and visceral abdominal depots[J].Int J Obes(Lond),2008,32(5):810-815.
[3]赵鹏,王玮玮,宋执敬.血浆网膜素-1水平与冠心病关系的临床研究[J].河北医药,2016,38(9):1303-1305.
[4]SHANG F J,WANG J P,LIU X T,et al.Serum omentin-1levels are inversely associated with the presence and severity of coronary artery disease in patients with metabolic syndrome[J].Biomarkers,2011,16(8):657-662.
[5]李浩彦.急性冠脉综合征患者血清网膜素-1,FMD水平研究[D].西宁:青海大学,2016.
[6]王馨,张琳,张晓东,等.急性冠状动脉综合征患者血浆网膜素-1、内脏脂肪特异性丝氨酸蛋白酶抑制剂水平变化[J].中国循环杂志,2016,31(5):446-448.
[7]JAGANATHAN R,RAVINDRAN R,DHANASEKA-RAN S.Emerging role of adipocytokines in type 2diabetes as mediators of insulin resistance and cardiovascular disease[J].Can J Diabetes,2018,42(4):446-456.
[8]YOO H J,HWANG S Y,HONG H C,et al.Association of circulating omentin-1level with arterial stiffness and carotid plaque in type 2diabetes[J].Cardiovasc Diabetol,2011,10(1):103.
[9]YOO H J,HWANG S Y,HONG H C,et al.Implication of circulating omentin-1level on the arterial stiffening in type 2diabetes mellitus[J].Endocrine,2013,44(3):680-687.
[10]PAN H Y,GUO L,LI Q.Changes of serum omentin-1levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2diabetes[J].Diabetes Res Clin Pract,2010,88(1):29-33.
[11]YAMAWAKI H,KURAMOTO J,KAMESHIMA S,et al.Omentin,a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells[J].Biochem Biophys Res Commun,2011,408(2):339-343.
[12]YAMAWAKI H,TSUBAKI N,MUKOHDA M,et al.Omentin,a novel adipokine,induces vasodilation in rat isolated blood vessels[J].Biochem Biophys Res Commun,2010,393(4):668-672.
[13]TAN B K,ADYA R,FARHATULLAH S,et al.Omentin-1,a novel adipokine,is decreased in overweight insulin resistant women with the polycystic ovary syndrome:ex vivo and in vivo regulation of omentin-1by insulin and glucose[J].Diabetes,2008,57(4):801-808.
[14]OUCHI N,PARKER J L,LUGUS J J,et al.Adipokines in inflammation and metabolic disease[J].Nat Rev Immunol,2011,11(2):85-97.
[15]傅庆华,刘适,郭莹.2型糖尿病合并冠心病患者脂肪细胞因子水平及其意义[J].重庆医学,2011,40(35):3611-3613.
[2]FAIN J N,SACKS H S,BUEHRER B,et al.Identification of omentin mRNA in human epicardial adipose tissue:comparison to omentin in subcutaneous,internal mammary artery periadventitial and visceral abdominal depots[J].Int J Obes(Lond),2008,32(5):810-815.
[3]赵鹏,王玮玮,宋执敬.血浆网膜素-1水平与冠心病关系的临床研究[J].河北医药,2016,38(9):1303-1305.
[4]SHANG F J,WANG J P,LIU X T,et al.Serum omentin-1levels are inversely associated with the presence and severity of coronary artery disease in patients with metabolic syndrome[J].Biomarkers,2011,16(8):657-662.
[5]李浩彦.急性冠脉综合征患者血清网膜素-1,FMD水平研究[D].西宁:青海大学,2016.
[6]王馨,张琳,张晓东,等.急性冠状动脉综合征患者血浆网膜素-1、内脏脂肪特异性丝氨酸蛋白酶抑制剂水平变化[J].中国循环杂志,2016,31(5):446-448.
[7]JAGANATHAN R,RAVINDRAN R,DHANASEKA-RAN S.Emerging role of adipocytokines in type 2diabetes as mediators of insulin resistance and cardiovascular disease[J].Can J Diabetes,2018,42(4):446-456.
[8]YOO H J,HWANG S Y,HONG H C,et al.Association of circulating omentin-1level with arterial stiffness and carotid plaque in type 2diabetes[J].Cardiovasc Diabetol,2011,10(1):103.
[9]YOO H J,HWANG S Y,HONG H C,et al.Implication of circulating omentin-1level on the arterial stiffening in type 2diabetes mellitus[J].Endocrine,2013,44(3):680-687.
[10]PAN H Y,GUO L,LI Q.Changes of serum omentin-1levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2diabetes[J].Diabetes Res Clin Pract,2010,88(1):29-33.
[11]YAMAWAKI H,KURAMOTO J,KAMESHIMA S,et al.Omentin,a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells[J].Biochem Biophys Res Commun,2011,408(2):339-343.
[12]YAMAWAKI H,TSUBAKI N,MUKOHDA M,et al.Omentin,a novel adipokine,induces vasodilation in rat isolated blood vessels[J].Biochem Biophys Res Commun,2010,393(4):668-672.
[13]TAN B K,ADYA R,FARHATULLAH S,et al.Omentin-1,a novel adipokine,is decreased in overweight insulin resistant women with the polycystic ovary syndrome:ex vivo and in vivo regulation of omentin-1by insulin and glucose[J].Diabetes,2008,57(4):801-808.
[14]OUCHI N,PARKER J L,LUGUS J J,et al.Adipokines in inflammation and metabolic disease[J].Nat Rev Immunol,2011,11(2):85-97.
[15]傅庆华,刘适,郭莹.2型糖尿病合并冠心病患者脂肪细胞因子水平及其意义[J].重庆医学,2011,40(35):3611-3613.