石墨烯及其衍生物毒性研究现状
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摘要
石墨烯是一种二维碳纳米材料。由于石墨烯的研发、生产和广泛应用,人体接触与暴露石墨烯机会增多,使石墨烯的生物毒性效应和安全性的研究逐渐成为当前热点问题。本文就近年来关于石墨烯在生物体内转运及分布、石墨烯及其衍生物的毒性、影响毒性的因素和毒性机制做一概述。
Graphene is a two-dimensional carbon nanomaterial.Owing to the research and development, production and extensive application,human exposure to graphene increased significantly,and the research on biotoxic effects and safety of graphene has gradually become a new hot issue.This paper will make a general summary on the transport and distribution of graphene in living organisms,the toxicity of graphene and its derivatives,the toxicity mechanism and the influencing factors on the toxicity.
Graphene is a two-dimensional carbon nanomaterial.Owing to the research and development, production and extensive application,human exposure to graphene increased significantly,and the research on biotoxic effects and safety of graphene has gradually become a new hot issue.This paper will make a general summary on the transport and distribution of graphene in living organisms,the toxicity of graphene and its derivatives,the toxicity mechanism and the influencing factors on the toxicity.
引文
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[34]Zhang H,Peng C,Yang JZ,et al.Uniform ultrasmall graphene oxide nanosheets with low cytotoxicity and high cellular uptake [J].ACS Appl Mater Int,2013(5):1761-1767.
[35]Hu WB,Peng C,Luo W,et al.Graphene-based antibacterial paper [J].ACS Nano,2010(4):4317-4323.
[36]Sies H.Oxidative stress:Oxidants and antioxidants[J].Experimental Physiology,1997,82(2):291-295.
[37]彭辉,周绮云,刘璇,等.大气可吸入颗粒物造成肺损伤的NF-κB研究进展[J].生命科学,2009,21(2):259-263.
[38]Park EJ,Lee GH,Han BS,et al.Toxic response of graphene nanoplatelets in vivo and in vitro [J].Archives of toxicology,2015,89(9):1557-1568.
[39]Lim B,Xia Y.Metal nanocrystals with highly branched morphologies [J].Angew Chem Int Ed,2011,50(1):76-85.
[40]Markovic ZM,Harhaji-Trajkovic LM,Todorovic-Markovic BM,et al.In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes [J].Biomaterials,2011,32(4):1121-1129.
[41]Ryoo SR,Kim YK,Kim MH,et al.Behavios of NIH3T3 fibroblasts on graphene/carbon nanotubes:Proliferation,focal adhesion,and gene transfection studies [J].ACS Nano,2010,4(11):6587.
[42]Liopo AV,Stewart MP,Hudson J,et al.Biocompatibility of native and functionalized single-walled carbon nanotubes for neuronal interface [J].J Nanosci Nanotechnol,2006,6(5):1365-1374.
[43]周国强,陈春英,李玉锋,等.纳米材料生物效应研究进展[J].生物化学与生物物理进展,2008,35(9):998-1006.
[2]Novoselov KS,Geim AK,Morozov SV,et al.Two-dimensional gas of massless Dirac fermions in grapheme [J].Nature,2005,438(7065):197.
[3]Novoselov KS,Fal'ko VI,Colombo L,et al.A roadmap for grapheme [J].Nature,2012,490(7419):192-200.
[4]田甜,吕敏,田旸,等.石墨烯的生物安全性研究进展[J].科学通报,2014,59(20):1927-1935.
[5]孙寒,冯雷雨,陈银广.石墨烯健康风险研究现状及展望[J].生物化学与生物物理进展,2015,42(1):5-15.
[6]沈贺,张立明,张智军.石墨烯在生物医学领域的应用[J].东南大学学报(医学版),2011,30(1):218-223.
[7]张锦,许少波,陈军,等.石墨烯类材料在疾病诊断治疗方面的研究进展[J].材料导报,2015,29(3):148-151.
[8]胡茂杰,潘丙才,毛亮.石墨烯及其衍生物在小鼠体内的分布与毒性效应[J].南京大学学报(自然科学) ,2014,50(4):431-439.
[9]Sanchez VC,Jachak A,Hurt RH,et al.Biological interactions of graphene-family nanomaterials:An interdisciplinary review [J].Chem Res Toxicol,2011,25(1):15-34.
[10]Zhan L,Yanxia G,Xiaoyong Z,et al.Biodistribution of co-exposure to multi-walled carbon nanotubes and graphene oxide nanoplatelets radiotracers [J].J Nanopart Res,2011,13(7):2939-2947.
[11]Zhang S,Yang K,Feng L,et al.In vitro and in vivo behaviors of dextran functionalized grapheme [J].Carbon,2011,49(12):4040-4049.
[12]Yang K,Gong H,Shi X,et al.In vivo biodistri-bution and toxicology of functionalized nanogra-phene oxide in mice after oral and intraperitoneal administration[J].Biomaterials,2013,34(11):2787-2795.
[13]Li B,Yang J,Huang Q,et al.Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice [J].Npg Asia Materials,2013,5(5):237-239.
[14]王海芳,刘佳慧,常艳丽,等.尺寸对氧化石墨烯生物效应的影响[J].中国药理学与毒理学杂志,2013,27(增刊):214.
[15]Zhang X,Yin J,Peng C,et al.Distribution and biocompatibility studies of graphene oxide inmice after intravenous administration[J].Carbon,2011,49(3):986-995.
[16]Keelan JA.Nanotoxicology:Nanoparticles versus the placenta [J].Nat Nanotechnol,2011,6(5):263-264.
[17]Wang K,Ruan J,Song H,et al.Biocompatibility of graphene oxide[J].Nanoscale Research Letters,2011,6(1):1-8.
[18]Singh SK,Singh MK,Nayak MK,et al.Thrombus inducing property of atomically thin graphene oxide sheets[J].ACS Nano,2011,5(6):4987-4996.
[19]Ma-Hock L,Strauss V,Treumann S,et al.Comparative inhalation toxicity of multi-wall carbon nanotubes,graphene,graphite nanoplatelets and low surface carbon black[J].Particle and Fibre Toxicology,2013,10(1):23.
[20]Schinwald A,Murphy FA,Jones A,et al.Graphenebased nanoplatelets:A new risk to the respiratory system as a consequence of their unusual aerodynamic properties[J].ACS Nano,2012,6(1):736-746
[21]刘艳,王硕,吴冠宇,等.纳米氧化石墨烯对小鼠心肌氧化损伤作用[J].环境卫生学杂志,2015,5(3):206-210.
[22]王硕,刘艳,吴冠宇,等.纳米氧化石墨烯一次性染毒对小鼠肝脏的急性氧化损伤作用[J].环境与健康杂志,2015,32(7):595-598.
[23]程相阵,周毅,姜再兴.氧化石墨烯在大鼠体内安全性的初步研究[J].生物医学工程与临床,2016,20(4):350-354.
[24]Li Y,Wang Y,Liu T,et al.Sub-acute toxicity study of graphene oxide in the sprague-dawley rat [J].Int J Environ Res Public Health,2016,13(11):1149.
[25]Qu G,Wang X,Liu Q,et al.The ex vivo and in vivo biological performances of graphene oxide and the impact of surfactant on graphene oxide's biocompatibility [J].J Environ Sci(China),2013,25(5):873-881.
[26]Miao W,Shim G,Lee S,et al.Safety and tumor tissue accumulation of pegylated graphene oxide nanosheets for codelivery of anticancer drug and photosensitizer [J].Biomaterials,2013,34(13):3402-3410.
[27]Yang K,Wan J,Zhang S,et al.In vivo pharmacokinetics,long-term biodistribution,and toxicology of pegylated graphene in mice[J].ACS Nano,2011,5(1):516-522.
[28]Nurunnabi M,Khatun Z,Huh KM,et al.In vivo biodistribution and toxicology of carboxy lated-graphene quantum dots[J].ACS Nano,2013,7(8):6858-6867.
[29]Singh SK,Singh MK,Kulkarni PP,et al.Amine-modified grapheme:Thrombo-protective safer alternative tographene oxide for biomedical applications[J].ACS Nano,2012,6(3):2731-2740.
[30]Kim JK,Shin JH,Lee JS.et al.28-Day inhalation toxicity of graphene nanoplatelets in Sprague-Dawley rats[J].Nanotoxicology,2016,10(7):891-901.
[31]Duch MC,Budinger GRS,Liang YT,et al.Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung [J].Nano Lett,2011(11):5201-5207 .
[32]赵香琴.氧化石墨烯对SD大鼠神经系统毒性的体内外研究 [D].重庆医科大学,2013:1-72.
[33]黎燕,卢伟.纳米材料生物安全性评价的研究进展[J].环境与职业医学,2007,34(3):346-349.
[34]Zhang H,Peng C,Yang JZ,et al.Uniform ultrasmall graphene oxide nanosheets with low cytotoxicity and high cellular uptake [J].ACS Appl Mater Int,2013(5):1761-1767.
[35]Hu WB,Peng C,Luo W,et al.Graphene-based antibacterial paper [J].ACS Nano,2010(4):4317-4323.
[36]Sies H.Oxidative stress:Oxidants and antioxidants[J].Experimental Physiology,1997,82(2):291-295.
[37]彭辉,周绮云,刘璇,等.大气可吸入颗粒物造成肺损伤的NF-κB研究进展[J].生命科学,2009,21(2):259-263.
[38]Park EJ,Lee GH,Han BS,et al.Toxic response of graphene nanoplatelets in vivo and in vitro [J].Archives of toxicology,2015,89(9):1557-1568.
[39]Lim B,Xia Y.Metal nanocrystals with highly branched morphologies [J].Angew Chem Int Ed,2011,50(1):76-85.
[40]Markovic ZM,Harhaji-Trajkovic LM,Todorovic-Markovic BM,et al.In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes [J].Biomaterials,2011,32(4):1121-1129.
[41]Ryoo SR,Kim YK,Kim MH,et al.Behavios of NIH3T3 fibroblasts on graphene/carbon nanotubes:Proliferation,focal adhesion,and gene transfection studies [J].ACS Nano,2010,4(11):6587.
[42]Liopo AV,Stewart MP,Hudson J,et al.Biocompatibility of native and functionalized single-walled carbon nanotubes for neuronal interface [J].J Nanosci Nanotechnol,2006,6(5):1365-1374.
[43]周国强,陈春英,李玉锋,等.纳米材料生物效应研究进展[J].生物化学与生物物理进展,2008,35(9):998-1006.