岩藻糖基转移酶Ⅳ和肿瘤相关性的研究进展
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摘要
岩藻糖基转移酶(FUTs)是一类催化糖蛋白或糖脂岩藻糖基化的酶。目前已发现13种FUTs,其中岩藻糖基转移酶Ⅳ(FUT4)是负责催化合成岩藻糖基化寡糖Lewis X(Le X)和Lewis Y(Le Y)等的关键酶。FUT4在很多上皮来源的恶性肿瘤中高表达。本文就FUT4基因在肿瘤细胞中的表达特点和调控机制,以及FUT4在肿瘤恶性发展过程中的作用作一综述,旨为肿瘤的发生发展提供理论依据,为肿瘤的诊断及治疗提供参考。
Fucosyltransferases(FUTs) are considered as key enzymes that regulate the synthesis of fucosylated oligosaccharides bonded to glycoproteins or glycolipids on the cells surface. It is known that 13 kinds of FUT have been cloned to date. FUT4 is one of key enzymes for the synthesis of(Lewis X) Le X and(Lewis Y) Le Y. Elevated FUT4 expression has been found in many tumors of epithelial cell origin. In this review,the features of FUT4 expression and regulation in tumor cells are summarized. The role of FUT4 in tumors progression is analyzed. The aim of this review is to provide a theoretical basis for the development of tumors,and a reference for the diagnosis and treatment of tumors.
Fucosyltransferases(FUTs) are considered as key enzymes that regulate the synthesis of fucosylated oligosaccharides bonded to glycoproteins or glycolipids on the cells surface. It is known that 13 kinds of FUT have been cloned to date. FUT4 is one of key enzymes for the synthesis of(Lewis X) Le X and(Lewis Y) Le Y. Elevated FUT4 expression has been found in many tumors of epithelial cell origin. In this review,the features of FUT4 expression and regulation in tumor cells are summarized. The role of FUT4 in tumors progression is analyzed. The aim of this review is to provide a theoretical basis for the development of tumors,and a reference for the diagnosis and treatment of tumors.
引文
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[8]Julien S,Ivetic A,Grigoriadis A,et al.Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers[J].Cancer Res,2011,71(24):7683-7693
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[10]Yan X,Lin Y,Liu S,et al.Fucosyltransferase IV(FUT4)a an effective biomarker for the diagnosis of breast cance[J].Biomed Pharmacother,2015,70:299-304.
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[14]Zhang Z,Sun P,Liu J,et al.Suppression of FUT1/FUT4expression by si RNA inhibits tumor growth[J].Biochim Biophys Acta,2008,1783(2):287-296.
[15]Yang XS,Liu SA,Liu JW,et al.FucosyltransferaseⅣenhances expression of MMP-12 stimulated by EGF via the ERK1/2,p38 and NF-κB pathways in A431Cells[J].Asian Pac J Cancer Prev,2012,13(4):1657-1662.
[16]PadróM,Mejías-Luque R,Cobler L,et al.Regulation of glycosyltransferases and Lewis antigens expression by IL-1βand IL-6 in human gastric cancer cells[J].Glycoconj J,2011,28(2):99-110.
[17]Shan X,Aziz F,Tian LL,et al.Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/Le Y expression[J].Int JOncol,2015,46(4):1667-1676.
[18]Cheng L,Luo S,Jin C,et al.FUT family mediates the multidrug resistance of human hepatocellular carcinoma via the PI3K/Akt signaling pathway[J].Cell Death Dis,2013,4:e923.
[19]Aziz F,Qiu Y.The role of anti-Le Y antibody in the downregulation of MAPKs/COX-2 pathway in gastric cancer[J].Curr Drug Targets,2014,15(4):469-476.
[20]Aziz F,Yang X,Wang X,et al.Anti-Le Y antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway:correlation with clinical study[J].J Cancer Res Clin Oncol,2015,141(7):1221-1235.
[21]Liu YC,Yen HY,Chen CY,et al.Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells[J].Proc Natl Acad Sci U S A,2011,108(28):11332-11337.
[22]Taniguchi A,Suga R,Matsumoto K.Expression and transcriptional regulation of the human alpha1,3-fucosyltransferase 4(FUT4)gene in myeloid and colon adenocarcinoma cell lines[J].Biochem Biophys Res Commun,2000,273(1):370-376.
[23]Withers DA,Hakomori SI.Human alpha(1,3)-fucosyltransferaseⅣ(FUTIV)gene expression is regulated by elk-1 in the U937 cell line[J].J Biol Chem,2000,275:40588-40593.
[24]Yang X,Zhang Z,Jia S,et al.HSF1 and Sp1 regulate FUT4 gene expression and cell proliferation in breast cancer cells[J].J Cell Biochem,2014,115(1):168-178.
[25]Moriwaki K,Narisada M,Imai T,et al.The effect of epigenetic regulation of fucosylation on TRAIL-induced apoptosis[J].Glycoconj J,2010,27(7-9):649-659.
[26]Li H,Tong S,Liu J,et al.Differential fucosyltransferaseⅣexpression in squamous carcinoma cells is regulated by promoter methylation[J].Cell Mol Biol Lett,2012,17(2):206-216.
[27]Li H,Tong S,Yan Q.Correlation between FUT4 expression and its promoter methylation in Ha Ca T cells[J].Yi Chuan,2015,37(1):48-54.
[2]Ma B,Simala-Grant JL,Taylor DE,et al.Fucosylation in prokaryotes and eukaryotes[J].Glycobiology,2006,16(12):158R-184R.
[3]Becker DJ,Lowe JB.Fucose:biosynthesis and biologica function in mammals[J].Glycobiology,2003,3(7):41R-53R
[4]Miyoshi E,Moriwaki K,Nakagawa T.Biological function of fucosylation in cancer biology[J].J Biochem,2008,143(6):725-729.
[5]Reguigne I,James MR,Richard CW,et al.The gene encoding myeloid alpha-3-fucosyl-transferase(FUT4)is located between D11S388 and D11S919 on 11q21[J].Cytogene Cell Genet,1994,66(2):104-106.
[6]de Vries T,Knegtel RM,Holmes EH,et al.Fucosyltrans ferases:structure/function studies[J].Glycobiology,2001,11(10):119R-128R.
[7]Yang X,Zhang Z,Jia S,et al.Overexpression of fucosyl transferase IV in A431 cell line increases cell proliferation[J].Int J Biochem Cell Biol,2007,39(9):1722-1730.
[8]Julien S,Ivetic A,Grigoriadis A,et al.Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers[J].Cancer Res,2011,71(24):7683-7693
[9]Yang X,Liu S,Yan Q.Role of fucosyltransferaseⅣin epithelial-mesenchymal transition in breast cancer cells[J]Cell Death Dis,2013,4:e735.
[10]Yan X,Lin Y,Liu S,et al.Fucosyltransferase IV(FUT4)a an effective biomarker for the diagnosis of breast cance[J].Biomed Pharmacother,2015,70:299-304.
[11]Mas E,Pasqualini E,Caillol N,et al.Fucosyltransferase activities in human pancreatic tissue:comparative study between cancer tissues and established tumoral cell line[J].Glycobiology,1998,8(6):605-613.
[12]Stirewalt DL,Meshinchi S,Kopecky KJ,et al.Identification of genes with abnormal expression changes in acute myeloid leukemia[J].Genes Chromosomes Cancer,2008,47(1):8-20.
[13]Escrevente C,Machado E,Brito C,et al.Different expres sion levels of alpha3/4 fucosyltransferases and Lewis de terminants in ovarian carcinoma tissues and cell lines[J]Int J Oncol,2006,29(3):557-566.
[14]Zhang Z,Sun P,Liu J,et al.Suppression of FUT1/FUT4expression by si RNA inhibits tumor growth[J].Biochim Biophys Acta,2008,1783(2):287-296.
[15]Yang XS,Liu SA,Liu JW,et al.FucosyltransferaseⅣenhances expression of MMP-12 stimulated by EGF via the ERK1/2,p38 and NF-κB pathways in A431Cells[J].Asian Pac J Cancer Prev,2012,13(4):1657-1662.
[16]PadróM,Mejías-Luque R,Cobler L,et al.Regulation of glycosyltransferases and Lewis antigens expression by IL-1βand IL-6 in human gastric cancer cells[J].Glycoconj J,2011,28(2):99-110.
[17]Shan X,Aziz F,Tian LL,et al.Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/Le Y expression[J].Int JOncol,2015,46(4):1667-1676.
[18]Cheng L,Luo S,Jin C,et al.FUT family mediates the multidrug resistance of human hepatocellular carcinoma via the PI3K/Akt signaling pathway[J].Cell Death Dis,2013,4:e923.
[19]Aziz F,Qiu Y.The role of anti-Le Y antibody in the downregulation of MAPKs/COX-2 pathway in gastric cancer[J].Curr Drug Targets,2014,15(4):469-476.
[20]Aziz F,Yang X,Wang X,et al.Anti-Le Y antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway:correlation with clinical study[J].J Cancer Res Clin Oncol,2015,141(7):1221-1235.
[21]Liu YC,Yen HY,Chen CY,et al.Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells[J].Proc Natl Acad Sci U S A,2011,108(28):11332-11337.
[22]Taniguchi A,Suga R,Matsumoto K.Expression and transcriptional regulation of the human alpha1,3-fucosyltransferase 4(FUT4)gene in myeloid and colon adenocarcinoma cell lines[J].Biochem Biophys Res Commun,2000,273(1):370-376.
[23]Withers DA,Hakomori SI.Human alpha(1,3)-fucosyltransferaseⅣ(FUTIV)gene expression is regulated by elk-1 in the U937 cell line[J].J Biol Chem,2000,275:40588-40593.
[24]Yang X,Zhang Z,Jia S,et al.HSF1 and Sp1 regulate FUT4 gene expression and cell proliferation in breast cancer cells[J].J Cell Biochem,2014,115(1):168-178.
[25]Moriwaki K,Narisada M,Imai T,et al.The effect of epigenetic regulation of fucosylation on TRAIL-induced apoptosis[J].Glycoconj J,2010,27(7-9):649-659.
[26]Li H,Tong S,Liu J,et al.Differential fucosyltransferaseⅣexpression in squamous carcinoma cells is regulated by promoter methylation[J].Cell Mol Biol Lett,2012,17(2):206-216.
[27]Li H,Tong S,Yan Q.Correlation between FUT4 expression and its promoter methylation in Ha Ca T cells[J].Yi Chuan,2015,37(1):48-54.