扩散峰度成像对常规MRI阴性颞叶癫痫的诊断价值
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摘要
目的探讨扩散峰度成像应用于常规MRI阴性颞叶癫痫的诊断价值。资料与方法收集临床确诊而常规MRI阴性的17例颞叶癫痫患者,同时选择与癫痫患者相匹配的17例正常志愿者作为对照组,行扩散峰度成像序列扫描。测量并比较两组双侧海马的各向异性分数(FA)、平均扩散系数、平均峰度、平行峰度、径向峰度。结果与对照组相比,癫痫组患侧及健侧海马FA均显著下降,差异均有统计学意义(P<0.05);癫痫组患侧与健侧海马之间各指标差异均无统计学意义(P>0.05)。结论扩散峰度成像可对常规MRI阴性的颞叶癫痫患者脑结构改变提供定量信息,为颞叶癫痫的研究提供依据。
Purpose To evaluate the diagnostic value of diffusion kurtosis imaging which is applied to evaluate conventional MRI negative temporal lobe epilepsy(TLE). Materials and Methods Seventeen patients who were clinically confirmed and negative through conventional MRI in TLE group and corresponding 17 volunteers in control group were collected and diffusion kurtosis imaging sequential scanning was performed. Fractional anisotropy, mean diffusivity, mean kurtosis, axial kurtosis and radial kurtosis values in bilateral hippocampi and temporal lobes were measured and compared between the two groups. Results Compared with hippocampi in control group, fractional anisotropy in diseased and normal temporal lobe in epilepsy group were all decreased significantly and the difference was of statistical significance(P<0.05). There was no statistical significance regarding difference in mean diffusivity, mean kurtosis, axial kurtosis and radial kurtosis of diseased and normal hippocampi in epilepsy group(P>0.05). Conclusion Diffusion kurtosis imaging could provide quantitative information of cerebral structure changes in patients with TLE with negative conventional MRI, offering basis for the study of TLE.
Purpose To evaluate the diagnostic value of diffusion kurtosis imaging which is applied to evaluate conventional MRI negative temporal lobe epilepsy(TLE). Materials and Methods Seventeen patients who were clinically confirmed and negative through conventional MRI in TLE group and corresponding 17 volunteers in control group were collected and diffusion kurtosis imaging sequential scanning was performed. Fractional anisotropy, mean diffusivity, mean kurtosis, axial kurtosis and radial kurtosis values in bilateral hippocampi and temporal lobes were measured and compared between the two groups. Results Compared with hippocampi in control group, fractional anisotropy in diseased and normal temporal lobe in epilepsy group were all decreased significantly and the difference was of statistical significance(P<0.05). There was no statistical significance regarding difference in mean diffusivity, mean kurtosis, axial kurtosis and radial kurtosis of diseased and normal hippocampi in epilepsy group(P>0.05). Conclusion Diffusion kurtosis imaging could provide quantitative information of cerebral structure changes in patients with TLE with negative conventional MRI, offering basis for the study of TLE.
引文
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[10]宋双双,李伟,张丕宁,等.质子磁共振波谱与脑电图在无病灶颞叶癫痫定侧诊断中的价值对照研究.中华神经科杂志,2017,50(12):912-916.
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[12]樊子健,张永波,鞠文萍,等.MRS在非海马硬化颞叶癫痫患者中的应用.中国医学影像技术,2017,33(9):1326-1330.
[2]Muhlhofer W,Tan YL,Mueller SG.MRI-negative temporal lobe epilepsy What do we know?Epilepsia,2017,58(5):727-742.
[3]Liacu D,De Marco G,Ducreux D,et al.Diffusion tensor changes in epileptogenic hippocampus of TLE patients.Neurophysiol Clin,2010,40(3):151-157.
[4]Lazar M,Jensen JH,Xuan Liang,et al.Estimation of the orientation distribution function from diffusional kurtosis imaging.Magn Reson Med,2008,60(4):774-781.
[5]叶德湫,陈向荣,黄永础,等.缺血性脑白质病额顶叶白质的扩散峰度表现.中国医学影像学杂志,2016,24(7):481-485.
[6]陈兴发.磁共振弥散峰度成像对原发性颞叶癫痫的初步研究.福州:福建医科大学,2014.
[7]Bonilha L,Lee CY,Jensen JH,et al.Altered microstructure in temporal lobe epilepsy:a diffusional kurtosis imaging study.Am J Neuroradiol,2015,36(4):719-724.
[8]Wieshmann UC,Clark CA,Symms MR,et al.Reduced anisotropy of water diffusion in structural cerebral abnormalities demonstrated with diffusion tensor imaging.Magn Reson Imaging,1999,17(9):1269-1274.
[9]Gao Y,Zhang YZ,Wong CS,et al.Diffusion abnormalities in temporal lobes of children with temporal lobe epilepsy:a preliminary diffusional kurtosis imaging study and comparison with diffusion tensor imaging.NMR Biomed,2012,25(12):1369-1377.
[10]宋双双,李伟,张丕宁,等.质子磁共振波谱与脑电图在无病灶颞叶癫痫定侧诊断中的价值对照研究.中华神经科杂志,2017,50(12):912-916.
[11]包怡心.DTI技术在颞叶癫痫海马及海马旁区微结构改变中的应用研究.温州:温州医科大学,2015.
[12]樊子健,张永波,鞠文萍,等.MRS在非海马硬化颞叶癫痫患者中的应用.中国医学影像技术,2017,33(9):1326-1330.