基于中医传承辅助系统的耳鸣耳聋内治方剂组方规律分析
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摘要
目的探讨耳鸣耳聋相关内治方剂的组方规律。方法提取《中医方剂大辞典》中耳鸣耳聋内治方剂,建立方剂数据库。运用中医传承辅助系统(V2.5)内置算法进行数据挖掘,分析其组方规律。结果共筛选耳鸣耳聋内治方剂260首,用药261味。用药频次分析中,石菖蒲、甘草、茯苓、当归、附子、川芎、熟地黄、防风、人参、磁石居于前10位;药物归经中,以肝、肾、心、脾、肺归经频次居多;支持度个数≥30的药物模式7个,置信度≥0.5的关联规则4个,均以熟地黄-茯苓组合最高;演化得到核心组合18个,新方剂9首。结论耳鸣耳聋治疗应依据虚证、实证、虚实夹杂的不同病性合理选药;方药配伍时不可只涉及单一脏腑,应多脏腑联合用药,且多以心脾、心肾、心肝、脾肾等多脏腑共治。运用中医传承辅助系统得出的耳鸣耳聋内治方剂组方规律确实对临床有指导意义。
Objective To explore the group rule of treating tinnitus and deafness. Methods To extract the prescriptions of traditional Chinese medicine dictionary of tinnitus deafness in prescription,prescription databases,the use of Traditional Chinese Medicine Inheritance Support System(V2.5) built-in algorithm in data mining,analyze its characteristics. Results The total number of tinnitus was 261. In the analysis of drug frequency, the stone calamus,liquorice,poria cocos,angelica,aconite,chuanxiong,ribosome,anti-wind,ginseng and magnetic stone were in the top 10.The drug is attributed to the liver,kidney,heart,spleen and lung. There were 7 drug models with more than 30 support degrees,and the confidence level was greater than 0.5,and all of them had the highest combination of ricosa and poria.Evolution got 18 cores and 9 new prescriptions. Conclusion The treatment of tinnitus deafness should be based on virtual syndrome,empirical and virtual inclusion of different diseases. The combination of prescription should not only involve the single viscera,but should be combined with the internal organs and the heart,the heart,the heart,the liver,the spleen and kidney and so on. The use of traditional Chinese medicine inheritance support system to obtain the prescription of tinnitus in the ear deafness is really helpful to clinic.
Objective To explore the group rule of treating tinnitus and deafness. Methods To extract the prescriptions of traditional Chinese medicine dictionary of tinnitus deafness in prescription,prescription databases,the use of Traditional Chinese Medicine Inheritance Support System(V2.5) built-in algorithm in data mining,analyze its characteristics. Results The total number of tinnitus was 261. In the analysis of drug frequency, the stone calamus,liquorice,poria cocos,angelica,aconite,chuanxiong,ribosome,anti-wind,ginseng and magnetic stone were in the top 10.The drug is attributed to the liver,kidney,heart,spleen and lung. There were 7 drug models with more than 30 support degrees,and the confidence level was greater than 0.5,and all of them had the highest combination of ricosa and poria.Evolution got 18 cores and 9 new prescriptions. Conclusion The treatment of tinnitus deafness should be based on virtual syndrome,empirical and virtual inclusion of different diseases. The combination of prescription should not only involve the single viscera,but should be combined with the internal organs and the heart,the heart,the heart,the liver,the spleen and kidney and so on. The use of traditional Chinese medicine inheritance support system to obtain the prescription of tinnitus in the ear deafness is really helpful to clinic.
引文
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[18]王金秀,李浩.耳鸣耳聋辨治思路探讨[J].中国中医基础医学杂志,2015,21(5):624-626.
[19]陈子杰,翟双庆.《内经》耳鸣耳聋与五脏相关理论探讨[J].辽宁中医药大学学报,2014,16(6):123-125.
[20]金连顺,祝鸿发,宋苹,等.基于中医传承辅助系统对张忠德教授治疗支气管扩张症的用药规律分析[J].中国医药导报,2017,14(25):94-97.
[2]秦彩红,陆小左.耳鸣耳聋的中医研究进展[J].江西中医药,2008,39(4):79-80.
[3]梁莹,屈欢欢,全春梅,等.慢性肾脏病患者耳鸣耳聋患病率及临床特点调查[J].中国中西医结合肾病杂志,2012,13(1):38-40.
[4]杜瑶玉,赵华.针灸疗法治疗肾精亏虚型耳鸣耳聋的研究进展[J].新疆中医药,2016,34(2):78-81.
[5]米丽古·努尔.中药在耳鸣耳聋综合治疗中疗效的临床回顾性研究[D].新疆医科大学,2013.
[6]于海峰,谭智敏.老年性耳鸣耳聋的中医药研究进展[J].世界中西医结合杂志,2017,12(9):1329-1332.
[7]彭怀仁.中医方剂大辞典(第一册)[M].北京:人民卫生出版社,1993:128.
[8]钟赣生.中药学[M].北京:中国中医药出版社. 2012:382.
[9]南京中医药大学.中药大辞典[M].上海:上海科学技术出版社,2006:387.
[10] YANG H J,CHEN J X,TANG SH,et al. New drug R&D of traditional Chinese medicine:role of data mining approaches[J]. Biol System,2009,17(3):329-347.
[11]刘蓬,阮紫娟,龚慧涵,等.不同原因耳聋患者耳鸣的发生率调查[J].听力学及言语疾病杂志,2011,19(2):133-136.
[12]史凌云.耳鸣耳聋治五脏[J].浙江中医药大学学报,2013,37(8):960-961.
[13]周雅婷,何扬子.耳鸣耳聋从三焦经论治初探[J].针灸临床杂志,2013,29(8):68-70.
[14]包艳,张若蒙,樊利,等.从肝胆论耳鸣、耳聋理论依据及治疗进展[J].亚太传统医药,2016,12(24):75-77.
[15]王虹.石菖蒲活性成分醒脑开窍、透过血脑屏障作用机制研究[D].中国人民解放军军医进修学院,2007.
[16]蓝肇熙,高虹.心脾关系辨析[J].四川中医,2006(7):26-27.
[17]孙冰,邓家刚,张作记,等.平性药配伍理论探讨[J].中华中医药杂志,2012,27(3):525-527.
[18]王金秀,李浩.耳鸣耳聋辨治思路探讨[J].中国中医基础医学杂志,2015,21(5):624-626.
[19]陈子杰,翟双庆.《内经》耳鸣耳聋与五脏相关理论探讨[J].辽宁中医药大学学报,2014,16(6):123-125.
[20]金连顺,祝鸿发,宋苹,等.基于中医传承辅助系统对张忠德教授治疗支气管扩张症的用药规律分析[J].中国医药导报,2017,14(25):94-97.