摘要
目的观察曲唑酮联合气道正压通气治疗阻塞性睡眠呼吸暂停低通气综合征合并抑郁的临床疗效。方法选取2015年4月—2017年8月在本院确诊为睡眠呼吸暂停低通气综合征(OSAHS)合并抑郁的患者104例作为研究对象,按随机数字表法进行分为观察组和对照组,每组各52例。使用持续性气道正压通气的为对照组,在此基础上合用曲唑酮的为观察组。观察比较两组患者的LSa O2、MSaO2、AHI临床数值,以及PsQI、BDI、SAQLI评分。结果两组MSaO2,l Sa O2数值比较,无统计学差异(P>0.05)。但AHI比较中,观察组低于对照组,差异具有统计学意义(P<0.05)。在PSQI、BDI、SAQLI评分上,观察组均明显优于对照组,差异具有显著统计学意义(P<0.05)。结论曲唑酮联合气道正压通气治疗阻塞性睡眠呼吸暂停低通气综合征合并抑郁的临床疗效显著,能有效改善患者的情绪问题和生活质量。
Objective To observe the efficacy of trazodone combined with positive airway pressure on obstructive sleep apnea hypopnea syndrome( OSAHS) with depression.Methods 104 patients with OSAHS and depression which diagnosed in our hospital during April 2015 and August 2017 were selected as study objects.They were divided into control group and observation group according to Random number table method.Patients in control group were treated with continuous positive airway pressure,and patients in observation group were treated with trazodone and continuous positive airway pressure. The indexes of AHI,m Sa O2,l Sa O2 and scores of PSQI,BDI,and SAQLI were observed and compared. Results There was no significant difference in m Sa O2 and l Sa O2 between the two groups( P>0.05).However,the value of AHI in the observation group was lower than the control group,and there was a statistical difference( P < 0. 05). The scores of PSQI,BDI,and SAQLI in the observation group was significantly better than the control group,and the difference was statistically significant( P < 0. 05).Conclusions The clinical efficacy of trazodone combined with positive airway pressure therapy in the treatment of OSAHS with depression is significant,which could effectively improve the emotional problems and quality of life of patients.
引文
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