曲唑酮联合治疗阻塞性睡眠呼吸暂停低通气综合征合并抑郁的疗效观察
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摘要
目的观察曲唑酮联合气道正压通气治疗阻塞性睡眠呼吸暂停低通气综合征合并抑郁的临床疗效。方法选取2015年4月—2017年8月在本院确诊为睡眠呼吸暂停低通气综合征(OSAHS)合并抑郁的患者104例作为研究对象,按随机数字表法进行分为观察组和对照组,每组各52例。使用持续性气道正压通气的为对照组,在此基础上合用曲唑酮的为观察组。观察比较两组患者的LSa O2、MSaO2、AHI临床数值,以及PsQI、BDI、SAQLI评分。结果两组MSaO2,l Sa O2数值比较,无统计学差异(P>0.05)。但AHI比较中,观察组低于对照组,差异具有统计学意义(P<0.05)。在PSQI、BDI、SAQLI评分上,观察组均明显优于对照组,差异具有显著统计学意义(P<0.05)。结论曲唑酮联合气道正压通气治疗阻塞性睡眠呼吸暂停低通气综合征合并抑郁的临床疗效显著,能有效改善患者的情绪问题和生活质量。
Objective To observe the efficacy of trazodone combined with positive airway pressure on obstructive sleep apnea hypopnea syndrome( OSAHS) with depression.Methods 104 patients with OSAHS and depression which diagnosed in our hospital during April 2015 and August 2017 were selected as study objects.They were divided into control group and observation group according to Random number table method.Patients in control group were treated with continuous positive airway pressure,and patients in observation group were treated with trazodone and continuous positive airway pressure. The indexes of AHI,m Sa O2,l Sa O2 and scores of PSQI,BDI,and SAQLI were observed and compared. Results There was no significant difference in m Sa O2 and l Sa O2 between the two groups( P>0.05).However,the value of AHI in the observation group was lower than the control group,and there was a statistical difference( P < 0. 05). The scores of PSQI,BDI,and SAQLI in the observation group was significantly better than the control group,and the difference was statistically significant( P < 0. 05).Conclusions The clinical efficacy of trazodone combined with positive airway pressure therapy in the treatment of OSAHS with depression is significant,which could effectively improve the emotional problems and quality of life of patients.
Objective To observe the efficacy of trazodone combined with positive airway pressure on obstructive sleep apnea hypopnea syndrome( OSAHS) with depression.Methods 104 patients with OSAHS and depression which diagnosed in our hospital during April 2015 and August 2017 were selected as study objects.They were divided into control group and observation group according to Random number table method.Patients in control group were treated with continuous positive airway pressure,and patients in observation group were treated with trazodone and continuous positive airway pressure. The indexes of AHI,m Sa O2,l Sa O2 and scores of PSQI,BDI,and SAQLI were observed and compared. Results There was no significant difference in m Sa O2 and l Sa O2 between the two groups( P>0.05).However,the value of AHI in the observation group was lower than the control group,and there was a statistical difference( P < 0. 05). The scores of PSQI,BDI,and SAQLI in the observation group was significantly better than the control group,and the difference was statistically significant( P < 0. 05).Conclusions The clinical efficacy of trazodone combined with positive airway pressure therapy in the treatment of OSAHS with depression is significant,which could effectively improve the emotional problems and quality of life of patients.
引文
[1]谭之能.阻塞性睡眠呼吸暂停低通气综合征合并慢性阻塞性肺疾病的治疗进展[J].饮食保健,2017,4(27):386-387.
[2]孙雪,梅峰.低氧环境下阻塞性睡眠呼吸暂停低通气综合征与尿蛋白的关系探讨[J].中国现代医药杂志,2017,19(4):101-104.
[3]张思颖.阻塞性睡眠呼吸暂停低通气综合征相关性高血压疾病严重程度评估指标的研究进展[J].中国循环杂志,2018,33(4):411-413.
[4]韩蕾.祛瘀化痰法治疗阻塞性睡眠呼吸暂停低通气综合征的初步疗效观察[J].临床医药文献电子杂志,2018,5(28):152-154.
[5]中华医学会呼吸病学分会睡眠呼吸疾病学组.阻塞性睡眠呼吸暂停低通气综合征诊治指南(草案)[J].中华结核和呼吸杂志,2002,25(4):195-198.
[6] Koh HW,Lim RB,Chia KS,et al. The Pittsburgh sleep quality index in a multi-ethnic Asian population contains a three factor structure[J].Sleep Breath,2015,19(4):1147-1154.
[7] Schutt PE,Kung S,Clark MM,et al. Comparing the Beck Depression Inventory-II(BDI-II)and Patient Health Question naire(PHQ-9)depression measures in an outpatient bariatric clinic[J].Obesity Surgery,2016,26(6):1274-1278.
[8]李方方,宋葆云,闫秀文.不同压力滴定技术对重度睡眠呼吸暂停患者自我管理水平的影响[J].中华实用诊断与治疗杂志,2016,30(4):391-392.
[9]叶京英,张俊波.腭咽部手术治疗阻塞性睡眠呼吸暂停低通气综合征疗效的预测[J].中华耳鼻咽喉头颈外科杂志,2016,51(4):317-320.
[10]齐娜仁.阻塞性睡眠呼吸暂停低通气综合征患者情绪特征及心理干预护理的效果评价[J].当代医学,2016,22(25):86-87.
[11]黄勉,姚涛,何静,等.阻塞性睡眠呼吸暂停低通气综合征(OSAHS)对急性缺血性脑卒中患者认知功能障碍的影响[J].中国实用神经疾病杂志,2016,19(6):21-22.
[12]李小花,鱼丽荣.持续气道正压通气治疗阻塞性睡眠呼吸暂停低通气综合征合并冠心病[J].中国组织工程研究,2016,15(2):137.
[13]李勤,宋甲富.持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征伴2型糖尿病患者胰岛素敏感性的影响[J].中外医疗,2016,35(31):73-74.
[14]新图叶.气道正压通气治疗对阻塞性睡眠呼吸暂停低通气综合征患者心脏功能和血管内皮功能的影响[J].中国全科医学,2017,20(20):2459-2463.
[15]邓继伟.盐酸曲唑酮联合有氧运动治疗女性更年期抑郁症的疗效分析[J].实用妇科内分泌杂志(电子版),2016,3(2):60-61.
[16]刘超.喹硫平与曲唑酮联合用药方案治疗60例重度抑郁症的临床疗效观察[J].航空航天医学杂志,2016,27(1):116.
[17]李雪丽,唐毅,贾福军,等.使用帕罗西汀和曲唑酮治疗抑郁症合并睡眠障碍的效果研究[J].当代医药论丛,2017,15(11):117.
[18]刘登华,蔡俐琼.曲唑酮对伴有焦虑抑郁围绝经期患者睡眠障碍的临床研究[J].内科急危重症杂志,2016,22(1):28-30.
[2]孙雪,梅峰.低氧环境下阻塞性睡眠呼吸暂停低通气综合征与尿蛋白的关系探讨[J].中国现代医药杂志,2017,19(4):101-104.
[3]张思颖.阻塞性睡眠呼吸暂停低通气综合征相关性高血压疾病严重程度评估指标的研究进展[J].中国循环杂志,2018,33(4):411-413.
[4]韩蕾.祛瘀化痰法治疗阻塞性睡眠呼吸暂停低通气综合征的初步疗效观察[J].临床医药文献电子杂志,2018,5(28):152-154.
[5]中华医学会呼吸病学分会睡眠呼吸疾病学组.阻塞性睡眠呼吸暂停低通气综合征诊治指南(草案)[J].中华结核和呼吸杂志,2002,25(4):195-198.
[6] Koh HW,Lim RB,Chia KS,et al. The Pittsburgh sleep quality index in a multi-ethnic Asian population contains a three factor structure[J].Sleep Breath,2015,19(4):1147-1154.
[7] Schutt PE,Kung S,Clark MM,et al. Comparing the Beck Depression Inventory-II(BDI-II)and Patient Health Question naire(PHQ-9)depression measures in an outpatient bariatric clinic[J].Obesity Surgery,2016,26(6):1274-1278.
[8]李方方,宋葆云,闫秀文.不同压力滴定技术对重度睡眠呼吸暂停患者自我管理水平的影响[J].中华实用诊断与治疗杂志,2016,30(4):391-392.
[9]叶京英,张俊波.腭咽部手术治疗阻塞性睡眠呼吸暂停低通气综合征疗效的预测[J].中华耳鼻咽喉头颈外科杂志,2016,51(4):317-320.
[10]齐娜仁.阻塞性睡眠呼吸暂停低通气综合征患者情绪特征及心理干预护理的效果评价[J].当代医学,2016,22(25):86-87.
[11]黄勉,姚涛,何静,等.阻塞性睡眠呼吸暂停低通气综合征(OSAHS)对急性缺血性脑卒中患者认知功能障碍的影响[J].中国实用神经疾病杂志,2016,19(6):21-22.
[12]李小花,鱼丽荣.持续气道正压通气治疗阻塞性睡眠呼吸暂停低通气综合征合并冠心病[J].中国组织工程研究,2016,15(2):137.
[13]李勤,宋甲富.持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征伴2型糖尿病患者胰岛素敏感性的影响[J].中外医疗,2016,35(31):73-74.
[14]新图叶.气道正压通气治疗对阻塞性睡眠呼吸暂停低通气综合征患者心脏功能和血管内皮功能的影响[J].中国全科医学,2017,20(20):2459-2463.
[15]邓继伟.盐酸曲唑酮联合有氧运动治疗女性更年期抑郁症的疗效分析[J].实用妇科内分泌杂志(电子版),2016,3(2):60-61.
[16]刘超.喹硫平与曲唑酮联合用药方案治疗60例重度抑郁症的临床疗效观察[J].航空航天医学杂志,2016,27(1):116.
[17]李雪丽,唐毅,贾福军,等.使用帕罗西汀和曲唑酮治疗抑郁症合并睡眠障碍的效果研究[J].当代医药论丛,2017,15(11):117.
[18]刘登华,蔡俐琼.曲唑酮对伴有焦虑抑郁围绝经期患者睡眠障碍的临床研究[J].内科急危重症杂志,2016,22(1):28-30.