溶剂配比与工作电压对电子烟气溶胶主要成分释放量的影响
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摘要
【目的】研究电子烟气溶胶中主要成分释放规律。【方法】在4种不同工作电压下抽吸7种不同溶剂配比的烟液,分析产生的气溶胶中主要成分(烟碱、1,2-丙二醇、丙三醇)释放量。【结果】1)烟碱、1,2-丙二醇和丙三醇的释放量分布范围分别是7.87~51.77μg/口、169.52~3707.47μg/口、510.16~2582.54μg/口。2)烟碱与1,2-丙二醇呈显著正相关,相关系数为0.898,而烟碱与丙三醇之间的相关性不显著,说明1,2-丙二醇对烟碱递送起关键作用,烟碱可能是被1,2-丙二醇包裹或夹带着由烟液向气溶胶中递送。3)方差分析表明工作电压、溶剂配比对气溶胶中主要成分释放量均有显著影响,工作电压对于烟碱和丙三醇的释放量贡献率大于溶剂配比,对1,2-丙二醇贡献率小于溶剂配比。【结论】上述规律可以为电子烟烟具开发、烟液开发以及产品安全评价提供参考。
[Objective]To study factors affecting main components in e-cigarette aerosol. [Method] Utilizing e-liquid of 7 different PG-VG ratios under 4 different working voltages, the yield of main components(nicotine, 1,2-propylene glycol, glycerol) of e-cigarette aerosol was analyzed. [Results] 1) The yield of nicotine, propylene glycol and glycerol ranged from 7.87 to 51.77 μg/puff, 169.52 to 3707.47 μg/puff, 510.16 to 2582.54 μg/puff, respectively. 2) The yield of nicotine was positively correlated with that of 1,2-propylene glycol, with Pearson correlation coefficient of 0.898. 1,2 propylene glycol played a key role in the delivery of nicotine. 3) Results of variance analysis showed that both working voltage and PG-VG ratio had significant effects on yield of main components of e-cigarette aerosol. The contribution rate of working voltage to the delivery of nicotine and glycerol was greater than PG-VG ratio, while its contribution rate to 1,2-propylene glycol was less than PG-VG ratio. [Conclusion] This study is of important significance to the development of electronic cigarette, e-liquid and product safety evaluation.
[Objective]To study factors affecting main components in e-cigarette aerosol. [Method] Utilizing e-liquid of 7 different PG-VG ratios under 4 different working voltages, the yield of main components(nicotine, 1,2-propylene glycol, glycerol) of e-cigarette aerosol was analyzed. [Results] 1) The yield of nicotine, propylene glycol and glycerol ranged from 7.87 to 51.77 μg/puff, 169.52 to 3707.47 μg/puff, 510.16 to 2582.54 μg/puff, respectively. 2) The yield of nicotine was positively correlated with that of 1,2-propylene glycol, with Pearson correlation coefficient of 0.898. 1,2 propylene glycol played a key role in the delivery of nicotine. 3) Results of variance analysis showed that both working voltage and PG-VG ratio had significant effects on yield of main components of e-cigarette aerosol. The contribution rate of working voltage to the delivery of nicotine and glycerol was greater than PG-VG ratio, while its contribution rate to 1,2-propylene glycol was less than PG-VG ratio. [Conclusion] This study is of important significance to the development of electronic cigarette, e-liquid and product safety evaluation.
引文
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[15]段沅杏,杨威,田永峰,等.电子烟抽吸参数、电池功率、雾化剂配比对气溶胶中烟碱释放量的影响研究[J].中国烟草学报,2017,23(5):9-14.DUAN Yuanxing,YANG Wei,TIAN Yongfeng,et al.Eff ects of vaping parameters,battery power and e-liquid composition on nicotine yield in electronic cigarette aerosol[J].Acta Tabacaria Sinica,2017,23(5)
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[19]张涛,苏明亮,赵伟,等.制丝工艺参数对9种主流烟气成分释放量的影响[J].烟草科技,2014(8):32-37.Zhang Tao,Su Mingliang,Zhao Wei,et al.Effects of Five Primary Processing Parameters on Deliveries of Nine Components in Mainstream Cigarette Smoke[J].Tobacco Science&Technology,2014(8):32-37.
[2]李保江.全球电子烟市场发展、主要争议及政府管制[J].中国烟草学报,2014,20(4):101-107.LI Baojiang.A global perspective on electronic cigarette’s future development and related controversial and regulatory issues[J].Acta TabacariaSinica,2014,20(4):101-107.
[3]Cressey D.Regulation stacks up for e-cigarettes[J].Nature,2013,501(7468):473.
[4]Rana T,Gearld A L.Comparison of select analytes inaerosol from e-cigarettes with smoke from conventionalcigarettes and with ambient air[J].RegulatoryToxicology and Pharmacology,2014,70(3):704-710.
[5]Grana RA,Ling PM,Benowitz N,Glantz S.Electronic cigarettes.Circulation.2014;129:e490–e492.
[6]Bullen C,McRobbie H,Thornley S,Glover M,Lin R,LaugesenM.Effect of an electronic nicotine delivery device(e cigarette)on desire to smoke and withdrawal,user preferences and nicotine delivery:randomised crossover trial.Tob Control.2010;19:98–103.
[7]Vansickel AR,Cobb CO,Weaver MF,Eissenberg TE.A clinical laboratory model for evaluating the acute effects of electronic“cigarettes”:nicotine delivery profile and cardiovascular and subjective effects.Cancer Epidemiol Biomarkers Prev.2010;19:1945–1953.
[8]Vansickel AR,Eissenberg T.Electronic cigarettes:effective nicotine delivery after acute administration.Nicotine Tob Res.2013;15:267–270.
[9]影响电子烟烟雾大小的因素[N/OL].烟草在线.2015-04-01.http://www.tobaccochina.com/revision/cigarette/wu/20154/2015331163035_668373.shtml.The factors affecting the aerosol mass of electronic cigarette.[N/OL].Tobacco online.2015-04-01.http://www.tobaccochina.com/revision/cigarette/wu/20154/2015331163035_668373.shtml.
[10]Amy McQueen,Stephanie Tower,Walton Sumner.Interviews with“Vapers”:Implications for future research with electronic cigarettes[J].Nicotine&Tobacco Research,2011,13(9):860-867.
[11]张霞,韩熠,李寿波,等.基于气溶胶粒径分布测定电子烟烟雾量[J].中国烟草学报,2016,22(4):1-7.ZHANG Xia,HAN Yi,LI Shoubo,et al.Determination of aerosol mass generated by electronic cigarette based on aerosol particle size distribution[J].Acta Tabacaria Sinica,2016,22(4):1-7.
[12]Talih S,Balhas Z,Eissenberg T,et al.Effects of user puff topography,device voltage,and liquid nicotine concentration on electronic cigarette nicotine yield:Measurements and model Predictions[J].Nicotine&Tobacco Research,2015,17(2):150-157.
[13]El-Hellani A,Salman R,Ei-Hage R,et al.Nicotine and carbonyl emissions from popular electronic cigarette products:Correlation to liquid composition and design characteristics[J].Nicotine&Tobacco Research,2016.doi:10.1093/ntr/ntw280.
[14]张霞,朱东来,李寿波,等.电子烟工作电压对气溶胶中关键成分释放量的影响[J].烟草科技,2017,50(9):42-48.ZHANG Xia,ZHU Donglai,LI Shoubo,et al.Effects of device voltage on release of key aerosol components in e-cigarette[J].Tobacco Science&Technology,2017,50(9):42-48.DOI:10.16135/j.issn1002–0861.2016.0566
[15]段沅杏,杨威,田永峰,等.电子烟抽吸参数、电池功率、雾化剂配比对气溶胶中烟碱释放量的影响研究[J].中国烟草学报,2017,23(5):9-14.DUAN Yuanxing,YANG Wei,TIAN Yongfeng,et al.Eff ects of vaping parameters,battery power and e-liquid composition on nicotine yield in electronic cigarette aerosol[J].Acta Tabacaria Sinica,2017,23(5)
[16]Coresta Recommended Method No 81,Routine analyticalmachine for e-cigarette aerosol generation and collection-definitions and standard conditions.
[17]Timothy R.Levine,Craig R.Hullett.Eta squared,partial eta squared,and misreporting of effect size in communication research[J].Human Communication Research,2002,28(4):612-625.
[18]Pierce C A,Block R A,Aguinis H.Cautionary note onreporting eta-squared values from multifactor designs[J].Educational and Psychological Measurement,2004,64(6):916-924.
[19]张涛,苏明亮,赵伟,等.制丝工艺参数对9种主流烟气成分释放量的影响[J].烟草科技,2014(8):32-37.Zhang Tao,Su Mingliang,Zhao Wei,et al.Effects of Five Primary Processing Parameters on Deliveries of Nine Components in Mainstream Cigarette Smoke[J].Tobacco Science&Technology,2014(8):32-37.