血清甘胆酸对肝病的诊断价值探讨
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摘要
目的探讨血清甘胆酸对肝病的诊断价值。方法于该院2015年11月—2017年11月收治的肝病患者中,随机选取88例作为样本,以疾病类型的不同作为划分依据,将患者分为A组(慢性活动性肝炎)、B组(慢性迁延性肝炎)、C组(肝硬化)、D组(肝癌)4组(每组患者各22例),随机选取该院健康检查的人群22名作为对照组,对比5组患者的血清甘胆酸水平。结果对照组CG(1.50±0.20)mg/L,与A、B、C、D组相比差异有统计学意义(t=5.641、6.900、5.711、6.000,P=0.045、0.032、0.041、0.033)。A组患者CG指标最高,为(22.10±1.25)mg/L。B组CG指标最低,为(7.30±0.15)mg/L。C组及D组CG指标对比,差异无统计学意义(P<0.05)。治疗后,A组CG(2.59±0.58)mg/L、B组CG(1.90±0.10)mg/L、C组CG(2.00±0.13)mg/L、D组CG(1.04±0.05)mg/L,与治疗前相比,数据差异有统计学意义(t=6.008、7.142、6.820、6.775,P<0.05)。结论借助血清甘胆酸诊断肝病,可有效提高疾病检出率,明确疾病类型,为临床对疾病的治疗提供指导。
Objective To investigate the diagnostic value of serum glycocholic acid for liver disease. Methods Among the patients with liver disease admitted to our hospital from November 2015 to November 2017, 88 patients were randomly selected as samples. The patients were divided into group A(chronic active hepatitis) and group B(chronic persistent hepatitis), group C(cirrhosis), group D(liver cancer) according to the different types of diseases(22 patients in each group), 22 patients in the hospital were randomly selected as the control group, compared with the serum of 5 groups of patients of glycocholic acid level. Results The control group had CG(1.50±0.20) mg/L, which was statistically significantly different from the A, B, C, and D groups(t=5.641,6.900,5.711,6.000, P=0.045,0.032,0.041,0.033). The CG index was the highest in group A(22.10±1.25) mg/L. The lowest CG index in group B was(7.30±0.15) mg/L. There was no statistically significant difference in the CG index between group C and group D(P<0.05). After treatment, group A CG(2.59±0.58) mg/L, group B CG(1.90±0.10) mg/L, group C CG(2.00±0.13) mg/L, group D CG(1.04±0.05) mg/L. The difference in data was statistically significant(t=6.008,7.142,6.820,6.775, P<0.05). Conclusion The diagnosis of liver disease by serum glycocholic acid can effectively improve the detection rate of diseases, identify the type of disease, and provide guidance for clinical treatment of diseases.
Objective To investigate the diagnostic value of serum glycocholic acid for liver disease. Methods Among the patients with liver disease admitted to our hospital from November 2015 to November 2017, 88 patients were randomly selected as samples. The patients were divided into group A(chronic active hepatitis) and group B(chronic persistent hepatitis), group C(cirrhosis), group D(liver cancer) according to the different types of diseases(22 patients in each group), 22 patients in the hospital were randomly selected as the control group, compared with the serum of 5 groups of patients of glycocholic acid level. Results The control group had CG(1.50±0.20) mg/L, which was statistically significantly different from the A, B, C, and D groups(t=5.641,6.900,5.711,6.000, P=0.045,0.032,0.041,0.033). The CG index was the highest in group A(22.10±1.25) mg/L. The lowest CG index in group B was(7.30±0.15) mg/L. There was no statistically significant difference in the CG index between group C and group D(P<0.05). After treatment, group A CG(2.59±0.58) mg/L, group B CG(1.90±0.10) mg/L, group C CG(2.00±0.13) mg/L, group D CG(1.04±0.05) mg/L. The difference in data was statistically significant(t=6.008,7.142,6.820,6.775, P<0.05). Conclusion The diagnosis of liver disease by serum glycocholic acid can effectively improve the detection rate of diseases, identify the type of disease, and provide guidance for clinical treatment of diseases.
引文
[1]王东平,王松霞,于同波.乙型肝炎病毒感染对孕妇妊娠晚期血清甘胆酸的影响[J].中国实用医药,2018,13(30):68-70.
[2]夏小梅,朱云波,尹小青.血清甘胆酸检测在慢性肝炎诊断中的临床意义[J].湖南师范大学学报:医学版,2018,15(4)154-156.
[3]康俊辉,谭辰琨,张建武.甘胆酸对慢性肝病的诊断意义[J]湖北中医药大学学报,2018,20(3):102-103.
[4]李亚玲.血清甘胆酸检测在肝病诊断中的应用研究[J].临床医药文献电子杂志,2018,5(32):47,50.
[5]刘茵,毛德文,张荣臻.血清甘胆酸与肝炎后肝硬化中医证候的临床观察[J].大众科技,2018,20(1):48-49,59.
[6]高慧,林锋,施理.老年慢性乙型病毒性肝炎患者血清甘胆酸水平变化及临床意义[J].中国老年学杂志,2017,37(13)3266-3267.
[7]肖婷,曾富强,谢思思.血清甘胆酸在乙型肝炎肝硬化肝细胞损害中的临床应用价值[J].医学理论与实践,2017,30(11):1576-1578,1584.
[8]薛红,俞冲,顾玉玲.血清肝纤维化指标、甘胆酸监测及肝脏硬度测定对慢性HBV感染的临床意义[J].南通大学学报医学版,2017,37(2):139-141.
[9]刘冰.血清甘胆酸测定在急性心肌梗死时对肝脏损伤的诊断价值[J].中国当代医药,2015,22(9):117-119.
[10]洪伟,江涛源,王建芳.血清甘胆酸含量与慢性乙型肝炎患者肝纤维化程度及炎性反应活动度的关系[J].吉林医学2010,31(12):1588-1589.
[2]夏小梅,朱云波,尹小青.血清甘胆酸检测在慢性肝炎诊断中的临床意义[J].湖南师范大学学报:医学版,2018,15(4)154-156.
[3]康俊辉,谭辰琨,张建武.甘胆酸对慢性肝病的诊断意义[J]湖北中医药大学学报,2018,20(3):102-103.
[4]李亚玲.血清甘胆酸检测在肝病诊断中的应用研究[J].临床医药文献电子杂志,2018,5(32):47,50.
[5]刘茵,毛德文,张荣臻.血清甘胆酸与肝炎后肝硬化中医证候的临床观察[J].大众科技,2018,20(1):48-49,59.
[6]高慧,林锋,施理.老年慢性乙型病毒性肝炎患者血清甘胆酸水平变化及临床意义[J].中国老年学杂志,2017,37(13)3266-3267.
[7]肖婷,曾富强,谢思思.血清甘胆酸在乙型肝炎肝硬化肝细胞损害中的临床应用价值[J].医学理论与实践,2017,30(11):1576-1578,1584.
[8]薛红,俞冲,顾玉玲.血清肝纤维化指标、甘胆酸监测及肝脏硬度测定对慢性HBV感染的临床意义[J].南通大学学报医学版,2017,37(2):139-141.
[9]刘冰.血清甘胆酸测定在急性心肌梗死时对肝脏损伤的诊断价值[J].中国当代医药,2015,22(9):117-119.
[10]洪伟,江涛源,王建芳.血清甘胆酸含量与慢性乙型肝炎患者肝纤维化程度及炎性反应活动度的关系[J].吉林医学2010,31(12):1588-1589.