雷尼替丁联合多潘立酮治疗小儿消化不良的临床疗效观察
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摘要
目的观察小儿消化不良采用多潘立酮与雷尼替丁联合治疗的临床效果。方法选取本院2016年10月至2017年10月所收治的消化不良患儿100例,根据患儿床号将其均分为观察组和参照组,每组各50例,参照组患儿给予雷尼替丁单一治疗,观察组患儿给予多潘立酮与雷尼替丁联合治疗,对比观察组与参照组患儿临床症状消失时间、治疗效果、不良反应发生情况。结果观察组不良反应总发生率4%低于参照组20%,组间对比差异有统计学意义(P<0.05)。比较两组患儿治疗效果,观察组总有效率98%高于参照组80%,治疗总有效率对比差异有统计学意义(P<0.05)。观察组患儿食欲减退、上腹疼痛、恶心呕吐、腹胀的临床症状消失时间均短于参照组患儿,组间对比差异有统计学意义(P<0.05)。结论治疗小儿消化不良采用雷尼替丁与多潘立酮联合治疗,其临床症状消失时间较快,对患儿造成的不良反应较少,其临床用药安全性较高,可将该种联合治疗措施广泛推广运用。
Objective To observe the clinical effect of domperidone combined with ranitidine in the treatment of dyspepsia in children.Methods 100 children with dyspepsia admitted to our hospital from October 2016 to October 2017 were enrolled.According to the bed number, the children were divided into observation group and reference group. Each group had 50 cases, and the reference group gave children. Single treatment with ranitidine, combined with domperidone and ranitidine in the observation group, comparing the time of disappearance of clinical symptoms, treatment effect,and adverse reactions in the observation group and the reference group. Results The total incidence of adverse reactions in the observation group was 4%lower than that in the reference group, and the difference between the groups was statistically significant(P<0.05). The therapeutic effect of the two groups were compared. The total effective rate of the observation group was 98% higher than that of the reference group, and the difference in total effective rate was statistically significant(P<0.05). In the observation group, the loss of appetite, upper abdominal pain, nausea and vomiting, and the clinical symptoms of bloating disappeared in the reference group. The difference between the groups was statistically significant(P<0.05). Conclusion The treatment of dyspepsia in children is treated with ranitidine and domperidone. The clinical symptoms disappeared quickly, and the adverse reactions to children were less. The safety of clinical medication was higher, and the combination therapy could be widely promoted. use.
Objective To observe the clinical effect of domperidone combined with ranitidine in the treatment of dyspepsia in children.Methods 100 children with dyspepsia admitted to our hospital from October 2016 to October 2017 were enrolled.According to the bed number, the children were divided into observation group and reference group. Each group had 50 cases, and the reference group gave children. Single treatment with ranitidine, combined with domperidone and ranitidine in the observation group, comparing the time of disappearance of clinical symptoms, treatment effect,and adverse reactions in the observation group and the reference group. Results The total incidence of adverse reactions in the observation group was 4%lower than that in the reference group, and the difference between the groups was statistically significant(P<0.05). The therapeutic effect of the two groups were compared. The total effective rate of the observation group was 98% higher than that of the reference group, and the difference in total effective rate was statistically significant(P<0.05). In the observation group, the loss of appetite, upper abdominal pain, nausea and vomiting, and the clinical symptoms of bloating disappeared in the reference group. The difference between the groups was statistically significant(P<0.05). Conclusion The treatment of dyspepsia in children is treated with ranitidine and domperidone. The clinical symptoms disappeared quickly, and the adverse reactions to children were less. The safety of clinical medication was higher, and the combination therapy could be widely promoted. use.
引文
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[8]王跃武.伊托必利、多潘立酮和甲氧氯普胺联合治疗功能性消化不良的疗效与安全性分析[J].现代消化及介入诊疗,2017,22(2):215-218.
[2]杨发文,黄曜勇,朱广明.加味逍遥散联合多潘立酮治疗围绝经期功能性消化不良的效果[J].广东医学,2016,37(1):244-245.
[3]周秀荣,苏瑞红,徐贵芳,等.胃肠安丸联合多潘立酮治疗儿童功能性消化不良的效果观察[J].河北医科大学学报,2018,39(1):77-81.
[4]王晓莉,刘汶.健脾和胃汤加减联合多潘立酮辨治功能性消化不良的临床研究[J].世界临床药物,2017,38(6):417-420.
[5]于凤杰,彭宪星,刘芹,等.蒙脱石散联合多潘立酮治疗腹泻型肠易激综合征重叠功能性消化不良效果观察[J].临床消化病杂志,2017,29(4):252-254.
[6]张兆林,徐虹,徐建军,等.多潘立酮联合黛力新治疗功能性消化不良的Meta分析[J].中国医刊,2017,52(1):41-45.
[7]何小莉,刘健.雷尼替丁联合多潘立酮治疗小儿消化不良的临床疗效分析[J].当代医学,2017,23(15):115-117.
[8]王跃武.伊托必利、多潘立酮和甲氧氯普胺联合治疗功能性消化不良的疗效与安全性分析[J].现代消化及介入诊疗,2017,22(2):215-218.