心得宁口服液对大鼠慢性心衰模型左心室指数、全心指数及心脏动力学的影响
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摘要
目的:观察心得宁口服液对大鼠慢性心衰模型左心室指数、全心指数及心脏动力学的影响。方法:采用每周腹腔注射盐酸阿霉素建立大鼠慢性心衰模型,观察心得宁口服液对慢性心衰模型大鼠左心室指数、全心指数及心脏动力学的影响。结果:大鼠慢性心衰模型造模成功。与模型组比,心得宁口服液组可明显升高心脏HR水平(P<0.05)、可明显升高心脏Lvsp水平(P<0.05),各给药组均有降低心脏Lvedp水平的趋势(P>0.05)。可显著降低左心室指数(P<0.01),可显著降低全心指数(P<0.01)。结论:心得宁口服液可明显改善大鼠慢性心衰模型的作用。
Objective: To observe the effects of propranolol oral solution on left ventricular index,whole heart index and cardiac dynamics in rats with chronic heart failure. Methods: The weekly intraperitoneal injection of doxorubicin hydrochloride was used to establish the model of chronic heart failure rats. We observed the effect of practolol and export total of heart index and cardiac index,left ventricular dynamics model of chronic heart failure in rats. Results: The model of chronic heart failure model in rats was successful. Compared with model group,the cardiac HR levels( P < 0. 05) and cardiac Lvsp levels( P < 0. 05) were significantly increased in the treatment group,and the Lvedp levels in all groups were decreased( P > 0. 05). Left ventricular index( P < 0. 01) was significantly reduced,and the whole heart index( P< 0. 01) was significantly decreased. Conclusion: The effect of the chronic heart failure model of rats can be improved obviously by the oral administration of propranolol.
Objective: To observe the effects of propranolol oral solution on left ventricular index,whole heart index and cardiac dynamics in rats with chronic heart failure. Methods: The weekly intraperitoneal injection of doxorubicin hydrochloride was used to establish the model of chronic heart failure rats. We observed the effect of practolol and export total of heart index and cardiac index,left ventricular dynamics model of chronic heart failure in rats. Results: The model of chronic heart failure model in rats was successful. Compared with model group,the cardiac HR levels( P < 0. 05) and cardiac Lvsp levels( P < 0. 05) were significantly increased in the treatment group,and the Lvedp levels in all groups were decreased( P > 0. 05). Left ventricular index( P < 0. 01) was significantly reduced,and the whole heart index( P< 0. 01) was significantly decreased. Conclusion: The effect of the chronic heart failure model of rats can be improved obviously by the oral administration of propranolol.
引文
[1]赵京生,易伟国,刘弘.心得宁口服液对大鼠慢性心衰模型的影响[J].中国现代应用药学,2014,31(4):412-416.
[2]刘弘,赵京生,杨君,等.心得宁口服液对慢性心衰模型大鼠心脏动力学及血清BNP、c TnⅠ、LDH水平的影响[J].中国药房,2015,26(1):59-61.
[3]易伟国,赵京生,杨君,等.心得宁口服液对急性心力衰竭大鼠左心室内压最大上升和最大下降速率的影响[J].中医学报,2013,28(10):1499-1501.
[4]耿阳,刘学刚.建立动物心衰模型的方法及意义[J].中华全科医学,2014,12(2):282-285.
[5]吴慧颖,才子斌,王芳,等.Wistar大鼠慢性心力衰竭模型的制备及指标判定[J].中国老年学杂志,2012,32(4):778-779.
[6]He KL,Dickstein M,Sabbah HN,et al.Mechanisms of heart failure with well preserved ejection fraction in dogs following limited coronary micro-embolization[J].Cardiovasc Res,2004,64(1):72-83.
[7]吴运香,张野,谢春林,等.SD大鼠阿霉素慢性心力衰竭模型的建立与评价[J].中国药理学通报,2011,27(8):1170-1173.
[8]李正全,田国忠,李梅秀.左室射血分数(LVEF)对大鼠慢性心衰的判定意义[J].黑龙江医药科学,2013,36(3):39-40.
[9]赵京生,杨君,易伟国,等,中药心得宁口服液对水负荷大鼠模型的影响[J].中国药师,2015(10):1810-1813.
[10]赵京生.心得宁口服液对微循环障碍模型鼠动静脉管径及毛细血管开放数的影响[J].实用医药杂志,2013(9):820-821.
[11]赵京生.心得宁口服液对急性心衰模型心率及血清心肌肌钙蛋白Ⅰ水平的影响[J].中医学报,2013(9):1326-1327.
[12]赵京生,易伟国.心得宁口服液对小鼠常压及减压耐缺氧时间的影响[J].中医学报,2013(10):1497-1498.
[13]易伟国,赵京生.心得宁口服液对急性心力衰竭大鼠左心室内压最大上升和最大下降速率的影响[J].中医学报,2013(10):1499-1501.
[14]常宏,蒋绍艳,史玉册,等,丹参注射液诱导大鼠骨髓间充质干细胞分化为神经元样细胞的研究[J].2008,19(30):2323-2326.
[15]朱曼迪,曲静,崔家鹏,等,独活对阿尔茨海默病模型大鼠学习记忆能力的影响[J].中华中医药学刊,2011(12):2641-2642,2843.
[2]刘弘,赵京生,杨君,等.心得宁口服液对慢性心衰模型大鼠心脏动力学及血清BNP、c TnⅠ、LDH水平的影响[J].中国药房,2015,26(1):59-61.
[3]易伟国,赵京生,杨君,等.心得宁口服液对急性心力衰竭大鼠左心室内压最大上升和最大下降速率的影响[J].中医学报,2013,28(10):1499-1501.
[4]耿阳,刘学刚.建立动物心衰模型的方法及意义[J].中华全科医学,2014,12(2):282-285.
[5]吴慧颖,才子斌,王芳,等.Wistar大鼠慢性心力衰竭模型的制备及指标判定[J].中国老年学杂志,2012,32(4):778-779.
[6]He KL,Dickstein M,Sabbah HN,et al.Mechanisms of heart failure with well preserved ejection fraction in dogs following limited coronary micro-embolization[J].Cardiovasc Res,2004,64(1):72-83.
[7]吴运香,张野,谢春林,等.SD大鼠阿霉素慢性心力衰竭模型的建立与评价[J].中国药理学通报,2011,27(8):1170-1173.
[8]李正全,田国忠,李梅秀.左室射血分数(LVEF)对大鼠慢性心衰的判定意义[J].黑龙江医药科学,2013,36(3):39-40.
[9]赵京生,杨君,易伟国,等,中药心得宁口服液对水负荷大鼠模型的影响[J].中国药师,2015(10):1810-1813.
[10]赵京生.心得宁口服液对微循环障碍模型鼠动静脉管径及毛细血管开放数的影响[J].实用医药杂志,2013(9):820-821.
[11]赵京生.心得宁口服液对急性心衰模型心率及血清心肌肌钙蛋白Ⅰ水平的影响[J].中医学报,2013(9):1326-1327.
[12]赵京生,易伟国.心得宁口服液对小鼠常压及减压耐缺氧时间的影响[J].中医学报,2013(10):1497-1498.
[13]易伟国,赵京生.心得宁口服液对急性心力衰竭大鼠左心室内压最大上升和最大下降速率的影响[J].中医学报,2013(10):1499-1501.
[14]常宏,蒋绍艳,史玉册,等,丹参注射液诱导大鼠骨髓间充质干细胞分化为神经元样细胞的研究[J].2008,19(30):2323-2326.
[15]朱曼迪,曲静,崔家鹏,等,独活对阿尔茨海默病模型大鼠学习记忆能力的影响[J].中华中医药学刊,2011(12):2641-2642,2843.