白头翁汤化学成分及药理作用研究进展
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摘要
综述白头翁汤化学成分、药理作用研究进展。白头翁汤的化学成分主要有生物碱类、香豆素类、皂苷类、柠檬苦素类等,具有抗炎、抗菌、免疫调节、抗肿瘤等药理作用。
This paper reviews the research progress in chemical constituents and pharmacological effects of Pulsatilla Decoction. The chemical components of Pulsatilla Decoction mainly include alkaloids,coumarins,saponinsand limonoids. Modern pharmacological research shows that Pulsatilla Decoction has pharmacological effects such as anti-inflammatory,antibacterial,immune regulation and anti-tumor.
This paper reviews the research progress in chemical constituents and pharmacological effects of Pulsatilla Decoction. The chemical components of Pulsatilla Decoction mainly include alkaloids,coumarins,saponinsand limonoids. Modern pharmacological research shows that Pulsatilla Decoction has pharmacological effects such as anti-inflammatory,antibacterial,immune regulation and anti-tumor.
引文
[1]朱华旭,丁林生.白头翁汤汤剂化学成分的分离研究[J].中成药,1999,21(6):39-43.
[2]朱华旭,丁林生.白头翁汤沉淀化学成分研究[J].中成药,2002,24(4):53-56.
[3]姚星丞,李佳.白头翁汤及其拆方对c AMP-磷酸二酯酶活性影响的研究[J].中国动物保健,2018,20(6):49-50.
[4]胡屹屹,穆祥,胡元亮.中药方剂白头翁汤抗细菌内毒素的作用研究[J].中国农业大学学报,2011,16(6):132-136.
[5]杨昌文.白头翁汤及拆方对模型小鼠抗炎作用的实验研究[J].中国中医急症,2016,25(9):1737-1739.
[6]姚静,胡容,郭青龙.炎症与癌症的发生发展[J].药物生物技术,2011,18(4):372-376.
[7]MUN N,LANCE L.Cancer and inflammation[J].Wiley Interdiscip Rev Syst Biol Med,2017,9(2):e1370.
[8]SETRERRAHMANE S,XU H.Tumor-related interleukins:old validated targets for new anti-cancer drug development[J].Molecular Cancer,2017,16(1):153.
[9]傅晔柳,诸梦露,楼霆.白头翁汤对链脲佐菌素诱导的糖尿病肝损伤的保护作用研究[J].药物评价研究,2018,41(8):1430-1435.
[10]王晓妹,田歌,段强军,等.白头翁汤正丁醇提取物对白念珠菌定植下溃疡性结肠炎小鼠的作用机制研究[J].中国中药杂志,2018,43(14):2979-2984.
[11]段强军,云云,陈志珍,等.白头翁汤正丁醇提取物对小鼠外阴阴道念珠菌病的治疗作用研究[J].中国真菌学杂志,2017,12(6):337-341.
[12]陈绍辉,常乐,肖荪,等.白头翁汤含药血清抑菌作用观察[J].中国兽医杂志,2008,44(9):14-15.
[13]王孝先.黄芩汤、白头翁汤、葛根芩连汤对肠道菌株抑菌作用的实验观察[J].中国中医基础医学杂志,2001,7(1):42-44.
[14]ANESTAKIS D,PETANIDIS S,KALYVAS S,et al.Mechanisms andpplications ofnterleukins in Cancer Immunotherapy[J].Int J Mol Sci,2015,16(1):1691-1710.
[15]马守宝,林丹丹,刘海燕.炎症细胞因子在肿瘤微环境中的作用及其作为治疗靶点的研究进展[J].生命科学,2016,28(2):182-191.
[16]杨玉红.白头翁汤对溃疡性结肠炎患者血清炎症因子水平的影响[J].实验与检验学,2018,36(2):216-217,221.
[17]谭朝晖,张斯汉,刘荣火,等.白头翁汤对溃疡性结肠炎患者Th17/Treg细胞失衡调节作用[J].辽宁中医药大学学报,2017,19(7):191-194.
[18]李毅,刘艳,闫曙光,等.调肠经典三方对UC大鼠结肠细胞因子IL-17、IL-23、IL-6、IL-10及TNF-α的影响[J].现代中西医结合杂志,2017,26(9):920-924.
[19]曹雪涛.医学免疫学[M].北京:人民卫生出版社,2013:90-91.
[20]ZOU W.Regulatory T cells,tumour immunity and immunotherapy.[J].Nat Rev Immunol,2006,6(4):295-307.
[21]BEDOYA S K,LAM B,LAU K,et al.Th17 Cells in Immunity and Autoimmunity[J].Cell Rep,2013,2013(7):986789.
[22]HE Y,LI J,ZHENG Y,et al.A randomized case-control study of dynamic changes in peripheral blood Th17/Treg cell balance and interleukin-17 levels in highly active antiretroviral-treated HIV type 1/AIDS patients[J].AIDS Res Hum Retroviruses,2012,28(4):339-345.
[23]WANG G Q,YANG C L,YUE D F,et al.The changes and its significance of Th17 and Treg cells and related cytokines in patients with tuberculosis pleurisy[J].Allergy,2014,10(1):28.
[24]谭朝晖,刘荣火,邹立华,等.白头翁汤对溃疡性结肠炎黏膜愈合的影响及部分机制研究[J].中国中医药信息杂志,2016,23(7):30-34.
[25]刘思邈,唐艳萍.清热利湿法治疗大肠湿热证溃疡性结肠炎30例[J].中国中西医结合外科杂志,2012,18(5):441-444.
[26]节阳华,何文婷,张洪亮.白头翁汤治疗晚期结直肠癌的药效基因组学研究[J].中国医药,2015,10(6):865-868.
[27]陈凯,张文明,喻凯,等.白头翁中抗肿瘤物质的筛选及其作用机制研究[J].天然产物研究与开发,2016,28(12):1875-1879.
[28]LIU Q,CHEN W,JIAO Y,et al.Pulsatillasaponin A,an active molecule from Pulsatillachinensis,induces cancer cell death and inhibits tumor growth in mouse xenograft models[J].J Surg Res,2014,188(2):387-395.
[29]XU L,CHENG G,LU Y,et al.An active molecule from Pulsatillachinensis,Pulsatillasaponin A,induces apoptosis and inhibits tumor growth of human colon cancer cells without or with 5-FU[J].Oncol Lett,2017,13(5):3799.
[30]李敏,方明治.白头翁皂苷B4、粉防己碱对奥沙利铂耐药的结肠癌细胞的耐药逆转作用及其机制[J].中国癌症杂志,2015,25(1):38-44.
[31]张保国,梁晓夏,刘庆芳.白头翁汤现代药效学研究[J].中成药,2009,31(4):607-608.
[2]朱华旭,丁林生.白头翁汤沉淀化学成分研究[J].中成药,2002,24(4):53-56.
[3]姚星丞,李佳.白头翁汤及其拆方对c AMP-磷酸二酯酶活性影响的研究[J].中国动物保健,2018,20(6):49-50.
[4]胡屹屹,穆祥,胡元亮.中药方剂白头翁汤抗细菌内毒素的作用研究[J].中国农业大学学报,2011,16(6):132-136.
[5]杨昌文.白头翁汤及拆方对模型小鼠抗炎作用的实验研究[J].中国中医急症,2016,25(9):1737-1739.
[6]姚静,胡容,郭青龙.炎症与癌症的发生发展[J].药物生物技术,2011,18(4):372-376.
[7]MUN N,LANCE L.Cancer and inflammation[J].Wiley Interdiscip Rev Syst Biol Med,2017,9(2):e1370.
[8]SETRERRAHMANE S,XU H.Tumor-related interleukins:old validated targets for new anti-cancer drug development[J].Molecular Cancer,2017,16(1):153.
[9]傅晔柳,诸梦露,楼霆.白头翁汤对链脲佐菌素诱导的糖尿病肝损伤的保护作用研究[J].药物评价研究,2018,41(8):1430-1435.
[10]王晓妹,田歌,段强军,等.白头翁汤正丁醇提取物对白念珠菌定植下溃疡性结肠炎小鼠的作用机制研究[J].中国中药杂志,2018,43(14):2979-2984.
[11]段强军,云云,陈志珍,等.白头翁汤正丁醇提取物对小鼠外阴阴道念珠菌病的治疗作用研究[J].中国真菌学杂志,2017,12(6):337-341.
[12]陈绍辉,常乐,肖荪,等.白头翁汤含药血清抑菌作用观察[J].中国兽医杂志,2008,44(9):14-15.
[13]王孝先.黄芩汤、白头翁汤、葛根芩连汤对肠道菌株抑菌作用的实验观察[J].中国中医基础医学杂志,2001,7(1):42-44.
[14]ANESTAKIS D,PETANIDIS S,KALYVAS S,et al.Mechanisms andpplications ofnterleukins in Cancer Immunotherapy[J].Int J Mol Sci,2015,16(1):1691-1710.
[15]马守宝,林丹丹,刘海燕.炎症细胞因子在肿瘤微环境中的作用及其作为治疗靶点的研究进展[J].生命科学,2016,28(2):182-191.
[16]杨玉红.白头翁汤对溃疡性结肠炎患者血清炎症因子水平的影响[J].实验与检验学,2018,36(2):216-217,221.
[17]谭朝晖,张斯汉,刘荣火,等.白头翁汤对溃疡性结肠炎患者Th17/Treg细胞失衡调节作用[J].辽宁中医药大学学报,2017,19(7):191-194.
[18]李毅,刘艳,闫曙光,等.调肠经典三方对UC大鼠结肠细胞因子IL-17、IL-23、IL-6、IL-10及TNF-α的影响[J].现代中西医结合杂志,2017,26(9):920-924.
[19]曹雪涛.医学免疫学[M].北京:人民卫生出版社,2013:90-91.
[20]ZOU W.Regulatory T cells,tumour immunity and immunotherapy.[J].Nat Rev Immunol,2006,6(4):295-307.
[21]BEDOYA S K,LAM B,LAU K,et al.Th17 Cells in Immunity and Autoimmunity[J].Cell Rep,2013,2013(7):986789.
[22]HE Y,LI J,ZHENG Y,et al.A randomized case-control study of dynamic changes in peripheral blood Th17/Treg cell balance and interleukin-17 levels in highly active antiretroviral-treated HIV type 1/AIDS patients[J].AIDS Res Hum Retroviruses,2012,28(4):339-345.
[23]WANG G Q,YANG C L,YUE D F,et al.The changes and its significance of Th17 and Treg cells and related cytokines in patients with tuberculosis pleurisy[J].Allergy,2014,10(1):28.
[24]谭朝晖,刘荣火,邹立华,等.白头翁汤对溃疡性结肠炎黏膜愈合的影响及部分机制研究[J].中国中医药信息杂志,2016,23(7):30-34.
[25]刘思邈,唐艳萍.清热利湿法治疗大肠湿热证溃疡性结肠炎30例[J].中国中西医结合外科杂志,2012,18(5):441-444.
[26]节阳华,何文婷,张洪亮.白头翁汤治疗晚期结直肠癌的药效基因组学研究[J].中国医药,2015,10(6):865-868.
[27]陈凯,张文明,喻凯,等.白头翁中抗肿瘤物质的筛选及其作用机制研究[J].天然产物研究与开发,2016,28(12):1875-1879.
[28]LIU Q,CHEN W,JIAO Y,et al.Pulsatillasaponin A,an active molecule from Pulsatillachinensis,induces cancer cell death and inhibits tumor growth in mouse xenograft models[J].J Surg Res,2014,188(2):387-395.
[29]XU L,CHENG G,LU Y,et al.An active molecule from Pulsatillachinensis,Pulsatillasaponin A,induces apoptosis and inhibits tumor growth of human colon cancer cells without or with 5-FU[J].Oncol Lett,2017,13(5):3799.
[30]李敏,方明治.白头翁皂苷B4、粉防己碱对奥沙利铂耐药的结肠癌细胞的耐药逆转作用及其机制[J].中国癌症杂志,2015,25(1):38-44.
[31]张保国,梁晓夏,刘庆芳.白头翁汤现代药效学研究[J].中成药,2009,31(4):607-608.