血浆D-D水平对心源性脑梗死患者生存状况的影响
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摘要
目的探究血浆D-二聚体(D-D)水平对心源性脑梗死患者生存状况的影响。方法选取2013年6月至2016年6月于我院进行诊治的118例心源性脑梗死患者为研究对象,将血浆D-D水平>0.5 mg/L(高水平)的21例患者作为对照组,将血浆D-D水平≤0.5 mg/L(正常水平)的97例患者作为观察组。比较两组患者的血浆D-D水平、一般资料、并发症发生情况及生存状况。结果观察组血浆D-D水平低于对照组,差异具有统计学意义(P<0.05)。观察组患者的NIHSS评分明显低于对照组,差异具有统计学意义(P<0.05)。观察组中枢性高热、入院昏迷与大面积脑梗死患者占比均低于对照组,1年后生存率高于对照组,差异具有统计学意义(P<0.05)。结论血浆D-D水平的升高能反映出心源性脑梗死患者的病情发展,且D-D的高表达量与患者的NIHSS评分及中枢性高热、入院昏迷、大面积脑梗死发生情况呈正相关,严重影响患者的生存状况。
Objective To explore the effect of plasma D-dimer(D-D) level on the survival status of patients with cardiogenic cerebral infarction. Methods One hundred and eighteen patients with cardiogenic cerebral infarction treated in our hospital from June 2013 to June 2016 were selected as the study objects. Twenty-one patients with plasma D-D level >0.5 mg/L(high level) were selected as control group, and 97 patients with plasma D-D level <0.5 mg/L(normal level) were selected as observation group. The plasma D-D level, general data, complications and survival status were compared between the two groups. Results The plasma D-D level in the observation group was lower than that in the control group, and the difference was statistically significant(P <0.05). The NIHSS score of the observation group was significantly lower than that of the control group(P<0.05). The proportion of patients with central high fever, admission coma and massive cerebral infarction in the observation group were lower than those in the control group, the survival rate after one year was higher than that in the control group, the differences were statistically significant(P<0.05). Conclusion The increase of plasma D-D level can reflect the progress of disease in patients with cardiogenic cerebral infarction. The high expression of D-D is positively correlated with NIHSS score and the incidences of central high fever, admission coma and large area cerebral infarction, which seriously affects the survival status of patients.
Objective To explore the effect of plasma D-dimer(D-D) level on the survival status of patients with cardiogenic cerebral infarction. Methods One hundred and eighteen patients with cardiogenic cerebral infarction treated in our hospital from June 2013 to June 2016 were selected as the study objects. Twenty-one patients with plasma D-D level >0.5 mg/L(high level) were selected as control group, and 97 patients with plasma D-D level <0.5 mg/L(normal level) were selected as observation group. The plasma D-D level, general data, complications and survival status were compared between the two groups. Results The plasma D-D level in the observation group was lower than that in the control group, and the difference was statistically significant(P <0.05). The NIHSS score of the observation group was significantly lower than that of the control group(P<0.05). The proportion of patients with central high fever, admission coma and massive cerebral infarction in the observation group were lower than those in the control group, the survival rate after one year was higher than that in the control group, the differences were statistically significant(P<0.05). Conclusion The increase of plasma D-D level can reflect the progress of disease in patients with cardiogenic cerebral infarction. The high expression of D-D is positively correlated with NIHSS score and the incidences of central high fever, admission coma and large area cerebral infarction, which seriously affects the survival status of patients.
引文
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[2]吴志勇,肖瑾,刘兵荣,等.血浆D-二聚体在心源性脑梗死患者中的表达[J].中国脑血管病杂志,2016,13(11):601-604.
[3]朱红敏.急性脑梗死不同病因学亚型患者BNP和D-二聚体含量变化的意义[J].中国实用神经疾病杂志,2016,19(7):69-71.
[4]张珺,李艳.脑梗死患者血浆D-二聚体检测及临床价值[J].海南医学院学报,2014,20(11):1548-1550.
[5]张易,许晓英,吴明德.静脉血液中D-二聚体、同型半胱氨酸、纤维蛋白原、红细胞沉降率与不同类型急性脑梗死的关系[J].临床和实验医学杂志,2016,15(12):1158-1160.
[6]陈芳.急性心肌梗死患者D-二聚体检测的临床价值[J].中国医药指南,2016,14(25):134-135.
[7]耿慧,孙伟,李素敏.急性脑梗死血浆D-二聚体NSE的动态分析[J].中国实用神经疾病杂志,2016,19(9):64-66.
[8]盛源,郑冰清,蔡泠,等.心房颤动并发血栓栓塞患者脑钠肽与D-二聚体的表达及相关性分析[J].现代生物医学进展,2015,15(7):1271-1274,1285.