基于复合光波导的生化传感器应用研究进展
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摘要
光波导在光电技术领域有广泛的应用,复合光波导结构是在平面光波导上涂覆高折射率薄膜而得到的。基于复合光波导的生化传感器具有非标记、可逆、响应速度快等优点,在环境污染监测领域有广阔的应用前景。介绍了复合光波导的结构和机理,综述了基于复合光波导的生化传感器应用研究进展。
Optical waveguide is widely used in the field of photoelectric technology,and the composite optical waveguide could be prepared by depositing thin film with high refractive index onto the surface of planer optical waveguide.Biochemical sensors based on composite optical waveguide has a series of features,such as label-free,reversible and fast response,which have a broad application prospect in the field of environmental pollution detection.In this paper,the structure and mechanism of composite optical waveguide,and the application and research progress of biochemical sensors based on composite optical waveguide are reviewed.
Optical waveguide is widely used in the field of photoelectric technology,and the composite optical waveguide could be prepared by depositing thin film with high refractive index onto the surface of planer optical waveguide.Biochemical sensors based on composite optical waveguide has a series of features,such as label-free,reversible and fast response,which have a broad application prospect in the field of environmental pollution detection.In this paper,the structure and mechanism of composite optical waveguide,and the application and research progress of biochemical sensors based on composite optical waveguide are reviewed.
引文
1 Bo S,Wang J,Zhao H,et al.LaF3∶Er,Yb doped sol-gel polymeric optical waveguide amplifiers[J].Appl Phys B:Lasers Opt,2008,91:79.
2 Mitani M,Yamashita K,Fukui T,et al.Polymer optical waveguide composed of europium-aluminum acrylate composite core for compact optical amplifier and laser[J].Proc SPIE,2015,9365:93650Q.
3 Huang L,Tsang K,Pun E Y B,et al.Sm3+-doped polymer optical waveguide amplifiers[J].Opt Commun,2010,283:1363.
4 Voznesenskiy S S,Sergeev A A,Mironenko A Y,et al.Integratedoptical sensors based on chitosan waveguide films for relative humidity measurements[J].Sens Actuators B,2013,188:482.
5 Li Q,Jia Y,Dai L,et al.Controlled rod nanostructured assembly of diphenyalanine and their optical waveguide properties[J].ACS Nano,2015,9(3):2689.
6 Oh M C,Kim K J,Lee J H.Polymeric waveguide biosensors with calixarene monolayer for detecting potassium ion concentration[J].Appl Phys Lett,2006,89:251104.
7 Zhang C,Zhao Y S,Yao J.Optical waveguides at micro/nanoscale based on functional small organic molecules[J].Phys Chem Chem Phys,2011,13:9060.
8 Nagamura T,Adachi T,Sasaki K,et al.Highly sensitive detection of transient absorption in dye-doped ultrathin polymer films by the TiO2/K+composite optical waveguide method upon pulsed laser excitation[J].Talanta,2005,65:1071.
9 Zhong N,Liao Q,Zhu X,et al.Temperature-independent polymer optical fiber evanescent wave sensor[J].Sci Rep,2015,5:11508.
10 Zhou Wei,Zhang Wei,Wang Zan,et al.Progress on fiber-optic evanescent wave biosensor technique in food safety detection[J].J Food Saf Qual,2014,5(12):3971(in Chinese).周巍,张巍,王赞,等.光纤倏逝波生物传感器在食品安全检测中应用进展[J].食品安全质量检测学报,2014,5(12):3971.
11 Latifi H,Ziball M I,Hosseini S M,et al.Nonadiabatic tapered optical fiber for biosensor applications[J].Photonic Sens,2012,2(4):340.
12 Adányi N,Majer-Baranyi K,Nagy A,et al.Optical waveguide lightmode spectroscopy immunosensor for detection of carp vitellogenin[J].Sens Actuators B,2013,176:932.
13 Murphy C,Stack E,Krivelo S,et al.Detection of the cyanobacterial toxin,microcystin-LR,using a novel recombinant antibody-based optical-planar waveguide platform[J].Biosens Bioelectron,2015,67:708.
14 Xu J,Suarez D,Gottfried D S.Detection of avian influenza virus using an interferometric biosensor[J].Anal Bioanal Chem,2007,389:1193.
15 Majer-Baranyi K,Zalán Z,M9rtl M,et al.Optical waveguide lightmode spectroscopy technique-based immunosensor development for aflatoxin B1determination in spice paprika samples[J].Food Chem,2016,211:972.
16 Bradshaw J T,Mendes S B,Saavedra S S.Planar integrated optical waveguide spectroscopy[J].Anal Chem,2005,77(1):28A.
17 Shankaran D R,Gobi K V,Miura N.Recent advancements in surface plasmon resonance immunosensors for detection of small molecules of biomedical,food and environmental interest[J].Sens Actuators B,2007,121:158.
18 Washburn A L,Gunn L C,Bailey R C.Label-free quantitation of a cancer biomarker in complex media using silicon photonic microring resonators[J].Anal Chem,2009,81(22):9499.
19 Yang T,Zheng C,Zhao S,et al.Optimized design and fabrication of Mach-Zehnder interferometer sensor in polymer technology[J].Fiber Integr Opt,2013,32:153.
20 Hiltunen M,Hiltunen J,Stenberg P,et al.Polymeric slot waveguide interferometer for sensor applications[J].Opt Express,2014,22(6):7229.
21 Gonzalez-Guerrero A B,Maldonado J,Herranz S,et al.Trends in photonic lab-on-chip interferometric biosensors for point-of-care diagnostics[J].Anal Methods,2016,8:8380.
22 Mukundan H,Anderson A S,Grace W K,et al.Waveguide-based biosensors for pathogen detection[J].Sensors,2009,9:5783.
23 Qi Z M,Liu R P,Lu D F.High-sensitivity biochemical analyzer based on composite-optical-waveguide polarimetric interferometer[J].Chin J Lasers,2011,38(1):0108001(in Chinese).祁志美,刘瑞鹏,逯丹凤.基于复合光波导偏振干涉技术的高灵敏度生化检测仪[J].中国激光,2011,38(1):0108001.
24 Adányi N,Majer-Baranyi K,Berki M,et al.Development of immunosensors based on optical waveguide lightmode spectroscopy(OWLS)technique for determining active substance in herbs[J].Sens Actuators B,2017,239:413.
25 Muriano A,Thayil K N A,Salvador J P,et al.Two-photon fluorescent immunosensor for androgenic hormones using resonant gra-ting waveguide structures[J].Sens Actuators B,2012,174:394.
26 Kozma P,Kehl F,Ehrentreich-F9rster E,et al.Integrated planar optical waveguide interferometer biosensors:A comparative review[J].Biosens Bioelectron,2014,58:287.
27 Wang B L,Hu L L,Zhang L Y.Application of sol-gel technique to the preparation of the planar waveguide[J].Piezoelectr Acoustoopt,2008,30(5):594(in Chinese).王宝玲,胡丽丽,张丽艳.溶胶-凝胶法在平面光波导薄膜制备中的应用[J].压电与声光,2008,30(5):594.
28 Liu L H,Zhou X H,Xu W Q,et al.Highly sensitive detection of sulfadimidine in water and dairy products by means of an evanescent wave optical biosensor[J].RSC Adv,2014,4:60227.
29 Qi Z M,Itoh K,Murabayashi M,et al.A composite optical waveguide-based polarimetric interferometer for chemical and biological sensing applications[J].J Lightwave Technol,2000,18(8):1106.
30 Mamtimin G,Yimit A.NiO-In2O3composite thin film/tin-diffused glass optical waveguide sensor and its gas sensitivity properties[J].Chin Sci Bull,2012,57(1):47(in Chinese).姑丽各娜·买买提依明,阿布力孜·伊米提.NiO-In2O3薄膜/锡掺杂玻璃光波导传感元件及其气敏性[J].科学通报,2012,57(1):47.
31 Mohemaiti M,Keram A,Nezamidin P,et al.Preparation of zinc oxide thin film/tin-diffused optical waveguide sensor and gas-sensing detection[J].Acta Chim Sin,2011,69(15):1840(in Chinese).米日古力·莫合买提,阿斯娅·克里木,帕提曼·尼扎木丁,等.溶胶-凝胶法制备氧化锌薄膜/锡掺杂玻璃光波导及其气敏性研究[J].化学学报,2011,69(15):1840.
32 Qi Z M,Yimit A,Itoh K,et al.Composite optical waveguide composed of a tapered film of bromothymol blue evaporated onto a potassium ion-exchanged waveguide and its application as a guided wave absorption-based ammonia-gas sensor[J].Opt Lett,2001,26(9):629.
33 Rahman E,Kerim A,Yasin P,et al.MB-stearic acid composite film optical waveguide sensor for the detection of HCl gas[J].Chem J Chin Universities,2012,33(10):2173(in Chinese).艾拜拉·热合曼,阿斯娅·克里木,帕提曼·亚森,等.MB-硬脂酸复合薄膜光波导传感器检测氯化氢气体[J].高等学校化学学报,2012,33(10):2173.
34 Qi Z M,Honma I,Zhou H.Chemical gas sensor application of openpore mesoporous thin films based on integrated optical polarimetric interferometry[J].Anal Chem,2006,78:1034.
35 Yimit A,Itoh K,Murabayashi M.Detection of ammonia in the ppt range based on a composite optical waveguide pH sensor[J].Sens Actuators B,2003,188:239.
36 Yimit A,Talip D,Tursun E,et al.The application of highly sensitive composite optical waveguide in the ozone detection[J].Chin J Anal Chem,2005,33(11):1663(in Chinese).阿布力孜·伊米提,迪丽努尔·塔力甫,艾尔肯·吐尔逊,等.高灵敏复合光波导在检测臭氧的应用研究[J].分析化学,2005,33(11):1663.
37 Yimit A,Huang X,Xu Y,et al.Development of a composite optical waveguide sensor for Immunoglobulin G[J].Chem Lett,2003,32(1):86.
38 Lu D F,Qi Z M.Characterization and chemical/biosensing application of a high-sensitivity integrated optical polarimetric interferometer[J].Acta Phys Sin,2012,61(11):114212(in Chinese).禄丹凤,祁志美.高灵敏度集成光偏振干涉仪特性及生化传感应用研究[J].物理学报,2012,61(11):114212.
39 Lu D F,Qi Z M,Liu R P.An interferometric biosensor composed of aprism-chamber assembly and a composite waveguide with a Ta2O5nanometric layer[J].Sens Actuators B,2011,157:575.
40 Kadir R,Yimit A,Ablat H,et al.Optical waveguide BTX gas sensor based on polyacrylate resin thin film[J].Environ Sci Technol,2009,43(13):5113.
41 Abdurahman R,Yimit A,Ablat H,et al.Optical waveguide sensor of volatile organic compounds based on PTA thin film[J].Anal Chim Act,2010,658:63.
42 Zhu M,Yimit A.The preparation and gas sensitive research of M-cresol purple-PVP composite film/K+ion-exchanged glass optical waveguide sensor[J].Chin J Sens Actuators,2015,28(9):1292(in Chinese).朱敏,阿布力孜·伊米提.间甲酚紫-PVP复合薄膜/K+交换玻璃光波导元件的制备及其气敏研究[J].传感技术学报,2015,28(9):1292.
43 Turdi G,Nizamudin P,Yan Y,et al.Tetraphenylporphyrin film optical waveguide OWG sensor for detect volatile organic compounds gas[J].Chin J Sens Actuators,2016,29(7):966(in Chinese).姑力米热·吐尔地,帕提曼·尼扎木丁,燕音,等.四苯基卟啉薄膜/K+-交换玻璃光波导传感器的研制及其气敏性研究[J].传感技术学报,2016,29(7):966.
2 Mitani M,Yamashita K,Fukui T,et al.Polymer optical waveguide composed of europium-aluminum acrylate composite core for compact optical amplifier and laser[J].Proc SPIE,2015,9365:93650Q.
3 Huang L,Tsang K,Pun E Y B,et al.Sm3+-doped polymer optical waveguide amplifiers[J].Opt Commun,2010,283:1363.
4 Voznesenskiy S S,Sergeev A A,Mironenko A Y,et al.Integratedoptical sensors based on chitosan waveguide films for relative humidity measurements[J].Sens Actuators B,2013,188:482.
5 Li Q,Jia Y,Dai L,et al.Controlled rod nanostructured assembly of diphenyalanine and their optical waveguide properties[J].ACS Nano,2015,9(3):2689.
6 Oh M C,Kim K J,Lee J H.Polymeric waveguide biosensors with calixarene monolayer for detecting potassium ion concentration[J].Appl Phys Lett,2006,89:251104.
7 Zhang C,Zhao Y S,Yao J.Optical waveguides at micro/nanoscale based on functional small organic molecules[J].Phys Chem Chem Phys,2011,13:9060.
8 Nagamura T,Adachi T,Sasaki K,et al.Highly sensitive detection of transient absorption in dye-doped ultrathin polymer films by the TiO2/K+composite optical waveguide method upon pulsed laser excitation[J].Talanta,2005,65:1071.
9 Zhong N,Liao Q,Zhu X,et al.Temperature-independent polymer optical fiber evanescent wave sensor[J].Sci Rep,2015,5:11508.
10 Zhou Wei,Zhang Wei,Wang Zan,et al.Progress on fiber-optic evanescent wave biosensor technique in food safety detection[J].J Food Saf Qual,2014,5(12):3971(in Chinese).周巍,张巍,王赞,等.光纤倏逝波生物传感器在食品安全检测中应用进展[J].食品安全质量检测学报,2014,5(12):3971.
11 Latifi H,Ziball M I,Hosseini S M,et al.Nonadiabatic tapered optical fiber for biosensor applications[J].Photonic Sens,2012,2(4):340.
12 Adányi N,Majer-Baranyi K,Nagy A,et al.Optical waveguide lightmode spectroscopy immunosensor for detection of carp vitellogenin[J].Sens Actuators B,2013,176:932.
13 Murphy C,Stack E,Krivelo S,et al.Detection of the cyanobacterial toxin,microcystin-LR,using a novel recombinant antibody-based optical-planar waveguide platform[J].Biosens Bioelectron,2015,67:708.
14 Xu J,Suarez D,Gottfried D S.Detection of avian influenza virus using an interferometric biosensor[J].Anal Bioanal Chem,2007,389:1193.
15 Majer-Baranyi K,Zalán Z,M9rtl M,et al.Optical waveguide lightmode spectroscopy technique-based immunosensor development for aflatoxin B1determination in spice paprika samples[J].Food Chem,2016,211:972.
16 Bradshaw J T,Mendes S B,Saavedra S S.Planar integrated optical waveguide spectroscopy[J].Anal Chem,2005,77(1):28A.
17 Shankaran D R,Gobi K V,Miura N.Recent advancements in surface plasmon resonance immunosensors for detection of small molecules of biomedical,food and environmental interest[J].Sens Actuators B,2007,121:158.
18 Washburn A L,Gunn L C,Bailey R C.Label-free quantitation of a cancer biomarker in complex media using silicon photonic microring resonators[J].Anal Chem,2009,81(22):9499.
19 Yang T,Zheng C,Zhao S,et al.Optimized design and fabrication of Mach-Zehnder interferometer sensor in polymer technology[J].Fiber Integr Opt,2013,32:153.
20 Hiltunen M,Hiltunen J,Stenberg P,et al.Polymeric slot waveguide interferometer for sensor applications[J].Opt Express,2014,22(6):7229.
21 Gonzalez-Guerrero A B,Maldonado J,Herranz S,et al.Trends in photonic lab-on-chip interferometric biosensors for point-of-care diagnostics[J].Anal Methods,2016,8:8380.
22 Mukundan H,Anderson A S,Grace W K,et al.Waveguide-based biosensors for pathogen detection[J].Sensors,2009,9:5783.
23 Qi Z M,Liu R P,Lu D F.High-sensitivity biochemical analyzer based on composite-optical-waveguide polarimetric interferometer[J].Chin J Lasers,2011,38(1):0108001(in Chinese).祁志美,刘瑞鹏,逯丹凤.基于复合光波导偏振干涉技术的高灵敏度生化检测仪[J].中国激光,2011,38(1):0108001.
24 Adányi N,Majer-Baranyi K,Berki M,et al.Development of immunosensors based on optical waveguide lightmode spectroscopy(OWLS)technique for determining active substance in herbs[J].Sens Actuators B,2017,239:413.
25 Muriano A,Thayil K N A,Salvador J P,et al.Two-photon fluorescent immunosensor for androgenic hormones using resonant gra-ting waveguide structures[J].Sens Actuators B,2012,174:394.
26 Kozma P,Kehl F,Ehrentreich-F9rster E,et al.Integrated planar optical waveguide interferometer biosensors:A comparative review[J].Biosens Bioelectron,2014,58:287.
27 Wang B L,Hu L L,Zhang L Y.Application of sol-gel technique to the preparation of the planar waveguide[J].Piezoelectr Acoustoopt,2008,30(5):594(in Chinese).王宝玲,胡丽丽,张丽艳.溶胶-凝胶法在平面光波导薄膜制备中的应用[J].压电与声光,2008,30(5):594.
28 Liu L H,Zhou X H,Xu W Q,et al.Highly sensitive detection of sulfadimidine in water and dairy products by means of an evanescent wave optical biosensor[J].RSC Adv,2014,4:60227.
29 Qi Z M,Itoh K,Murabayashi M,et al.A composite optical waveguide-based polarimetric interferometer for chemical and biological sensing applications[J].J Lightwave Technol,2000,18(8):1106.
30 Mamtimin G,Yimit A.NiO-In2O3composite thin film/tin-diffused glass optical waveguide sensor and its gas sensitivity properties[J].Chin Sci Bull,2012,57(1):47(in Chinese).姑丽各娜·买买提依明,阿布力孜·伊米提.NiO-In2O3薄膜/锡掺杂玻璃光波导传感元件及其气敏性[J].科学通报,2012,57(1):47.
31 Mohemaiti M,Keram A,Nezamidin P,et al.Preparation of zinc oxide thin film/tin-diffused optical waveguide sensor and gas-sensing detection[J].Acta Chim Sin,2011,69(15):1840(in Chinese).米日古力·莫合买提,阿斯娅·克里木,帕提曼·尼扎木丁,等.溶胶-凝胶法制备氧化锌薄膜/锡掺杂玻璃光波导及其气敏性研究[J].化学学报,2011,69(15):1840.
32 Qi Z M,Yimit A,Itoh K,et al.Composite optical waveguide composed of a tapered film of bromothymol blue evaporated onto a potassium ion-exchanged waveguide and its application as a guided wave absorption-based ammonia-gas sensor[J].Opt Lett,2001,26(9):629.
33 Rahman E,Kerim A,Yasin P,et al.MB-stearic acid composite film optical waveguide sensor for the detection of HCl gas[J].Chem J Chin Universities,2012,33(10):2173(in Chinese).艾拜拉·热合曼,阿斯娅·克里木,帕提曼·亚森,等.MB-硬脂酸复合薄膜光波导传感器检测氯化氢气体[J].高等学校化学学报,2012,33(10):2173.
34 Qi Z M,Honma I,Zhou H.Chemical gas sensor application of openpore mesoporous thin films based on integrated optical polarimetric interferometry[J].Anal Chem,2006,78:1034.
35 Yimit A,Itoh K,Murabayashi M.Detection of ammonia in the ppt range based on a composite optical waveguide pH sensor[J].Sens Actuators B,2003,188:239.
36 Yimit A,Talip D,Tursun E,et al.The application of highly sensitive composite optical waveguide in the ozone detection[J].Chin J Anal Chem,2005,33(11):1663(in Chinese).阿布力孜·伊米提,迪丽努尔·塔力甫,艾尔肯·吐尔逊,等.高灵敏复合光波导在检测臭氧的应用研究[J].分析化学,2005,33(11):1663.
37 Yimit A,Huang X,Xu Y,et al.Development of a composite optical waveguide sensor for Immunoglobulin G[J].Chem Lett,2003,32(1):86.
38 Lu D F,Qi Z M.Characterization and chemical/biosensing application of a high-sensitivity integrated optical polarimetric interferometer[J].Acta Phys Sin,2012,61(11):114212(in Chinese).禄丹凤,祁志美.高灵敏度集成光偏振干涉仪特性及生化传感应用研究[J].物理学报,2012,61(11):114212.
39 Lu D F,Qi Z M,Liu R P.An interferometric biosensor composed of aprism-chamber assembly and a composite waveguide with a Ta2O5nanometric layer[J].Sens Actuators B,2011,157:575.
40 Kadir R,Yimit A,Ablat H,et al.Optical waveguide BTX gas sensor based on polyacrylate resin thin film[J].Environ Sci Technol,2009,43(13):5113.
41 Abdurahman R,Yimit A,Ablat H,et al.Optical waveguide sensor of volatile organic compounds based on PTA thin film[J].Anal Chim Act,2010,658:63.
42 Zhu M,Yimit A.The preparation and gas sensitive research of M-cresol purple-PVP composite film/K+ion-exchanged glass optical waveguide sensor[J].Chin J Sens Actuators,2015,28(9):1292(in Chinese).朱敏,阿布力孜·伊米提.间甲酚紫-PVP复合薄膜/K+交换玻璃光波导元件的制备及其气敏研究[J].传感技术学报,2015,28(9):1292.
43 Turdi G,Nizamudin P,Yan Y,et al.Tetraphenylporphyrin film optical waveguide OWG sensor for detect volatile organic compounds gas[J].Chin J Sens Actuators,2016,29(7):966(in Chinese).姑力米热·吐尔地,帕提曼·尼扎木丁,燕音,等.四苯基卟啉薄膜/K+-交换玻璃光波导传感器的研制及其气敏性研究[J].传感技术学报,2016,29(7):966.