含光果甘草提取物的美白乳液的制备
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摘要
以光果甘草提取物、烟酰胺和维生素C衍生物为主要美白活性物质,制备一种具有保湿护肤、美白提亮等优点的美白乳液。通过紫外分光光度计测量不同浓度提取液的吸光值以确定该提取液对酪氨酸酶活性的抑制率,确定在美白乳液制备过程中加入的提取液的最佳浓度。检测美白乳液的均质程度,分析其耐冷耐热性和防腐性,利用皮肤黑色素和血红素测试探头等仪器对该乳液的美白功效进行评价。人体皮肤测试结果表明:使用该美白乳液28d后,受试者皮肤的黑色素含量(MI值)下降,皮肤亮度(L值)上升,该美白乳液具备良好的美白功效。
A whitening emulsion was prepared using glabra extract,nicotamide and vitamin C derivatives as active ingredient with,the advantages of protecting,moisturizing,whitening and brightening the skin.The effects of different concentrations of extracts oninhibition of tyrosinase activity was investigated by spectrophotometry and the optimal concentration of the extracts in the preparation of whitening emulsion was further determined.Homogeneity,cold and heat resistance,and antiseptic propertyof the emulsion were investigated.By using the skin melanin and heme test probes,the whitening effect of the emulsion was evaluated.The human skin test results showed that the melanin content(MI value)of the subjects skin decreased and the skin brightness(Lvalue)increased after 28 days of usage,thus suggestingthe whitening effect of the emulsion.
A whitening emulsion was prepared using glabra extract,nicotamide and vitamin C derivatives as active ingredient with,the advantages of protecting,moisturizing,whitening and brightening the skin.The effects of different concentrations of extracts oninhibition of tyrosinase activity was investigated by spectrophotometry and the optimal concentration of the extracts in the preparation of whitening emulsion was further determined.Homogeneity,cold and heat resistance,and antiseptic propertyof the emulsion were investigated.By using the skin melanin and heme test probes,the whitening effect of the emulsion was evaluated.The human skin test results showed that the melanin content(MI value)of the subjects skin decreased and the skin brightness(Lvalue)increased after 28 days of usage,thus suggestingthe whitening effect of the emulsion.
引文
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[13]宋必卫,刘洁琼,章方珺,等.黄蜀葵提取物对大鼠背部深度烫伤的治疗作用[J].浙江工业大学学报,2017,45(1):47-54.
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[16]万禁禁,刘瑞学,冷群英,等.一种美白霜的研制及其美白功效评价[J].日用化学工业,2017,47(9):513-516.
[17]郑艳萍,刘芳.甘草、山药中提取美白成分研制美白保湿护肤霜[J].广东化工,2016,323(43):60-61.
[18]郭毅.化妆品中微生物的检测及应用[J].化工管理,2018,23(8):233-234.
[2]范玉涵,马全武,王建国,等.甘草废渣中有效成分对酪氨酸酶活性的抑制作用[J].时珍国医国药,2013,24(11):2650-2652.
[3]木合布力·阿布力孜,热娜·卡斯木,马淑燕,等.甘草中光甘草定的提取和抗氧化活性研究[J].天然产物研究与开发,2007,19(4):675-677.
[4]王瑞雪,赵珍,钟雁,等.几种常用美白剂协同作用研究[J].日用化学工业,2014,44(10):572-576.
[5]王建国,周忠,刘海峰,等.甘草的活性成分及其在化妆品中的应用[J].日用化学工业,2004,34(4):249-251.
[6]郭项雨,任清,刘永国.一种高效美白剂组合的研究[J].日用化学品科学,2010,33(10):28-30.
[7]CHA J,YANG H,MOON H,et al.Inhibitory effect and mechanism on melanogenesis from fermented herbal composition for medical or food uses[J].Food research international,2011,45(1):225-231.
[8]欧霖拱.皮肤黑素成因分析与美白祛斑化妆品的研究[J].福建轻纺,2011,6(6):22-26.
[9]刘雨萌,李影影,李明静.光果甘草乙酸乙酯相对酪氨酸酶的抑制作用[J].化学研究,2015,26(3):271-273.
[10]沈钧,何莉萍,张瑞斌.甘草提取物对酪氨酸酶活性的抑制作用[J].中国临床药理学与治疗学,2006,11(8):9441.
[11]骆从燕,慕春海,王园姬,等.光甘草定抑制酪氨酸酶及体外抗氧化活性的研究[J].中药材,2010,33(11):1776-1780.
[12]李玉会.光果甘草中光甘草定和甘草酸的同时提取工艺研究[D].无锡:江南大学,2011.
[13]宋必卫,刘洁琼,章方珺,等.黄蜀葵提取物对大鼠背部深度烫伤的治疗作用[J].浙江工业大学学报,2017,45(1):47-54.
[14]李行诺,翟文丰,周孟宇,等.黄柏化学成分研究[J].浙江工业大学学报,2012,40(3):244-246.
[15]王平,杨君,童应鹏,等.西红花花瓣不同烘干工艺提取物HPLC指纹图谱研究[J].浙江工业大学学报,2018,46(1):106-109.
[16]万禁禁,刘瑞学,冷群英,等.一种美白霜的研制及其美白功效评价[J].日用化学工业,2017,47(9):513-516.
[17]郑艳萍,刘芳.甘草、山药中提取美白成分研制美白保湿护肤霜[J].广东化工,2016,323(43):60-61.
[18]郭毅.化妆品中微生物的检测及应用[J].化工管理,2018,23(8):233-234.