干酪中的生物活性肽及其作用
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摘要
介绍了不同类型干酪在成熟过程中表现和释放的主要生物活性肽。包括抗高血压肽(如布里干酪)、抗氧化肽(如巴尔米贾诺雷吉亚诺干酪)、神经肽(如霉菌干酪)、抗增殖肽(如蒙塔格纳德干酪)、抗菌肽(如莫扎里拉干酪)等。
This article focuses on the major bioactive peptides, which including antihypertensive peptides, antioxidant peptides, peptides on the nervous system, antiproliferative peptides and antimicrobial peptides, are expressed and released during the maturation of different types of cheese.
This article focuses on the major bioactive peptides, which including antihypertensive peptides, antioxidant peptides, peptides on the nervous system, antiproliferative peptides and antimicrobial peptides, are expressed and released during the maturation of different types of cheese.
引文
[1]WALTHER B,SCHMID A,SIEBER R,et al.Cheese in nutrition and health[J].Dairy Sci Technol,2008,88:389-405.
[2]HERNáNDEZ-LEDESMA B,DEL MAR CONTRERAS M,RE-CIO I.Antihypertensive peptides:production,bioavailability and incorporation into foods[J].Adv Colloid Interface Sci,2011,165:23-35.
[3]L.PEZ-EXP.SITO I,AMIGO L,RECIO I.A mini-review on health and nutritional aspects of cheese with a focus on bioactive peptides[J].Dairy Sci Technol,2012,92:419-438.
[4]MEIRA S M M,DAROIT D J,HELFER V E,et al.Bioactive peptides in water-soluble extracts of ovine cheeses from Southern Brazil and Uruguay[J].Food research international,2012,48:322-329.
[5]STUKNYT.M,CATTANEO S,MASOTTI F,et al.Occurrence and fate of ACE-inhibitor peptides in cheeses and in their digestates following in vitro static gastrointestinal digestion[J].Food Chem,2015,168:27-33.
[6]SIEBER R,BüTIKOFER U,EGGER C,et al.ACE-inhibitory activity and ACE-inhibiting peptides in different cheese varieties[J].Dairy Sci Technol,2010,90:47-73.
[7]QURESHI T M,VEGARUD G E,ABRAHAMSEN R K,et al.Angiotensin I-converting enzyme-inhibitory activity of the Norwegian autochthonous cheeses Gamalost and Norvegia after in vitro human gastrointestinal digestion[J].J Dairy Sci,2013,96:838-853.
[8]SAGARDIA I,ILORO I,ELORTZA F,et al.Quantitative structure-activity relationship based screening of bioactive peptides identified in ripened cheese[J].Int Dairy J,2013,33:184-190.
[9]TORRES-LLANEZ M J,GONZáLEZ-C.RDOVA A F,HER-NANDEZ-MENDOZA A,et al.Vallejo-Cordoba,B.Angiotensinconverting enzyme inhibitory activity in Mexican Fresco cheese[J].JDairy Sci,2011,94:3794-3800.
[10]STADTMAN E R.Role of oxidant species in aging[J].Curr Med Chem,2004,11:1105-1112.
[11]SARMADI B H,ISMAIL A.Antioxidative peptides from food proteins:a review[J].Peptides,2010,31:1949-1956.
[12]BOTTESINI C,PAOLELLA S,LAMBERTINI F,et al.Antioxidant capacity of water soluble extracts from Parmigiano-Reggiano cheese[J].Int J Food Sci Nutr,2013,64:953-958.
[13]TIM.N M L,PARRA V,OTTE J,et al.Identification of radical scavenging peptides(<3?kDa)from Burgos-type cheese[J].LWT-Food Science and Technology,2014,57:359-365.
[14]PLAISANCI.P,CLAUSTRE J,ESTIENNE M,et al.A novel bioactive peptide from yoghurts modulates expression of the gel-forming MUC2 mucin as well as population of goblet cells and Paneth cells along the small intestine[J].The Journal of Nutritional Biochemistry,2013,24:213-221.
[15]YIN H,MIAO J,ZHANG Y.Protective effect ofβ-casomorphin-7 on type 1 diabetes rats induced with streptozotocin[J].Peptides,2010,31:1725-1729.
[16]UL HAQ D M,KAPILA R,SHANDILYA U,et al.Impact of Milk Derivedβ-Casomorphins on Physiological Functions and Trends in Research:A Review[J].International Journal of Food Properties,2014,17:1726-1741.
[17]SIENKIEWICZ-SZ?APKA E,JARMO?OWSKA B,KRAWC-ZUK S,et al.Contents of agonistic and antagonistic opioid peptides in different cheese varieties[J].Int Dairy J,2009,19:258-263.
[18]DE NONI I,CATTANEO S.Occurrence ofβ-casomorphins 5 and7 in commercial dairy products and in their digests following in vitro simulated gastro-intestinal digestion[J].Food Chem,2010,119:560-566.
[19]TOELSTEDE S,HOFMANN T.Sensomics Mapping and Identification of the Key Bitter Metabolites in Gouda Cheese[J].J.Agric.Food Chem,2008,56:2795-2804.
[20]RIZZELLO C G,LOSITO I,GOBBETTI M,et al.Antibacterial Activities of Peptides from the Water-Soluble Extracts of Italian Cheese Varieties[J].J Dairy Sci,2005,88:2348-2360.
[21]SINGH M,ROSEN C L,CHANG K J,et al.Plasmaβ-Casomorphin-7 Immunoreactive Peptide Increases after Milk Intake in Newborn but not in Adult Dogs[J].Pediatric research,1989,26:34.
[22]KOST N V,SOKOLOV O Y,KURASOVA O B,et al.b-Casomorphins-7 in infants on different type of feeding and different levels of psychomotor development[J].Peptides,2009,30:1854-1860.
[23]YASUDA S,OHKURA N,SUZUKI K,et al.Effects of highly ripened cheeses on HL-60 human leukemia cells:Antiproliferative activity and induction of apoptotic DNA damage[J].J Dairy Sci,2010,93:1393-1400.
[24]DE SIMONE C,PICARIELLO G,MAMONE G,et al.Characterisation and cytomodulatory properties of peptides from Mozzarella di Bufala Campana cheese whey[J].Journal of Peptide Science,2008,15:251-258.
[25]DE SIMONE C,FERRANTI P,PICARIELLO G,et al.Peptides from water buffalo cheese whey induced senescence cell death via ceramide secretion in human colon adenocarcinoma cell line[J].Mol Nutr Food Res,2010,55:229-238.
[26]TH.OLIER J,HAMMAMI R,FLISS I,et al.Antibacterial and antifungal activity of water-soluble extracts from Mozzarella,Gouda,Swiss,and Cheddar commercial cheeses produced in Canada[J].Dairy Sci Technol,2014,94:427-438.
[27]LIGNITTO L,SEGATO S,BALZAN S,et al.Preliminary investigation on the presence of peptides inhibiting the growth of Listeria innocua and Listeria monocytogenes in Asiago d’Allevo cheese[J].Dairy Sci Technol,2012,92:297-308.
[28]NGUYEN THI P,DUPAS C,ADT I,et al.Partial characterisation of peptides inhibiting Listeria growth in two Alpine cheeses[J].Dairy Sci Technol,2014,94:61-72.
[29]GUILLOTEAU P,ROM.V,DELABY L,et al.A new role of phosphopeptides as bioactive peptides released during milk casein digestion in the young mammal:Regulation of gastric secretion[J].Peptides,2009,30:2221-2227.
[30]TULIPANO G,BULGARI O,CHESSA S,et al.Direct effects of casein phosphopeptides on growth and differentiation of in vitro cultured osteoblastic cells(MC3T3-E1)[J].Regul Pept,2010,160:168-174.
[31]SFORZA S,CAVATORTA V,LAMBERTINI F,et al.Cheese peptidomics:a detailed study on the evolution of the oligopeptide fraction in Parmigiano-Reggiano cheese from curd to 24 months of aging[J].J Dairy Sci,2012,95:3514-3526.
[32]GAGNAIRE V,CARPINO S,PEDILIGGIERI C,et al.Uncommonly Thorough Hydrolysis of Peptides during Ripening of Ragusano Cheese Revealed by Tandem Mass Spectrometry[J].J.Agric.Food Chem,2011,59:12443-12452.
[33]MILLS S,ROSS R P,HILL C,et al.Milk intelligence:Mining milk for bioactive substances associated with human health[J].Int Dairy J,2011,21:377-401.
[34]DUPAS C,ADT I,COTTAZ A,et al.A chromatographic procedure for semi-quantitative evaluation of caseinphosphopeptides in cheese[J].Dairy Sci Technol,2009,89:519-529.
[2]HERNáNDEZ-LEDESMA B,DEL MAR CONTRERAS M,RE-CIO I.Antihypertensive peptides:production,bioavailability and incorporation into foods[J].Adv Colloid Interface Sci,2011,165:23-35.
[3]L.PEZ-EXP.SITO I,AMIGO L,RECIO I.A mini-review on health and nutritional aspects of cheese with a focus on bioactive peptides[J].Dairy Sci Technol,2012,92:419-438.
[4]MEIRA S M M,DAROIT D J,HELFER V E,et al.Bioactive peptides in water-soluble extracts of ovine cheeses from Southern Brazil and Uruguay[J].Food research international,2012,48:322-329.
[5]STUKNYT.M,CATTANEO S,MASOTTI F,et al.Occurrence and fate of ACE-inhibitor peptides in cheeses and in their digestates following in vitro static gastrointestinal digestion[J].Food Chem,2015,168:27-33.
[6]SIEBER R,BüTIKOFER U,EGGER C,et al.ACE-inhibitory activity and ACE-inhibiting peptides in different cheese varieties[J].Dairy Sci Technol,2010,90:47-73.
[7]QURESHI T M,VEGARUD G E,ABRAHAMSEN R K,et al.Angiotensin I-converting enzyme-inhibitory activity of the Norwegian autochthonous cheeses Gamalost and Norvegia after in vitro human gastrointestinal digestion[J].J Dairy Sci,2013,96:838-853.
[8]SAGARDIA I,ILORO I,ELORTZA F,et al.Quantitative structure-activity relationship based screening of bioactive peptides identified in ripened cheese[J].Int Dairy J,2013,33:184-190.
[9]TORRES-LLANEZ M J,GONZáLEZ-C.RDOVA A F,HER-NANDEZ-MENDOZA A,et al.Vallejo-Cordoba,B.Angiotensinconverting enzyme inhibitory activity in Mexican Fresco cheese[J].JDairy Sci,2011,94:3794-3800.
[10]STADTMAN E R.Role of oxidant species in aging[J].Curr Med Chem,2004,11:1105-1112.
[11]SARMADI B H,ISMAIL A.Antioxidative peptides from food proteins:a review[J].Peptides,2010,31:1949-1956.
[12]BOTTESINI C,PAOLELLA S,LAMBERTINI F,et al.Antioxidant capacity of water soluble extracts from Parmigiano-Reggiano cheese[J].Int J Food Sci Nutr,2013,64:953-958.
[13]TIM.N M L,PARRA V,OTTE J,et al.Identification of radical scavenging peptides(<3?kDa)from Burgos-type cheese[J].LWT-Food Science and Technology,2014,57:359-365.
[14]PLAISANCI.P,CLAUSTRE J,ESTIENNE M,et al.A novel bioactive peptide from yoghurts modulates expression of the gel-forming MUC2 mucin as well as population of goblet cells and Paneth cells along the small intestine[J].The Journal of Nutritional Biochemistry,2013,24:213-221.
[15]YIN H,MIAO J,ZHANG Y.Protective effect ofβ-casomorphin-7 on type 1 diabetes rats induced with streptozotocin[J].Peptides,2010,31:1725-1729.
[16]UL HAQ D M,KAPILA R,SHANDILYA U,et al.Impact of Milk Derivedβ-Casomorphins on Physiological Functions and Trends in Research:A Review[J].International Journal of Food Properties,2014,17:1726-1741.
[17]SIENKIEWICZ-SZ?APKA E,JARMO?OWSKA B,KRAWC-ZUK S,et al.Contents of agonistic and antagonistic opioid peptides in different cheese varieties[J].Int Dairy J,2009,19:258-263.
[18]DE NONI I,CATTANEO S.Occurrence ofβ-casomorphins 5 and7 in commercial dairy products and in their digests following in vitro simulated gastro-intestinal digestion[J].Food Chem,2010,119:560-566.
[19]TOELSTEDE S,HOFMANN T.Sensomics Mapping and Identification of the Key Bitter Metabolites in Gouda Cheese[J].J.Agric.Food Chem,2008,56:2795-2804.
[20]RIZZELLO C G,LOSITO I,GOBBETTI M,et al.Antibacterial Activities of Peptides from the Water-Soluble Extracts of Italian Cheese Varieties[J].J Dairy Sci,2005,88:2348-2360.
[21]SINGH M,ROSEN C L,CHANG K J,et al.Plasmaβ-Casomorphin-7 Immunoreactive Peptide Increases after Milk Intake in Newborn but not in Adult Dogs[J].Pediatric research,1989,26:34.
[22]KOST N V,SOKOLOV O Y,KURASOVA O B,et al.b-Casomorphins-7 in infants on different type of feeding and different levels of psychomotor development[J].Peptides,2009,30:1854-1860.
[23]YASUDA S,OHKURA N,SUZUKI K,et al.Effects of highly ripened cheeses on HL-60 human leukemia cells:Antiproliferative activity and induction of apoptotic DNA damage[J].J Dairy Sci,2010,93:1393-1400.
[24]DE SIMONE C,PICARIELLO G,MAMONE G,et al.Characterisation and cytomodulatory properties of peptides from Mozzarella di Bufala Campana cheese whey[J].Journal of Peptide Science,2008,15:251-258.
[25]DE SIMONE C,FERRANTI P,PICARIELLO G,et al.Peptides from water buffalo cheese whey induced senescence cell death via ceramide secretion in human colon adenocarcinoma cell line[J].Mol Nutr Food Res,2010,55:229-238.
[26]TH.OLIER J,HAMMAMI R,FLISS I,et al.Antibacterial and antifungal activity of water-soluble extracts from Mozzarella,Gouda,Swiss,and Cheddar commercial cheeses produced in Canada[J].Dairy Sci Technol,2014,94:427-438.
[27]LIGNITTO L,SEGATO S,BALZAN S,et al.Preliminary investigation on the presence of peptides inhibiting the growth of Listeria innocua and Listeria monocytogenes in Asiago d’Allevo cheese[J].Dairy Sci Technol,2012,92:297-308.
[28]NGUYEN THI P,DUPAS C,ADT I,et al.Partial characterisation of peptides inhibiting Listeria growth in two Alpine cheeses[J].Dairy Sci Technol,2014,94:61-72.
[29]GUILLOTEAU P,ROM.V,DELABY L,et al.A new role of phosphopeptides as bioactive peptides released during milk casein digestion in the young mammal:Regulation of gastric secretion[J].Peptides,2009,30:2221-2227.
[30]TULIPANO G,BULGARI O,CHESSA S,et al.Direct effects of casein phosphopeptides on growth and differentiation of in vitro cultured osteoblastic cells(MC3T3-E1)[J].Regul Pept,2010,160:168-174.
[31]SFORZA S,CAVATORTA V,LAMBERTINI F,et al.Cheese peptidomics:a detailed study on the evolution of the oligopeptide fraction in Parmigiano-Reggiano cheese from curd to 24 months of aging[J].J Dairy Sci,2012,95:3514-3526.
[32]GAGNAIRE V,CARPINO S,PEDILIGGIERI C,et al.Uncommonly Thorough Hydrolysis of Peptides during Ripening of Ragusano Cheese Revealed by Tandem Mass Spectrometry[J].J.Agric.Food Chem,2011,59:12443-12452.
[33]MILLS S,ROSS R P,HILL C,et al.Milk intelligence:Mining milk for bioactive substances associated with human health[J].Int Dairy J,2011,21:377-401.
[34]DUPAS C,ADT I,COTTAZ A,et al.A chromatographic procedure for semi-quantitative evaluation of caseinphosphopeptides in cheese[J].Dairy Sci Technol,2009,89:519-529.