高尿酸血症患者血清肝功、肾功和血脂等生化指标水平
|
摘要
目的分析高尿酸血症患者血清肝功、肾功和血脂等生化指标水平。方法随机筛选无症状高尿酸血症患者67例为观察组;同时随机取67例血尿酸水平正常者为对照组。两组均进行血清肝功、肾功、血脂等生化指标测定,分析两组的检测结果。结果观察组的UA、ALT、AST、γ-GGT、ALP、TP、ALB、TBIL、Cr、TG、TC、LDL-C、HCY及GLU水平均高于对照组,HDL-C水平低于对照组(P<0.05)。观察组中,男性患者的UA、ALT、γ-GGT、TBIL、Cr、TG及HCY水平均高于女性患者(P<0.05)。观察组患者血UA水平与血清γ-GGT、ALT、AST、TG、Cr及HCY水平均呈正相关,而与HDL-C水平则呈负相关(P<0.05)。结论无症状高尿酸血症患者与正常人群对比可见明显不同的血清肝功、肾功、血脂代谢状态,而血清γ-GGT活性可在一定程度上对患者体内氧化应激水平进行反映。
Objective To analyze the levels of serum liver function, renal function and blood lipid in patients with hyperuricemia. Methods Sixty-seven patients with asymptomatic hyperuricemia were randomly selected as observation group, while 67 cuses with normal blood uric acid level were randomly selected as control group. The biochemical indexes of serum liver function, renal function and blood lipid were measured in both groups. The results of the two groups were analyzed. Results The levels of UA, ALT, AST, γ-GGT, ALP, TP, ALB, TBIL, Cr, TG, TC, LDL-C, HCY and GLU in the observation group were higher than those in the control group, and the level of HDL-C was lower than that in the control group(P<0.05). In the observation group, the levels of UA, ALT, γ-GGT, TBIL, Cr, TG and HCY in males were higher than those in females(P<0.05). The level of UA in the observation group was positively correlated with levels of serum γ-GGT, ALT, AST, TG, Cr and HCY, but negatively correlated with the levels of HDL-C(P<0.05). Conclusion Compared with normal people, patients with asymptomatic hyperuricemia have different serum liver function, renal function and lipid metabolism, and the level of oxidative stress in patients to a certain extent can be reflected by serum γ-GGT activity.
Objective To analyze the levels of serum liver function, renal function and blood lipid in patients with hyperuricemia. Methods Sixty-seven patients with asymptomatic hyperuricemia were randomly selected as observation group, while 67 cuses with normal blood uric acid level were randomly selected as control group. The biochemical indexes of serum liver function, renal function and blood lipid were measured in both groups. The results of the two groups were analyzed. Results The levels of UA, ALT, AST, γ-GGT, ALP, TP, ALB, TBIL, Cr, TG, TC, LDL-C, HCY and GLU in the observation group were higher than those in the control group, and the level of HDL-C was lower than that in the control group(P<0.05). In the observation group, the levels of UA, ALT, γ-GGT, TBIL, Cr, TG and HCY in males were higher than those in females(P<0.05). The level of UA in the observation group was positively correlated with levels of serum γ-GGT, ALT, AST, TG, Cr and HCY, but negatively correlated with the levels of HDL-C(P<0.05). Conclusion Compared with normal people, patients with asymptomatic hyperuricemia have different serum liver function, renal function and lipid metabolism, and the level of oxidative stress in patients to a certain extent can be reflected by serum γ-GGT activity.
引文
[1]邓安彦,蒋文军,邓小倩,等.无症状高尿酸血症患者的肝、肾功和血脂水平分析[J].成都医学院学报,2016,11(6):698-701.
[2]吴菱,狄亚珍,陈圆玲,等.住院儿童高尿酸血症发生率及与反映器官损害生化指标的关联性调查[J].中华风湿病学杂志,2014,18(9):632-636.
[3]刘灿,黄雨晴,余雪菊,等.高龄男性原发性高血压患者高尿酸血症患病率调查及相关因素分析[J].中华老年心脑血管病杂志,2016,18(3):251-253.
[4]赵冰,屈飞飞,崔慧景,等.北京高校教职工血尿酸水平调查及其与相关生化指标间关系的临床研究[J].中国临床保健杂志,2016,19(6):574-577.
[5]王琦,周峰,刘晓虹.疾病细节管理在社区高尿酸血症管理中的应用效果分析[J].中华全科医师杂志,2015,14(7):531-535.
[6]张彩香,林章梅,梁艳玲,等.高尿酸血症患者血清白介素-6和转化生长因子-β1水平及应用非布司他治疗前后的变化[J].中国糖尿病杂志,2016,24(3):250-253.
[7]陈文慧,丁国华,陈星华,等.别嘌醇对2型糖尿病肾脏疾病合并高尿酸血症患者白蛋白尿排泄的影响[J].临床肾脏病杂志,2017,17(3):143-147.
[8]张亚玲.1 645例体检人员高尿酸血症发生情况及其影响因素分析[J].中华实用诊断与治疗杂志,2016,30(9):933-934.
[9]欧淑萍,林萍华.高尿酸血症对老年糖尿病肾病早期患者肾功能的影响[J].中国慢性病预防与控制,2015,23(12):940-941.
[2]吴菱,狄亚珍,陈圆玲,等.住院儿童高尿酸血症发生率及与反映器官损害生化指标的关联性调查[J].中华风湿病学杂志,2014,18(9):632-636.
[3]刘灿,黄雨晴,余雪菊,等.高龄男性原发性高血压患者高尿酸血症患病率调查及相关因素分析[J].中华老年心脑血管病杂志,2016,18(3):251-253.
[4]赵冰,屈飞飞,崔慧景,等.北京高校教职工血尿酸水平调查及其与相关生化指标间关系的临床研究[J].中国临床保健杂志,2016,19(6):574-577.
[5]王琦,周峰,刘晓虹.疾病细节管理在社区高尿酸血症管理中的应用效果分析[J].中华全科医师杂志,2015,14(7):531-535.
[6]张彩香,林章梅,梁艳玲,等.高尿酸血症患者血清白介素-6和转化生长因子-β1水平及应用非布司他治疗前后的变化[J].中国糖尿病杂志,2016,24(3):250-253.
[7]陈文慧,丁国华,陈星华,等.别嘌醇对2型糖尿病肾脏疾病合并高尿酸血症患者白蛋白尿排泄的影响[J].临床肾脏病杂志,2017,17(3):143-147.
[8]张亚玲.1 645例体检人员高尿酸血症发生情况及其影响因素分析[J].中华实用诊断与治疗杂志,2016,30(9):933-934.
[9]欧淑萍,林萍华.高尿酸血症对老年糖尿病肾病早期患者肾功能的影响[J].中国慢性病预防与控制,2015,23(12):940-941.