功能性低聚糖及其缓解机体过敏反应的研究进展
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摘要
功能性低聚糖是一类有膳食纤维和双歧因子双重生理学特性的益生元,也是益生元的重要组成部分。本文概括了功能性低聚糖的分类和组成,重点阐述了功能性低聚糖的生理功能及其缓解机体过敏反应的研究进展,以期为进一步开发低聚糖益生元预防和治疗机体过敏反应药物提供参考。
Functional oligosaccharides are a type of prebiotics with dietary fiber and bifidus factor dual physiological characteristics,and are also important components of prebiotics. This review summarizes the species and composition of functional oligosaccharides,and focuses on physiological function and the research progress in alleviating allergic reactions of functional oligosaccharides,in order to provide reference for the development of prebiotics to prevent and treat allergic reaction medicines in body.
Functional oligosaccharides are a type of prebiotics with dietary fiber and bifidus factor dual physiological characteristics,and are also important components of prebiotics. This review summarizes the species and composition of functional oligosaccharides,and focuses on physiological function and the research progress in alleviating allergic reactions of functional oligosaccharides,in order to provide reference for the development of prebiotics to prevent and treat allergic reaction medicines in body.
引文
[1]SAVAGE J,JOHNS C B.Food allergy:epidemiology and natural history[J].Im m unology and Allergy Clinics of North Am erica,2015,35(1):45-59.
[2]KIM J H,JEUN E J,HONG C P,et al.Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through suppression of m ast cell suppression[J].Journal of Allergy and Clinical Im m unology,2016,137(2):507-516.e8.
[3]SUN P,LI D F,DONG B,et al.Vitamin C:an immunom odulator that attenuates anaphylactic reactions to soybean glycinin hypersensitivity in a sw ine m odel[J].Food Chemistry,2009,113(4):914-918.
[4]FANG S F,ZHANG Y,ZHANG Y,et al.Lactobacillus rhamnosus GG im proves sym ptom s and its m echnism in m ice w ith ovalbum in-induced food allergy[J].Chinese Journal of Cellular and Molecular Immunology,2017,33(5):597-600.
[5]孙鹏.大豆抗原蛋白Glycinin诱发仔猪过敏反应的机理及其缓解机制的研究[D].博士学位论文.北京:中国农业大学,2009.
[6]刘丹丹,赵元,张诗尧.大豆抗原蛋白对肠道致敏性的研究进展[J].中国畜牧杂志,2015,51(5):77-81.
[7]张建营,秦贵信,鲍男.发酵豆粕对反刍动物的影响研究[J].黑龙江畜牧兽医,2015(13):111-113.
[8]CHO Y S,LEE J,LEE T H,et al.α-Lipoic acid inhibits airw ay inflam m ation and hyperresponsiveness in a m ouse m odel of asthm a[J].Journal of Allergy and Clinical Im m unology,2004,114(2):429-435.
[9]WANG J L,PATIL S P,YANG N,et al.Safety,tolerability,and im m unologic effects of a food allergy herbal form ula in food allergic individuals:a randomized,double-blinded,placebo-controlled,dose escalation,phase 1 study[J].Annals of Allergy,Asthm a&Im m unology,2010,105(1):75-84.
[10]季晓梅,李艾黎,姚蕾,等.嗜酸乳杆菌缓解牛乳过敏的研究[J].中国食品学报,2016,16(7):33-38.
[11]GOURBEYRE P,DESBUARDS N,GREMY G,et al.Perinatal and postw eaning exposure to galactooligosaccharides/inulin prebiotics induced biom arkers linked to tolerance m echanism in a m ouse m odel of strong allergic sensitization[J].Journal of Agricultural and Food Chem istry,2013,61(26):6311-6320.
[12]ZHAO C,WU Y J,LIU X Y,et al.Functional properties,structural studies and chem o-enzym atic synthesis of oligosaccharides[J].Trends in Food Science&Technology,2017,66:135-145.
[13]单黎然,龚月桦,贾建光,等.4种重要功能性低聚糖的研究进展[J].西北农林科技大学(自然科学版),2006,34(7):96-100.
[14]魏红军.功能性低聚糖的生理功能及其在食品中的应用[J].农产品加工(学刊),2011(9):127-128.
[15]李鑫,张梁,羊梦诗,等.低聚壳聚糖几何结构和物理化学属性的理论研究[J].物理学报,2014,63(7):076102.
[16]ZHOU X L,KONG X F,LIAN G Q,et al.Dietary supplem entation w ith soybean oligosaccharides increases short-chain fatty acids but decreases protein-derived catabolites in the intestinal lum inal content of w eaned Huanjiang m ini-piglets[J].Nutrition Research,2014,34(9):780-788.
[17]SELIM K M,REDA R M.Beta-glucans and mannan oligosaccharides enhance grow th and im m unity in Nile Tilapia[J].North Am erican Journal of Aquaculture,2015,77(1):22-30.
[18]李涵.低聚糖在母猪繁殖和仔猪生产的应用[J].中国动物保健,2017,19(11):22-25.
[19]ATTIA Y A,AI-HAMID A E,ALLAKANY H F,et al.Supplem entation of non-nutritive feed additive during days 21-42 of age follow ing 3 w eeks of feeding aflatoxin to broiler chickens[J].Journal of Applied Anim al Research,2016,44(1):87-98.
[20]王乃强,李国庆,刘辉,等.低聚果糖促进钙离子吸收的研究[J].精细与专用化学品,2013,21(5):20-23.
[21]张丹凤.功能性低聚糖及其在乳制品中的应用[J].新疆畜牧业,2005(6):21-23.
[22]刘花兰,姜竹茂,刘云国,等.功能性低聚糖的制备、功能及应用研究进展[J].中国食品添加剂,2015(12):158-166.
[23]刘协,胡启之,李小宁,等.低聚果糖的润肠通便功能研究[J].江苏预防医学,2002,13(1):62-63.
[24]刘力,张欢,马文军,等.马齿苋水煎剂对溃疡性结肠炎小鼠结肠组织中IL-8、IL-10表达的影响[J].辽宁中医药大学学报,2011,13(5):18-20.
[25]CANANI R B,COATANZO M D.Gut microbiota as potential therapeutic target for the treatm ent of cow’s m ilk allergy[J].Nutrients,2013,5(3):651-662.
[26]GOURBEYRE P,DESBUARDS N,GREMY G,et al.Exposure to a galactooligosaccharides/inulin prebiotic m ix at different developm ental tim e points differentially m odulates im m une responses in m ice[J].Journal of Agricultural and Food Chem istry,2012,60(48):11942-11951.
[27]CUELLO-GARCIA C,FIOCCHI A,PAWANKAR R,et al.Prebiotics for the prevention of allergies:a system atic review and m eta-analysis of random ized controlled trials[J].Clinical and Experim ental Allergy,2017,47(11):1468-1477.
[28]MORO G,ARSLANOGLU S,STAHL B,et al.A m ixture of prebiotic oligosaccharides reduces the incidence of atopic derm atitis during the first six m onths of age[J].Archives of Disease in Childhood,2006,91(10):814-819.
[29]ARSLANOGLU S,MORO G E,SCHMITT J,et al.Early dietary intervention w ith a m ixture of prebiotic oligosaccharides reduces the incidence of allergic m anifestations and infections during the first tw o years of life[J].Journal of Nutrition,2008,138(6):1091-1095.
[30]时超岚,曾润颖,曹敏杰,等.龙须菜寡糖分离纯化和抗食物过敏功效的研究[J].集美大学学报(自然科学版),2015,20(1):14-22.
[31]李玉欣.毕赤酵母甘露寡糖对猪生产性能和免疫性能的影响[D].博士学位论文.北京:中国农业大学,2015.
[32]CHE T M.Effects of mannan oligosaccharide on imm une function and disease resistance in pigs[D].Ph.D.Thesis.Cham paign:University of Illinois at Urbana,2010.
[33]丁鹏,胡贵丽,刘勇强,等.酵母甘露寡糖对猪鸡生产性能和免疫功能的影响[J].湖南饲料,2017(5):24-30.
[34]SHINOBU F,KOZO U,TARO K,et al.Increased num ber of CCR4-positive cells in the duodenum of ovalbum in-induced food allergy m odel Nc/jic m ice and antiallergic activity of fructooligosaccharides[J].Allergology International,2007,56(2):131-138.
[35]VONK M M,DIKS M A P,WAGENAAR L,et al.Im proved efficacy of oral im m unotherapy using nondigestible oligosaccharides in a m urine cow’s m ilk allergy m odel:a potential role for foxp3+regulatory t cells[J].Frontiers in Im m unology,2017,8:1230.
[36]DE KIVIT S,SAELAND E,KRANEVELD A D,et al.Galectin-9 induced by dietary synbiotics is involved in suppression of allergic sym ptom s in m ice and hum ans[J].Allergy,2012,67(3),343-352.
[37]赵海君,钱易,崔毓桂,等.紧密连接的结构与功能[J].国际生殖健康/计划生育杂志,2013,32(5):384-386.
[38]FORBES E E,GROSCHWITZ K,ABONIA J P,et al.IL-9 and m ast cell-m ediated intestinal perm eability predisposes to oral antigen hypersensitivity[J].Journal of Experim ental M edicine,2008,205(4):897-913.
[39]AWAD W A,GHAREEB K,ABDEL-RAHEEM S,et al.Effects of dietary inclusion of probiotic and synbiotic on grow th perform ance,organ w eights,and intestinal histom orphology of broiler chickens[J].Poultry Science,2009,88(1):49-56.
[40]ALIZADEH A,AKBARI P,DIFILIPPO E,et al.The piglet as a m odel for studying dietary com ponents in infant diets:effects of galacto-oligosaccharides on intestinal functions[J].British Journal of Nutrition,2016,115(4):605-618.
[41]谢婷.益生元对CRS大鼠肠上皮紧密连接及屏障功能的影响[D].硕士学位论文.上海:第二军医大学,2007.
[42]WATANABE J,SASAJIMA N,ARAMAKIA A,et al.Consum ption of fructo-oligosaccharide reduces 2,4-dinitrofluorobenzene-induced contact hypersensitivity in m ice[J].British Journal of Nutrition,2008,100(2):339-346.
[43]TANNER S A,LACROIX C,DEL’HOMME C,et al.Effect of Bifidobacterium thermophilum RBL67 and fructo-oligosaccharides on the gut m icrobiota in G9ttingen m inipigs[J].British Journal of Nutrition,2015,114(5):746-755.
[44]JUNG S J,HOUDE R,BAURHOO B,et al.Effects of galacto-oligosaccharides and a Bifidobacteria lactisbased probiotic strain on the grow th perform ance and fecal m icroflora of broiler chickens[J].Poultry Science,2008,87(9):1694-1699.
[45]GOURBEYRE P,DENERY S,BODINIER M.Probiotics,prebiotics,and synbiotics:im pact on the gut imm une system and allergic reactions[J].Journal of Leukocyte Biology,2011,89(5):685-695.
[46]TEDELIND S,WESTBERG T,KJERRULF M,et al.Anti-inflam m atory properties of the short-chain fatty acids acetate and propionate:a study w ith relevance to inflam m atory bow el disease[J].World Journal of Gastroenterology,2007,13(20):2826-2832.
[47]LIU H,ZHANG J,ZHAGN S H,et al.Oral administration of Lactobacillus fermentum I5007 favors intestinal developm ent and alters the intestinal m icrobiota in form ula-fed piglets[J].Journal of Agricultural and Food Chem istry,2014,62(4):860-866.
[48]SUN M M,WU W,LIU Z J,et al.Microbiota metabolite short chain fatty acids,GPCR,and inflam m atory bow el diseases[J].Journal of Gastroenterology,2017,52(1):1-8.
[49]林日添,吴维,刘占举.短链脂肪酸对肠黏膜稳态免疫调节作用的研究进展[J].免疫学杂志,2017,33(10):900-904.
[50]CAVAGLIERI C R,NISHIYAMA A,FERNANDES L C,et al.Differential effects of short-chain fatty acids on proliferation and production of pro-and anti-inflam m atory cytokines by cultured lym phocytes[J].Life Sciences,2003,73(13):1683-1690.
[51]WOPEREIS H,SIM K,SHAW A,et al.Intestinal microbiota in infants at high risk for allergy:effects of prebiotics and role in eczem a developm ent[J].Journal of Allergy and Clinical Im m unology,2017,doi:10.1016/j.jaci.2017.05.054.
[2]KIM J H,JEUN E J,HONG C P,et al.Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through suppression of m ast cell suppression[J].Journal of Allergy and Clinical Im m unology,2016,137(2):507-516.e8.
[3]SUN P,LI D F,DONG B,et al.Vitamin C:an immunom odulator that attenuates anaphylactic reactions to soybean glycinin hypersensitivity in a sw ine m odel[J].Food Chemistry,2009,113(4):914-918.
[4]FANG S F,ZHANG Y,ZHANG Y,et al.Lactobacillus rhamnosus GG im proves sym ptom s and its m echnism in m ice w ith ovalbum in-induced food allergy[J].Chinese Journal of Cellular and Molecular Immunology,2017,33(5):597-600.
[5]孙鹏.大豆抗原蛋白Glycinin诱发仔猪过敏反应的机理及其缓解机制的研究[D].博士学位论文.北京:中国农业大学,2009.
[6]刘丹丹,赵元,张诗尧.大豆抗原蛋白对肠道致敏性的研究进展[J].中国畜牧杂志,2015,51(5):77-81.
[7]张建营,秦贵信,鲍男.发酵豆粕对反刍动物的影响研究[J].黑龙江畜牧兽医,2015(13):111-113.
[8]CHO Y S,LEE J,LEE T H,et al.α-Lipoic acid inhibits airw ay inflam m ation and hyperresponsiveness in a m ouse m odel of asthm a[J].Journal of Allergy and Clinical Im m unology,2004,114(2):429-435.
[9]WANG J L,PATIL S P,YANG N,et al.Safety,tolerability,and im m unologic effects of a food allergy herbal form ula in food allergic individuals:a randomized,double-blinded,placebo-controlled,dose escalation,phase 1 study[J].Annals of Allergy,Asthm a&Im m unology,2010,105(1):75-84.
[10]季晓梅,李艾黎,姚蕾,等.嗜酸乳杆菌缓解牛乳过敏的研究[J].中国食品学报,2016,16(7):33-38.
[11]GOURBEYRE P,DESBUARDS N,GREMY G,et al.Perinatal and postw eaning exposure to galactooligosaccharides/inulin prebiotics induced biom arkers linked to tolerance m echanism in a m ouse m odel of strong allergic sensitization[J].Journal of Agricultural and Food Chem istry,2013,61(26):6311-6320.
[12]ZHAO C,WU Y J,LIU X Y,et al.Functional properties,structural studies and chem o-enzym atic synthesis of oligosaccharides[J].Trends in Food Science&Technology,2017,66:135-145.
[13]单黎然,龚月桦,贾建光,等.4种重要功能性低聚糖的研究进展[J].西北农林科技大学(自然科学版),2006,34(7):96-100.
[14]魏红军.功能性低聚糖的生理功能及其在食品中的应用[J].农产品加工(学刊),2011(9):127-128.
[15]李鑫,张梁,羊梦诗,等.低聚壳聚糖几何结构和物理化学属性的理论研究[J].物理学报,2014,63(7):076102.
[16]ZHOU X L,KONG X F,LIAN G Q,et al.Dietary supplem entation w ith soybean oligosaccharides increases short-chain fatty acids but decreases protein-derived catabolites in the intestinal lum inal content of w eaned Huanjiang m ini-piglets[J].Nutrition Research,2014,34(9):780-788.
[17]SELIM K M,REDA R M.Beta-glucans and mannan oligosaccharides enhance grow th and im m unity in Nile Tilapia[J].North Am erican Journal of Aquaculture,2015,77(1):22-30.
[18]李涵.低聚糖在母猪繁殖和仔猪生产的应用[J].中国动物保健,2017,19(11):22-25.
[19]ATTIA Y A,AI-HAMID A E,ALLAKANY H F,et al.Supplem entation of non-nutritive feed additive during days 21-42 of age follow ing 3 w eeks of feeding aflatoxin to broiler chickens[J].Journal of Applied Anim al Research,2016,44(1):87-98.
[20]王乃强,李国庆,刘辉,等.低聚果糖促进钙离子吸收的研究[J].精细与专用化学品,2013,21(5):20-23.
[21]张丹凤.功能性低聚糖及其在乳制品中的应用[J].新疆畜牧业,2005(6):21-23.
[22]刘花兰,姜竹茂,刘云国,等.功能性低聚糖的制备、功能及应用研究进展[J].中国食品添加剂,2015(12):158-166.
[23]刘协,胡启之,李小宁,等.低聚果糖的润肠通便功能研究[J].江苏预防医学,2002,13(1):62-63.
[24]刘力,张欢,马文军,等.马齿苋水煎剂对溃疡性结肠炎小鼠结肠组织中IL-8、IL-10表达的影响[J].辽宁中医药大学学报,2011,13(5):18-20.
[25]CANANI R B,COATANZO M D.Gut microbiota as potential therapeutic target for the treatm ent of cow’s m ilk allergy[J].Nutrients,2013,5(3):651-662.
[26]GOURBEYRE P,DESBUARDS N,GREMY G,et al.Exposure to a galactooligosaccharides/inulin prebiotic m ix at different developm ental tim e points differentially m odulates im m une responses in m ice[J].Journal of Agricultural and Food Chem istry,2012,60(48):11942-11951.
[27]CUELLO-GARCIA C,FIOCCHI A,PAWANKAR R,et al.Prebiotics for the prevention of allergies:a system atic review and m eta-analysis of random ized controlled trials[J].Clinical and Experim ental Allergy,2017,47(11):1468-1477.
[28]MORO G,ARSLANOGLU S,STAHL B,et al.A m ixture of prebiotic oligosaccharides reduces the incidence of atopic derm atitis during the first six m onths of age[J].Archives of Disease in Childhood,2006,91(10):814-819.
[29]ARSLANOGLU S,MORO G E,SCHMITT J,et al.Early dietary intervention w ith a m ixture of prebiotic oligosaccharides reduces the incidence of allergic m anifestations and infections during the first tw o years of life[J].Journal of Nutrition,2008,138(6):1091-1095.
[30]时超岚,曾润颖,曹敏杰,等.龙须菜寡糖分离纯化和抗食物过敏功效的研究[J].集美大学学报(自然科学版),2015,20(1):14-22.
[31]李玉欣.毕赤酵母甘露寡糖对猪生产性能和免疫性能的影响[D].博士学位论文.北京:中国农业大学,2015.
[32]CHE T M.Effects of mannan oligosaccharide on imm une function and disease resistance in pigs[D].Ph.D.Thesis.Cham paign:University of Illinois at Urbana,2010.
[33]丁鹏,胡贵丽,刘勇强,等.酵母甘露寡糖对猪鸡生产性能和免疫功能的影响[J].湖南饲料,2017(5):24-30.
[34]SHINOBU F,KOZO U,TARO K,et al.Increased num ber of CCR4-positive cells in the duodenum of ovalbum in-induced food allergy m odel Nc/jic m ice and antiallergic activity of fructooligosaccharides[J].Allergology International,2007,56(2):131-138.
[35]VONK M M,DIKS M A P,WAGENAAR L,et al.Im proved efficacy of oral im m unotherapy using nondigestible oligosaccharides in a m urine cow’s m ilk allergy m odel:a potential role for foxp3+regulatory t cells[J].Frontiers in Im m unology,2017,8:1230.
[36]DE KIVIT S,SAELAND E,KRANEVELD A D,et al.Galectin-9 induced by dietary synbiotics is involved in suppression of allergic sym ptom s in m ice and hum ans[J].Allergy,2012,67(3),343-352.
[37]赵海君,钱易,崔毓桂,等.紧密连接的结构与功能[J].国际生殖健康/计划生育杂志,2013,32(5):384-386.
[38]FORBES E E,GROSCHWITZ K,ABONIA J P,et al.IL-9 and m ast cell-m ediated intestinal perm eability predisposes to oral antigen hypersensitivity[J].Journal of Experim ental M edicine,2008,205(4):897-913.
[39]AWAD W A,GHAREEB K,ABDEL-RAHEEM S,et al.Effects of dietary inclusion of probiotic and synbiotic on grow th perform ance,organ w eights,and intestinal histom orphology of broiler chickens[J].Poultry Science,2009,88(1):49-56.
[40]ALIZADEH A,AKBARI P,DIFILIPPO E,et al.The piglet as a m odel for studying dietary com ponents in infant diets:effects of galacto-oligosaccharides on intestinal functions[J].British Journal of Nutrition,2016,115(4):605-618.
[41]谢婷.益生元对CRS大鼠肠上皮紧密连接及屏障功能的影响[D].硕士学位论文.上海:第二军医大学,2007.
[42]WATANABE J,SASAJIMA N,ARAMAKIA A,et al.Consum ption of fructo-oligosaccharide reduces 2,4-dinitrofluorobenzene-induced contact hypersensitivity in m ice[J].British Journal of Nutrition,2008,100(2):339-346.
[43]TANNER S A,LACROIX C,DEL’HOMME C,et al.Effect of Bifidobacterium thermophilum RBL67 and fructo-oligosaccharides on the gut m icrobiota in G9ttingen m inipigs[J].British Journal of Nutrition,2015,114(5):746-755.
[44]JUNG S J,HOUDE R,BAURHOO B,et al.Effects of galacto-oligosaccharides and a Bifidobacteria lactisbased probiotic strain on the grow th perform ance and fecal m icroflora of broiler chickens[J].Poultry Science,2008,87(9):1694-1699.
[45]GOURBEYRE P,DENERY S,BODINIER M.Probiotics,prebiotics,and synbiotics:im pact on the gut imm une system and allergic reactions[J].Journal of Leukocyte Biology,2011,89(5):685-695.
[46]TEDELIND S,WESTBERG T,KJERRULF M,et al.Anti-inflam m atory properties of the short-chain fatty acids acetate and propionate:a study w ith relevance to inflam m atory bow el disease[J].World Journal of Gastroenterology,2007,13(20):2826-2832.
[47]LIU H,ZHANG J,ZHAGN S H,et al.Oral administration of Lactobacillus fermentum I5007 favors intestinal developm ent and alters the intestinal m icrobiota in form ula-fed piglets[J].Journal of Agricultural and Food Chem istry,2014,62(4):860-866.
[48]SUN M M,WU W,LIU Z J,et al.Microbiota metabolite short chain fatty acids,GPCR,and inflam m atory bow el diseases[J].Journal of Gastroenterology,2017,52(1):1-8.
[49]林日添,吴维,刘占举.短链脂肪酸对肠黏膜稳态免疫调节作用的研究进展[J].免疫学杂志,2017,33(10):900-904.
[50]CAVAGLIERI C R,NISHIYAMA A,FERNANDES L C,et al.Differential effects of short-chain fatty acids on proliferation and production of pro-and anti-inflam m atory cytokines by cultured lym phocytes[J].Life Sciences,2003,73(13):1683-1690.
[51]WOPEREIS H,SIM K,SHAW A,et al.Intestinal microbiota in infants at high risk for allergy:effects of prebiotics and role in eczem a developm ent[J].Journal of Allergy and Clinical Im m unology,2017,doi:10.1016/j.jaci.2017.05.054.