锌铁钙复合制剂佐治婴幼儿佝偻病的临床效果观察
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摘要
目的探讨观察锌铁钙复合制剂佐治婴幼儿佝偻病的临床效果。方法将2017年5月～2018年5月在我院儿保科治疗的120例婴幼儿佝偻病患儿随机分为两组,对照组采用常规维生素D和钙剂治疗,观察组使用维生素D和锌铁钙复合制剂治疗,比较两组患儿的临床疗效、血生化指标变化、骨密度变化、临床症状变化。结果观察组治疗有效率为95.00%,明显高于对照组的78.33%(P<0.05);观察组治疗后Ca、P、Zn、NBAP、25-(OH)D3水平明显高于对照组(P<0.05);观察组治疗后桡骨、尺骨的骨密度明显高于对照组(P<0.05);观察组治疗后多汗、夜惊、厌食等症状发生率明显低于对照组(P<0.05)。结论锌铁钙复合制剂佐治婴幼儿佝偻病的临床效果显著,能有效提升血中微量元素水平,提高骨密度,改善临床症状,具有积极的临床意义。
Objective To investigate the clinical effect of zinc-iron-calcium composite preparation in treating infantile rickets. Methods A total of 120 infants with rickets treated in the department of children's health care in our hospital from May 2017 to May 2018 were randomly divided into two groups. The control group was treated with conventional vitamin D and calcium, and the observation group was treated with vitamin D and zinc-iron-calcium composite preparations. The clinical efficacy, blood biochemical changes, bone density changes, and clinical symptoms were compared between the two groups. Results The effective rate of the observation group was 95.00%, which was significantly higher than that of the control group(78.33%), P<0.05. The levels of Ca, P, Zn, NBAP and 25-(OH)D3 in the observation group were significantly higher than those in the control group after treatment(P<0.05). The bone mineral density of the tibia and ulna was significantly higher in the observation group than that in the control group(P<0.05). The incidence of hyperhidrosis, night terror, anorexia and other symptoms in the observation group was significantly lower than that in the control group after treatment(P<0.05). Conclusion The zinc-iron-calcium composite preparation in treating infantile rickets has significant clinical effect, which can effectively improve the levels of trace elements in blood, increase bone density and improve clinical symptoms. It has positive clinical significance.
Objective To investigate the clinical effect of zinc-iron-calcium composite preparation in treating infantile rickets. Methods A total of 120 infants with rickets treated in the department of children's health care in our hospital from May 2017 to May 2018 were randomly divided into two groups. The control group was treated with conventional vitamin D and calcium, and the observation group was treated with vitamin D and zinc-iron-calcium composite preparations. The clinical efficacy, blood biochemical changes, bone density changes, and clinical symptoms were compared between the two groups. Results The effective rate of the observation group was 95.00%, which was significantly higher than that of the control group(78.33%), P<0.05. The levels of Ca, P, Zn, NBAP and 25-(OH)D3 in the observation group were significantly higher than those in the control group after treatment(P<0.05). The bone mineral density of the tibia and ulna was significantly higher in the observation group than that in the control group(P<0.05). The incidence of hyperhidrosis, night terror, anorexia and other symptoms in the observation group was significantly lower than that in the control group after treatment(P<0.05). Conclusion The zinc-iron-calcium composite preparation in treating infantile rickets has significant clinical effect, which can effectively improve the levels of trace elements in blood, increase bone density and improve clinical symptoms. It has positive clinical significance.
引文
[1]林晓燕,韩粉香,刘梅美.钙铁锌复合制剂佐治婴幼儿佝偻病临床效果观察[J].海南医学,2016,27(2):308-310.
[2]王丹.锌铁制剂佐治婴幼儿维生素D缺乏性佝偻病的疗效分析[J].中国医药科学,2012,2(5):86.
[3]胡亚美,江载芳.诸福棠实用儿科学[M].第8版,北京:人民卫生出版社,2007:536-542
[4]游诚,钟燕,赵莎,等.大剂量口服维生素D3治疗婴幼儿维生素D缺乏性佝偻病的临床疗效观察[J].中国医师杂志,2015,17(7):1088-1091.
[5]钟巧明.锌铁制剂及高铅干预治疗对婴幼儿佝偻病的防治效果[J].深圳中西医结合杂志,2018,28(1):84-85
[6]居星耀,盛红斌,沈健.锌、维生素D、钙联用对婴幼儿佝偻病疗效及对生化指标和骨密度的影响[J].儿科药学杂志,2015,21(5):21-24.
[7]林晓燕,张龙,曾璐.维生素D3、钙、锌联合应用对婴幼儿佝偻病疗效研究[J].海南医学院学报,2016,22(12):1286-1288.
[8]张佳佳,罗兰,陈继莉,等.维生素D联合锌铁钙复合制剂治疗佝偻病患儿疗效观察[J].实用临床医药杂志,2017,21(17):197-199.
[9]郭敬民,欧萍,邱君,等.锌钙维生素D3联用对佝偻病疗效及血微量元素影响的临床研究[J].现代预防医学,2013,40(15):2799-2801.
[10]余晓虹,谢炳林.锌剂、维生素D、钙剂三联疗法治疗婴幼儿佝偻病疗效及对血微量元素的影响研究[J].中国现代药物应用,2016,10(1):131-133.
[11]刘婧.试析锌、维生素D联合钙治疗婴幼儿佝偻病的临床疗效及生化指标的变化情况[J].当代医学,2018,24(3):35-37.
[12]杨晓庶.锌、维生素D、钙联用治疗婴幼儿佝偻病36例临床分析[J].实用医院临床杂志,2007,4(4):87-88.
[13]梁惠怡.大剂量维生素D3联合铁锌钙剂治疗婴幼儿佝偻病临床疗效观察[J].现代诊断与治疗,2015,26(7):1519-1520.
[14]王旭,刘小芳.锌、维生素D联合钙治疗婴幼儿佝偻病的临床疗效及生化指标变化情况分析[J].临床医学,2016,36(9):8-10.
[15]李冬梅.观察小儿四维葡钙颗粒联合维生素D治疗维生素D缺乏性佝偻病的临床疗效[J].中外女性健康研究,2015(16):178,204.
[2]王丹.锌铁制剂佐治婴幼儿维生素D缺乏性佝偻病的疗效分析[J].中国医药科学,2012,2(5):86.
[3]胡亚美,江载芳.诸福棠实用儿科学[M].第8版,北京:人民卫生出版社,2007:536-542
[4]游诚,钟燕,赵莎,等.大剂量口服维生素D3治疗婴幼儿维生素D缺乏性佝偻病的临床疗效观察[J].中国医师杂志,2015,17(7):1088-1091.
[5]钟巧明.锌铁制剂及高铅干预治疗对婴幼儿佝偻病的防治效果[J].深圳中西医结合杂志,2018,28(1):84-85
[6]居星耀,盛红斌,沈健.锌、维生素D、钙联用对婴幼儿佝偻病疗效及对生化指标和骨密度的影响[J].儿科药学杂志,2015,21(5):21-24.
[7]林晓燕,张龙,曾璐.维生素D3、钙、锌联合应用对婴幼儿佝偻病疗效研究[J].海南医学院学报,2016,22(12):1286-1288.
[8]张佳佳,罗兰,陈继莉,等.维生素D联合锌铁钙复合制剂治疗佝偻病患儿疗效观察[J].实用临床医药杂志,2017,21(17):197-199.
[9]郭敬民,欧萍,邱君,等.锌钙维生素D3联用对佝偻病疗效及血微量元素影响的临床研究[J].现代预防医学,2013,40(15):2799-2801.
[10]余晓虹,谢炳林.锌剂、维生素D、钙剂三联疗法治疗婴幼儿佝偻病疗效及对血微量元素的影响研究[J].中国现代药物应用,2016,10(1):131-133.
[11]刘婧.试析锌、维生素D联合钙治疗婴幼儿佝偻病的临床疗效及生化指标的变化情况[J].当代医学,2018,24(3):35-37.
[12]杨晓庶.锌、维生素D、钙联用治疗婴幼儿佝偻病36例临床分析[J].实用医院临床杂志,2007,4(4):87-88.
[13]梁惠怡.大剂量维生素D3联合铁锌钙剂治疗婴幼儿佝偻病临床疗效观察[J].现代诊断与治疗,2015,26(7):1519-1520.
[14]王旭,刘小芳.锌、维生素D联合钙治疗婴幼儿佝偻病的临床疗效及生化指标变化情况分析[J].临床医学,2016,36(9):8-10.
[15]李冬梅.观察小儿四维葡钙颗粒联合维生素D治疗维生素D缺乏性佝偻病的临床疗效[J].中外女性健康研究,2015(16):178,204.