环磷酸鸟苷-腺苷酸合成酶-干扰素基因刺激蛋白信号通路与细胞自噬和凋亡及慢性阻塞性肺疾病的相关性研究
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摘要
细胞自噬和凋亡与肺纤维化、肺动脉高压、肺癌、慢性阻塞性肺疾病(COPD)等疾病密切相关。肺上皮细胞中Ⅰ型干扰素(IFN)的高表达可能是引起细胞自噬和凋亡从而导致COPD发生发展的重要因素。本文就环磷酸鸟苷-腺苷酸合成酶-干扰素基因刺激蛋白信号通路调控Ⅰ型IFN的表达并诱导细胞自噬和凋亡及其与COPD的关系进行综述。
引文
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[26]黄高渊,徐永健,刘先胜,等.吸烟伴COPD患者肺组织中凋亡相关蛋白Bax与Bcl-2的表达[J].华中科技大学学报:医学版,2010,39(6):762-765.
[2]Cai X,Chiu YH,Chen ZJ.The c GAS-c GAMP-STING pathway of cytosolic DNA sensing and signaling[J].Mol Cell,2014,54(2):289-296.
[3]Ishikawa H,Ma Z,Barber GN.STING regulates intracellular DNA-mediated,type I interferon-dependent innate immunity[J].Nature,2009,461(7 265):788-792.
[4]Burdette DL,Monroe KM,Sotelo-Troha K,et al.STING is a direct innate immune sensor of cyclic di-GMP[J].Nature,2011,478(7 370):515-518.
[5]Sun LJ,Wu JX,Du FH,et al.Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway[J].Science,2013,339(6 121):786-791.
[6]Wu J,Sun L,Chen X,et al.Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA[J].Science,2013,339(6 121):826-830.
[7]Zhang X,Shi HP,Wu JX,et al.Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING[J].Mol Cell,2013,51(2):226-235.
[8]Liang Q,Seo GJ,Choi YJ,et al.Crosstalk between c GAS DNA sensor and Beclin-1 autophagy protein shapes innate anti-microbial immune responses[J].Cell Host Microbe,2014,15(2):228-238.
[9]Seo GJ,Yang A,Tan B,et al.Akt kinase-mediated checkpoint of c GAS DNA sensing pathway[J].Cell Rep,2015,13(2):440-449.
[10]Ablasser A,Goldeck M,Cavlar T,et al.c GAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING[J].Nature,2013,498(7 454):380-384.
[11]Li XD,Wu J,Gao D,et al.Pivotal roles of c GAS-c GAMP signaling in antiviral defense and immune adjuvant effects[J].Science,2013,341(6152):1 390-1 394.
[12]Hu MM,Yang Q,Xie XQ,et al.Sumoylation promotes the stability of the DNA sensor c GAS and the adaptor STING to regulate the kinetics of response to DNA virus[J].Immunity,2016,45(3):555-569.
[13]Kaur S,Sassano A,Dolniak B,et al.Role of the Akt pathway in mRNA translation of interferon-stimulated genes[J].Proc Natl Acad Sci U S A,2008,105(12):4 808-4 813.
[14]Gui YS,Wang LM,Tian XL,et al.m TOR overactivation and compromised autophagy in the pathogenesis of pulmonary fibrosis[J].PLo S One,2015,10(9):e0138625.
[15]Chitra P,Saiprasad G,Manikandan RA.Berberine inhibits Smad and non-Smad signaling cascades and enhances autophagy against pulmonary fibrosis[J].J Mol Med(Berl),2015,93(9):1 015-1 031.
[16]Schmeisser H,Bekisz J,Zoon KC.New function of typeⅠIFN:induction of autophagy[J].J Interferon Cytokine Res,2014,34(2):71-78.
[17]Lee HK,Lund JM,Ramanathan BA,et al.Autophagy-dependent viral recognition by plasmacytoid dendritic cells[J].Science,2007,315(5 817):1 398-1 401.
[18]Zhou D,Kang KH,Spector SA.Production of interferonαby human immunodeficiency virus type 1 in human plasmacytoid dendritic cells is dependent on induction of autophagy[J].J Infect Dis,2012,205(8):1 258-1 267.
[19]Rasmussen SB,Horan KA,Holm CK,et al.Activation of autophagy by alpha-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes[J].J Immunol,2011,187(10):5 268-5 276.
[20]Liu C,Yue R,Yang Y,et al.AIM2 inhibits autophagy and IFN-βproduction during M.bovis infection[J].Oncotarget,2016,7(30):46 972-46 987.
[21]Mizushima N,Komatsu M.Autophagy:renovation of cells and tissues[J].Cell,2011,147(4):728-741.
[22]Fischer BM,Pavlisko E,Voynow JA.Pathogenic triad in COPD:oxidative stress,protease-antiprotease imbalance,and inflammation[J].Int J Chron Obstruct Pulmon Dis,2011,6(1):413-421.
[23]Chen ZH,Kim HP,Sciurba FC,et al.Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease[J].PLo S One,2008,3(10):e3316.
[24]於海洋,李妍,韩锋锋,等.慢性阻塞性肺疾病大鼠肺组织自噬相关蛋白的变化[J].中国呼吸与危重监护杂志,2016,15(5):470-476.
[25]Park JW,Ryter SW,Choi AM.Functional significance of apoptosis in chronic obstructive pulmonary disease[J].COPD,2007,4(4):347-353.
[26]黄高渊,徐永健,刘先胜,等.吸烟伴COPD患者肺组织中凋亡相关蛋白Bax与Bcl-2的表达[J].华中科技大学学报:医学版,2010,39(6):762-765.