干扰素基因刺激蛋白信号通路与感染性及自身免疫性疾病的相关性研究进展
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摘要
环鸟苷酸-腺苷酸合成酶(cGAS)是近年新发现的一种细胞内DNA感受器,能催化合成环鸟苷酸-腺苷酸激活干扰素基因刺激蛋白(STING),进而引起一系列下游分子激活,最终诱导产生Ⅰ型干扰素(IFN)。越来越多的研究证明cGAS-STING信号通路在固有免疫过程中发挥重要作用。cGAS-STING信号通路参与识别进入胞内微生物的DNA及自身DNA,并在感染性疾病和自身免疫性疾病发病过程中发挥重要作用。本文就对cGAS-STING信号通路与感染性及自身免疫性疾病的相关性研究进展进行综述。
引文
[1]Kato K,Omura H,Ishitani R,et al.Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA[J].Annu Rev Biochem,2017,86(1):541-566.
[2]Schoggins JW,Wilson SJ,Panis M,et al.A diverse range of gene products are effectors of the type I interferon antiviral response[J].Nature,2011,472(7 344):481-485.
[3]Kranzusch PJ,Lee AS,Berger JM,et al.Structure of human c GAS reveals a conserved family of second-messenger enzymes in innate immunity[J].Cell Rep,2013,3(5):1 362-1 368.
[4]Diner EJ,Burdette DL,Wilson SC,et al.The innate immune DNA sensor c GAS produces a noncanonical cyclic dinucleotide that activates human STING[J].Cell Rep,2013,3(5):1 355-1 361.
[5]Broz P,Monack DM.Newly described pattern recognition receptors team up against intracellular pathogens[J].Nat Rev Immunol,2013,13(8):551-565.
[6]Tanaka Y,Chen ZJ.STING specifies IRF3 phosphorylation by TBK1 in the cytosollic DNA signaling pathway[J].Sci signal,2012,5(214):ra20.
[7]Ishikawa H,Barber GN.STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling[J].Nature,2008,455(7 213):674-678.
[8]Konno H,Konno K,Barber GN.Cyclic dinucleotides trigger ULK1(ATG1)phosphorylation of STING to prevent sustained innate immune signaling[J].Cell,2013,155(3):688-698.
[9]Liang QM,Seo GJ,Choi YJ,et al.Crosstalk between the c GAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses[J].Cell Host Microbe,2014,15(2):228-238.
[10]Goubau D,Deddouche S,Reise Sousa C.Cytosolic sensing of viruses[J].Immunity,2013,38(5):855-869.
[11]Gao DX,Li T,Li XD,et al.Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases[J].Proc Natl Acad Sci U S A,2015,112(42):E5 699-E5 705.
[12]Hasan M,Koch J,Rakheja D,et al.Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes[J].Nat Immunol,2013,14(1):61-71.
[13]Kawane K,Ohtani M,Miwa K,et al.Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages[J].Nature,2006,443(7 114):998-1 002.
[14]Manel N,Hogstad B,Wang YM,et al.A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells[J].Nature,2010,467(7 312):214-217.
[15]Gao D,Wu J,Wu YT,et al.Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses[J].Science,2013,341(6 148):903-906.
[16]Nissen SK,Hojen JF,Andersen K,et al.Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates with chronic immune activation[J].Clin Exp Immunol,2014,177(1):295-309.
[17]Laguette N,Sobhian B,Casartelli N,et al.SAMHD1 is the dendritic-and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx[J].Nature,2011,474(7 353):654-657.
[18]Maelfait J,Bridgeman A,Benlahrech A,et al.Restriction by SAMHD1 limits c GAS/STING-dependent innate and adaptive immune responses to HIV-1[J].Cell Rep,2016,16(6):1 492-1 501.
[19]Yoh SM,Schneider M,Seifried JA,et al.PQBP1 is a proximal sensor of the c GAS-dependent innate response to HIV-1[J].Cell,2015,161(6):1 293-1 305.
[20]Vermeire J,Roesch F,Sauter D,et al.HIV triggers a c GASdependent,Vpu-and Vpr-regulated typeⅠinterferon response in CD4+T cells[J].Cell Rep,17(2):413-424.
[21]Sun LJ,Wu JX,Du FH,et al.Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the typeⅠinterferon pathway[J].Science,2013,339(6 121):786-791.
[22]Orzalli MH,Broekema NM,Diner BA,et al.c GAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection[J].Proc Natl Acad Sci U S A,2015,112(14):E1 773-E1 781.
[23]Li XD,Wu J,Gao D,et al.Pivotal roles of c GAS-c GAMP signaling in antiviral defense and immune adjuvant effects[J].Science,2013,341(6 152):1 390-1 394.
[24]Zhou Q,Lin H,Wang SY,et al.The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered,MITA/STING-dependent innate immune signaling[J].Cell Host Microbe,2014,16(4):450-461.
[25]Collins AC,Cai H,Li T,et al.Cyclic GMP-AMP synthase is an innate immune DNA sensor for mycobacterium tuberculosis[J].Cell Host Microbe,2015,17(6):820-828.
[26]Wu JJ,Li WW,Shao YM,et al.Inhibition of c GAS DNA sensing by a herpesvirus virion protein[J].Cell Host Microbe,2015,18(3):333-344.
[27]Liu Y,Jesus AA,Marrero B,et al.Activated STING in a vascular and pulmonary syndrome[J].N Engl J Med,2014,371(6):507-518.
[28]Sharma S,Campbell AM,Chan J,et al.Supression of systemic autoimmunity by the systemtic autoimmunity by the innate immunity adaptor STING[J].Proc Natl Acad Sci U S A,2015,112(7):E 710-717.
[29]Crow YJ,Hayward BE,Parmar R,et al.Mutations in the gene encoding the 3'-5'DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus[J].Nat Genet,2006,38(8):917-920.
[30]Yang H,Wang HZ,Ren JY,et al.c GAS is essential for cellular senescence[J].Proc Natl Acad Sci U S A,2017,114(23):E4 612-E4 620.
[31]Wang H,Hu SQ,Chen X,et al.c GAS is essential for the antitumor effect of immune checkpoint blockade[J].Proc Natl Acad Sci U S A,2017,114(7):1 637-1 642.
[2]Schoggins JW,Wilson SJ,Panis M,et al.A diverse range of gene products are effectors of the type I interferon antiviral response[J].Nature,2011,472(7 344):481-485.
[3]Kranzusch PJ,Lee AS,Berger JM,et al.Structure of human c GAS reveals a conserved family of second-messenger enzymes in innate immunity[J].Cell Rep,2013,3(5):1 362-1 368.
[4]Diner EJ,Burdette DL,Wilson SC,et al.The innate immune DNA sensor c GAS produces a noncanonical cyclic dinucleotide that activates human STING[J].Cell Rep,2013,3(5):1 355-1 361.
[5]Broz P,Monack DM.Newly described pattern recognition receptors team up against intracellular pathogens[J].Nat Rev Immunol,2013,13(8):551-565.
[6]Tanaka Y,Chen ZJ.STING specifies IRF3 phosphorylation by TBK1 in the cytosollic DNA signaling pathway[J].Sci signal,2012,5(214):ra20.
[7]Ishikawa H,Barber GN.STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling[J].Nature,2008,455(7 213):674-678.
[8]Konno H,Konno K,Barber GN.Cyclic dinucleotides trigger ULK1(ATG1)phosphorylation of STING to prevent sustained innate immune signaling[J].Cell,2013,155(3):688-698.
[9]Liang QM,Seo GJ,Choi YJ,et al.Crosstalk between the c GAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses[J].Cell Host Microbe,2014,15(2):228-238.
[10]Goubau D,Deddouche S,Reise Sousa C.Cytosolic sensing of viruses[J].Immunity,2013,38(5):855-869.
[11]Gao DX,Li T,Li XD,et al.Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases[J].Proc Natl Acad Sci U S A,2015,112(42):E5 699-E5 705.
[12]Hasan M,Koch J,Rakheja D,et al.Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes[J].Nat Immunol,2013,14(1):61-71.
[13]Kawane K,Ohtani M,Miwa K,et al.Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages[J].Nature,2006,443(7 114):998-1 002.
[14]Manel N,Hogstad B,Wang YM,et al.A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells[J].Nature,2010,467(7 312):214-217.
[15]Gao D,Wu J,Wu YT,et al.Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses[J].Science,2013,341(6 148):903-906.
[16]Nissen SK,Hojen JF,Andersen K,et al.Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates with chronic immune activation[J].Clin Exp Immunol,2014,177(1):295-309.
[17]Laguette N,Sobhian B,Casartelli N,et al.SAMHD1 is the dendritic-and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx[J].Nature,2011,474(7 353):654-657.
[18]Maelfait J,Bridgeman A,Benlahrech A,et al.Restriction by SAMHD1 limits c GAS/STING-dependent innate and adaptive immune responses to HIV-1[J].Cell Rep,2016,16(6):1 492-1 501.
[19]Yoh SM,Schneider M,Seifried JA,et al.PQBP1 is a proximal sensor of the c GAS-dependent innate response to HIV-1[J].Cell,2015,161(6):1 293-1 305.
[20]Vermeire J,Roesch F,Sauter D,et al.HIV triggers a c GASdependent,Vpu-and Vpr-regulated typeⅠinterferon response in CD4+T cells[J].Cell Rep,17(2):413-424.
[21]Sun LJ,Wu JX,Du FH,et al.Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the typeⅠinterferon pathway[J].Science,2013,339(6 121):786-791.
[22]Orzalli MH,Broekema NM,Diner BA,et al.c GAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection[J].Proc Natl Acad Sci U S A,2015,112(14):E1 773-E1 781.
[23]Li XD,Wu J,Gao D,et al.Pivotal roles of c GAS-c GAMP signaling in antiviral defense and immune adjuvant effects[J].Science,2013,341(6 152):1 390-1 394.
[24]Zhou Q,Lin H,Wang SY,et al.The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered,MITA/STING-dependent innate immune signaling[J].Cell Host Microbe,2014,16(4):450-461.
[25]Collins AC,Cai H,Li T,et al.Cyclic GMP-AMP synthase is an innate immune DNA sensor for mycobacterium tuberculosis[J].Cell Host Microbe,2015,17(6):820-828.
[26]Wu JJ,Li WW,Shao YM,et al.Inhibition of c GAS DNA sensing by a herpesvirus virion protein[J].Cell Host Microbe,2015,18(3):333-344.
[27]Liu Y,Jesus AA,Marrero B,et al.Activated STING in a vascular and pulmonary syndrome[J].N Engl J Med,2014,371(6):507-518.
[28]Sharma S,Campbell AM,Chan J,et al.Supression of systemic autoimmunity by the systemtic autoimmunity by the innate immunity adaptor STING[J].Proc Natl Acad Sci U S A,2015,112(7):E 710-717.
[29]Crow YJ,Hayward BE,Parmar R,et al.Mutations in the gene encoding the 3'-5'DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus[J].Nat Genet,2006,38(8):917-920.
[30]Yang H,Wang HZ,Ren JY,et al.c GAS is essential for cellular senescence[J].Proc Natl Acad Sci U S A,2017,114(23):E4 612-E4 620.
[31]Wang H,Hu SQ,Chen X,et al.c GAS is essential for the antitumor effect of immune checkpoint blockade[J].Proc Natl Acad Sci U S A,2017,114(7):1 637-1 642.