HPMC E3对改善大枣提取液喷雾干燥热熔型粘壁现象的作用
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摘要
目的研究羟丙甲基纤维素(HPMC E3)对解决大枣提取液喷雾干燥热熔型粘壁的效果。方法在大枣提取液中加入一定比例的HPMC E3进行喷雾干燥,观察HPMC E3对决定喷雾干燥粘壁效果的作用,同时喷雾干燥的工艺进行优化,并通过对喷雾干燥粉体关键物理性质的表征评价优化效果。结果大枣提取液中添加占干膏量8%的HPMC E3,在工艺为进风温度120℃,雾化压力1.05 bar,进液体积流量4.5 mL/min的条件下进行喷雾干燥,可有效改善热熔型粘壁问题。结论 HPMC E3对改善大枣提取液喷雾干燥热熔型粘壁非常有效。
Objective To study the effect of hypromellose E3(HPMC E3) on the melting wall sticking of Fructus Jujubae Extractum during spray drying. Methods A certain percentage of HPMC E3 were added to the total Fructus Jujubae Extractum to conduct the spray drying. The effect of HPMC E3 against the wall sticking effect of the spray drying was studied. Moreover, the spray drying parameters were investigated. The optimized effect was evaluated by the characterization of the critical physical attributes of the spray drying powder. Results The best formula consisted of 8% HPMC E3, and the optimal spray-drying parameters were composed of inlet air temperature of 120℃,1.05 bar atomization pressure, and 4.5 mL/min pump speed, respectively. Conclusion HPMC E3 is a vital role in improving the melting wall sticking of Fructus Jujubae Extractum.
Objective To study the effect of hypromellose E3(HPMC E3) on the melting wall sticking of Fructus Jujubae Extractum during spray drying. Methods A certain percentage of HPMC E3 were added to the total Fructus Jujubae Extractum to conduct the spray drying. The effect of HPMC E3 against the wall sticking effect of the spray drying was studied. Moreover, the spray drying parameters were investigated. The optimized effect was evaluated by the characterization of the critical physical attributes of the spray drying powder. Results The best formula consisted of 8% HPMC E3, and the optimal spray-drying parameters were composed of inlet air temperature of 120℃,1.05 bar atomization pressure, and 4.5 mL/min pump speed, respectively. Conclusion HPMC E3 is a vital role in improving the melting wall sticking of Fructus Jujubae Extractum.
引文
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[23]于才渊,王宝和,王喜忠.喷雾干燥技术[M].北京:化学工业出版社,2013.
[2]吕子明,于向红,陈凯,等.正交试验法优选黄连浸膏的喷雾干燥工艺[J].中国实验方剂学杂志,2013,19(1):10-12.
[3]严红梅,贾晓斌,张振海,等.大豆多糖辅助淫羊藿总黄酮喷雾干燥及其对粉体学性质的影响[J].中国中药杂志,2015,40(15):2994-2998.
[4]何雁,谢茵,郑龙金,等.空气湿度对中药浸膏喷雾干燥过程的影响及浸膏粉的稳定性预测[J].中国中药杂志,2015,40(3):424-429.
[5]王优杰,冯怡,杨胤,等.辅料对改善强力宁提取液喷雾干燥粘壁现象的作用研究[J].中成药,2012,34(1):34-38.
[6]于才渊,王宝和,王喜忠.喷雾干燥技术[M].北京:化学工业出版社,2013:122.
[7]肖丹,边燕红.白芷配方颗粒的喷雾干燥工艺研究[J].中草药,2006,37(6):874-876.
[8]包汝泼,赵浩如,张志宇.清香片的喷雾干燥工艺研究[J].中成药,2006,28(12):1731-1734.
[9]王晖,陈丽,陈垦,等.多指标综合评价方法及权重系数的选择.广东药学院学报,2007,23(5):583-589.
[10]丁冬梅,张振海,蒋艳荣,等.丹参酮ⅡA喷雾干燥粉体药剂学性质的研究[J].中草药,2014,45(10):1398-1401.
[11]李杰,柳文洁,程泽能.喷雾干燥固体分散技术增加药物溶解性的主要影响因素研究[J].中国药房,2017,28(22):3139-3142.
[12]储茂泉,古宏晨,刘国杰.喷雾干燥法制备丹参酮前体脂质体的研究[J].中国药学杂志,2002,37(1):32-35.
[13]蔡薇,韩静,李智.喷雾干燥技术在中药领域中的应用及进展[J].沈阳药科大学学报,2006,23(9):613-616.
[14]韩飞,曾鸿鹄,张洁,等.安神补眠颗粒喷雾干燥工艺[J].医药导报,2015,(10):1332-1335.
[15]王元清,严建业,杨红艳.喷雾干燥技术及其在中药制剂中的应用[J].时珍国医国药,2005,16(2):161-162.
[16]李智,韩静,岑琴,等.喷雾干燥法改善中药浸膏吸湿性的研究[J].中国药房,2007,18(27):2114-2116.
[17]李金枝.基于HPMC和喷雾干燥的粉末直接压片共处理辅料研究[D].上海中医药大学,2016.
[18]徐忠瑞,张露蓉.正交试验法优选阳虚肺癌协定方的喷雾干燥工艺[J].中国医药导报,2016,13(4):11-15.
[19]吕子明,陈凯,雷波,等.正交试验法优选延胡索浸膏的喷雾干燥工艺[J].中国医药导报,2013,10(2):109-111.
[20]李喜凤,安硕,张伟晓,等.桔梗方提取液喷雾干燥工艺优选[J].天然产物研究与开发,2015,27(7):1151-1155.
[21]周扬,刘力,徐德生,等.纳米喷雾干燥技术用于生地黄低聚糖微粉的制备工艺研究[J].中草药,2016,47(1):65-71.
[22]李金枝,王优杰,林晓,等.星点设计-效应面法优化共处理辅料甘露醇-HPMC的喷雾干燥工艺参数[J].中国医药工业杂志,2015,46(11):1202-1207.
[23]于才渊,王宝和,王喜忠.喷雾干燥技术[M].北京:化学工业出版社,2013.